LOCUS       NM_001271749            6720 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens complement C5a receptor 2 (C5AR2), transcript variant
            1, mRNA.
ACCESSION   NM_001271749
VERSION     NM_001271749.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6720)
  AUTHORS   Wright,O., Harris,A., Nguyen,V.D., Zhou,Y., Durand,M.,
            Jayyaratnam,A., Gormley,D., O'Neill,L.A.J., Triantafilou,K.,
            Nichols,E.M. and Booty,L.M.
  TITLE     C5aR2 Regulates STING-Mediated Interferon Beta Production in Human
            Macrophages
  JOURNAL   Cells 12 (23), 2707 (2023)
   PUBMED   38067135
  REMARK    GeneRIF: C5aR2 Regulates STING-Mediated Interferon Beta Production
            in Human Macrophages.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6720)
  AUTHORS   Irfan,M. and Chung,S.
  TITLE     C5L2 modulates BDNF production in human dental pulp stem cells via
            p38alpha pathway
  JOURNAL   Sci Rep 13 (1), 74 (2023)
   PUBMED   36593314
  REMARK    GeneRIF: C5L2 modulates BDNF production in human dental pulp stem
            cells via p38alpha pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6720)
  AUTHORS   Emtenani,S., Holtsche,M.M., Stahlkopf,R., Seiler,D.L., Burn,T.,
            Liu,H., Parker,M., Yilmaz,K., Dikmen,H.O., Lang,M.H., Sadik,C.D.,
            Karsten,C.M., van Beek,N., Ludwig,R.J., Kohl,J. and Schmidt,E.
  TITLE     Differential expression of C5aR1 and C5aR2 in innate and adaptive
            immune cells located in early skin lesions of bullous pemphigoid
            patients
  JOURNAL   Front Immunol 13, 942493 (2022)
   PUBMED   36466856
  REMARK    GeneRIF: Differential expression of C5aR1 and C5aR2 in innate and
            adaptive immune cells located in early skin lesions of bullous
            pemphigoid patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6720)
  AUTHORS   Li,X.X., Clark,R.J. and Woodruff,T.M.
  TITLE     C5aR2 Activation Broadly Modulates the Signaling and Function of
            Primary Human Macrophages
  JOURNAL   J Immunol 205 (4), 1102-1112 (2020)
   PUBMED   32611725
  REMARK    GeneRIF: C5aR2 Activation Broadly Modulates the Signaling and
            Function of Primary Human Macrophages.
REFERENCE   5  (bases 1 to 6720)
  AUTHORS   Laursen,N.S., Magnani,F., Gottfredsen,R.H., Petersen,S.V. and
            Andersen,G.R.
  TITLE     Structure, function and control of complement C5 and its
            proteolytic fragments
  JOURNAL   Curr Mol Med 12 (8), 1083-1097 (2012)
   PUBMED   22812419
  REMARK    Review article
REFERENCE   6  (bases 1 to 6720)
  AUTHORS   Otto,M., Hawlisch,H., Monk,P.N., Muller,M., Klos,A., Karp,C.L. and
            Kohl,J.
  TITLE     C5a mutants are potent antagonists of the C5a receptor (CD88) and
            of C5L2: position 69 is the locus that determines agonism or
            antagonism
  JOURNAL   J Biol Chem 279 (1), 142-151 (2004)
   PUBMED   14570896
  REMARK    GeneRIF: A8Delta71-73 is the first antagonist of c5a that blocks
            C5a and C5adesArg74 binding to C5L2 making it a valuable tool for
            studying C5L2 functions.
REFERENCE   7  (bases 1 to 6720)
  AUTHORS   Kalant,D., Cain,S.A., Maslowska,M., Sniderman,A.D., Cianflone,K.
            and Monk,P.N.
  TITLE     The chemoattractant receptor-like protein C5L2 binds the C3a
            des-Arg77/acylation-stimulating protein
  JOURNAL   J Biol Chem 278 (13), 11123-11129 (2003)
   PUBMED   12540846
  REMARK    GeneRIF: C3a des Arg77 binds to C5L2 but not to the C3a receptor
            (LocusID: 719).  C3a and C3a des Arg77 both stimulate triglyceride
            synthesis (acylation stimulating protein, ASP) in adipocytes and
            fibroblasts and so C5L2 could be the receptor for ASP.
