LOCUS       NM_020199               2188 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens chromosome 5 open reading frame 15 (C5orf15), mRNA.
ACCESSION   NM_020199
VERSION     NM_020199.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2188)
  AUTHORS   Ding,Y., Chu,L., Cao,Q., Lei,H., Li,X. and Zhuang,Q.
  TITLE     A meta-validated immune infiltration-related gene model predicts
            prognosis and immunotherapy sensitivity in HNSCC
  JOURNAL   BMC Cancer 23 (1), 45 (2023)
   PUBMED   36639648
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2188)
  AUTHORS   Xie,T., Deng,L., Mei,P., Zhou,Y., Wang,B., Zhang,J., Lin,J.,
            Wei,Y., Zhang,X. and Xu,R.
  TITLE     Genome-wide association study combining pathway analysis for
            typical sporadic amyotrophic lateral sclerosis in Chinese Han
            populations
  JOURNAL   Neurobiol Aging 35 (7), 1778 (2014)
   PUBMED   24529757
REFERENCE   3  (bases 1 to 2188)
  AUTHORS   Anney,R.J., Lasky-Su,J., O'Dushlaine,C., Kenny,E., Neale,B.M.,
            Mulligan,A., Franke,B., Zhou,K., Chen,W., Christiansen,H.,
            Arias-Vasquez,A., Banaschewski,T., Buitelaar,J., Ebstein,R.,
            Miranda,A., Mulas,F., Oades,R.D., Roeyers,H., Rothenberger,A.,
            Sergeant,J., Sonuga-Barke,E., Steinhausen,H., Asherson,P.,
            Faraone,S.V. and Gill,M.
  TITLE     Conduct disorder and ADHD: evaluation of conduct problems as a
            categorical and quantitative trait in the international multicentre
            ADHD genetics study
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (8), 1369-1378 (2008)
   PUBMED   18951430
REFERENCE   4  (bases 1 to 2188)
  AUTHORS   Bonkobara,M., Das,A., Takao,J., Cruz,P.D. and Ariizumi,K.
  TITLE     Identification of novel genes for secreted and membrane-anchored
            proteins in human keratinocytes
  JOURNAL   Br J Dermatol 148 (4), 654-664 (2003)
   PUBMED   12752121
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP245947.1, BC020875.1 and BM681428.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020199.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF226055.1, BC020875.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1970526,
                                           SAMEA2149876 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000231512.5/ ENSP00000231512.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BP245947.1         91-109
            20-2179             BC020875.1         1-2160
            2180-2188           BM681428.1         21-29               c
FEATURES             Location/Qualifiers
     source          1..2188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..2188
                     /gene="C5orf15"
                     /gene_synonym="HTGN29; KCT2"
                     /note="chromosome 5 open reading frame 15"
                     /db_xref="GeneID:56951"
                     /db_xref="HGNC:HGNC:20656"
     exon            1..180
                     /gene="C5orf15"
                     /gene_synonym="HTGN29; KCT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..839
                     /gene="C5orf15"
                     /gene_synonym="HTGN29; KCT2"
                     /note="keratinocytes associated transmembrane protein 2;
                     keratinocyte-associated transmembrane protein 2"
                     /codon_start=1
                     /product="keratinocyte-associated transmembrane protein 2
                     precursor"
                     /protein_id="NP_064584.1"
                     /db_xref="CCDS:CCDS4167.1"
                     /db_xref="GeneID:56951"
                     /db_xref="HGNC:HGNC:20656"
                     /translation="MAAAVPKRMRGPAQAKLLPGSAIQALVGLARPLVLALLLVSAAL
