LOCUS       NM_001017365             960 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens complement component 4 binding protein beta (C4BPB),
            transcript variant 3, mRNA.
ACCESSION   NM_001017365
VERSION     NM_001017365.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 960)
  AUTHORS   Kadava,T., Hevler,J.F., Kalaidopoulou Nteak,S., Yin,V.C.,
            Strasser,J., Preiner,J. and Heck,A.J.
  TITLE     Higher-order structure and proteoforms of co-occurring C4b-binding
            protein assemblies in human serum
  JOURNAL   EMBO J 43 (14), 3009-3026 (2024)
   PUBMED   38811852
  REMARK    GeneRIF: Higher-order structure and proteoforms of co-occurring
            C4b-binding protein assemblies in human serum.
REFERENCE   2  (bases 1 to 960)
  AUTHORS   Serrano,I., Luque,A., Ruiz-Cerulla,A., Navas,S., Blom,A.M.,
            Rodriguez de Cordoba,S., Fernandez,F.J., Cristina Vega,M.,
            Rodriguez-Moranta,F., Guardiola,J. and Aran,J.M.
  TITLE     C4BP(beta-)-mediated immunomodulation attenuates inflammation in
            DSS-induced murine colitis and in myeloid cells from IBD patients
  JOURNAL   Pharmacol Res 197, 106948 (2023)
   PUBMED   37806602
  REMARK    GeneRIF: C4BP(beta-)-mediated immunomodulation attenuates
            inflammation in DSS-induced murine colitis and in myeloid cells
            from IBD patients.
REFERENCE   3  (bases 1 to 960)
  AUTHORS   Kupreishvili,K., Meischl,C., Vonk,A.B.A., Stooker,W., Eijsman,L.,
            Blom,A.M., Quax,P.H.A., van Hinsbergh,V.W.M., Niessen,H.W.M. and
            Krijnen,P.A.J.
  TITLE     Arterial Blood Pressure Induces Transient C4b-Binding Protein in
            Human Saphenous Vein Grafts
  JOURNAL   Ann Vasc Surg 41, 259-264 (2017)
   PUBMED   28163174
  REMARK    GeneRIF: Exposure to arterial blood pressure leads to a transient
            presence of C4bp in the saphenous vein wall.
REFERENCE   4  (bases 1 to 960)
  AUTHORS   Jiang,T.T., Shi,L.Y., Wei,L.L., Li,X., Yang,S., Wang,C., Liu,C.M.,
            Chen,Z.L., Tu,H.H., Li,Z.J. and Li,J.C.
  TITLE     Serum amyloid A, protein Z, and C4b-binding protein beta chain as
            new potential biomarkers for pulmonary tuberculosis
  JOURNAL   PLoS One 12 (3), e0173304 (2017)
   PUBMED   28278182
  REMARK    GeneRIF: SAA, PROZ, and C4BPB may serve as new potential biomarkers
            for TB
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 960)
  AUTHORS   Dikhoff,M.J., ter Weeme,M., Vonk,A.B., Kupreishvili,K., Blom,A.M.,
            Krijnen,P.A., Stooker,W. and Niessen,H.W.
  TITLE     C4b-Binding Protein Deposition is Induced in Diseased Aortic Heart
            Valves, Coinciding with C3d
  JOURNAL   J Heart Valve Dis 24 (4), 451-456 (2015)
   PUBMED   26897815
  REMARK    GeneRIF: C4BP is deposited in the diseased aortic valve, coincident
            with C3d expression.
REFERENCE   6  (bases 1 to 960)
  AUTHORS   Sanchez-Corral,P., Criado Garcia,O. and Rodriguez de Cordoba,S.
  TITLE     Isoforms of human C4b-binding protein. I. Molecular basis for the
            C4BP isoform pattern and its variations in human plasma
  JOURNAL   J Immunol 155 (8), 4030-4036 (1995)
   PUBMED   7561113
REFERENCE   7  (bases 1 to 960)
  AUTHORS   Hillarp,A., Pardo-Manuel,F., Ruiz,R.R., Rodriguez de Cordoba,S. and
            Dahlback,B.
  TITLE     The human C4b-binding protein beta-chain gene
  JOURNAL   J Biol Chem 268 (20), 15017-15023 (1993)
   PUBMED   8325877
REFERENCE   8  (bases 1 to 960)
  AUTHORS   Andersson,A., Dahlback,B., Hanson,C., Hillarp,A., Levan,G.,
            Szpirer,J. and Szpirer,C.
  TITLE     Genes for C4b-binding protein alpha- and beta-chains (C4BPA and
            C4BPB) are located on chromosome 1, band 1q32, in humans and on
            chromosome 13 in rats
  JOURNAL   Somat Cell Mol Genet 16 (5), 493-500 (1990)
   PUBMED   2237642
REFERENCE   9  (bases 1 to 960)
  AUTHORS   Hillarp,A. and Dahlback,B.