            Erratum:[J Biol Chem. 2004 Jan 2;279(1):820]
REFERENCE   8  (bases 1 to 6720)
  AUTHORS   Cain,S.A. and Monk,P.N.
  TITLE     The orphan receptor C5L2 has high affinity binding sites for
            complement fragments C5a and C5a des-Arg(74)
  JOURNAL   J Biol Chem 277 (9), 7165-7169 (2002)
   PUBMED   11773063
  REMARK    GeneRIF: These results suggest that C5L2 is an
            anaphylatoxin-binding protein with unique ligand binding and
            signaling properties.
            GeneRIF: C5L2 is a high affinity binding protein for C5a and C5a
            des Arg74, and has a moderate affinity for C3a. Unlike the original
            receptors for C5a (CD88) and C3a (C3aR), C5L2 couples weakly to
            Gi-mediated signalling pathways.
REFERENCE   9  (bases 1 to 6720)
  AUTHORS   Lee,D.K., George,S.R., Cheng,R., Nguyen,T., Liu,Y., Brown,M.,
            Lynch,K.R. and O'Dowd,B.F.
  TITLE     Identification of four novel human G protein-coupled receptors
            expressed in the brain
  JOURNAL   Brain Res Mol Brain Res 86 (1-2), 13-22 (2001)
   PUBMED   11165367
REFERENCE   10 (bases 1 to 6720)
  AUTHORS   Ohno,M., Hirata,T., Enomoto,M., Araki,T., Ishimaru,H. and
            Takahashi,T.A.
  TITLE     A putative chemoattractant receptor, C5L2, is expressed in
            granulocyte and immature dendritic cells, but not in mature
            dendritic cells
  JOURNAL   Mol Immunol 37 (8), 407-412 (2000)
   PUBMED   11090875
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313994.1, AB038237.1 and
            AC008754.8.
            
            On May 17, 2019 this sequence version replaced NM_001271749.1.
            
            Summary: This gene encodes a G-protein coupled receptor 1 family
            member involved in the complement system of the innate immune
            response. Unlike classical G-protein coupled receptors, the encoded
            protein does not associate with intracellular G-proteins. It may
            instead modulate signal transduction through the beta-arrestin
            pathway, and may alternatively act as a decoy receptor. This gene
            may be involved in coronary artery disease and in the pathogenesis
            of sepsis. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313994.1, DA980912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000595464.3/ ENSP00000472620.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1204              AK313994.1         29-1232
            1205-1406           AB038237.1         1086-1287
            1407-6720           AC008754.8         55445-60758         c
FEATURES             Location/Qualifiers
     source          1..6720
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..6720
                     /gene="C5AR2"
                     /gene_synonym="C5L2; GPF77; GPR77"
                     /note="complement C5a receptor 2"
                     /db_xref="GeneID:27202"
                     /db_xref="HGNC:HGNC:4527"
                     /db_xref="MIM:609949"
     exon            1..175
                     /gene="C5AR2"
                     /gene_synonym="C5L2; GPF77; GPR77"
                     /inference="alignment:Splign:2.1.0"
     exon            176..6720
                     /gene="C5AR2"
                     /gene_synonym="C5L2; GPF77; GPR77"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1204
                     /gene="C5AR2"
                     /gene_synonym="C5L2; GPF77; GPR77"
                     /note="G protein-coupled receptor C5L2; C5a anaphylatoxin
