LOCUS       NM_001099783            5513 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens chromosome 4 open reading frame 33 (C4orf33),
            transcript variant 2, mRNA.
ACCESSION   NM_001099783
VERSION     NM_001099783.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5513)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 5513)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5513)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5513)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 5513)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN483524.1, BE566349.1, BQ549846.1, BC032582.1, BU783470.1 and
            AC093826.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001099783.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF184141.1, SRR1163658.327488.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000425929.6/ ENSP00000401090.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CN483524.1         26-46
            22-350              BE566349.1         2-330
            351-523             BQ549846.1         407-579
            524-1385            BC032582.1         752-1613
            1386-1564           BU783470.1         20-198              c
            1565-5513           AC093826.2         132482-136430
FEATURES             Location/Qualifiers
     source          1..5513
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.2"
     gene            1..5513
                     /gene="C4orf33"
                     /note="chromosome 4 open reading frame 33"
                     /db_xref="GeneID:132321"
                     /db_xref="HGNC:HGNC:27025"
     exon            1..58
                     /gene="C4orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            59..248
                     /gene="C4orf33"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..667
                     /gene="C4orf33"
                     /codon_start=1
                     /product="UPF0462 protein C4orf33"
                     /protein_id="NP_001093253.1"
                     /db_xref="CCDS:CCDS3741.1"
                     /db_xref="GeneID:132321"
                     /db_xref="HGNC:HGNC:27025"
                     /translation="MDFKIEHTWDGFPVKHEPVFIRLNPGDRGVMMDISAPFFRDPPA
                     PLGEPGKPFNELWDYEVVEAFFLNDITEQYLEVELCPHGQHLVLLLSGRRNVWKQELP
                     LSFRMSRGETKWEGKAYLPWSYFPPNVTKFNSFAIHGSKDKRSYEALYPVPQHELQQG
                     QKPDFHCLEYFKSFNFNTLLGEEWKQPESDLWLIEKCDI"
     exon            249..309
                     /gene="C4orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            310..361
                     /gene="C4orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            362..561
                     /gene="C4orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            562..5513
                     /gene="C4orf33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1509..1514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C4orf33"
                     /note="hexamer: AATAAA"
     regulatory      1522..1527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C4orf33"
                     /note="hexamer: TATAAA"
     polyA_site      1531
                     /gene="C4orf33"
                     /note="major polyA site"
     regulatory      1539..1544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C4orf33"
                     /note="hexamer: ATTAAA"
     polyA_site      1539
                     /gene="C4orf33"
     polyA_site      1559
                     /gene="C4orf33"
