LOCUS       NM_001104629            3643 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens PDCD10 and GCKIII kinases associated 1 (PGCKA1),
            transcript variant 1, mRNA.
ACCESSION   NM_001104629
VERSION     NM_001104629.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3643)
  AUTHORS   Kuzmin,E., Baker,T.M., Lesluyes,T., Monlong,J., Abe,K.T.,
            Coelho,P.P., Schwartz,M., Del Corpo,J., Zou,D., Morin,G., Pacis,A.,
            Yang,Y., Martinez,C., Barber,J., Kuasne,H., Li,R., Bourgey,M.,
            Fortier,A.M., Davison,P.G., Omeroglu,A., Guiot,M.C., Morris,Q.,
            Kleinman,C.L., Huang,S., Gingras,A.C., Ragoussis,J., Bourque,G.,
            Van Loo,P. and Park,M.
  TITLE     Evolution of chromosome-arm aberrations in breast cancer through
            genetic network rewiring
  JOURNAL   Cell Rep 43 (4), 113988 (2024)
   PUBMED   38517886
REFERENCE   2  (bases 1 to 3643)
  AUTHORS   Huang,S., Li,J., Wu,S., Zheng,Z., Wang,C., Li,H., Zhao,L.,
            Zhang,X., Huang,H., Huang,C. and Xie,Q.
  TITLE     C4orf19 inhibits colorectal cancer cell proliferation by
            competitively binding to Keap1 with TRIM25 via the USP17/Elk-1/CDK6
            axis
  JOURNAL   Oncogene 42 (17), 1333-1346 (2023)
   PUBMED   36882524
REFERENCE   3  (bases 1 to 3643)
  AUTHORS   Wang,W., Lin,X., Yu,R., Zhou,S., Liu,Y., Jia,H., Han,F., Bu,Y. and
            Pu,J.
  TITLE     Down-regulated C4orf19 confers poor prognosis in colon
            adenocarcinoma identified by gene co-expression network
  JOURNAL   J Cancer 13 (4), 1145-1159 (2022)
   PUBMED   35281862
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3643)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3643)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3643)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3643)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   8  (bases 1 to 3643)
  AUTHORS   Baranzini,S.E., Srinivasan,R., Khankhanian,P., Okuda,D.T.,
            Nelson,S.J., Matthews,P.M., Hauser,S.L., Oksenberg,J.R. and
            Pelletier,D.
  TITLE     Genetic variation influences glutamate concentrations in brains of
            patients with multiple sclerosis
  JOURNAL   Brain 133 (9), 2603-2611 (2010)
   PUBMED   20802204
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022463.5, DA684897.1, CF995148.1, AK225192.1, AC027607.7 and
            AI050941.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001104629.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.114875.1,
                                           SRR1803611.130019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381980.9/ ENSP00000371408.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC022463.5         127937-127941
            6-226               DA684897.1         6-226
            227-709             CF995148.1         226-708
            710-1917            AK225192.1         669-1876
            1918-3280           AC027607.7         77717-79079
            3281-3643           AI050941.1         11-373              c
FEATURES             Location/Qualifiers
     source          1..3643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..3643
                     /gene="PGCKA1"
                     /gene_synonym="C4orf19"
                     /note="PDCD10 and GCKIII kinases associated 1"
                     /db_xref="GeneID:55286"
