LOCUS       NM_001135586            5083 bp    mRNA    linear   PRI 18-MAR-2025
DEFINITION  Homo sapiens chromosome 5 open reading frame 24 (C5orf24),
            transcript variant 1, mRNA.
ACCESSION   NM_001135586
VERSION     NM_001135586.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5083)
  AUTHORS   Gao,R., Xu,Y., Zhang,M., Zeng,Q., Zhu,G., Su,W. and Wang,R.
  TITLE     From Gene Discovery to Stroke Risk: C5orf24's Pivotal Role
            Uncovered
  JOURNAL   Mol Neurobiol (2025) In press
   PUBMED   40038197
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 5083)
  AUTHORS   Shi,X., Hu,X., Fang,X., Jia,L., Wei,F., Peng,Y., Liu,M., Gao,A.,
            Zhao,K., Chen,F., Hu,X., Hong,J., Ning,G., Song,Y., Wang,J. and
            Wang,Y.
  TITLE     A feeding-induced myokine modulates glucose homeostasis
  JOURNAL   Nat Metab 7 (1), 68-83 (2025)
   PUBMED   39747483
  REMARK    Erratum:[Nat Metab. 2025 Feb 11. doi: 10.1038/s42255-025-01231-y.
            PMID: 39934457]
REFERENCE   3  (bases 1 to 5083)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA760705.1 and AC006077.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 both encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.8967.1,
                                           SRR1660807.133133.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394976.4/ ENSP00000378427.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               DA760705.1         1-153
            154-172             DA760705.1         155-173
            173-570             DA760705.1         175-572
            571-5083            AC006077.1         22385-26897
FEATURES             Location/Qualifiers
     source          1..5083
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..5083
                     /gene="C5orf24"
                     /note="chromosome 5 open reading frame 24"
                     /db_xref="GeneID:134553"
                     /db_xref="HGNC:HGNC:26746"
     exon            1..245
                     /gene="C5orf24"
                     /inference="alignment:Splign:2.1.0"
     exon            246..5083
                     /gene="C5orf24"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..815
                     /gene="C5orf24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0461 protein C5orf24; feimin"
                     /codon_start=1
                     /product="UPF0461 protein C5orf24 isoform 1"
                     /protein_id="NP_001129058.1"
                     /db_xref="CCDS:CCDS4179.1"
                     /db_xref="GeneID:134553"
                     /db_xref="HGNC:HGNC:26746"
                     /translation="MMHPVASSNPAFCGPGKPSCLNEDAMRAADQFDIYSSQQSKYSH
                     TVNHKPMVCQRQDPLNETHLQTTSGRSIEIKDELKKKKNLNRSGKRGRPSGTTKSAGY
                     RTSTGRPLGTTKAAGFKTSPGRPLGTTKAAGYKVSPGRPPGSIKALSRLADLGYGCGT
                     AAFPYPMMHGRAVHGVEETSSEVKPPNE"
     regulatory      5060..5065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C5orf24"
                     /note="hexamer: AATAAA"
     polyA_site      5083
                     /gene="C5orf24"
                     /note="major polyA site"
ORIGIN      
