LOCUS       NM_198566               2502 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens chromosome 5 open reading frame 34 (C5orf34), mRNA.
ACCESSION   NM_198566 XM_351609
VERSION     NM_198566.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2502)
  AUTHORS   Yang,M., Deng,Y., Ma,Y., Song,C., Wu,Z., Yibulayin,X., Sun,X.,
            Guo,Y. and He,D.
  TITLE     Comprehensive pan-cancer analysis reveals that C5orf34 regulates
            the proliferation and mortality of lung cancer
  JOURNAL   Funct Integr Genomics 24 (4), 119 (2024)
   PUBMED   38951221
  REMARK    GeneRIF: Comprehensive pan-cancer analysis reveals that C5orf34
            regulates the proliferation and mortality of lung cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2502)
  AUTHORS   Li,Y., Zhang,Y., Sun,D., Zhang,X., Long,S., Feng,J. and Wang,Z.
  TITLE     Integration of genomics and transcriptomics highlights the crucial
            role of chromosome 5 open reading frame 34 in various human
            malignancies
  JOURNAL   Aging (Albany NY) 15 (23), 14384-14410 (2023)
   PUBMED   38078888
  REMARK    GeneRIF: Integration of genomics and transcriptomics highlights the
            crucial role of chromosome 5 open reading frame 34 in various human
            malignancies.
REFERENCE   3  (bases 1 to 2502)
  AUTHORS   He,D., Wu,Z., He,J., Wang,Y., Li,Z. and Gao,S.
  TITLE     Up-regulation of C5orf34 promotes lung adenocarcinoma migration and
            is correlated with worse prognosis
  JOURNAL   Gene 696, 47-53 (2019)
   PUBMED   30771479
  REMARK    GeneRIF: Study results firstly revealed that C5orf34 might play a
            facilitating role in lung adenocarcinoma (LAD) development and
            progression by regulating MAPK signaling pathway. Furthermore, data
            implied that C5orf34 may be a potential predictor and treatment
            target for LAD.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB453004.1, BC036867.1 and AK056925.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198566.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.129952.1,
                                           SRR1803617.85599.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306862.7/ ENSP00000303490.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               DB453004.1         24-138
            116-358             BC036867.1         1-243
            359-1167            AK056925.1         297-1105
            1168-2502           BC036867.1         1054-2388
FEATURES             Location/Qualifiers
     source          1..2502
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p12"
     gene            1..2502
                     /gene="C5orf34"
                     /note="chromosome 5 open reading frame 34"
                     /db_xref="GeneID:375444"
                     /db_xref="HGNC:HGNC:24738"
     exon            1..343
                     /gene="C5orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            344..574
                     /gene="C5orf34"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..2296
                     /gene="C5orf34"
                     /codon_start=1
                     /product="uncharacterized protein C5orf34"
                     /protein_id="NP_940968.1"
                     /db_xref="CCDS:CCDS3946.1"
                     /db_xref="GeneID:375444"
                     /db_xref="HGNC:HGNC:24738"
                     /translation="MAAELRMILYEDDSVQVQYVDGSTLQLSPCGSEFLFEKSPPVSA
                     HPLEQPERIRQRTHFVISTYREQLQRALDFRNSSATCPFLSETIIPSERKKHIFIDIT
                     EVRWPSLDTDGTMIYMESGIVKITSLDGHAYLCLPRSQHEFTVHFLCKVSQKSDSSAV
                     LSETNNKAPKDKLVEKTGKICIRGNLPGQRLKNKENEFHCQIMKSKETLKKMSCVNGT
                     EGREELPSPGTKHTCVYTWVKQCWSVAACPEEWKYPLSLALHFHNKISNMSKIDAHIT
                     QSRFLTSDISEERGKVVSVLPRALSLSCPVPHLHRWNFCDSLLQRQSDEYSYPELVKM
                     VWYKGVTYRLTHQNMNSIEIYSGDGSVFKSEGAYFGNYFTYYSIQEGSGKREEKTYSV
                     NNLPPDRPGSPFTVGSLIKQATRILQHCVKMRLSLSHNYRICCWKMVPGINDSNILPL
                     VLKESLIPSVGRFLAYSDDKVHAIFLDGITLTLNWNFSSPIEKRQVNQGLNLGWCKLT
                     FPDGQEQLIQIEHPEPYERYVTTVTSWCRRLTQTSPREMPTHSSSSVLQENWSVASEL
                     EKIQKFNLLLENSGILNQISNKKNEQQSFDHYKPGSSETLLGEVNENRVSIALKKTSE
                     ILHDIDCLLSNSKK"
     exon            575..664
