LOCUS       NM_000715               2272 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens complement component 4 binding protein alpha (C4BPA),
            mRNA.
ACCESSION   NM_000715
VERSION     NM_000715.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2272)
  AUTHORS   Kadava,T., Hevler,J.F., Kalaidopoulou Nteak,S., Yin,V.C.,
            Strasser,J., Preiner,J. and Heck,A.J.
  TITLE     Higher-order structure and proteoforms of co-occurring C4b-binding
            protein assemblies in human serum
  JOURNAL   EMBO J 43 (14), 3009-3026 (2024)
   PUBMED   38811852
  REMARK    GeneRIF: Higher-order structure and proteoforms of co-occurring
            C4b-binding protein assemblies in human serum.
REFERENCE   2  (bases 1 to 2272)
  AUTHORS   Xie,H.G., Jiang,L.P., Tai,T., Ji,J.Z. and Mi,Q.Y.
  TITLE     The Complement System and C4b-Binding Protein: A Focus on the
            Promise of C4BPalpha as a Biomarker to Predict Clopidogrel
            Resistance
  JOURNAL   Mol Diagn Ther 28 (2), 189-199 (2024)
   PUBMED   38261250
  REMARK    GeneRIF: The Complement System and C4b-Binding Protein: A Focus on
            the Promise of C4BPalpha as a Biomarker to Predict Clopidogrel
            Resistance.
            Review article
REFERENCE   3  (bases 1 to 2272)
  AUTHORS   Beirag,N., Varghese,P.M., Neto,M.M., Al Aiyan,A., Khan,H.A.,
            Qablan,M., Shamji,M.H., Sim,R.B., Temperton,N. and Kishore,U.
  TITLE     Complement Activation-Independent Attenuation of SARS-CoV-2
            Infection by C1q and C4b-Binding Protein
  JOURNAL   Viruses 15 (6), 1269 (2023)
   PUBMED   37376569
  REMARK    GeneRIF: Complement Activation-Independent Attenuation of
            SARS-CoV-2 Infection by C1q and C4b-Binding Protein.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2272)
  AUTHORS   Wang,Y., Ma,Y., Yang,C., Huang,X., Yang,K., Lan,F., Fu,J., Song,Z.,
            Tian,A., Feng,Y., Tu,T., Li,H., Hong,T., Wang,Y. and Zhang,H.
  TITLE     Potential biomarkers of spinal dural arteriovenous fistula: C4BPA
            and C1QA
  JOURNAL   J Neuroinflammation 19 (1), 165 (2022)
   PUBMED   35733178
  REMARK    GeneRIF: Potential biomarkers of spinal dural arteriovenous
            fistula: C4BPA and C1QA.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2272)
  AUTHORS   Serrano,I., Luque,A., Mitjavila,F., Blom,A.M., Rodriguez de
            Cordoba,S., Vega,M.C., Torras,J. and Aran,J.M.
  TITLE     The Hidden Side of Complement Regulator C4BP: Dissection and
            Evaluation of Its Immunomodulatory Activity
  JOURNAL   Front Immunol 13, 883743 (2022)
   PUBMED   35547734
  REMARK    GeneRIF: The Hidden Side of Complement Regulator C4BP: Dissection
            and Evaluation of Its Immunomodulatory Activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2272)
  AUTHORS   Dahlback,B.
  TITLE     Protein S and C4b-binding protein: components involved in the
            regulation of the protein C anticoagulant system
  JOURNAL   Thromb Haemost 66 (1), 49-61 (1991)
   PUBMED   1833851
  REMARK    Review article
REFERENCE   7  (bases 1 to 2272)
  AUTHORS   Aso,T., Okamura,S., Matsuguchi,T., Sakamoto,N., Sata,T. and Niho,Y.
  TITLE     Genomic organization of the alpha chain of the human C4b-binding
            protein gene
  JOURNAL   Biochem Biophys Res Commun 174 (1), 222-227 (1991)
   PUBMED   1989602
REFERENCE   8  (bases 1 to 2272)
  AUTHORS   Andersson,A., Dahlback,B., Hanson,C., Hillarp,A., Levan,G.,
            Szpirer,J. and Szpirer,C.
