LOCUS       NM_001017364            1128 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens complement component 4 binding protein beta (C4BPB),
            transcript variant 2, mRNA.
ACCESSION   NM_001017364
VERSION     NM_001017364.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1128)
  AUTHORS   Kadava,T., Hevler,J.F., Kalaidopoulou Nteak,S., Yin,V.C.,
            Strasser,J., Preiner,J. and Heck,A.J.
  TITLE     Higher-order structure and proteoforms of co-occurring C4b-binding
            protein assemblies in human serum
  JOURNAL   EMBO J 43 (14), 3009-3026 (2024)
   PUBMED   38811852
  REMARK    GeneRIF: Higher-order structure and proteoforms of co-occurring
            C4b-binding protein assemblies in human serum.
REFERENCE   2  (bases 1 to 1128)
  AUTHORS   Serrano,I., Luque,A., Ruiz-Cerulla,A., Navas,S., Blom,A.M.,
            Rodriguez de Cordoba,S., Fernandez,F.J., Cristina Vega,M.,
            Rodriguez-Moranta,F., Guardiola,J. and Aran,J.M.
  TITLE     C4BP(beta-)-mediated immunomodulation attenuates inflammation in
            DSS-induced murine colitis and in myeloid cells from IBD patients
  JOURNAL   Pharmacol Res 197, 106948 (2023)
   PUBMED   37806602
  REMARK    GeneRIF: C4BP(beta-)-mediated immunomodulation attenuates
            inflammation in DSS-induced murine colitis and in myeloid cells
            from IBD patients.
REFERENCE   3  (bases 1 to 1128)
  AUTHORS   Kupreishvili,K., Meischl,C., Vonk,A.B.A., Stooker,W., Eijsman,L.,
            Blom,A.M., Quax,P.H.A., van Hinsbergh,V.W.M., Niessen,H.W.M. and
            Krijnen,P.A.J.
  TITLE     Arterial Blood Pressure Induces Transient C4b-Binding Protein in
            Human Saphenous Vein Grafts
  JOURNAL   Ann Vasc Surg 41, 259-264 (2017)
   PUBMED   28163174
  REMARK    GeneRIF: Exposure to arterial blood pressure leads to a transient
            presence of C4bp in the saphenous vein wall.
REFERENCE   4  (bases 1 to 1128)
  AUTHORS   Jiang,T.T., Shi,L.Y., Wei,L.L., Li,X., Yang,S., Wang,C., Liu,C.M.,
            Chen,Z.L., Tu,H.H., Li,Z.J. and Li,J.C.
  TITLE     Serum amyloid A, protein Z, and C4b-binding protein beta chain as
            new potential biomarkers for pulmonary tuberculosis
  JOURNAL   PLoS One 12 (3), e0173304 (2017)
   PUBMED   28278182
  REMARK    GeneRIF: SAA, PROZ, and C4BPB may serve as new potential biomarkers
            for TB
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1128)
  AUTHORS   Dikhoff,M.J., ter Weeme,M., Vonk,A.B., Kupreishvili,K., Blom,A.M.,
            Krijnen,P.A., Stooker,W. and Niessen,H.W.
  TITLE     C4b-Binding Protein Deposition is Induced in Diseased Aortic Heart
            Valves, Coinciding with C3d
  JOURNAL   J Heart Valve Dis 24 (4), 451-456 (2015)
   PUBMED   26897815
  REMARK    GeneRIF: C4BP is deposited in the diseased aortic valve, coincident
            with C3d expression.
REFERENCE   6  (bases 1 to 1128)
  AUTHORS   Sanchez-Corral,P., Criado Garcia,O. and Rodriguez de Cordoba,S.
  TITLE     Isoforms of human C4b-binding protein. I. Molecular basis for the
            C4BP isoform pattern and its variations in human plasma
  JOURNAL   J Immunol 155 (8), 4030-4036 (1995)
   PUBMED   7561113
REFERENCE   7  (bases 1 to 1128)
  AUTHORS   Hillarp,A., Pardo-Manuel,F., Ruiz,R.R., Rodriguez de Cordoba,S. and
            Dahlback,B.
  TITLE     The human C4b-binding protein beta-chain gene
  JOURNAL   J Biol Chem 268 (20), 15017-15023 (1993)
   PUBMED   8325877
REFERENCE   8  (bases 1 to 1128)
  AUTHORS   Andersson,A., Dahlback,B., Hanson,C., Hillarp,A., Levan,G.,
            Szpirer,J. and Szpirer,C.
  TITLE     Genes for C4b-binding protein alpha- and beta-chains (C4BPA and
            C4BPB) are located on chromosome 1, band 1q32, in humans and on
            chromosome 13 in rats
  JOURNAL   Somat Cell Mol Genet 16 (5), 493-500 (1990)
   PUBMED   2237642
REFERENCE   9  (bases 1 to 1128)
  AUTHORS   Hillarp,A. and Dahlback,B.
