LOCUS       NM_018356               3572 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens chromosome 5 open reading frame 22 (C5orf22),
            transcript variant 1, mRNA.
ACCESSION   NM_018356
VERSION     NM_018356.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3572)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3572)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3572)
  AUTHORS   Zi,Z., Zhang,Y., Zhang,P., Ding,Q., Chu,M., Chen,Y., Minna,J.D. and
            Yu,Y.
  TITLE     A Proteomic Connectivity Map for Characterizing the Tumor Adaptive
            Response to Small Molecule Chemical Perturbagens
  JOURNAL   ACS Chem Biol 15 (1), 140-150 (2020)
   PUBMED   31846293
  REMARK    GeneRIF: A Proteomic Connectivity Map for Characterizing the Tumor
            Adaptive Response to Small Molecule Chemical Perturbagens.
REFERENCE   4  (bases 1 to 3572)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA783320.1, BC021215.2, AK074385.1, AV710784.1, BM683466.1 and
            AI300780.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018356.2.
            
            Transcript Variant: This variant (1) encodes the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.82345.1,
                                           SRR1660803.105886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325366.14/ ENSP00000326879.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DA783320.1         10-37
            29-1787             BC021215.2         1-1759
            1788-2362           AK074385.1         791-1365
            2363-2875           AV710784.1         85-597
            2876-3298           BM683466.1         48-470              c
            3299-3572           AI300780.1         10-283              c
FEATURES             Location/Qualifiers
     source          1..3572
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.3"
     gene            1..3572
                     /gene="C5orf22"
                     /note="chromosome 5 open reading frame 22"
                     /db_xref="GeneID:55322"
                     /db_xref="HGNC:HGNC:25639"
     exon            1..173
                     /gene="C5orf22"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1421
                     /gene="C5orf22"
                     /codon_start=1
                     /product="UPF0489 protein C5orf22"
                     /protein_id="NP_060826.2"
                     /db_xref="CCDS:CCDS3895.1"
                     /db_xref="GeneID:55322"
                     /db_xref="HGNC:HGNC:25639"
                     /translation="MSDSAGGRAGLRRYPKLPVWVVEDHQEVLPFIYRAIGSKHLPAS
                     NVSFLHFDSHPDLLIPVNMPADTVFDKETLFGELSIENWIMPAVYAGHFSHVIWFHPT
                     WAQQIREGRHHFLVGKDTSTTTIRVTSTDHYFLSDGLYVPEDQLENQKPLQLDVIMVK
                     PYKLCNNQEENDAVSSAKKPKLALEDSENTASTNCDSSSEGLEKDTATQRSDQTCLEP
                     SCSCSSENQECQTAASTGEILEILKKGKAFVLDIDLDFFSVKNPFKEMFTQEEYKILQ
                     ELYQFKKPGTNLTEEDLVDIVDTRIHQLEDLEATFADLCDGDDEETVQRWASNPGMES
                     LVPLVQSLKKRMEVPDYEMVHQAGLTCDYSELPHHISTEQEIECLIQSVHYLLKNLPN
                     PTLVTIARSSLDDYCPSDQVDTIQEKVLNMLRALYGNLDLQVYAAESPPS"
     exon            174..319
                     /gene="C5orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            320..469
                     /gene="C5orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            470..899
                     /gene="C5orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            900..962
                     /gene="C5orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1084
                     /gene="C5orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1151
                     /gene="C5orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1291
                     /gene="C5orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..3572
                     /gene="C5orf22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3305..3310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C5orf22"
                     /note="hexamer: AATAAA"
     polyA_site      3327
                     /gene="C5orf22"
                     /note="major polyA site"
     regulatory      3374..3379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C5orf22"
                     /note="hexamer: AATAAA"
     polyA_site      3405
                     /gene="C5orf22"
     regulatory      3538..3543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C5orf22"
                     /note="hexamer: ATTAAA"
     polyA_site      3572
