LOCUS       NM_032149               1619 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens chromosome 4 open reading frame 17 (C4orf17), mRNA.
ACCESSION   NM_032149
VERSION     NM_032149.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1619)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1619)
  AUTHORS   Luykx,J.J., Bakker,S.C., Lentjes,E., Neeleman,M., Strengman,E.,
            Mentink,L., DeYoung,J., de Jong,S., Sul,J.H., Eskin,E., van
            Eijk,K., van Setten,J., Buizer-Voskamp,J.E., Cantor,R.M., Lu,A.,
            van Amerongen,M., van Dongen,E.P., Keijzers,P., Kappen,T.,
            Borgdorff,P., Bruins,P., Derks,E.M., Kahn,R.S. and Ophoff,R.A.
  TITLE     Genome-wide association study of monoamine metabolite levels in
            human cerebrospinal fluid
  JOURNAL   Mol Psychiatry 19 (2), 228-234 (2014)
   PUBMED   23319000
REFERENCE   3  (bases 1 to 1619)
  AUTHORS   Wade,T.D., Gordon,S., Medland,S., Bulik,C.M., Heath,A.C.,
            Montgomery,G.W. and Martin,N.G.
  TITLE     Genetic variants associated with disordered eating
  JOURNAL   Int J Eat Disord 46 (6), 594-608 (2013)
   PUBMED   23568457
REFERENCE   4  (bases 1 to 1619)
  AUTHORS   Ostensson,M., Monten,C., Bacelis,J., Gudjonsdottir,A.H.,
            Adamovic,S., Ek,J., Ascher,H., Pollak,E., Arnell,H., Browaldh,L.,
            Agardh,D., Wahlstrom,J., Nilsson,S. and Torinsson-Naluai,A.
  TITLE     A possible mechanism behind autoimmune disorders discovered by
            genome-wide linkage and association analysis in celiac disease
  JOURNAL   PLoS One 8 (8), e70174 (2013)
   PUBMED   23936387
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1619)
  AUTHORS   Wada,S., Hamada,M., Kobayashi,K. and Satoh,N.
  TITLE     Novel genes involved in canonical Wnt/beta-catenin signaling
            pathway in early Ciona intestinalis embryos
  JOURNAL   Dev Growth Differ 50 (4), 215-227 (2008)
   PUBMED   18336583
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK223345.1 and AL136838.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032149.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136838.1, AK223345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326581.9/ ENSP00000322582.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1602              AK223345.1         5-1606
            1603-1619           AL136838.1         1581-1597
FEATURES             Location/Qualifiers
     source          1..1619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q23"
     gene            1..1619
                     /gene="C4orf17"
                     /note="chromosome 4 open reading frame 17"
                     /db_xref="GeneID:84103"
                     /db_xref="HGNC:HGNC:25274"
     exon            1..252
                     /gene="C4orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            253..472
                     /gene="C4orf17"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..1425
                     /gene="C4orf17"
                     /codon_start=1
                     /product="uncharacterized protein C4orf17"
                     /protein_id="NP_115525.2"
                     /db_xref="CCDS:CCDS3649.1"
                     /db_xref="GeneID:84103"
                     /db_xref="HGNC:HGNC:25274"
                     /translation="MNLNPPTSALQIEGKGSHIMARNVSCFLVRHTPHPRRVCHIKGL
                     NNIPICTVNDDENAFGTLWGVGQSNYLEKNRIPFANCSYPSSTAVQESPVRGMSPAPN
                     GAKVPPRPHSEPSRKIKECFKTSSENPLVIKKEEIKAKRPPSPPKACSTPGSCSSGMT
                     STKNDVKANTICIPNYLDQEIKILAKLCSILHTDSLAEVLQWLLHATSKEKEWVSALI
                     HSELAEINLLTHHRRNTSMEPAAETGKPPTVKSPPTVKLPPNFTAKSKVLTRDTEGDQ
                     PTRVSSQGSEENKEVPKEAEHKPPLLIRRNNMKIPVAEYFSKPNSPPRPNTQESGSAK
                     PVSARSIQEYNLCPQRACYPSTHRR"
     exon            473..682
                     /gene="C4orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            683..747
                     /gene="C4orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            748..891
                     /gene="C4orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            892..973
                     /gene="C4orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1181
                     /gene="C4orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1225
                     /gene="C4orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1619
                     /gene="C4orf17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1580..1585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C4orf17"
                     /note="hexamer: AATAAA"
     polyA_site      1619
                     /gene="C4orf17"
                     /note="major polyA site"
ORIGIN      
        1 aacatatctt aacaaccagg gagccacaca ggctccttgg agtaagagtg tgagaaactg
       61 gatgaagaca gctgtattct tttggaagcg ttcgagattg gtctgtctct accaactaaa
      121 aacttctagc ttaagtgcag agatttaagg agatcaacaa aaactcagtc tagacatatt
      181 atgaggctgg gagggtatca acagacttga gttcttgtca gcaagatcac ctgcttttaa
      241 tattgtcctc agggtctgag cacatctgga agtgaggtca atcaagttag accccaaaaa
      301 cttttgtgac aacagtgaag aggggaaaat aaacacacca caaacatgaa cctcaacccc
      361 ccgacatctg ctcttcagat cgagggcaaa ggcagccata ttatggctag aaatgtaagc
      421 tgctttctag tcaggcacac ccctcatccc agaagagtct gccacatcaa aggcttgaat
      481 aacattccaa tctgtactgt gaatgatgat gagaatgcat ttggaacatt gtggggagtt
      541 ggccagtcta actacttaga gaagaacagg ataccatttg ccaattgcag ttacccctcc
      601 agcactgcag tccaggagag ccctgtaaga ggaatgtcgc cagccccaaa cggtgccaaa
      661 gtgcctccac ggcctcattc tgagcccagt agaaaaatta aagagtgctt caaaacttcc
      721 agtgagaatc ccttagtaat taaaaaggaa gaaattaagg ccaaaagacc accatcacct
      781 ccaaaggcat gctctactcc tggctcctgt tcttcaggga tgacaagtac caagaatgat
      841 gtgaaagcaa acaccatttg cataccaaac tatctggatc aggaaataaa aatcctggca
      901 aagctctgta gcattttgca tactgattct ctggcagaag ttttacagtg gctgcttcat
      961 gcaacttcaa aagaaaaaga gtgggtctca gctttgattc attctgagct tgccgagata
     1021 aacctgttaa ctcatcacag aagaaacacc tcaatggaac cagcagcaga gactgggaag
     1081 ccacccacag ttaaatcacc acccacagtt aaattgcccc caaattttac tgcaaaatca
     1141 aaagtgctga ccagagatac agaaggggat caaccaacca gagtgtcaag tcaaggatct
     1201 gaagaaaaca aggaagtacc aaaagaggct gagcacaagc ctccactact tataagaaga
     1261 aataatatga aaatacctgt tgcagaatat ttcagcaaac caaattctcc tcccaggcct
     1321 aacactcagg agagtggatc agcaaaacca gtgtcagcaa ggagtataca agaatacaac
     1381 ctctgtcccc aaagagcatg ttatccttca acacaccgga ggtagaagtt ctagactggg
     1441 tgaattcttt catgaatatg agcttcacat ttacatcatc aaattatttt tcaaatgaat
     1501 atttttggta ttgaggaatc aagtggtcct ctttatggtg gcacatgtaa atctaaaaat
     1561 acctgtatgt aatgctacaa ataaatatta ctggaaatga tatttccatt tgtagttaa
//