                     /db_xref="HGNC:HGNC:25618"
     exon            1..116
                     /gene="PGCKA1"
                     /gene_synonym="C4orf19"
                     /inference="alignment:Splign:2.1.0"
     exon            117..166
                     /gene="PGCKA1"
                     /gene_synonym="C4orf19"
                     /inference="alignment:Splign:2.1.0"
     exon            167..220
                     /gene="PGCKA1"
                     /gene_synonym="C4orf19"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1133
                     /gene="PGCKA1"
                     /gene_synonym="C4orf19"
                     /codon_start=1
                     /product="uncharacterized protein C4orf19"
                     /protein_id="NP_001098099.1"
                     /db_xref="CCDS:CCDS3442.1"
                     /db_xref="GeneID:55286"
                     /db_xref="HGNC:HGNC:25618"
                     /translation="MGCRCCKIIQSYLFDPVQVPSPGYVNEVNSCKLDEDDTDKLKGK
                     WSSEVLVQKNDPQRQGSKKTESSSRTADPWEPCWPHQGPLPQGDAGGEHHACGVNGIG
                     PAATPQPTGNSSPTQDDRGSWASTANTVPPTQPFLEGGGTRKQDCVLLASEGTQVMRN
                     GDSRAPSEAESFALEVQDHVFQIPAPDYLQHWGPAGDNVDHNEKDCVFKNHTEDESLE
                     GIQPPVGEHGLNTPFSVRRSWDSLNEDVETEVLSICFNEKGPVHAMPVVDSGNRQEDT
                     HGSDGDGDGEIVDEDAAVAEALAALEAATAGEDLDETD"
     exon            221..3643
                     /gene="PGCKA1"
                     /gene_synonym="C4orf19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1925..1930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGCKA1"
                     /gene_synonym="C4orf19"
                     /note="hexamer: ATTAAA"
     polyA_site      1949
                     /gene="PGCKA1"
                     /gene_synonym="C4orf19"
                     /note="major polyA site"
     regulatory      3623..3628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGCKA1"
                     /gene_synonym="C4orf19"
                     /note="hexamer: AATAAA"
     polyA_site      3643
                     /gene="PGCKA1"
                     /gene_synonym="C4orf19"
                     /note="major polyA site"
ORIGIN      
        1 ggcgggctca gggcagcgcg gagccgctag cgtctcccgg cgcggctgcc cgaggccggc
       61 gaagccatgg gcgccgggac cccgccgccg ccgccgccgc cgccgtctgg ccccaggaag
      121 agaagttaaa cttctagaga aacctaacag acaatatcca caacaggtgg taacagaaaa
      181 caatccagat ggggtgcagg tgctgtaaaa taatacaaag ctatctcttt gatccagttc
      241 aagtgccctc tcctggctat gtcaatgaag tcaacagctg caagctagat gaagacgaca
      301 ctgataaatt aaaaggcaaa tggagcagtg aagtcttggt gcagaaaaat gaccctcaga
      361 ggcagggctc aaagaagact gagagcagca gcaggacagc tgatccatgg gagccctgct
      421 ggcctcacca agggccgctc ccacaggggg acgctggagg ggaacaccat gcctgcggtg
      481 tcaacggcat cggccctgct gccactccac agcccactgg gaattccagc cccacccagg
      541 atgacagggg ctcctgggcc agtactgcaa atactgttcc cccaactcaa cccttcctgg
      601 aaggaggggg caccaggaaa caggactgtg tgctgctggc ctcagaaggg acccaagtca
      661 tgagaaatgg agactccaga gctccttctg aggcagaaag ttttgccttg gaagtacaag
      721 accatgtctt ccagatacca gccccagatt accttcagca ttggggccca gctggagaca
      781 acgttgatca taatgaaaag gactgtgttt tcaagaacca tactgaggat gaatccctag
      841 agggaattca gcccccagtg ggggagcatg gtttgaatac gcccttctct gtgaggagaa
      901 gctgggattc attgaatgag gatgtggaaa cagaagttct aagcatctgc tttaatgaga