                     /gene="C5orf22"
ORIGIN      
        1 gcccggagag agctggccgg gatgaggcgc cggctttccc gggtcttctc cagctgccac
       61 cgctttactg caaaactgac gggcgcaaaa acatgagtga ctccgcggga gggcgcgctg
      121 gtctccggcg ttaccccaag ctcccagtgt gggtggtgga ggatcatcag gaggttctac
      181 cctttatata ccgggccata ggctcaaagc atcttcctgc cagtaatgta agttttttac
      241 atttcgactc acatccagac ctccttattc ctgtgaatat gccagcagac accgtgtttg
      301 ataaggaaac actctttgga gaattaagta ttgaaaattg gattatgcct gcagtttatg
      361 ctggccattt ttcacatgta atatggtttc atcccacatg ggctcagcag atcagagagg
      421 gcagacacca ctttttagta ggcaaagaca cttctaccac aacaatcagg gttacaagta
      481 cagatcatta tttcctaagt gatggtctgt atgtacctga agaccagcta gagaaccaaa
      541 aacctttaca attggatgta attatggtaa aaccttataa actctgtaac aatcaagaag
      601 aaaacgatgc agtgtcttct gctaagaaac caaagctagc cctggaagat tcggaaaaca
      661 ctgcctctac taactgtgac tcttcttcag aaggactgga aaaggacaca gcaacacaga
      721 gaagtgacca gacttgccta gaaccatcat gttcatgttc ttctgaaaat caggaatgcc
      781 agactgctgc cagcactggg gaaattctgg aaattttgaa gaaagggaag gcatttgttt
      841 tagatattga cttggatttt ttttcagtca agaatccctt caaagaaatg ttcactcagg
      901 aagagtacaa aatcttacaa gagctgtacc aatttaagaa acctggcacc aacctaacag
      961 aggaagattt ggtagatatt gttgatactc gaattcatca attagaggat ttagaagcca
     1021 ctttcgctga tttgtgtgat ggtgatgatg aagaaacggt acagagatgg gcttcaaacc
     1081 ctggaatgga atcactagtt ccccttgtac agagtttgaa aaaacggatg gaagtaccag
     1141 actatgaaat ggttcaccag gctggtttaa cctgcgatta ttcagaactt cctcaccata
     1201 tcagcacaga acaagaaata gagtgtctta ttcaatctgt gcattatttg ctgaaaaatt
     1261 taccaaatcc tactcttgtg acaattgcaa ggtcaagtct ggatgattac tgtccttctg
     1321 accaagttga cactattcaa gaaaaggtcc tcaatatgct acgtgccctc tatggaaatc
     1381 tagacctcca agtgtatgca gcagagtctc ctccatcttg aaacaaacaa aacattaggc
     1441 tcctgttgta tcttggttta gtaacaggcc cttaattaac ttatttgtac atgagtcttc
     1501 cagagaacac tgttttatat taactttcag ttgaaatctt tcagatattt tgaatctctg
     1561 aacaaccatt gtcagttgtg aatgatggta aattttttgg catcaagtct cataacccca
     1621 actgatagaa ctgttgctta tctgtcttcc ttaagtattt tttagggttt tgtttttttt
     1681 tttgtttgtt tgtttgtttg tcttcacttt tcccccaggt ctgttgagct gtatgagatt
     1741 cattcatact tcatttattc attcaactaa tatttgttga acacttacat gtaccagaca
     1801 ttattaagtg ctgggtatat ggtaatgaac agaatagaca aggcccctgc ccttttaggg
     1861 gagacagatg agaagtaaat tacgggttat gagaaatgtt atgaaggaaa ggacaacaac
     1921 agacatgtct tagtacttag ggtatcatgg ctttatagga aagtaacatt ctctatcttt
     1981 tttttttttt ttaattttat aaaaatagag atggggtctc accatgttac ccaggctggt
     2041 ctcaaactcc tgggcacaag caatccacct gccttcgcct cccgaagtgc tgggattaca
     2101 gatgtaagtc actaccccag ccagaaacta acattctcaa aagctactac caaaaaaacc
     2161 ccacaaattt gccaatccat gaaagtatca taggaagtct acctttccaa ggaatttggc
     2221 attgtggccc tgctcttgcc aaatgctctc cagcattgtt ggtatcaagg tggtctggtt
     2281 gagtaaactt gaccaaacaa aaattaactg ttttttgctt ttctgttttt gttttgctga
     2341 tcaaaaaagc ccttcagggt ctcttgtgca tccaggaggt cattgtagat atcaataata
     2401 tagtgcctaa gtgccacttt attgccaagt ctagattgat acttttttca gataaaccag
     2461 ctttttatgt aaagagtaag ggaaaaagtt aaatctttaa ttctgacctg ccataaatac
     2521 ccaaagatat aaactgtctt ccaccacccc cctcataact aagacatcct tcctgagtca
     2581 ctcttaatca tgaaacttga ttttctcaat tggccagtct tctgatcttt agtatctctt
     2641 tagttcagta atttttacct acctacttga tttattttcc tttaaaaggt gaaatgacat
     2701 ttaaagaaaa acaaacaccc atcattcctc agtcccaaca cagcagttct tttcactctt
     2761 gcttgtaact ttcaggcctt acccacatgt gttcctatag agttgcatgt agctaaaatt
     2821 atagtgtgct gcctaacttt gtgctaataa cgaaggacac acattatcat tgcctcacag
     2881 tggatggcac ctgaccccat ttttccaagg attctatttt ccagtgaatt tttgtcaccg
     2941 agttaatttc ccaagtctga tagcatgaat gcttatttgt gctgtgaaaa gcagagcagc
     3001 ctgactcagc tttccatttt cataggataa tatgtgccaa aaaaggttta ttttcttggt
     3061 aaaatcagaa ttgtagaatt gtgctatttt taatttttaa aatttttggt tagagcttat
     3121 agacattact tttatgatta ttttgcgtgc taaataagtt aaagggtatg ttttgaacta
     3181 tagcactaat taatgtgtgt gatcctagta tgttgatagc tttgattttg tgagtggttt
     3241 actagtcatt tattatgatt cccatgaact ctgatatgat tcattgtggt tttaactcag
     3301 gttgaataaa agcatccatt tcttttatag gaaggtttgt ttaattctca tgttctgtga
     3361 tcatctcttt gagaataaaa ttcagtccct aatagttgaa aagaatcaac ttagtaaatt
     3421 atgtcttgca cattccaaat aggaaggtat ttactttatc aagatgtgtt tcatttgtgt
     3481 tctgagtacc agtgagggga taccgtggta cagtgttttg aattgtgtac taatatcatt
     3541 aaagcatggg attttagtgg ctttttaaaa aa
//