     regulatory      5490..5495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C4orf33"
                     /note="hexamer: AATAAA"
     polyA_site      5513
                     /gene="C4orf33"
ORIGIN      
        1 gccctctcct gtgacctcgg ctgaaaagaa gaagccagtg tttgagaaaa gcttcgtgag
       61 acttcagatg gattttaaaa ttgaacacac ttgggatggt tttccagtga agcatgagcc
      121 cgtatttatc aggctgaatc caggtgacag aggagtgatg atggacatta gtgctccatt
      181 tttcagggat cctccagccc cacttggaga accaggaaaa cctttcaatg aactgtggga
      241 ttatgaagtt gtggaagcat ttttcttgaa tgatataact gagcaatatt tagaagttga
      301 actttgtccc cacggacagc atttagtgct tttactttct ggaagaagaa atgtgtggaa
      361 acaagaactt cctttatcgt tcagaatgtc cagaggagag acaaaatggg aaggcaaagc
      421 ttatctccct tggagttatt ttccaccaaa tgtgacaaaa ttcaattcat ttgcaattca
      481 tggatcaaaa gataaacgaa gttatgaagc tctttaccct gtacctcagc atgaactgca
      541 gcaaggacaa aaacctgatt tccattgcct agaatacttc aagtctttca attttaacac
      601 actgcttgga gaagagtgga aacaaccgga atcagacctg tggctaatag agaaatgtga
      661 tatataggag taatagataa ccataccgat cattttttcc tctatacctt ttaagataaa
      721 caaaaaataa atatcaattt tttaagatgt catgcataca tttcaacaac aaatatcttc
      781 atagaagtca ctgaaaatat agtatctgtg gcaaattgta tatgattaac aagaaaatat
      841 atgattcttt gtagatgatt tcatctgtaa agtcacaatg tttctcagag tcacttagtc
      901 caggatgttg cattcccagc acacagtaca gttattcttg aaaactacaa gtgaaaaagg
      961 gggaacaatt gaggttgtcc aaggccacct agaggactgt cttgcactac cttgtgattc
     1021 aaccatttca ttcctagata tataccccag aaaaatgact gctcatagca gctttattca
     1081 taatagcaca aaattgtaaa cagtgaaatt tccatccata ggaaaatgga tagacaaact
     1141 acaatatagt cagtggaata ctgttcattt aaaaaaggac tgctgataca tgcaacaacc
     1201 tgtatgaatc tcaaaaacat taagttgagc aaaacaaacc aaacataaca tactatctaa
     1261 ttacttttat attaaagcca cttccaggca aaactaatat ttgatgatag ataccagaac
     1321 agtggctgct tagagtgagg gcagggaatt caaattgaat ggaaaagggg cctgaggaaa
     1381 ttttccgggg tgattgaaat gttttgtatt ttgatctgga tgatggttat gtagctgcat
     1441 atatttgtca acattcctca tgctgtatgt ttagatttgt gattttacta tatgtaaatt
     1501 aattccttaa taaaatacta ttataaaata agctgtaaat taaatggaat taacttcaag
     1561 tttacattga gtttatatgt ttccattgaa caatcactag tgatggttaa atgtggctta
     1621 tcgacttact catttcttat atatgttctc tatctaaaaa gagagctggt gtaagataaa
     1681 tgctaacttt tacaaaaggt attattaagt atcctgacta cacatcatgg tggcagtgtt
     1741 aggcatctta gataaattga gaaattattc ttaaaactga caatagcaac taattaattt
     1801 gatatagaaa cgatctgcct gttttagata cgaatggcat attttaaata acctaggacg
     1861 atttatttat aaattacctg aataatttta taaatgcata taaaactatc aaaataaaaa
     1921 caagatatat tttagagcat cttgatttta gaagcgaatc gaacactgtg aatcacagtt
     1981 tcagatataa atcataacta tttataatat ggataaaaat gaagcacaaa tatgatagat
     2041 acaatcacaa caatataaaa tactgaattt gaatgttgta gcttgtgagc tttctcaaat
     2101 ctaatgtgta tctttttaaa atttgtttag atgtttttta aacatctctt aactttcttt
     2161 catctagata aggcatttcc ttttcttcca ataccaagca agcaaaaata cattatataa
     2221 acattttctt ttgaaaggaa catgcatatc aactacagaa tttcggaaag cttgtccatt
     2281 agtcaggtac aaatgatata ttctagaaac ttgtatccaa gaaactttta tttgagagtg
     2341 ggtgtttgta atagccattt caaatttgtt tttcaacttc aggaccatga aagaataatc
     2401 atccttttgt ttaaaatatg cataaatgca tttctttgct gtgatttgaa ttgttcactg
     2461 cagtgtcaag cagattctct cttctcacca cctaaataga ttacacaatg tgcatattta
     2521 ttcaggtgca ttctcatgct ttttcccagc tccaggaaag tgtaagtcac agtctgaagg
     2581 gaaatgtgct ttttattttt ggctccaaac tacttttttt aaacgttaaa aaggtttttt
     2641 gccacaggaa aaaaaacatt taatttcccc tccttctcct ccttttgctc cttttttaaa
