LOCUS       NM_001736               2324 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens complement C5a receptor 1 (C5AR1), mRNA.
ACCESSION   NM_001736
VERSION     NM_001736.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2324)
  AUTHORS   Perrino,M.R., Ahmari,N., Hall,A., Jackson,M., Na,Y., Pundavela,J.,
            Szabo,S., Woodruff,T.M., Dombi,E., Kim,M.O., Kohl,J., Wu,J. and
            Ratner,N.
  TITLE     C5aR plus MEK inhibition durably targets the tumor milieu and
            reveals tumor cell phagocytosis
  JOURNAL   Life Sci Alliance 7 (5), e202302229 (2024)
   PUBMED   38458648
  REMARK    GeneRIF: C5aR plus MEK inhibition durably targets the tumor milieu
            and reveals tumor cell phagocytosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2324)
  AUTHORS   Luan,X., Lei,T., Fang,J., Liu,X., Fu,H., Li,Y., Chu,W., Jiang,P.,
            Tong,C., Qi,H. and Fu,Y.
  TITLE     Blockade of C5a receptor unleashes tumor-associated macrophage
            antitumor response and enhances CXCL9-dependent CD8+ T cell
            activity
  JOURNAL   Mol Ther 32 (2), 469-489 (2024)
   PUBMED   38098230
  REMARK    GeneRIF: Blockade of C5a receptor unleashes tumor-associated
            macrophage antitumor response and enhances CXCL9-dependent CD8[+] T
            cell activity.
REFERENCE   3  (bases 1 to 2324)
  AUTHORS   Liu,X., Hu,Y., Yu,X., Tan,Y., Yu,F., Chen,M. and Zhao,M.
  TITLE     Differential contributions of the C5b-9 and C5a/C5aR pathways to
            microvascular and macrovascular thrombosis in complement-mediated
            thrombotic microangiopathy patients
  JOURNAL   Clin Immunol 259, 109871 (2024)
   PUBMED   38101498
  REMARK    GeneRIF: Differential contributions of the C5b-9 and C5a/C5aR
            pathways to microvascular and macrovascular thrombosis in
            complement-mediated thrombotic microangiopathy patients.
REFERENCE   4  (bases 1 to 2324)
  AUTHORS   Li,X.X., Fung,J.N., Clark,R.J., Lee,J.D. and Woodruff,T.M.
  TITLE     Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to
            mediate fungal killing
  JOURNAL   Proc Natl Acad Sci U S A 121 (5), e2314627121 (2024)
   PUBMED   38252818
  REMARK    GeneRIF: Cell-intrinsic C5a synergizes with Dectin-1 in macrophages
            to mediate fungal killing.
REFERENCE   5  (bases 1 to 2324)
  AUTHORS   Deng,S., Jiang,Y., Luo,L., Tang,H., Hu,X., Wu,C., Tang,J., Ge,H.,
            Gong,X., Cai,R., Wang,G., Li,X. and Feng,J.
  TITLE     C5a enhances inflammation and chemotaxis of gammadelta T cells in
            malignant pleural effusion
  JOURNAL   Int Immunopharmacol 127, 111332 (2024)
   PUBMED   38071913
  REMARK    GeneRIF: C5a enhances inflammation and chemotaxis of gammadelta T
            cells in malignant pleural effusion.
REFERENCE   6  (bases 1 to 2324)
  AUTHORS   Giannini,E., Brouchon,L. and Boulay,F.
  TITLE     Identification of the major phosphorylation sites in human C5a
            anaphylatoxin receptor in vivo
  JOURNAL   J Biol Chem 270 (32), 19166-19172 (1995)
   PUBMED   7642584
REFERENCE   7  (bases 1 to 2324)
  AUTHORS   Foreman,K.E., Vaporciyan,A.A., Bonish,B.K., Jones,M.L.,
            Johnson,K.J., Glovsky,M.M., Eddy,S.M. and Ward,P.A.
  TITLE     C5a-induced expression of P-selectin in endothelial cells
  JOURNAL   J Clin Invest 94 (3), 1147-1155 (1994)
   PUBMED   7521884
REFERENCE   8  (bases 1 to 2324)
  AUTHORS   Bao,L., Gerard,N.P., Eddy,R.L. Jr., Shows,T.B. and Gerard,C.
  TITLE     Mapping of genes for the human C5a receptor (C5AR), human FMLP
            receptor (FPR), and two FMLP receptor homologue orphan receptors
            (FPRH1, FPRH2) to chromosome 19
  JOURNAL   Genomics 13 (2), 437-440 (1992)
   PUBMED   1612600
REFERENCE   9  (bases 1 to 2324)
  AUTHORS   Boulay,F., Mery,L., Tardif,M., Brouchon,L. and Vignais,P.
  TITLE     Expression cloning of a receptor for C5a anaphylatoxin on
            differentiated HL-60 cells
  JOURNAL   Biochemistry 30 (12), 2993-2999 (1991)
   PUBMED   2007135
REFERENCE   10 (bases 1 to 2324)
  AUTHORS   Gerard,N.P. and Gerard,C.
