LOCUS       NM_001364689            4527 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens chromosome 4 open reading frame 50 (C4orf50),
            transcript variant 1, mRNA.
ACCESSION   NM_001364689
VERSION     NM_001364689.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4527)
  AUTHORS   Evans,D.M., Zhu,G., Dy,V., Heath,A.C., Madden,P.A., Kemp,J.P.,
            McMahon,G., St Pourcain,B., Timpson,N.J., Golding,J., Lawlor,D.A.,
            Steer,C., Montgomery,G.W., Martin,N.G., Smith,G.D. and
            Whitfield,J.B.
  TITLE     Genome-wide association study identifies loci affecting blood
            copper, selenium and zinc
  JOURNAL   Hum Mol Genet 22 (19), 3998-4006 (2013)
   PUBMED   23720494
REFERENCE   2  (bases 1 to 4527)
  AUTHORS   Ishida,Y., Hadano,S., Nagayama,T., Tomiyasu,H., Wakasa,K. and
            Ikeda,J.
  TITLE     Isolation and characterization of 21 novel expressed DNA sequences
            from the distal region of human chromosome 4p
  JOURNAL   Genomics 22 (2), 302-312 (1994)
   PUBMED   7545969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092442.5.
            
            On Feb 23, 2023 this sequence version replaced NM_001364689.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN03465403
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000711657.1/ ENSP00000518823.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AC092442.5         101862-102148       c
            288-426             AC092442.5         95547-95685         c
            427-963             AC092442.5         91713-92249         c
            964-1093            AC092442.5         78064-78193         c
            1094-1221           AC092442.5         76520-76647         c
            1222-3699           AC092442.5         72064-74541         c
            3700-3864           AC092442.5         63891-64055         c
            3865-3921           AC092442.5         59616-59672         c
            3922-4104           AC092442.5         57376-57558         c
            4105-4153           AC092442.5         51131-51179         c
            4154-4275           AC092442.5         48741-48862         c
            4276-4527           AC092442.5         43092-43343         c
FEATURES             Location/Qualifiers
     source          1..4527
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.2-p16.1"
     gene            1..4527
                     /gene="C4orf50"
                     /note="chromosome 4 open reading frame 50"
                     /db_xref="GeneID:389197"
                     /db_xref="HGNC:HGNC:33766"
     CDS             1..4527
                     /gene="C4orf50"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C4orf50"
                     /codon_start=1
                     /product="uncharacterized protein C4orf50 isoform 1"
                     /protein_id="NP_001351618.1"
                     /db_xref="CCDS:CCDS93473.1"
                     /db_xref="GeneID:389197"
                     /db_xref="HGNC:HGNC:33766"
