LOCUS       NM_206966                528 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens chromosome 5 open reading frame 46 (C5orf46), mRNA.
ACCESSION   NM_206966 XM_371774
VERSION     NM_206966.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 528)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 528)
  AUTHORS   Zhong,K., Wang,Y., Wang,Z., Zhang,Z., Zhao,S., Li,H., Huang,J.,
            Guo,W., Zheng,X., Guo,G., Zhou,L., Yang,H. and Tong,A.
  TITLE     AP-64, Encoded by C5orf46, Exhibits Antimicrobial Activity against
            Gram-Negative Bacteria
  JOURNAL   Biomolecules 11 (4), 485 (2021)
   PUBMED   33804835
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 528)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 528)
  AUTHORS   Harney,D.J., Hutchison,A.T., Su,Z., Hatchwell,L., Heilbronn,L.K.,
            Hocking,S., James,D.E. and Larance,M.
  TITLE     Small-protein Enrichment Assay Enables the Rapid, Unbiased Analysis
            of Over 100 Low Abundance Factors from Human Plasma
  JOURNAL   Mol Cell Proteomics 18 (9), 1899-1915 (2019)
   PUBMED   31308252
REFERENCE   5  (bases 1 to 528)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 528)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 528)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011352.6 and AY358656.1.
            
            On Nov 22, 2018 this sequence version replaced NM_206966.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX115935.1, AY358656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2151887
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318315.5/ ENSP00000315370.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC011352.6         24677-24724
            49-528              AY358656.1         13-492
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..528
                     /gene="C5orf46"
                     /gene_synonym="AP-64; SSSP1"
                     /note="chromosome 5 open reading frame 46"
                     /db_xref="GeneID:389336"
                     /db_xref="HGNC:HGNC:33768"
     exon            1..107
                     /gene="C5orf46"
                     /gene_synonym="AP-64; SSSP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..301
                     /gene="C5orf46"
                     /gene_synonym="AP-64; SSSP1"
                     /note="uncharacterized protein C5orf46; skin and saliva
                     secreted protein 1; CTC-327F10.5"
                     /codon_start=1
                     /product="uncharacterized protein C5orf46 precursor"
                     /protein_id="NP_996849.2"
                     /db_xref="CCDS:CCDS34267.1"
                     /db_xref="GeneID:389336"
                     /db_xref="HGNC:HGNC:33768"
                     /translation="MAVSVLRLTVVLGLLVLFLTCYADDKPDKPDDKPDDSGKDPKPD
                     FPKFLSLLGTEIIENAVEFILRSMSRSTGFMEFDDNEGKHSSK"
     exon            108..252
                     /gene="C5orf46"
                     /gene_synonym="AP-64; SSSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..310
                     /gene="C5orf46"
                     /gene_synonym="AP-64; SSSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..528
                     /gene="C5orf46"
                     /gene_synonym="AP-64; SSSP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      501..506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C5orf46"
                     /gene_synonym="AP-64; SSSP1"
                     /note="hexamer: AATAAA"
     polyA_site      528
                     /gene="C5orf46"
                     /gene_synonym="AP-64; SSSP1"
                     /note="major polyA site"
ORIGIN      
        1 gaacaattta tctgcacgaa taccccgtgc taccagaatg gctgtctcag tacttcgcct
       61 gacagttgtc ctgggactgc ttgtcttatt cctgacctgc tatgcagacg acaaaccaga
      121 caagccagac gacaagccag acgactcggg caaagaccca aagccagact tccccaaatt
      181 cctaagcctc ctgggcacag agatcattga gaatgcagtc gagttcatcc tccgctccat
      241 gtccaggagc acaggattta tggaatttga tgataatgaa ggaaaacatt catcaaagtg
      301 acatcctcag gacacaccca tgtggctcct ggacaatcca agagcagcca aatcctgctt
      361 ttccagtttg gctccacaag tcctccagga cagagccctc aaagcaactc ccaacgagtt
      421 ctcaggattc aggctctggc ttcaaccaaa cagaactcat tttgaacacc ctgactgcat
      481 ttttgctttt agaaagttag aataaatatg gcgctttggg atcacata
//