  TITLE     Cloning of cDNA coding for the beta chain of human complement
            component C4b-binding protein: sequence homology with the alpha
            chain
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 1183-1187 (1990)
   PUBMED   2300577
REFERENCE   10 (bases 1 to 1128)
  AUTHORS   Hillarp,A. and Dahlback,B.
  TITLE     Novel subunit in C4b-binding protein required for protein S binding
  JOURNAL   J Biol Chem 263 (25), 12759-12764 (1988)
   PUBMED   2970465
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005378.1 and BM987840.1.
            
            Summary: This gene encodes a member of a superfamily of proteins
            composed predominantly of tandemly arrayed short consensus repeats
            of approximately 60 amino acids. A single, unique beta-chain
            encoded by this gene assembles with seven identical alpha-chains
            into the predominant isoform of C4b-binding protein, a multimeric
            protein that controls activation of the complement cascade through
            the classical pathway. C4b-binding protein has a regulatory role in
            the coagulation system also, mediated through the beta-chain
            binding of protein S, a vitamin K-dependent protein that serves as
            a cofactor of activated protein C. The genes encoding both alpha
            and beta chains are located adjacent to each other on human
            chromosome 1 in the regulator of complement activation gene
            cluster. Alternative splicing gives rise to multiple transcript
            variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate, in-frame
            splice site in the 5' coding region, compared to variant 1.
            Variants 2 and 4 encode isoform 2, which has a shorter N-terminus,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005378.1, ERR279826.9025.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1110              BC005378.1         1-1110
            1111-1128           BM987840.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1128
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /note="complement component 4 binding protein beta"
                     /db_xref="GeneID:725"
                     /db_xref="HGNC:HGNC:1328"
                     /db_xref="MIM:120831"
     exon            1..351
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1049
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; C4b-binding protein beta chain"
                     /codon_start=1
                     /product="C4b-binding protein beta chain isoform 2
                     precursor"
                     /protein_id="NP_001017364.1"
                     /db_xref="CCDS:CCDS31005.1"
                     /db_xref="GeneID:725"
                     /db_xref="HGNC:HGNC:1328"
                     /db_xref="MIM:120831"
                     /translation="MFFWCACCLMVAWRVSASDEHCPELPPVDNSIFVAKEVEGQILG
                     TYVCIKGYHLVGKKTLFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKI
                     TFMCNDHYILKGSNRSQCLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTI
                     SYYCEDRYYLVGVQEQQCVDGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAM
                     ENFMQQLKESGMTMEELKYSLELKKAELKAKLL"
     exon            352..522
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            523..699
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            700..793
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            794..908
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1113
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1088..1093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /note="hexamer: AATAAA"
     polyA_site      1113
                     /gene="C4BPB"
                     /gene_synonym="C4BP"
                     /note="major polyA site"
ORIGIN      
        1 attcccagaa accaggaaat ttctgaaact gagttttaaa cctggcaact cttttaccat
       61 ccctttgtat ttttgcagtt cctccctata ccagcttcct tacagctgtt ctgatttcct
      121 gtcgtaagat tttttctttt cattttctcc agggagggta aatcaatata acctcttctc
      181 tagagaggag gtggttaggt tggtcttaag cagtgttaga agatctattt tttttcaaac
      241 caggtgtctg agctgggtga attccagcct ggggagagga ctttgatcac cagatgtttt
      301 tttggtgtgc gtgctgtctt atggttgcgt ggcgagtttc tgcttcagat gagcactgtc
      361 cagagcttcc tccagtggac aatagcatat ttgtcgcaaa ggaggtggaa ggacagattc
      421 tggggactta cgtttgtatc aagggctacc acctggtagg aaagaagacc cttttttgca
      481 atgcctctaa ggagtgggat aacaccacta ctgagtgccg cttgggccac tgtcctgatc
      541 ctgtgctggt gaatggagag ttcagttctt cagggcctgt gaatgtaagt gacaaaatca
      601 cgtttatgtg caatgaccac tacatcctca agggcagcaa tcggagccag tgtctagagg
      661 accacacctg ggcacctccc tttcccatct gcaaaagtag ggactgtgac cctcctggga
      721 atccagttca tggctatttt gaaggaaata acttcacctt aggatccacc attagttatt
      781 actgtgaaga caggtactac ttagtgggcg tgcaggagca gcaatgcgtt gatggggagt
      841 ggagcagtgc acttccagtc tgcaagttga tccaggaagc tcccaaacca gagtgtgaga
      901 aggcacttct tgcctttcag gagagtaaga acctctgcga agccatggag aactttatgc
      961 aacaattaaa ggaaagtggc atgacaatgg aggagctaaa atattctctg gagctgaaga
     1021 aagctgagtt gaaggcaaaa ttgttgtaac actacagctg agcagatgta atagaaataa
     1081 acctatgaat aaattttctt cttggttctg aaaaaaaaaa aaaaaaaa
//
