LOCUS       NM_001001701            2671 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens allregulin (ARLN), transcript variant 2, mRNA.
ACCESSION   NM_001001701 XM_376339
VERSION     NM_001001701.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2671)
  AUTHORS   Rathod,N., Bak,J.J., Primeau,J.O., Fisher,M.E.,
            Espinoza-Fonseca,L.M., Lemieux,M.J. and Young,H.S.
  TITLE     Nothing Regular about the Regulins: Distinct Functional Properties
            of SERCA Transmembrane Peptide Regulatory Subunits
  JOURNAL   Int J Mol Sci 22 (16), 8891 (2021)
   PUBMED   34445594
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2671)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2671)
  AUTHORS   Anderson,D.M., Makarewich,C.A., Anderson,K.M., Shelton,J.M.,
            Bezprozvannaya,S., Bassel-Duby,R. and Olson,E.N.
  TITLE     Widespread control of calcium signaling by a family of
            SERCA-inhibiting micropeptides
  JOURNAL   Sci Signal 9 (457), ra119 (2016)
   PUBMED   27923914
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2671)
  AUTHORS   Kalsi,G., Kuo,P.H., Aliev,F., Alexander,J., McMichael,O.,
            Patterson,D.G., Walsh,D., Zhao,Z., Schuckit,M., Nurnberger,J. Jr.,
            Edenberg,H., Kramer,J., Hesselbrock,V., Tischfield,J.A.,
            Vladimirov,V., Prescott,C.A., Dick,D.M., Kendler,K.S. and
            Riley,B.P.
  TITLE     A systematic gene-based screen of chr4q22-q32 identifies
            association of a novel susceptibility gene, DKK2, with the
            quantitative trait of alcohol dependence symptom counts
  JOURNAL   Hum Mol Genet 19 (12), 2497-2506 (2010)
   PUBMED   20332099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Hum Mol Genet. 2010 Oct 15;19(20):4121. Hesselbrock,
            Victor [added]; Tischfield, Jay A [added]]
REFERENCE   5  (bases 1 to 2671)
  AUTHORS   Guo,J., Cheng,J., Ji,D., Zhao,L.F., Gao,X.S., Liu,Y. and Wu,S.H.
  TITLE     [Screening and cloning target genes transactivated by hepatitis C
            virus F protein using suppression subtractive hybridization
            technique]
  JOURNAL   Zhonghua Gan Zang Bing Za Zhi 13 (9), 660-663 (2005)
   PUBMED   16174453
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA353224.1, BC017399.1, CN361054.1, AK024537.1, AK025703.1 and
            BU739784.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001001701.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and uses a downstream start codon,
            compared to variant 1. The encoded isoform (2) is shorter at the
            N-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.196756.1,
                                           SRR1803616.260300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000504110.2/ ENSP00000485697.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               DA353224.1         169-328
            161-414             BC017399.1         152-405
            415-1005            CN361054.1         134-724
            1006-1460           AK024537.1         370-824
            1461-2038           AK025703.1         1394-1971
            2039-2671           BU739784.1         16-648              c
FEATURES             Location/Qualifiers
     source          1..2671
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q26"
     gene            1..2671
                     /gene="ARLN"
                     /gene_synonym="ALN; C4orf3; HCVFTP1"
                     /note="allregulin"
                     /db_xref="GeneID:401152"
                     /db_xref="HGNC:HGNC:19225"
                     /db_xref="MIM:620530"
     exon            1..310
                     /gene="ARLN"
                     /gene_synonym="ALN; C4orf3; HCVFTP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..311
                     /gene="ARLN"
                     /gene_synonym="ALN; C4orf3; HCVFTP1"
                     /note="isoform 2 is encoded by transcript variant 2; HCV
                     F-transactivated protein 1; hepatitis C virus F
                     protein-transactivated protein 1; uncharacterized protein
                     C4orf3; another-regulin; SERCA regulator ALN;
                     sarcoplasmic/endoplasmic reticulum calcium ATPase
                     regulator ALN; SERCA regulator ARLN;
                     sarcoplasmic/endoplasmic reticulum calcium ATPase
                     regulator ARLN"
                     /codon_start=1
                     /product="sarcoplasmic/endoplasmic reticulum calcium
                     ATPase regulator ARLN isoform 2"
                     /protein_id="NP_001001701.2"
                     /db_xref="CCDS:CCDS43266.1"
                     /db_xref="GeneID:401152"
                     /db_xref="HGNC:HGNC:19225"
                     /db_xref="MIM:620530"
                     /translation="MEVDAPGVDGRDGLRERRGFSEGGRQNFDVRPQSGANGLPKHSY
                     WLDLWLFILFDVVVFLFVYFLP"