                     /translation="MEPTAKGRTEESFSYVIRAPSSEGFDIMNVDVKIDTSWIFQDME
                     DSAEERECLQEEAAGRPDMDMGALRRQLESSEQKLSAAEDKYVTSESGLRSRIQELEL
                     SERKLLRKVDQLSTHVAQERSAWLQAQEKLAALQGELASQIREESVARRQQWRLRRLQ
                     ERLRRKDEALGQQAAALERCRRTQRRQLGLVREQERVLREQVQRLERNVRRLCRAAGL
                     LLAQWDTAAPGSQGATEAAAELRALQARAERSEREREEAARSLQEHRATERQLRGQLE
                     ELRCCIYGLKLSEIGLQGQVEDLAQQNQCLREELGAQAPIGHCSLDALGCVQGDSLPL
                     PREEALDPCRSQDWRNSLRSNDAPRQRAPAGQSPEGPCTWSRIRPGRASSVLAPGPET
                     TSELPRDLAGSNREQLTLAEPSLDEQILLLVCGCPPEECLDESLLRMDLAWISENLAA
                     DPAAEAFLLVQTSALPLWGPAGDSASWRPLLLQEVPSDGQKIQEELATRSPPPPKATG
                     HPGWDCHQTRGRGASLFHEAPYISNHPFLKKHPKDLKDTWNNGGGSLAGRTEEGKARG
                     TLGRKGKNLGDKYQLSQESHQNLSLENGAGAAEDVQDQNGASETKAATCRPGSWQEFL
                     MPLLQGEASVSKEGPESLSRRERVEGYVWGLRGGLSSENEEVAPPATFSRAHETKEPW
                     PTDSQLLAGKVRATGRTARGKEENQVWLGNALLLQGGSLEDKGLEEEDEMPHQEASGL
                     GCRGAPEEPDSQEHESKEMLFFAGETGLPLFPRFALSVEGAEPTDHGHPQAVSKGHNR
                     CALTIDELAQDVEACFQQLSTLQPGSRGWQCSASACRGENWSFAQKWHSGWERAHSQQ
                     VWGNWGICSNEEAKSKESGEGDKPGKTTALGTSEVPGNPGTLPHWDEASPNPPQGPAE
                     PWGALERVRSRFHQLISGLKKQRSQILHDNTKLHGDQERFHERVCALEREREREVTKI
                     SRLERDNHRLVGDISQLKKELDQYLQAISDLEDCNGKSYCKILELEEENETLKGNLGQ
                     LQKATSESVRKSKDTMEQVTLENWKLQTLISELGVSYKELIKDIVLGIEDMIRALSGE
                     NEHLLRRVHVLEREVTLQRSTDQGRLVRGREHLQGKAKMHALDKEVQVTPLTGQLLSR
                     ACGPPLEEEMSLAAGQTGPSTGTGNSRRGADSPPPSLVWRNTGVANALQGNVSGAEVK
                     EAHLEKEEKRPRCSVAQGQALSSLSNGPMLRDSEAEVTEEDPRLRAQQLHHRVLTLQC
                     QLRDQGAAHQASLDEATRLQEELQAKLEELQKKQHEAKLAVTPLKAKIASLVRKCRER
                     NRLITHLLQELHRHGLGNLLLSELAQNMLNDVALAEYTATFLAPGVPETSHHLDVKSE
                     MTAALRAQTYLLNPEMDSVLQSSLSSESWPIPEPEWPAQTAQLDSLKLPLSLVSTLDP
                     GTCLAAVTVEPGLPAQRLQEKGGMPCPALQVDNVPAPSELLSPARILAFHQELRQSIC
                     SNSQVHKSPLELEM"
     exon            1..287
                     /gene="C4orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            288..426
                     /gene="C4orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            427..963
                     /gene="C4orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1093
                     /gene="C4orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1221
                     /gene="C4orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..3699
                     /gene="C4orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..3864
                     /gene="C4orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            3865..3921
                     /gene="C4orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            3922..4104
                     /gene="C4orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4153