                     /gene="C5orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            665..1311
                     /gene="C5orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1407
                     /gene="C5orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1531
                     /gene="C5orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1623
                     /gene="C5orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1693
                     /gene="C5orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1864
                     /gene="C5orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1959
                     /gene="C5orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2058
                     /gene="C5orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2099
                     /gene="C5orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2502
                     /gene="C5orf34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2483..2488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C5orf34"
                     /note="hexamer: AATAAA"
     polyA_site      2502
                     /gene="C5orf34"
                     /note="major polyA site"
ORIGIN      
        1 gttgcggagc tctgaagcgg ctccctgagg gcgctggttt tgaactggtc ttgtgcggtt
       61 tgcgctttct cttagtggtt acagttggcg ctgtctccgc tttcctgttt cgtggcgggc
      121 atcttggcca aaacactctc cctgccacct tattcctcta gggttgtgat ttttttcttt
      181 caccaagaaa tatcactcgc tggtaatttg tcaaactgaa gaaacccctg aagaagcagt
      241 ggtgggcagg cgccgacgct gcggcttcca gagcattttg gcaaatcaaa gccagggacc
      301 gttgctgggc ctcatttccg caacttttcg gctccgaact gcttctttga cttagaagat
      361 atcttatcct gccgttgtaa tggcagctga actgcgaatg atactttatg aagatgattc
      421 agtacaagta caatatgttg atggttccac attgcaactt tctccctgtg gctctgaatt
      481 tttatttgaa aagtcaccac ctgtttcagc acatccttta gaacaaccag aaagaattcg
      541 tcaaaggaca cattttgtca ttagcactta cagagagcaa ctacagcgag ccctagattt
      601 tcgaaactct tcagctactt gccctttttt atctgaaacc atcatacctt ctgaaagaaa
      661 aaagcatatc ttcattgaca taacagaagt gagatggccc agtcttgata cagatggtac
      721 catgatatat atggagagtg gcattgtgaa gataacatct ttagatggtc atgcatacct
      781 ctgcctgccc agatctcagc atgaatttac agtacatttt ttgtgtaaag ttagccagaa
      841 gtcagactca tctgcagtgt tgtcagaaac aaataataaa gccccaaaag ataaactagt
      901 tgaaaaaact ggcaaaatct gtatacgtgg aaatttacca ggacagagac tgaagaataa
      961 agaaaatgag tttcattgcc agatcatgaa atccaaagaa actttaaaga agatgagttg
     1021 tgtaaatgga actgaaggga gggaagagct gccttcgcct ggtacaaagc acacatgtgt
     1081 atacacatgg gtcaagcagt gctggtctgt ggctgcctgt ccagaggaat ggaaatatcc
     1141 tttgtcttta gcacttcatt ttcataataa aatcagcaat atgtctaaaa ttgatgcaca
     1201 tataactcag agtagatttt taacttctga tatttcagag gaaagaggaa aagtggtttc
     1261 tgttcttccc agggccctgt cactcagctg tccagtccca cacctacaca ggtggaattt
     1321 ttgtgattca cttttacaga gacaatctga tgaatattcc tatcctgaac tagtgaaaat
     1381 ggtttggtac aaaggtgtta catatagact tacccatcaa aatatgaact caatagagat
     1441 ttattctggg gatggatctg ttttcaaatc agaaggggct tattttggga actattttac
     1501 ttattattct attcaagaag gatcaggaaa gagagaagag aaaacttact cagtaaataa
     1561 ccttcctcca gatagaccgg gaagtccatt cactgtcggt tctctaatta aacaggcaac
     1621 aagaattctt caacattgtg tgaagatgag actttcttta agccataact atcgtatatg
     1681 ctgctggaaa atggtacctg ggataaatga tagcaatata ctgcctttgg ttttgaaaga
     1741 gtcactcata cccagtgtgg gaagatttct tgcctactct gatgacaaag tacatgctat
     1801 ctttttagat ggcattactc taaccctaaa ttggaatttc agctctccta ttgagaagag
     1861 acaggtaaat caaggtctta acttaggttg gtgtaagtta acttttcctg atggacaaga
     1921 gcagttaatt cagattgaac accctgaacc atatgaaaga tatgtgacaa cagtaacatc
     1981 atggtgcagg agactgaccc agactagtcc cagagagatg cccactcatt cgtcatcttc
     2041 tgttctccaa gaaaattggt ctgttgcttc tgaacttgaa aagatacaga agtttaactt
     2101 gctactagaa aatagtggta tcctaaacca gatttctaac aagaaaaatg aacaacagtc
     2161 ttttgatcat tataaaccag gatcttcaga aaccttgcta ggagaagtta atgaaaatag
     2221 agtatcaata gcattgaaaa aaacctctga aatccttcac gatattgact gtcttctatc
     2281 aaactctaaa aagtgaaaaa tggaattatt acaacatatt attaaagttt aaggatgttg
     2341 tttcaagtga ctggtataaa attactagta agccaagata ttgtacgtat taccccggca
     2401 caatgattgt gaaagaactg acatttaact ttgaaggtat ttttaacttg tacattttta
     2461 aaatatgtat ttatatctta ataataaata tttcgaagtt tt
//