        1 aacactacag ggtggtagcg gcctcttcgt actgcgtccg gggcaggacc gtgcgcggcg
       61 gccgcggcgg gtgctgggag ccagcgcctg cctcgccgcc gccctcgctg cctgccactc
      121 cgtcttggcc cgttctccgc accgtgcaga ggcggcgggc tggggaggga gcggcgccag
      181 cacgaggttc ccagccgctg ggaagcccct agacgcgccg aggggccggg ctacgagcgg
      241 ctgagaaaat gatgcatcct gttgccagca gtaatccagc tttctgtggg cctggcaagc
      301 cttcctgcct caatgaagat gccatgagag ctgctgatca gtttgacata tattcctccc
      361 agcaaagcaa atacagccac acagtcaacc acaaaccaat ggtttgtcag aggcaagacc
      421 cattaaatga aacacacttg cagactacaa gtggcagaag catagaaata aaagatgaac
      481 taaagaaaaa gaagaatctc aaccgatctg gtaagcgtgg ccggccttcg ggaaccacca
      541 aatcagcagg ataccggacc agcacaggca gacccctggg aaccaccaaa gcagctggat
      601 ttaagacaag tccaggcaga cctttgggga caactaaagc tgcgggatac aaagtcagcc
      661 caggcagacc tccaggtagc attaaagctc tatcccgtct tgccgatctt ggttatggct
      721 gtggcactgc tgcttttcct taccctatga tgcatggcag agcagttcat ggggtagagg
      781 aaactagcag tgaagtcaaa ccacccaatg agtgaatgag gcaggaaaag agggccaggt
      841 ttagaaggaa gattgtgaat aatcccaaag cttcttggtt ttattttgat atacataatt
      901 ttatggcctg ggctttccaa atttgttttc ctgtttggtt tttttcctgc ttttgctcaa
      961 aaactgccat atgctgacag atgcactcag ggcatgagca gcggcattgt atttgtacat
     1021 aggttcaagt gtaacaccta actaaatcat ttttcctttt cctttagagt tatggtcatg
     1081 tctcatgttt cattactact ttggggctgt tctaaataga tgctttatgt gataaacaac
     1141 tgaaaccatt atacctatta gtttgtgaag taagcctaca gtataataaa gacactaacg
     1201 tatttttaac tgatggagca aaaaagcaaa ctaatgaatc aggattactt gaggtaatgg
     1261 ctgtgtgagt ttttgtaaca tttattttca caagatggga cacatatttg tatgctttgg
     1321 catttacatc cacttcaaat gttaaaaaac ttatttttaa tgttttaggt ttaagcagct
     1381 tgtaatttat tgatctacat ggcattaatt gatttaacca ttatacctga aataattctt
     1441 cagtgtttgc ctttgagcag tgataggttg tgtatttttt aattgcctaa gagcatatat
     1501 accaaacact acaaacaatt catatttaca gaaaatttaa actattttat aaaaactgca
     1561 cattacattt ttggtgaaat atagtgcatt ctgaggatag catatttcat ataatagaaa
     1621 aagaagcatt ctctaggttt gcatgtagct atagtcacta tattttgcct ttcatataga
     1681 aagttttaaa gtattatgtt taaaaacatt tattggctgg gtgtggtggc tcacacccag
     1741 cactttggga ggccgaggca ggcggatcac ttgaggtcag cagttcaaga ctagcctggc
     1801 caacatggtg aaaccccatc tctactaaaa atataaaaat tagccaggcg tggtggcggg
     1861 cgcctgtaat ccaagctact ggggaggctg aggcaggaga attgcttaaa tccaggaggc
     1921 ggaggttgca gtgagccaag attgtgccac tgcactccag cctgggtgac agagtaagac
     1981 tccgtctcaa ataaataaat aaataaataa ataaataaat aaataaataa aaccatttat
     2041 tgatgttgct catttatttg gaacgttttt agtttttctc agaaattgtc ccattgcatt
     2101 agcacttact gtgttttcag gttgatatct accaaaggac acaaattgaa tggtagactg
     2161 taaaactggt ataaacagaa tgcagtttcc cgaccatcag aacccaaata ttaagaagca
     2221 tataggaatc catctatgca tgaaacatgt aaaaaatatg ttggttagtt taattaaaaa
     2281 tcttattgtg ggtccagtga gaccatctca tccaaaagat tttttttccc ccaatgatgt
     2341 ttgctttaga agcaagatag aaaggaaaaa aagtattagg tagatatgta tagtagggac
     2401 agagggaaat ctttcttctt tcctttctga aagtaatact tcttgttaca cattttattt
     2461 attgagtttg ttctaaataa aatattataa acttcagact tgaaaaaatt ccacttaact
     2521 ttaaagttac aatgtttgta tttgggattt taaatgcctt tgagattaaa atgtagaatt