  TITLE     The chemotactic receptor for human C5a anaphylatoxin
  JOURNAL   Nature 349 (6310), 614-617 (1991)
   PUBMED   1847994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099491.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001736.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M62505.1, SRR5189664.103501.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355085.4/ ENSP00000347197.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC099491.2         10873-10910
            39-2324             AC099491.2         20793-23078
FEATURES             Location/Qualifiers
     source          1..2324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2324
                     /gene="C5AR1"
                     /gene_synonym="C5A; C5AR; C5R1; CD88"
                     /note="complement C5a receptor 1"
                     /db_xref="GeneID:728"
                     /db_xref="HGNC:HGNC:1338"
                     /db_xref="MIM:113995"
     exon            1..38
                     /gene="C5AR1"
                     /gene_synonym="C5A; C5AR; C5R1; CD88"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1088
                     /gene="C5AR1"
                     /gene_synonym="C5A; C5AR; C5R1; CD88"
                     /note="C5a ligand; C5a anaphylatoxin receptor; C5a-R;
                     complement component 5a receptor 1"
                     /codon_start=1
                     /product="C5a anaphylatoxin chemotactic receptor 1"
                     /protein_id="NP_001727.2"
                     /db_xref="CCDS:CCDS33063.1"
                     /db_xref="GeneID:728"
                     /db_xref="HGNC:HGNC:1338"
                     /db_xref="MIM:113995"
                     /translation="MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIF
                     AVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHW
                     PFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVA
                     WGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTL
                     TICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFL
                     LLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKS
                     FTRSTVDTMAQKTQAV"
     exon            39..2324
                     /gene="C5AR1"
                     /gene_synonym="C5A; C5AR; C5R1; CD88"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2305..2310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C5AR1"
                     /gene_synonym="C5A; C5AR; C5R1; CD88"
                     /note="hexamer: AATAAA"
     polyA_site      2324
                     /gene="C5AR1"
                     /gene_synonym="C5A; C5AR; C5R1; CD88"
                     /note="major polyA site"
ORIGIN      
        1 accttcgatc ctcggggagc ccaggagacc agaacatgga ctccttcaat tataccaccc
       61 ctgattatgg gcactatgat gacaaggata ccctggacct caacacccct gtggataaaa
      121 cttctaacac gctgcgtgtt ccagacatcc tggccttggt catctttgca gtcgtcttcc
      181 tggtgggagt gctgggcaat gccctggtgg tctgggtgac ggcattcgag gccaagcgga
      241 ccatcaatgc catctggttc ctcaacttgg cggtagccga cttcctctcc tgcctggcgc
      301 tgcccatctt gttcacgtcc attgtacagc atcaccactg gccctttggc ggggccgcct
      361 gcagcatcct gccctccctc atcctgctca acatgtacgc cagcatcctg ctcctggcca
      421 ccatcagcgc cgaccgcttt ctgctggtgt ttaaacccat ctggtgccag aacttccgag
      481 gggctggctt ggcctggatc gcctgtgccg tggcttgggg tttagccctg ctgctgacca
      541 taccctcctt cctgtaccgg gtggtccggg aggagtactt tccaccaaag gtgttgtgtg
      601 gcgtggacta cagccacgac aaacggcggg agcgagccgt ggccatcgtc cggctggtcc
      661 tgggcttcct gtggcctcta ctcacgctca cgatttgtta cactttcatc ctgctccgga
      721 cgtggagccg cagggccacg cggtccacca agacactcaa ggtggtggtg gcagtggtgg
      781 ccagtttctt tatcttctgg ttgccctacc aggtgacggg gataatgatg tccttcctgg
      841 agccatcgtc acccaccttc ctgctgctga agaagctgga ctccctgtgt gtctcctttg
      901 cctacatcaa ctgctgcatc aaccccatca tctacgtggt ggccggccag ggcttccagg
      961 gccgactgcg gaaatccctc cccagcctcc tccggaacgt gttgactgaa gagtccgtgg
     1021 ttagggagag caagtcattc acgcgctcca cagtggacac tatggcccag aagacccagg
     1081 cagtgtaggc gacagcctca tgggccactg tggcccgatg tccccttcct tcccggccat
     1141 tctccctctt gttttcactt cacttttcgt gggatggtgt taccttagct aactaactct
     1201 cctccatgtt gcctgtcttt cccagacttg tccctccttt tccagcggga ctcttctcat
     1261 ccttcctcat ttgcaaggtg aacacttcct tctagggagc accctcccac cccccacccc
     1321 ccccacacac accatctttc catcccaggc ttttgaaaaa caaacagaaa cccgtgtatc
     1381 tgggatattt ccatatggca ataggtgtga acagggaact cagaatacag acaagtagaa
     1441 agattctcgc ttaaaaaaaa tgtatttatt ttatggcaag ttggaaaata tgtaactgga
     1501 atctcaaaag ttctttggga caaaacagaa gtccatggag ttatctaagc tcttgtaagt
     1561 gagttaattt aaaaaagaaa attaggctga gagcagtggc tcacgcctgt aatcccagaa
     1621 ctttgggagg ctaaggtggg tggatcacct gaggtcaaga gttccagacc aggctggcca
     1681 gcatggtgaa accccgtctg tactaaaaat acaaaaaatt aactgggcat ggtagtgggt
     1741 gcctgtaatc ccagctactt gggaggctga ggtgggagaa ttgctcgaac ttggaggtgg
     1801 aggttgtggt gagccatgat cgcaccactg cactctagcc tgggtgaccg agggaggctc
     1861 tgtctcaaaa gcaaagcaaa aacaaaaaca aaaacaccta aaaaacctgc agttttgttt
     1921 gtactttgtt tttaaattat gctttctatt ttgagatcat tgcaaactca acacaattgt
     1981 aagtaatgat acagagggat cttgtgtacc cttcacccag cctcccccaa tggcaacatc
     2041 ttgcaaaact acaatgtagt ctcataacca ggatattgac attgatacag tgaagataca
     2101 ggacattctc atcaccacag ggatccccag gatgcccact tccctccacc cccacacccc
     2161 agccgtgtcc ctaacccctg gcaaccagga atccactctc catttctata atgttgtcat
     2221 ttcaagaatg ttattcaatg gaatcatata gtatgtaacc tgttttgagc ttaaaaaaaa
     2281 agtatacatg actttaatga ggaaaataaa aatgaatatt gaaa
//