                     chemotactic receptor C5L2; G protein-coupled receptor 77;
                     complement component 5a receptor 2"
                     /codon_start=1
                     /product="C5a anaphylatoxin chemotactic receptor 2"
                     /protein_id="NP_001258678.1"
                     /db_xref="CCDS:CCDS12699.1"
                     /db_xref="GeneID:27202"
                     /db_xref="HGNC:HGNC:4527"
                     /db_xref="MIM:609949"
                     /translation="MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAA
                     IFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPY
                     GAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWT
                     LALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVAS
                     CHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLI
                     VGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSE
                     MEV"
     regulatory      2713..2718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C5AR2"
                     /gene_synonym="C5L2; GPF77; GPR77"
                     /note="hexamer: AATACA"
     polyA_site      2737
                     /gene="C5AR2"
                     /gene_synonym="C5L2; GPF77; GPR77"
                     /note="major polyA site"
     regulatory      3752..3757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C5AR2"
                     /gene_synonym="C5L2; GPF77; GPR77"
                     /note="hexamer: AATAAA"
     polyA_site      3771
                     /gene="C5AR2"
                     /gene_synonym="C5L2; GPF77; GPR77"
                     /note="major polyA site"
     regulatory      6458..6463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C5AR2"
                     /gene_synonym="C5L2; GPF77; GPR77"
                     /note="hexamer: ATTAAA"
     polyA_site      6483
                     /gene="C5AR2"
                     /gene_synonym="C5L2; GPF77; GPR77"
ORIGIN      
        1 ggcagtgctc agcagcatcc gacaggagcc ctggcaaaca ggacggattt ccaggactct
       61 accagctgcc agacacggca gggagagacc ccagacctcc tgggtcctgg ctgtgggccc
      121 ggattgggct cccaagtggc gtttgactca cgtggggaca ctcttggaag agacgacacc
      181 aggagcctga atggggaacg attctgtcag ctacgagtat ggggattaca gcgacctctc
      241 ggaccgccct gtggactgcc tggatggcgc ctgcctggcc atcgacccgc tgcgcgtggc
      301 cccgctccca ctgtatgccg ccatcttcct ggtgggggtg ccgggcaatg ccatggtggc
      361 ctgggtggct gggaaggtgg cccgccggag ggtgggtgcc acctggttgc tccacctggc
      421 cgtggcggat ttgctgtgct gtttgtctct gcccatcctg gcagtgccca ttgcccgtgg
      481 aggccactgg ccgtatggtg cagtgggctg tcgggcgctg ccctccatca tcctgctgac
      541 catgtatgcc agcgtcctgc tcctggcagc tctcagtgcc gacctctgct tcctggctct
      601 cgggcctgcc tggtggtcta cggttcagcg ggcgtgcggg gtgcaggtgg cctgtggggc
      661 agcctggaca ctggccttgc tgctcaccgt gccctccgcc atctaccgcc ggctgcacca
      721 ggagcacttc ccagcccggc tgcagtgtgt ggtggactac ggcggctcct ccagcaccga
      781 gaatgcggtg actgccatcc ggtttctttt tggcttcctg gggcccctgg tggccgtggc
      841 cagctgccac agtgccctcc tgtgctgggc agcccgacgc tgccggccgc tgggcacagc
      901 cattgtggtg gggttttttg tctgctgggc accctaccac ctgctggggc tggtgctcac
      961 tgtggcggcc ccgaactccg cactcctggc cagggccctg cgggctgaac ccctcatcgt
     1021 gggccttgcc ctcgctcaca gctgcctcaa tcccatgctc ttcctgtatt ttgggagggc
     1081 tcaactccgc cggtcactgc cagctgcctg tcactgggcc ctgagggagt cccagggcca