     2581 gcaggaccca aaaactttta aaataattaa aattttaaaa gagcacatgt tgtgtttttt
     2641 gggcttgcta ttaatgcaaa ctctgattgc aaatggatgt catgtttcat acctttttta
     2701 tcaggaaaaa agcagcaagc cttcaggtgt tccagtgatg cctgacacaa ttgagctgga
     2761 ctttatgctg ctctttacag taagaggtgt tgcattgtat gtggggacta tgtgcactgg
     2821 cgtctaagac agtgacctca acaatattag ctttgcacaa accatagaga acgatgttgg
     2881 atggttacat aatcagttat aacattctgg cagctaaatt gctacaagag ctttttcttg
     2941 caaaagctta aaatacaaga tttttaataa tttactcaga acagtataac ttctgacaca
     3001 cacaaatgct tgcctcttta ttcatatgtt cgttacctac tctgtacatg tatctgtcat
     3061 ttagctgttt ctcaagatga tgttcagcag ttggctgctt agaaatcttt ttcaagccag
     3121 tttctaaaga catttgttta atgttctacc atagaataat gcacaccatt gtcaaagatt
     3181 tgattattgt gttttatagt aagtccattt gacatttatt tccctttcag tttattttcc
     3241 ttccttattt tgttatacat acccttccct ttctcccctg cctttcgtac attcattcct
     3301 cttcctctac cctccagcac atctacttac tggtgctgtg ctgtgtgtca gaagataaaa
     3361 caggtgtatt attgtataat gaattttgta tacatgttta tgaaatggtg agatcaacta
     3421 aaggaggcat gttcataaca gtgtttatta tcagcagcta tgtcccagga aaaaaaaatg
     3481 ggaggggcaa atggctacag ttgtaaatgg ataacatcat ttagaaagcc gaatttactg
     3541 ttcatctgag cggttacctg gagtattata tctatgcact ggtgagcatc tcctgattcc
     3601 acttactttt ctccctgtga acagtttacc ggtgccatgc tgaagagaaa gacatctaag
     3661 tgataacatg aatgaagtct taaaatttaa agtattttta ctgctatata aactaaagac
     3721 tacattgtgc atattttgtt aacactgtct cttgttatga taaacactga aatagcatgt
     3781 taaacagttg cctatacttt aatataatca gttggggaaa actggccttt tctcccccac
     3841 tgtatgattg tttcttgaaa ggtaaattgc taattttata cagtgtaatt ctgttcttca
     3901 caaaataggt ttcattattc tatatttaaa ctgttggtca gaaaatgatc tgcaattcaa
     3961 gtaagtctgc attacttttt tctttaaaaa gtactttaac atgccttatt tattatatta
     4021 gcaaatgagc taataacaga tgaaattttc attttttgac agatataacc ttgcataagt
     4081 agtatttagg gtgattttga tactatcttt agagttttgc attggatatt aaaaaatata
     4141 ttggcacaat gtattggaag aaaatgagta gtatctggtt taatttttaa tatttaggga
     4201 cattttaaaa aatcaatgtt ttaattagac taaaaattct ttatattttt tatttacttt
     4261 ttaaagaaac atctgtcaaa gtaatattga ttccaaactg atgtttgtgt gaatttacat
     4321 gtctattttc atgaactaag aatagagttt ctttgagttg aggagaaaaa aatatatatg
     4381 tgggtccatt tattaggtta aagttgaccc attcagtgta aaaataacca tagtgtgtga
     4441 gctaaagaaa aaaaaaagta aatttctcct ttatattcta agaagcttta aaagaacaat
     4501 tcaggggtta ttgataactg ctactctgtc ggtcattgtc tctatatgca gtaaaatttt
     4561 atggtccctt tataggaata taaagaattc aaaacagttt ttcaaaagat ttttttcctt
     4621 ggacataaaa aattttgatg ctattctatt tttgttttta ttacagctta actgtatgct
     4681 gttaaactct aggatgtatc tgaatctttc cttttttccc ccctcctcca aatatataaa
     4741 tctgtgctct cacatgtaat gtatttaatt tttggaaaat ttaatgctat atagtaaatc
     4801 aagtgtgtga tttaaagtaa tcagatcact ttgattcttt taagttttca gaatttcttt
     4861 tttccacagg taattttgga gaaaataatt accaattaac tgataataag cacgctgtcc
     4921 tctgctgtaa aaagtctgaa tagatactgt gtatgttttt atgtccatga acttgagcta
     4981 ctcgtgtgca attatgtgta tgggaatgga gtagtgttca tgatttgtat ctacatcatc
     5041 atatggatgt atatttatta ataaagtcat tactttaaaa cca
//