     exon            311..2671
                     /gene="ARLN"
                     /gene_synonym="ALN; C4orf3; HCVFTP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      581..586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARLN"
                     /gene_synonym="ALN; C4orf3; HCVFTP1"
                     /note="hexamer: TATAAA"
     polyA_site      602
                     /gene="ARLN"
                     /gene_synonym="ALN; C4orf3; HCVFTP1"
                     /note="major polyA site"
     regulatory      2019..2024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARLN"
                     /gene_synonym="ALN; C4orf3; HCVFTP1"
                     /note="hexamer: AATAAA"
     polyA_site      2038
                     /gene="ARLN"
                     /gene_synonym="ALN; C4orf3; HCVFTP1"
     polyA_site      2067
                     /gene="ARLN"
                     /gene_synonym="ALN; C4orf3; HCVFTP1"
     regulatory      2351..2356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARLN"
                     /gene_synonym="ALN; C4orf3; HCVFTP1"
                     /note="hexamer: AATAAA"
     polyA_site      2389
                     /gene="ARLN"
                     /gene_synonym="ALN; C4orf3; HCVFTP1"
     regulatory      2652..2657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARLN"
                     /gene_synonym="ALN; C4orf3; HCVFTP1"
                     /note="hexamer: AATAAA"
     polyA_site      2671
                     /gene="ARLN"
                     /gene_synonym="ALN; C4orf3; HCVFTP1"
ORIGIN      
        1 gcactgcgca ggcggccgga ctccgctcag tttccggtgc ggcgaacacc aaagtccggg
       61 aacttaagca ttttcggttt ctagggttgt tacgaagctg caggagcgag atggaggtgg
      121 acgcaccggg tgttgatggt cgagatggtc tccgggagcg gcgaggcttt agcgagggag
      181 ggaggcagaa cttcgatgtg aggcctcagt ctggggcaaa tgggcttccc aaacactcct
      241 actggttgga cctctggctt ttcatccttt tcgatgtggt ggtgtttctc tttgtgtatt
      301 ttttgccatg acttgttcgc tgatatctaa attaagaagt tggttcttga gtgaattctg
      361 aaaatggcta caaacttctt gaataaagaa gacaggactc tcaatagaag aatttcacat
      421 ctccaaggga cccttccttt cattttacac tttgttacta atttgcagaa ctctattaat
      481 tgggtaggat ttcacccatt cctagctaag ttcttaaaat taaacccttt ggttcgtgtt
      541 taaaaacttt caaacatctg atggctttac aggggctgaa tataaaagca tttgtactta
      601 aaggtcttgt gtattcatta agaaatatag taatgtcttt taatgtttta agagttgatc
      661 agggtttact atgatgcaag taataggatg attaataagg gaaggttttt atgaattcaa
      721 aagtcaatta ttcaaaagca gggaaagatt ttgagagagg gaacaaagta ttcttagatt
      781 gcgtagaagc tgctaggttc cagttttaat ttttaggttt agttggactc tgttatgaaa
      841 agataggtta tgggtgggcg acaggttgat acagtcttag aaaaagcagg taatatcaaa
      901 gtattggaaa gctagcatgc atgccctctt acctgggtat cttccccctt ttttcctttt
      961 aaactcttga gcctcctata acgaaggatt atgtgtttca aacctatttt ttttttactg
     1021 tttcattaag tgtgcttgtg cccaaaatat ttacttgtat aatatctgta acttgcttaa
     1081 atacttcagc aaagtcagca tatttactca ttcaacaaat atttgagcca ggcattattt
     1141 tagacacagc agtgaacaaa acaaaaaggc attcttgcct tcatggagct tacattctta
     1201 ttgttattta aatctaaatg ttataaaaca agaatttata ttctagggtt gatcagctag
     1261 tatttaatca aaaaggccac actcccatag cagctactct aagctgtagt agctaataaa
     1321 aaatattaat gttggccggg cacagtggct cacgcctata atcccagcac tttgggaggc
     1381 caagggtggt agatcacttg aggtcaagag ttgtgacacc agcctggcca acctggtgaa
     1441 accctatctc tattaaaaaa tacaaaaaaa tacaaaaaaa ttagctgggc atgttggcat
     1501 gcacctgtag tcccagctat ttgggaggct gaggcacgag aattgcttga atccgggagg
     1561 tggaggttgc agtgagccaa gatggggcca ctgcactcta acgtgggcaa cagagaccct
     1621 gtctcaaaaa gaaaatattc ctgttagccc taaaggcttt acatgaggaa tggtagaagt
     1681 ggtcttttgt ttaaattagt tgcattcagc atatatgaat tgtcttaaat attttgggga
     1741 tactcccccg ccttttaaac agggcataag atctggtaaa ctctctgtat atcttcctac
     1801 ctttcaaaat cgttcttagg gttagtcaag tctggaatat aattgctgac tataaagtta
     1861 gcaattatgc ttttaaggtg ttgtcacatc aacctaaaga gaaccatcta tggaaggtat
     1921 ggttgaaaca tctgtaggaa cacagaactg ggatttcact gagtttacca aatcaactgt
     1981 gtgaactgtt tctgcactgc ttgctaatgg tttcatctaa taaatgttta cttatatagc
     2041 tgagtttggt tttattctaa caaattacct ggtggtgtga ttgtgaggtg attaacagtt
     2101 ctcacatagt ttactgttag gtcacacaca gacttccgat cataatccat actgcctttt
     2161 tgagcctaaa atcagcctac taccacaatt accaaatatt ctgaaaattt ctagtatggt
     2221 gaagatggag agatcttggt gtgaaggtta attttatatg tcatcttgat tatgctagga
     2281 gatgcccaga tttctgggtt tgtccatgag ggtgtttcca gaagagatta gcatttgaat
     2341 cagtagactg aataaaaaag agccacccac tccactgcgg gtgggccaac cccttgaggg
     2401 cctagctgga ataaaaaggc agaggaaggg caaattctgt cttctctctg cttgaacagg
     2461 gacatccatg ttctatcctt ggacattggt tctcctgatt ctctggcttt cagacatgga
     2521 ccagggcccc tggttctcag acctttgggt ttggactgga actacaccat tggctttcct
     2581 gggcttactg tctgcggaaa gcagattgtg ggacttctca gcctccataa tcacaagagc
     2641 caatccctca taataaattt atttctatat a
//