     2701 tgttaggctt ttggaggaca gaagataatg agcataatta atctgatatt gaaaaagaaa
     2761 gggtagcaag tggataaagc aattacagta agccctcagc ccttttctca tgcctcaaag
     2821 cttaaggatt gtctcttctt ttccatgtaa atttccataa tattttacac attgctttat
     2881 tacagcattt atttcactgg tcctagatag ctcttctgac ccacctccta tcctctcagc
     2941 ctaacttttt actccagcca tcagttgcat acagtgaact gactggccag ttgcctcagc
     3001 tgtactgtgt atgtcttact tcctgcccct agggcttctc tgcttcctct gctgtgtgga
     3061 acacttgcag gaacccattt agccattctc tcacatgaac tacccgggat gtgtgaaggg
     3121 actaaaacac cccatggggc acctcttgac caaagagggt gggagttgat ggataactac
     3181 ttctctgtta catccctcag tttaacaatt tatggtccct tccacacagc tcctcagaag
     3241 ttctcttaaa aggattccac cctgattacc cacagcagtg gccaactagt aacacatttt
     3301 tgcattatct ttccttcatt tccatcattt tctgttttgc tcttcctggt acctctctcc
     3361 tctctggaat tgcttaacta cagtcaacct ctttggaagt tattgtccta tgtttgcttc
     3421 atggggaacc caggctaagt cagtgattac ctaaagcagc cctagaaagc cgttcgtcag
     3481 gatgagaatc tagaattgta tcacagggca tttggtgaca aggaccccat tgttggtggt
     3541 aatggctctg ctataagtaa cttcacagtt attaaaacag tggtagactg gcttgaggtg
     3601 cagctgaggc acctgaagct atgaaagcca tctagtcata atgactcttc gtgtcaactg
     3661 ttcagcaggc aaatagaagc gggctaccat gcagagctag agttataact attaatggaa
     3721 gcagtataga gtatgtcctt cctaggggat tcattgagtc atcctttggt gtttcaatgt
     3781 caagtggtaa tcttaaatgg gcaactgtag caaccacagc ctgacaaggt aaagcaacta
     3841 aggactctga ccctttgagg ataaaggtct aggtcacctc accattcaaa ccacttgaaa
     3901 ctactgaaga gtttggccaa atgtgagaga aatacagaat ttgtgatgga agagagagat
     3961 gataactatc aattatagac ttgaaatcag ttacaggagc cacataactt gttccactaa
     4021 atcttttgca tttagtattt gtataatggc tgcccacttc cttgaagact ctgtgacaga
     4081 ttggactcaa tgtggaatgt gtgtggctct gagtgctgca aggagtggac tgtatttaat
     4141 atctcttgtg tcctacctca catcctctta ggccattttt caattcaccc attttactct
     4201 ttgatagcac tttacctctt ttgtcccatg tatctctaga tttctgtatt agtgcttttc
     4261 tgacacctca gttatgtgga acacctgtgg gaatctgcta atctactctg acgtatatgc
     4321 aaacctggaa gtttgaggga attgacaata gggacaggat tcagtggata aatactcccc
     4381 ttttccgtcc cttgggcaga caattctgaa gtgcattctg tatagttcct tagtggtctc
     4441 cagtaggact ccactagggt cttcagttac ctacagtact gatcagctta aaaatgcaat
     4501 cttagattgg cttgctttat ttaatttttc caaagttccc aatcccattc cttagaatca
     4561 cattccaaaa ttaatgcact gcacacaacc ctctgctttt gtcaggggta gaaggggtat
     4621 ccagcctaag gcacctaagt ccaagaggaa tatgtgccta acaaatcttc taactaaata
     4681 tatatatata tatatatata tatataaaat atatatgttt atatataaca tatatatata
     4741 gagagagagc ataaaatgtg ctgtgtatgt gtgtagcata ttttttgtta aatcaccatt
     4801 cctgggccct actcattttc tgataatttc ttatcttaat ttgctctgaa agagcaaaac
     4861 ttataaaatt gactattgta actctatttt ttaccaacta tcatttttca tggaaggaat
     4921 agtaaaaaga gttacctctg aagctaagat gacacatgta tgaggaatat aggaagccag
     4981 aaatcatgaa tctatgaaaa gtgaggggtg tctgtgcata ttttatttta tttcataata
     5041 aataaccagt aattaaaata ttcttttcca tgtaatggga tctacgagta aatttttgtc
     5101 tgatatttat aaatctaata tgtaatataa aggagaaata ggaaatgctg tcaaatgaca
     5161 tttcacttta ctacttattt gaattacaat gaaataatat atagctacat cactggctcc
     5221 tgagagagct ttgggtgttc tgtaaatttt ttactttgca ctcttgaaaa attcgcagag
     5281 aatgcaaggt ttagtaaaaa tttattttct tttggcagcc tatcacctgt aatttccgtt
     5341 aaacagcatt tctgactcaa tagtacactg aaagcccatg tttgtaataa tgccctaaag
     5401 cactgcagta cctagagtat atattttgaa gagatagctt tgctgaaata gaaaaccaaa
     5461 ctgtaaattg aagtctgagc attcagagaa ataaaaatta tgctaaaaac aaa
//