                     SSVVSRTDSPSPTVLNSHISTPNVNALTHENQTKPSISQISTTLPPTTSTKKSGGASV
                     VPHPSPTPLSQEEADNNEDPSIEEEDLLMLNSSPSTAKDTLDNGDYGEPDYDWTTGPR
                     DDDESDDTLEENRGYMEIEQSVKSFKMPSSNIEEEDSHFFFHLIIFAFCIAVVYITYH
                     NKRKIFLLVQSRKWRDGLCSKTVEYHRLDQNVNEAMPSLKITNDYIF"
     exon            181..707
                     /gene="C5orf15"
                     /gene_synonym="HTGN29; KCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..2188
                     /gene="C5orf15"
                     /gene_synonym="HTGN29; KCT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2164..2169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C5orf15"
                     /gene_synonym="HTGN29; KCT2"
                     /note="hexamer: AATAAA"
     polyA_site      2188
                     /gene="C5orf15"
                     /gene_synonym="HTGN29; KCT2"
                     /note="major polyA site"
ORIGIN      
        1 gtagagccta gcaacagcgc aggctcccag ccgagtccgt tatggccgct gccgtcccga
       61 agaggatgag ggggccagca caagcgaaac tgctgcccgg gtcggccatc caagcccttg
      121 tggggttggc gcggccgctg gtcttggcgc tcctgcttgt gtccgccgct ctatccagtg
      181 ttgtatcacg gactgattca ccgagcccaa ccgtactcaa ctcacatatt tctaccccaa
      241 atgtgaatgc tttaacacat gaaaaccaaa ccaaaccttc tatttcccaa atcagcacca
      301 ccctccctcc cacgacgagt accaagaaaa gtggaggagc atctgtggtc cctcatccct
      361 cgcctactcc tctgtctcaa gaggaagctg ataacaatga agatcctagt atagaggagg
      421 aggatcttct catgctgaac agttctccat ccacagccaa agacactcta gacaatggcg
      481 attatggaga accagactat gactggacca cgggccccag ggacgacgac gagtctgatg
      541 acaccttgga agaaaacagg ggttacatgg aaattgaaca gtcagtgaaa tcttttaaga
      601 tgccatcctc aaatatagaa gaggaagaca gccatttctt ttttcatctt attatttttg
      661 ctttttgcat tgctgttgtt tacattacat atcacaacaa aaggaagatt tttcttctgg
      721 ttcaaagcag gaaatggcgt gatggccttt gttccaaaac agtggaatac catcgcctag
      781 atcagaatgt taatgaggca atgccttctt tgaagattac caatgattat attttttaaa
      841 gcactgtgat ttgaatttgc ttatgtaatt ttatttgctt gactttttat atgatattgt
      901 gcaaatgttt gccataggca attggtactt aaatgagagg tgagtctctc ttttgccttg
      961 gtgctttgga aattaaatgt cacaaacgag tatataattt tttatctgta cttttagagc
     1021 tgagtttaat caggtgtcca aaatgtgagt taaacattac cttatattta cactgttagt
     1081 ttttattgtt ttagatttat tatgcttctt ctggaagtat tagtgatgct acttttaaaa
     1141 gatcccaaac ttgtaactaa attctgacat atctgttact gctgactcac attcattctc
     1201 cgccattcaa atactatttt ttatccacat ttttttttgt tcccaaactg taatgtacaa
     1261 ggatatgtgt gataatgctt tggatttgag taatattttt ttttcttcca agaaaactgc
     1321 tttggatatt tttagataat ttaaacataa tttaggataa tgatattgct caatctgacc
     1381 acaattttag gtaaaacatt aaatgtgtca agaaatcttg gcaacagaga ctctgcagct
     1441 tgcagtggac atagataaaa tgttacagag atactatttt tttggttgga attactatat
     1501 taaatttaga agcagaaact ggtaaaatgt taaatacatg tacaattgct tttagttagc
     1561 aattgattgt agcatgggtt cctccaaggt ttcaagcaat gggcagagtt taaaattata
     1621 tcagattcgt ttacttcgtt tattatttta cagtaaattt gaataaatct taggggtcat
     1681 tatcacttaa ataatactgt acctaggtct ttcaaattaa aattatacct gaatgaagtt
     1741 gtttgtatac ataaaggata tttgtgtaca attacctttt ttcccccaca cttgttttct
     1801 ttgtttttgt tttttatggc aactggaaag tatttactat gggattcatt tatgtctgtc
     1861 tttctatcat aaagaattga tcaatatgta aatatgtgat ttgaaccatg gttgacttac
     1921 aagtgtcact acagcttttt agaaaacata gccctaatat atgttaagca ggacccgggt
     1981 gagccagtgg gcttgcgctt tatgtagagc tggaagaagg ccgtccatcc tgtctcttgg
     2041 gcggacagtg tactttccta atagggaagg gaagcacaat ggaaataccc ctgaaccgtt
     2101 ttattgcagt aatttttttc atatctgaaa ctattattta atattttgaa taagatttta
     2161 aaaaataaat ggcaaagata taaatcta
//