      961 agggtcctgt tcatgccatg cctgtggttg actcaggaaa caggcaggag gatacccatg
     1021 gctccgatgg agatggggat ggggagattg tggacgagga tgcagcggtg gcggaggccc
     1081 ttgcagcttt agaagctgct actgcaggag aagatttgga tgagactgat taggggaggg
     1141 gatttgcaca gggaggtaag ctggtgtcat gctgagcatg cagatgcatt tgctccctgg
     1201 atgcatagca ggtgattctg ccagcatgca ccagtgcagc cttaccagtt gtttacatcc
     1261 agcatctgtt ctgattgtca gcatctgtcc catgctgctt gtcacatatc tggagtttca
     1321 ctctgtgtag atgagctgtc attcaggaca ctaggagaaa aatctgagtg ggtcattgtg
     1381 cccatatcca cagaaaatgc agaagttgaa cagcttgctt gacaaccctc aaacatcttt
     1441 gagcacctgg tacagatgtt tatgagaata ctctaagatc tcaacccttg atcccaaagg
     1501 cacacaatca cagagcattc cttttgactg taaactgttt accttgcttt tgagagccaa
     1561 acattgtacc caacctggaa aaagtaacta ccccaattaa agtgcctcat gtgtccccag
     1621 agcatggctt aacttcaggg acaatcaccc agggaactaa taactaacca gttgttcaac
     1681 agcgggttaa gctcagcagt tttcacagta gagcagaagt ccccaggaaa caaagggtta
     1741 gtcattagct gagatgttga ttttaaaaca ccttgacctt aactttttta cattattact
     1801 tttaaatctc ctttgggatt ggggaggctg gccaaaataa gtcttaaaac tgcttatgtc
     1861 atatttggat tttaagttca tgacattcgg aacagcaaag ccatatatgc aatgttttta
     1921 tgccattaaa tgtctgattc caattaaaat ataacaacgt atgtgtcttt ctagaagtct
     1981 taactcaaag gtggttctaa ttttctcaga atatcagtga ccctggatgt tactttcaat
     2041 gtaaagaact aatctagatg gccgggcgtg gtggctcatg cctgtaatcc cagcactttg
     2101 ggaggccgag gcgggtggat cacaaggtca ggagttcaag atcagcctgg ccaacatagt
     2161 gaaaccctgt ctctactaaa aatacaaaaa attatccggg cacggtggcg ggcgcctgta
     2221 atcccagcta cttgggaggc tgaggcaagg agaatcactt gaacctggga ggtggaggtt
     2281 gcagtgagct gagatcgtgc cactgcactc cagcctgggt gacagtgcaa gactccatct
     2341 caaaaaaaaa aaaaaaaaaa agagctaagc taggcacagt ggctcatgtc tgtaatctga
     2401 gcactttgga aggctgaggt gagaggattg ccagggccag gaattcgaga ccaacctggg
     2461 caatttagcg agaccccatc tctatgaaaa aaaaaaaaaa aaaaagagct agactacaaa
     2521 attatactca aggaagggac cgagctggtt tgcagagcca tagctttggc tttctctctg
     2581 tcaaacttga tgccataact aaatgtcctg atcttacctc aaagatgaac aagccctctc
     2641 tggatttcag ccttctaatt cactgaaaca aggacaacca ttctaacgta actcaatgga
     2701 gaatttaaag gcattaagga tgctcaaaac tatctagaaa aaaataaaca tggaagatgc
     2761 tttagtttgg tgttttgtaa cacagaattg aaatctgact gaacttcatt tgatttccag
     2821 ctttgccatg tgaccttgga caagttatgt atccctttac ccatctgtaa agtgagaaga
     2881 ataattgtat gtgcttgtaa aggttaaatg agatgatgta agtgtttagc acagtgcttg
     2941 gcacactagg cactcaaaaa tgatgtttta ctagttgaaa acaattcctt taacaaacat
     3001 ttttacatcc ccacaactga aaactctaaa actgggaagt atgtataatg tcattatttg
     3061 actttggcaa ttatttagta taaaacatga tttctgagcc ttccagcacc tttaaggacg
     3121 gcacccttac aaatgcttaa tgagcctatg ggtttgtttg gtactgtaat gacaagccat
     3181 cgcaagtgac ctctatatac agggtcactc agagccctta aaaagataaa gtcttggcat
     3241 tgttaattgc attagaggta tgtctccttt tgtatttagt acaccaaata cttaatattt
     3301 cagaatgctt attccttcaa tgatttccta agtgtatcag ttgagattat gttcagttgt
     3361 atgggacgag tgttttatac aaatagaggc ttatttacct cttatgtaaa agaagtctgg
     3421 agttagtgat ccagggtggt agagaatgta tcactggccc gtgtatcaat gacccacata
     3481 tcaatgaccc acgtatcaat gacccgcata tgaatgaccc atgctgcttc aatcattttg
     3541 gtttccttct caagatcact ttgtagtcca taatggctgc tgtggcttca gtcattacat
     3601 ttgcattcca tgttggaaaa agaataaagg aataaaaacc cca
//