  TITLE     Genes for C4b-binding protein alpha- and beta-chains (C4BPA and
            C4BPB) are located on chromosome 1, band 1q32, in humans and on
            chromosome 13 in rats
  JOURNAL   Somat Cell Mol Genet 16 (5), 493-500 (1990)
   PUBMED   2237642
REFERENCE   9  (bases 1 to 2272)
  AUTHORS   Pardo-Manuel,F., Rey-Campos,J., Hillarp,A., Dahlback,B. and
            Rodriguez de Cordoba,S.
  TITLE     Human genes for the alpha and beta chains of complement C4b-binding
            protein are closely linked in a head-to-tail arrangement
  JOURNAL   Proc Natl Acad Sci U S A 87 (12), 4529-4532 (1990)
   PUBMED   2352933
REFERENCE   10 (bases 1 to 2272)
  AUTHORS   Matsuguchi,T., Okamura,S., Aso,T., Sata,T. and Niho,Y.
  TITLE     Molecular cloning of the cDNA coding for proline-rich protein
            (PRP): identity of PRP as C4b-binding protein
  JOURNAL   Biochem Biophys Res Commun 165 (1), 138-144 (1989)
   PUBMED   2590215
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445493.8, BC022312.1 and
            BQ019292.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000715.3.
            
            Summary: This gene encodes a member of a superfamily of proteins
            composed predominantly of tandemly arrayed short consensus repeats
            of approximately 60 amino acids. Along with a single, unique
            beta-chain, seven identical alpha-chains encoded by this gene
            assemble into the predominant isoform of C4b-binding protein, a
            multimeric protein that controls activation of the complement
            cascade through the classical pathway. The genes encoding both
            alpha and beta chains are located adjacent to each other on human
            chromosome 1 in the regulator of complement activation gene
            cluster. Two pseudogenes of this gene are also found in the
            cluster. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.108922.1,
                                           SRR5189658.219109.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367070.8/ ENSP00000356037.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL445493.8         63703-63731
            30-2261             BC022312.1         1-2232
            2262-2272           BQ019292.1         18-28               c
FEATURES             Location/Qualifiers
     source          1..2272
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     gene            1..2272
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /note="complement component 4 binding protein alpha"
                     /db_xref="GeneID:722"
                     /db_xref="HGNC:HGNC:1325"
                     /db_xref="MIM:120830"
     exon            1..198
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /inference="alignment:Splign:2.1.0"
     exon            199..365
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..2017
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /note="proline-rich protein; C4b-binding protein alpha
                     chain"
                     /codon_start=1
                     /product="C4b-binding protein alpha chain precursor"
                     /protein_id="NP_000706.1"
                     /db_xref="CCDS:CCDS1477.1"
                     /db_xref="GeneID:722"
                     /db_xref="HGNC:HGNC:1325"
                     /db_xref="MIM:120830"
                     /translation="MHPPKTPSGALHRKRKMAAWPFSRLWKVSDPILFQMTLIAALLP
                     AVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEW
                     VYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG
                     VGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCT
                     VENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGS
                     SVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHP
                     GYKPTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYG
                     DEISFSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEI
                     IYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEPENVT
                     IQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGKRLMQCLPNPEDVK
                     MALEVYKLSLEIEQLELQRDSARQSTLDKEL"
     exon            366..551
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /inference="alignment:Splign:2.1.0"
     exon            552..651
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /inference="alignment:Splign:2.1.0"
     exon            652..737
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /inference="alignment:Splign:2.1.0"
     exon            738..929
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1112
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1307
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1496
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1667
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1843
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2272
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2247..2252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /note="hexamer: ATTAAA"
     polyA_site      2272
                     /gene="C4BPA"
                     /gene_synonym="C4BP; PRP"
                     /note="major polyA site"
ORIGIN      
        1 aaccgtcctt gaccagccaa ccacatggct gaaattcagg gactctttgg tggagcaatt
       61 accagtcaac ttcagggtat tatgataaac tctgatctgg ggaggaacca ggactacata
      121 gatcaaggca gttttcttct ttgagaaact atcccagata tcatcataga gtcttctgct
      181 cttcctcaac taccaaagaa aaacatcagc gaagcagcag gccatgcacc ccccaaaaac
      241 tccatctggg gctcttcata gaaaaaggaa aatggcagcc tggcccttct ccaggctgtg
      301 gaaagtctct gatccaattc tcttccaaat gaccttgatc gctgctctgt tgcctgctgt
      361 tcttggcaat tgtggtcctc cacccacttt atcatttgct gccccgatgg atattacgtt
      421 gactgagaca cgcttcaaaa ctggaactac tctgaaatac acctgcctcc ctggctacgt
      481 cagatcccat tcaactcaga cgcttacctg taattctgat ggcgaatggg tgtataacac
      541 cttctgtatc tacaaacgat gcagacaccc aggagagtta cgtaatgggc aagtagagat
      601 taagacagat ttatcttttg gatcacaaat agaattcagc tgttcagaag gatttttctt
      661 aattggctca accactagtc gttgtgaagt ccaagataga ggagttggct ggagtcatcc
      721 tctcccacaa tgtgaaattg tcaagtgtaa gcctcctcca gacatcagga atggaaggca
      781 cagcggtgaa gaaaatttct acgcatacgg cttttctgtc acctacagct gtgacccccg
      841 cttctcactc ttgggccatg cctccatttc ttgcactgtg gagaatgaaa caataggtgt
      901 ttggagacca agccctccta cctgtgaaaa aatcacctgt cgcaagccag atgtttcaca
      961 tggggaaatg gtctctggat ttggacccat ctataattac aaagacacta ttgtgtttaa
     1021 gtgccaaaaa ggttttgttc tcagaggcag cagtgtaatt cattgtgatg ctgatagcaa
     1081 atggaatcct tctcctcctg cttgtgagcc caatagttgt attaatttac cagacattcc
     1141 acatgcttcc tgggaaacat atcctaggcc gacaaaagag gatgtgtatg ttgttgggac
     1201 tgtgttaagg taccgctgtc atcctggcta caaacccact acagatgagc ctacgactgt
     1261 gatttgtcag aaaaatttga gatggacccc ataccaagga tgtgaggcgt tatgttgccc
     1321 tgaaccaaag ctaaataatg gtgaaatcac tcaacacagg aaaagtcgtc ctgccaatca
     1381 ctgtgtttat ttctatggag atgagatttc attttcatgt catgagacca gtaggttttc
     1441 agctatatgc caaggagatg gcacgtggag tccccgaaca ccatcatgtg gagacatttg
     1501 caattttcct cctaaaattg cccatgggca ttataaacaa tctagttcat acagcttttt
     1561 caaagaagag attatatatg aatgtgataa aggctacatt ctggtcggac aggcgaaact
     1621 ctcctgcagt tattcacact ggtcagctcc agcccctcaa tgtaaagctc tgtgtcggaa
     1681 accagaatta gtgaatggaa ggttgtctgt ggataaggat cagtatgttg agcctgaaaa
     1741 tgtcaccatc caatgtgatt ctggctatgg tgtggttggt ccccaaagta tcacttgctc
     1801 tgggaacaga acctggtacc cagaggtgcc caagtgtgag tgggagaccc ccgaaggctg
     1861 tgaacaagtg ctcacaggca aaagactcat gcagtgtctc ccaaacccag aggatgtgaa
     1921 aatggccctg gaggtatata agctgtctct ggaaattgaa caactggaac tacagagaga
     1981 cagcgcaaga caatccactt tggataaaga actataattt ttctcaaaag aaggaggaaa
     2041 aggtgtcttg ctggcttgcc tcttgcaatt caatacagat cagtttagca aatctactgt
     2101 caatttggca gtgatattca tcataataaa tatctagaaa tgataatttg ctaaagttta
     2161 gtgctttgag attgtgaaat tattaatcat cctctgtgtg gctcatgttt ttgcttttca
     2221 acacacaaag cacaaatttt ttttcgatta aaaatgtatg tataaaaaac ta
//