  TITLE     Cloning of cDNA coding for the beta chain of human complement
            component C4b-binding protein: sequence homology with the alpha
            chain
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 1183-1187 (1990)
   PUBMED   2300577
REFERENCE   10 (bases 1 to 960)
  AUTHORS   Hillarp,A. and Dahlback,B.
  TITLE     Novel subunit in C4b-binding protein required for protein S binding
  JOURNAL   J Biol Chem 263 (25), 12759-12764 (1988)
   PUBMED   2970465
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG568018.1, L11244.1 and
            BM987840.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001017365.2.
            
            Summary: This gene encodes a member of a superfamily of proteins
            composed predominantly of tandemly arrayed short consensus repeats
            of approximately 60 amino acids. A single, unique beta-chain
            encoded by this gene assembles with seven identical alpha-chains
            into the predominant isoform of C4b-binding protein, a multimeric
            protein that controls activation of the complement cascade through
            the classical pathway. C4b-binding protein has a regulatory role in
            the coagulation system also, mediated through the beta-chain
            binding of protein S, a vitamin K-dependent protein that serves as
            a cofactor of activated protein C. The genes encoding both alpha
            and beta chains are located adjacent to each other on human
            chromosome 1 in the regulator of complement activation gene
            cluster. Alternative splicing gives rise to multiple transcript
            variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3), also known as A12, differs in
            the 5' UTR compared to variant 1. Variants 1, 3 and 5 encode the
            same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.150523.1,
                                           SRR5189658.161197.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367078.8/ ENSP00000356045.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BG568018.1         20-29
            11-957              L11244.1           208-1154
            958-960             BM987840.1         16-18               c
FEATURES             Location/Qualifiers
     source          1..960
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..960
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /note="complement component 4 binding protein beta"
                     /db_xref="GeneID:725"
                     /db_xref="HGNC:HGNC:1328"
                     /db_xref="MIM:120831"
     exon            1..87
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            88..195
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..896
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; C4b-binding protein beta chain"
                     /codon_start=1
                     /product="C4b-binding protein beta chain isoform 1
                     precursor"
                     /protein_id="NP_001017365.1"
                     /db_xref="CCDS:CCDS1476.1"
                     /db_xref="GeneID:725"
                     /db_xref="HGNC:HGNC:1328"
                     /db_xref="MIM:120831"
                     /translation="MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQIL
                     GTYVCIKGYHLVGKKTLFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDK
                     ITFMCNDHYILKGSNRSQCLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGST
                     ISYYCEDRYYLVGVQEQQCVDGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEA
                     MENFMQQLKESGMTMEELKYSLELKKAELKAKLL"
     exon            196..369
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            370..546
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            547..640
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            641..755
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            756..960
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      935..940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /note="hexamer: AATAAA"
     polyA_site      960
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /note="major polyA site"
ORIGIN      
        1 actgcaggac tttggagctc tcagctttgg agtcagttaa gaccagttcc ttgctgggaa
       61 gccctaactc tggagggaca gagacaggtg tctgagctgg gtgaattcca gcctggggag
      121 aggactttga tcaccagatg tttttttggt gtgcgtgctg tcttatggtt gcgtggcgag
      181 tttctgcttc agatgcagag cactgtccag agcttcctcc agtggacaat agcatatttg
      241 tcgcaaagga ggtggaagga cagattctgg ggacttacgt ttgtatcaag ggctaccacc
      301 tggtaggaaa gaagaccctt ttttgcaatg cctctaagga gtgggataac accactactg
      361 agtgccgctt gggccactgt cctgatcctg tgctggtgaa tggagagttc agttcttcag
      421 ggcctgtgaa tgtaagtgac aaaatcacgt ttatgtgcaa tgaccactac atcctcaagg
      481 gcagcaatcg gagccagtgt ctagaggacc acacctgggc acctcccttt cccatctgca
      541 aaagtaggga ctgtgaccct cctgggaatc cagttcatgg ctattttgaa ggaaataact
      601 tcaccttagg atccaccatt agttattact gtgaagacag gtactactta gtgggcgtgc
      661 aggagcagca atgcgttgat ggggagtgga gcagtgcact tccagtctgc aagttgatcc
      721 aggaagctcc caaaccagag tgtgagaagg cacttcttgc ctttcaggag agtaagaacc
      781 tctgcgaagc catggagaac tttatgcaac aattaaagga aagtggcatg acaatggagg
      841 agctaaaata ttctctggag ctgaagaaag ctgagttgaa ggcaaaattg ttgtaacact
      901 acagctgagc agatgtaata gaaataaacc tatgaataaa ttttcttctt ggttctgaaa
//