     1141 ggacgaaagt gtggacagca agaaatccac cagccatgac ctggtctcgg agatggaggt
     1201 gtaggctgga gagacattgt gggtgtgtat cttcttatct catttcacaa gactggcttc
     1261 aggcatagct ggatccagga gctcaatgat gtcttcattt tattccttcc ttcattcaac
     1321 agatatccat catgcacttg ctatgtgcaa ggccttttta ggcactagag atatagcagt
     1381 gaccaaaaca gacacaaatc ctgccctcag ggagctgata ttcttctagt ggaggaagac
     1441 agactataaa caaagatata tagggccatt tgcggtggct cacgcctgta attccagggc
     1501 tttgggaggc tgaggcaggt agatcacttg aggtcaggac ttcaagacca gcctagccaa
     1561 tatggtgaaa ccctgtctct actaaaaata caaaaattag ccgggcatgg tggcgcatgc
     1621 ctgtagtccc agctacttgg gaggctgagg cagaagaatc gttttgaacc cgggaggcag
     1681 aggtgacagt gagccaagat tgagcccctg cactccagcc tgggcgacag agcgagactc
     1741 cgtctcaaaa aataaataaa taaaagattc tatttattta tttatttttt tgagatggag
     1801 tctcgctctg tcgcccaggc tggagtgcag tggcacaatc tcggctcact gcaagctccg
     1861 cctcctgagt tcacgccatt ctcctgcctc agcctcctga gtagctggga ctacaggcgc
     1921 ccgccaccat gcccagctaa tttttgtatt tttagtagag aaggggtttc accttgttag
     1981 ccaggatggt cttgatctcc tgacctggtg atccacccgc ctcagcctcc caaagtgctg
     2041 ggattacagg cgtgagccac cgcacccggc caaaagattt taataggatc cctctggttg
     2101 ctggtggagg tgagagtatg gtgtaggggc agtgaagatc ccagagagga ggctactgta
     2161 atggtccaag caggaggtga tagcgatttg gatcagggta acagagctga ggtggtgaga
     2221 ggctgacagg tcatgcatct attttgaagg aaaggccaag tccaggctcc ttagctcggc
     2281 attcaaggct tctctccacc actggacaca cttactctct agcttctcag accctgtagc
     2341 aatcagaatc atgacccccg gtgatgtcca catcttaatc ccctgaacct gtgaagaggt
     2401 gaccttccat ggcaaaaggg actttgcagg tgagattaag taaaggatct tgagaagggg
     2461 tggttatcct ggattgtctg ggtgggctca atggagtcac gagggtcctt ttaagaggga
     2521 ggcaggaggg tcagggtcag tcacaggagg tgacaacgga agcagatgtc atagtgacgt
     2581 gaggaggtgc caagaaatgc aggcagcttc cagaagctga aacagacaag gaaacagatt
     2641 ctctctgaag ctcccagaag gaacacagac ctcctgacac ttttagacct ctgatccgca
     2701 gacctttaag aaaatacatt tgtattgttt taagtcacta tgtttggggt gatttgttat
     2761 agcagccgtg ggaagctaat acacaccctt cgggctatat tcacgcttct gcatctttcc
     2821 tgaagctgtg ccactggctg gaatgtcctt ctgatctatg ttgtgcagtt caacaatcaa
     2881 gagccatctg tggctattca aattcgaatc aattggccag gcctggtggc tcctgcctat
     2941 aatctcagca ctttgggagg ccgaggtggg aggattgcat gagcccagga gtttgagacc
     3001 agcctgggcg acatagcaag accccatctc tacaaaaaat acaaaaatta gccagacgtg
     3061 gtggggcgtg cctgtagttc cagctactga ggagggagtt gcttgaatcc ttctgcttca
     3121 atcctcctta aagcaggtag attgcttgag cccgggaagt ggagtttgca gtgagcttag
     3181 atcacaccgc tgcactccag cctggatgtc agaatgagac tccatctcaa aaaaaaaaag
     3241 aaagaaagaa taaattttca tttcaaattt agttcctcgg gcacactggc catagttcaa
     3301 gtgctcagta gccacatatg gctggtgact gccatattcg acagcacagc tatagaacat
     3361 tgccatcata acagagattt ctgttacaaa atgctgttct agaatttact tttgaactct
     3421 acctgctcag atcttttaaa ttacatggta ggccaggcat ggtggctcac gcctgtgatc
     3481 ccagcacttt cggaggccca gtcgggagga tcccttgagc ccagaagctg gagacctgcc
     3541 tgggcaacag agcaagaccc catctctaca aaaataaaaa aaagaaaatt agcctggttt
     3601 ggtggcacat gcctgtagtg ccagctacta gggagactga agtgggagga ttgcttcagc
     3661 ctgggaggtt gaggctgcag tgagccgtga tctcatcact gcactctagc ctaggtgacg
     3721 gagcgggacc ctgccgctaa ataaataaat aaataaataa catagtagtg atacctgtgt
     3781 ctgcggtcat tactccagaa cagcacttca catatagttt ctcctttaag gtcattctca
     3841 caacagccca gggagatagg gtggcatgct tcattttata agctgaggtc ctgggagggg
     3901 aggtcattta cccaagatca cacagcaaga acaccagaca gctggaattt gatcccagtt