                     /gene="C4orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            4154..4275
                     /gene="C4orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            4276..4527
                     /gene="C4orf50"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagccaa cagccaaggg acggactgag gagagtttca gctacgtcat cagagccccc
       61 agcagtgagg ggttcgacat aatgaacgtt gatgtgaaga ttgacacatc ctggatattc
      121 caggacatgg aagatagtgc tgaggagcgg gaatgtcttc aggaagaagc agctggccgc
      181 ccagacatgg atatgggtgc gctcaggagg cagctggagt cctccgagca gaagctgtca
      241 gcagcagagg acaagtacgt gacatcggag tccgggctga gaagcagaat tcaggagctg
      301 gagctgtcag aaaggaaact cctccggaag gtggaccagc tgagcaccca cgtggcccag
      361 gagagaagcg cctggctcca ggcccaggag aagctggcgg cgctgcaggg ggagctggcc
      421 agccagatcc gggaggagag cgtggccagg cggcagcagt ggcggctgcg gcggttgcag
      481 gagcggttgc ggcgcaagga cgaggcactg gggcagcagg cggcggccct ggagcgctgc
      541 cggcggaccc agcggcgcca gctgggcctg gtgcgggagc aggagcgcgt cctgcgggag
      601 caggtgcagc ggctggagcg caacgtgcgg cgcctctgcc gcgccgcggg cctcctgctg
      661 gcccagtggg acaccgcggc cccaggctcc cagggcgcca ccgaggcggc tgcggaactg
      721 cgcgccctgc aggcgagggc agagcgcagc gagcgcgagc gggaagaggc ggcgcgcagc
      781 ctgcaggagc accgggccac cgagcgccag ctccgcgggc agctggagga gctgcgctgc
      841 tgcatctatg ggctgaagct gtcagagatt ggcctgcagg gccaggtgga ggacctcgcc
      901 cagcaaaacc agtgcctgcg agaggagctg ggagcccagg cccctattgg tcactgcagc
      961 ctggatgctc tgggctgtgt tcagggtgac tcactgcccc tgcccaggga ggaggccctg
     1021 gacccctgca gaagccaaga ctggcggaac tccctgcggt ccaatgatgc acccagacaa
     1081 agggccccag caggccagtc cccagagggg ccctgcacct ggagccgcat caggcctgga
     1141 cgggcctctt ctgttttggc tccaggcccg gagaccacaa gcgagctccc cagagacctg
     1201 gccggatcca accgtgaaca gcttactctg gcagagccca gcttggatga acagattctt
     1261 ctcctggtct gtggctgccc accagaggag tgcttggacg agtcactcct ccgcatggac
     1321 ctggcctgga tttcagagaa tctagcagct gacccagctg cagaagcctt tctcctggtg
     1381 cagacatccg cactccctct ctgggggccg gctggggact ccgcttcttg gcgaccactg
     1441 ctgctccagg aggttccctc agatggacaa aaaatccaag aagagttggc caccaggtcc
     1501 ccgcctcctc ccaaagccac aggacaccca ggctgggatt gtcaccagac aagaggccgc
     1561 ggtgcctccc tcttccacga ggccccctac atttcaaatc acccatttct gaaaaaacac
     1621 cccaaggatc tgaaagacac ttggaacaat ggaggaggaa gccttgcggg gagaactgaa
     1681 gaggggaagg caagggggac tttgggcagg aaggggaaaa accttggtga caagtaccag
     1741 ctaagtcagg aaagccatca gaacctgagc ttggagaatg gggctggagc tgcagaggac
     1801 gtgcaggatc agaatggggc ttcagagact aaggccgcca cctgccgccc tgggtcctgg
     1861 caggagtttt tgatgcctct tctacagggg gaggcctcag tatcaaagga gggtcccgaa
     1921 tccctgagca ggagggaaag ggtggaagga tacgtctggg gtctccgagg aggactgtca
     1981 tcagagaatg aggaagtggc acccccagcc accttctcca gggctcatga gaccaaagag
     2041 ccatggccaa cagacagtca gctcctcgca gggaaagtca gagccactgg gaggacagct
     2101 aggggcaagg aggaaaacca agtgtggctt ggaaatgctc tgcttctgca aggaggaagc
