LOCUS       NM_001008393            3366 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens chromosome 4 open reading frame 46 (C4orf46),
            transcript variant 1, mRNA.
ACCESSION   NM_001008393 XM_376349
VERSION     NM_001008393.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3366)
  AUTHORS   Shah,B., Khan,R., Shah,W., Aftab,A., Khan,M., Dil,S. and Shi,Q.
  TITLE     Inactivation of testis-specific gene C4orf46 is dispensable for
            spermatogenesis and fertility in mouse
  JOURNAL   Mamm Genome 32 (5), 364-370 (2021)
   PUBMED   34076717
REFERENCE   2  (bases 1 to 3366)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3366)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3366)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 3366)
  AUTHORS   Yu,Z., Ni,L., Chen,D., Su,Z., Yu,W., Zhang,Q., Wang,Y., Li,C.,
            Gui,Y. and Lai,Y.
  TITLE     Expression and clinical significance of RCDG1 in renal cell
            carcinoma: a novel renal cancer-associated gene
  JOURNAL   Mol Med Rep 10 (3), 1583-1589 (2014)
   PUBMED   25059753
  REMARK    GeneRIF: A reduction in RCDG1 expression may be associated with the
            oncogenesis of renal cell carcinoma and the differentiation of
            clear cell renal cell carcinoma.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC094775.1, AC107219.5 and BU688970.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001008393.3.
            
            Summary: This gene encodes a small, conserved protein of unknown
            function that is expressed in a variety of tissues. There are
            pseudogenes for this gene on chromosomes 6, 8, 16, and X.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB137547.1, AK074948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379205.5/ ENSP00000368503.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2212              BC094775.1         160-2371
            2213-2668           AC107219.5         32080-32535         c
            2669-3366           BU688970.1         17-714              c
FEATURES             Location/Qualifiers
     source          1..3366
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..3366
                     /gene="C4orf46"
                     /gene_synonym="RCDG1"
                     /note="chromosome 4 open reading frame 46"
                     /db_xref="GeneID:201725"
                     /db_xref="HGNC:HGNC:27320"
                     /db_xref="MIM:616210"
     exon            1..272
                     /gene="C4orf46"
                     /gene_synonym="RCDG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..428
                     /gene="C4orf46"
                     /gene_synonym="RCDG1"
                     /codon_start=1
                     /product="renal cancer differentiation gene 1 protein"
                     /protein_id="NP_001008394.1"
                     /db_xref="CCDS:CCDS34088.1"
                     /db_xref="GeneID:201725"
                     /db_xref="HGNC:HGNC:27320"
                     /db_xref="MIM:616210"
                     /translation="MADPEELQVSSPPPPPPSSPSSSDASAASSPGGPVSLGWPVPSR
                     SSGPTVDQLEEVELQIGDAAFSLTKLLEATSAVSAQVEELAFKCTENARFLKTWRDLL
                     KEGYDSLKPDD"
     exon            273..3366
                     /gene="C4orf46"
                     /gene_synonym="RCDG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3338..3343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C4orf46"
                     /gene_synonym="RCDG1"
                     /note="hexamer: AATAAA"
     polyA_site      3366
                     /gene="C4orf46"
                     /gene_synonym="RCDG1"
                     /note="major polyA site"
ORIGIN      
        1 ctttcggctt tgggcgcgag tggttaaaag acagttggtg tcggttcggc ttctcgggtc
       61 ggattccgcg gtcccaaccc ttccccatgg ccgaccctga ggagttgcag gtttcttcgc
      121 cgcccccgcc gcctccctct tctccctcct cttcagacgc ctctgcagca tcttccccgg