     3961 ttgactccaa tgctcttgct cttcatcatc aataatttcc ttcaaggcgt ccctcaaatg
     4021 tcacttcctc caggaagccc tccctgattt atgctccttc cagaaagaat gggctcttcc
     4081 tttctctgag tctctggaac acaaggtccc agctaaactg taaattcccc aagggtaaca
     4141 actggactaa ttttttttaa tttaatttaa ttttattttt ttgagatgaa gtcttgctct
     4201 gtcacccagg ctggattgta gtggcacgat ctcggctgac cgcaacctcc acctcccggg
     4261 ttcaagcgat tcttatgcct cagcctcccg agtagctggg attacaggcg ctgccaccac
     4321 acttggctaa tttttgtatt tttagtagag acagggtttc accatgttgg ccaggctggt
     4381 ctcgaactcc tgacctcagg tgatccaccc accttggcct cccaaagtgc tgggaataca
     4441 ggcatgagcc accgttcccg gccttatcct tgacttagaa tacctaacct cctgggaatg
     4501 cagcccatag gtctcagcct tatttcaccc agctcctgtt caagatggag tcactctggt
     4561 tcacatgcct ctgacatttc cccgctccct tttataagag aacctttaat cctaagggtt
     4621 gtagagggag gaagatacaa cttctgtgac ttcttcaggc tggacagggg tgacgatata
     4681 cctgcctaac tcttaggatc tattggattc agggtagaca ggagctcagt cagaaagcac
     4741 tggtatcact tttttttttt tttttttttt ttgagacgga gtttcactct tgttgcccag
     4801 gctggagtgc aatggcacga tctcagctca ccacagcctc cgcctcccag gttcaagcga
     4861 ttctcctgcc tcagcctccc cagtagctgg gactacaggc gtgtgccacc aaacccagct
     4921 aatgtttttt tttttttatt tttagtagag acggggtttc tccatgttgg ccaggctggt
     4981 ctcgaactcc cgacctcagg tgatccaccc gcctcggcct cccaaagtgc tgggattaca
     5041 gacatgagcc accacgcccg gcctgatatt ttattactta gtattttact ctgaattatc
     5101 atgcgtgaat taagaccaag gctgtcttgt aaaataaaat ttgttgtgga acaatttata
     5161 cagctccttt gaggtaggag gcaggactca actctggaga tggggctcgg ctcgaatatt
     5221 ggaccaaatt gaggaccagc taaaacaggg aggaggctga agcaacttat tatttttatt
     5281 tatttttatt ttttggagaa ggagtcttgc tctgttaccc aggctggagt gcagtgacac
     5341 gatctcggct cactgcaacc tccaccttcc ggattcaagt gattctcctg ccgcagcctc
     5401 ccgagtagct gggactacag gcgcatgcca ccatgcccag ctaatatttt tgtatttttt
     5461 agtagagatg gggtttcgcc atattagcca ggctggtctt gaactcctga ctcaggtgat
     5521 ctgcccacct cggcctccca aagtgctggg attacaggtg tgggccacca cgcctggccc
     5581 gaagcaactt tctatgacac gcctaccagt gtgccatgtc agtttgccat tgccatggca
     5641 acacacccag gagttactgc cccttcccat ggcaatgacc ccatgaccca gaagttactg
     5701 ccccttccct agatatttct gcataaactg ccccttaatc tacatgtaat taaaaatagg
     5761 tataggctat ttttatacct atataaatag gtataggcta aaaataggta taggctgggc
     5821 gtggtggctc atgtctgtaa tcccagtact ttgggaggcc aatgcaggtg gatcacctga
     5881 ggtcaggaga tcaagaccat cctggctaac atagtgaaac cctgtctcta ctaaaaatac
     5941 aaaaaattag ccaggcgtgt tggcgggagc ctgtagactc agctactcgg gaggttgagg
     6001 caggagaatg gcgtgaaccc aggaggcgga gcttgcagtg agccgagatc acaccactgc
     6061 actccagcct gggtgacaga gcaagactcc gtctaaaaaa aaaaaatagt aagaaagaag
     6121 gaaagacaca aagacagaaa gaaggaagga aagaaagcaa gctgttttcc cctgccttgc
     6181 ccctgctcac ctttgaattc ttttctgggc aaagccaaga accctcgtgg gctaaaaccc
     6241 cgctttgggg cttaaagttt gcaaaatcct cccattaatc tattgggacc agttgccact
     6301 taggagcatt ctttgataac ttttacaaaa catcttttgt ggtttttgaa atgttttcat
     6361 tttgtagatc attagccctt cttttttgaa ctggaataca tttcacggga attttcaaat
     6421 ttaagtctgt gcaatgttac ataaaatacc tttgattatt aaaagccatc tgttttgcta
     6481 taacttccct tttttgttct aaagtttgtc tatttctgct atttgttttt ttaccataga
     6541 aatattgatt tccttaagtt ttcaaagaac caagttatta ataatttctc taagaactag
     6601 tctcaagctt gctatacaat cctatggttg atagactgtg gctttcttgt tgatttccat
     6661 ttgttgttca tttcctccaa ttttcctttt ttaaaaatta taattattgt ttggattatt
//