     2161 ctggaggaca aagggctaga ggaagaggat gagatgccgc atcaagaagc atccggtctg
     2221 gggtgcaggg gtgcccccga ggagcctgac tcccaggaac atgagagcaa ggaaatgctt
     2281 ttctttgcag gagagacagg tttgccactg tttcccagat ttgccttatc agttgaaggg
     2341 gccgaaccca ctgatcatgg tcatccacag gctgtgagca aaggacacaa caggtgtgca
     2401 ctcacaatcg atgagcttgc acaggacgtg gaggcttgtt tccagcagct gtccaccctg
     2461 cagccgggca gcaggggctg gcagtgctca gcctctgcat gtaggggaga gaactggagc
     2521 tttgctcaga agtggcacag tggctgggag agagctcact ctcagcaggt ttggggaaat
     2581 tggggtattt gttctaatga agaagcgaag tctaaagaga gtggtgaagg tgataagccg
     2641 ggaaagacca cggccctggg caccagcgaa gttcctggta acccagggac actgcctcat
     2701 tgggatgaag ccagcccaaa ccctccacag gggcctgctg agccctgggg tgccctcgag
     2761 agagtgagga gcaggtttca tcagctcatt tctggattga agaaacagag aagccagatt
     2821 ttacatgaca acaccaaact tcacggagac caagagaggt tccatgaaag agtgtgcgcc
     2881 cttgaaagag agagagagag agaggtgaca aaaatatcca ggctcgagcg ggataaccac
     2941 aggctggtag gggacatctc tcagttaaag aaagaactgg atcaatattt acaggcaatc
     3001 tctgaccttg aagactgcaa tgggaagagt tactgcaaaa ttttggagct tgaagaggaa
     3061 aatgaaacac tgaaagggaa tctgggccaa ctccagaaag ccacgtctga gagtgtcagg
     3121 aaatccaaag acacgatgga gcaagtcacc ctggaaaact ggaagctcca gacactgatc
     3181 tcggagcttg gcgtcagtta taaagagctg ataaaggata tcgtgctagg aatagaagac
     3241 atgatccggg ccttaagtgg ggagaacgag caccttctac gcagggtcca tgtcctggag
     3301 agggaagtca ccttgcagag gagcacggat caggggcgtt tggtgagggg aagggagcac
     3361 ctccagggaa aagccaagat gcacgctcta gacaaagagg tgcaggtgac tccactcaca
     3421 ggacagctgc tttcaagagc ctgtgggcca cccttggagg aggaaatgag tctggctgca
     3481 gggcagacag gaccttccac aggcaccggg aattccagac gcggtgctga ttctccccct
     3541 ccatcgctgg tctggagaaa cactggtgta gccaatgccc tgcaaggaaa tgtcagtgga
     3601 gcagaagtga aagaagcaca tttggagaaa gaggagaaga ggcccaggtg ttctgtggct
     3661 caggggcaag ctctgagctc cctgagcaat ggccccatgc tccgggactc agaggccgag
     3721 gttactgagg aggatcccag gctgcgggcc cagcagctcc atcaccgggt gctgaccctg
     3781 cagtgccagc tcagggacca gggcgctgcc caccaggcgt ctctggacga ggccacccgc
     3841 ctccaggagg agctccaggc caagcttgaa gaacttcaga aaaagcaaca tgaagcaaag
     3901 ttggcagtga ctcccctgaa ggccaagata gcttccctcg tccggaagtg ccgggagagg
     3961 aaccgcctga tcacccacct gctgcaggag ctgcacagac atgggctggg gaacctcctg
     4021 ctctccgagc tggcgcagaa catgctcaac gacgtggcac tggctgagta cacggccacc
     4081 ttcctggctc cgggagtccc agagacaagc caccacctgg acgtcaagtc tgagatgacg
     4141 gcagctttaa gagctcagac atacctcttg aatcctgaaa tggacagtgt cctccaaagc
     4201 tcattgtctt cagagtcctg gcctattccc gagccggagt ggccagcaca gacagcccaa
     4261 ctggattctc tgaagctccc tctgtccttg gtgtccacgc ttgatcctgg aacgtgcctg
     4321 gcagcggtca ctgtggaacc aggtctcccc gcacaacgtc tgcaagaaaa aggcggaatg
     4381 ccctgtcctg ccctccaagt cgataacgtc ccagcaccct ctgagctcct gagcccagca
     4441 aggatcctgg cttttcacca agagcttaga caaagcattt gcagcaattc ccaggtccat
     4501 aaatcaccgc tggagttaga aatgtaa
//