      181 gcggcccagt gagtttgggc tggccagttc cgagcaggag cagcggccca acggtggacc
      241 agctggagga agtggagctg cagatcggag acgcagcctt ttcattaacc aaacttcttg
      301 aagccacatc tgcagtatca gctcaagtgg aagaacttgc cttcaaatgt acagaaaatg
      361 cacgtttcct taaaacgtgg cgggacctct tgaaagaagg ctatgattct ttgaaacctg
      421 atgactgatt tggcatactt cgttgtttaa taatgactgc aataattcat acttcttatg
      481 tcatattttg tacatgtacc acacatatag gatgacctct gtccagcagt tctgtatata
      541 ctcagaatga aatttttctt ggttttcttg gtttttgtga aagcagaata ccgatgctat
      601 ttttgttgcg gaccagtact tgtttgtcct taaatacttt atgcctctga actttcatag
      661 aatcctttat gaaagttaac ttcatcaata gacggttaat attaatagag ccacagtgct
      721 accagtagca aactaggtag accattattt gttttgcaac aagatgctaa gcatggcaga
      781 ctttgaagtt gcgtttcatc ttaaggacca agggaggtaa ctttaaggtt gccagtggtg
      841 gatccagctc cgttaggcta agttgtctac agctaatgat tgtgtcttta ttctatatcc
      901 ccagcaccta aaacagggtc acacaacatt cactaaatgt ttgttgaata aaagagttaa
      961 caaacataat tgaaagcttt ttttcttcct atatttagca tgaagactgt cattgtttct
     1021 ctaggaaatg tatgaatctg aacttttttg acttgaagaa aaacattctt tttttacaga
     1081 gatttggact ttgatgatag gttttaaaaa tatatgataa atattttttg tacttgtttg
     1141 attttttttt taaagacttt acttcagaaa gggaaagact gtttagaaag aatgcatatt
     1201 ttttccctat ttatttctgt ggttactgct tttgcagttt aacagtgttt gtatttgata
     1261 tttgtatatg tttgattgct atctttaaag tgccttatca gatttatggc tctgtgctat
     1321 tactttttga gctttgcaag ttgtgtacat aataattcta aagaagttac tttgtttgca
     1381 atgcatcaaa tttaaatgat gtgatttttt ttgtattatt tgatcttagt gacagtgttc
     1441 tattttgcat cctgtatctt atgttgcttt tggtgttttg tgttgtgtgt caacgattaa
     1501 gccaactaat tctctaccat atataacttc tggacatttt tgatacaaca tcttaattct
     1561 ttgtagatat ggagataggt acagaactat attctaatgc cccacaatgg ggctatgaga
     1621 ggggacagat ggatgggcaa agaatagttt tgtttaacat attaggtcat agttcttgat
     1681 tagttttttt agttaaagat aaacacatag ggtgtgattt ctataccaaa gatatgctta
     1741 tttcagtatt agaaaaatat tcttcttaca tctcctgaaa attgcaattt ttaaaatgtg
     1801 taaaaataaa ttattattaa aagcacattt tatttccatt tgtttggatt cattacctta
     1861 aaactttatt gacatatttc aaagatatag gaaaggtaaa tgatttcaag aaaatccgtg
     1921 tatttctacc atgcagatgt aataaatgtt agcatttggc tatattttct tcagacacac
     1981 atatgcatgt aattgcaaat gttagataca tttgaagttt gctttgttac ctgtttgatc
     2041 ctgtcccgtt cctccctccc cagagtcccc agaggtaacc actagagggg gcataatata
     2101 gcatgtgttt ttatattttt aatacaaata tattttttaa aagcgctaca aaatattgtt
     2161 ttatatatgt ggtagccagc ttccagatgg ccccagtgat ccctggcctc ctggtgttca
     2221 tgccccagta tagccttctc ctgcatttta cagtgctgac ttttgtaact accaggatat
     2281 tgagcaaatg cagtgtgtga tttctgaggc catatctttt actctttttt ttttttttaa
     2341 gagacaagat ctcactctat tgctcaggct ggagtgtggt ggcaggatca tagctcactg
     2401 taaccttaaa cttggactca aacaatcctc ccatctcgcc tcctcctata aagcactggg
     2461 attacaggca tttttgctca tttttctatg ttgttttttt tacttgtcag tttttagata
     2521 ttacatattt tgaatactaa tgatctgtta tgtatgttcc aattatcttt tttagtctgg
     2581 tttgtcttca tattttggtt atgaaatctt gaatttttaa aaacgtaatt ttaccaatct
     2641 ttcataatga tttgcttttt ctggtttttg tataggaaat gtcataaaaa tagtcctatt
     2701 cagccttcca aaagttacaa aatttttgtt tttaacattt agatgtttag tccaactgaa
     2761 atttgttttc ttttatggca tgattttgga atcttgtttt aattattttt acatatttat
     2821 agctgttcct ccaagtatca atttttcaag tgcaacatct gtcatgcagt tactatgtaa
     2881 gggccagatt ctgacctttc tgttcttttt atctgaagga aatttgaaca tgccaccccc
     2941 aaatatgccg atttggcata ctgattattt cgagctaaag gtgcttgact aacagtagtt
     3001 gcagaaatgg ctattttaac tgtcctttcc tacctgtagc aagccataca aacttctttg
     3061 ataaagatgc tttcctgata ccaagatgag aagatggctc taatcagctg agacagcacc
     3121 agaggaatct acaaacaaga aactattagt ttcttaacat atatttacct tccacagttt
     3181 ctgcctctgg aagcctaaaa ctgctttcct tcgtcttgtc acacttctct gaaatgtatt
     3241 ctttgtggaa gatgctatat agtccagagt tgtaagccac tacttgtgtt taccttttca
     3301 ttgagttttc tcctgtgtga tgtacgttgc atatattaat aaaattactt gtttttctct
     3361 tgttaa
//
