LOCUS       NM_001002029            5427 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens complement C4B (Chido/Rodgers blood group) (C4B),
            mRNA.
ACCESSION   NM_001002029 NM_000592 XM_001722806
VERSION     NM_001002029.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5427)
  AUTHORS   Li,S., Qiu,Y., Yu,J., Shao,M., Li,Y., Cao,W. and Sun,X.
  TITLE     Serum complement component 3, complement component 4 and complement
            component 1q levels predict progressive visual field loss in older
            women with primary angle closure glaucoma
  JOURNAL   Br J Ophthalmol 107 (6), 828-835 (2023)
   PUBMED   35017157
  REMARK    GeneRIF: Serum complement component 3, complement component 4 and
            complement component 1q levels predict progressive visual field
            loss in older women with primary angle closure glaucoma.
REFERENCE   2  (bases 1 to 5427)
  AUTHORS   Sulzen,H., Began,J., Dhillon,A., Kereiche,S., Pompach,P.,
            Votrubova,J., Zahedifard,F., Subrtova,A., Safner,M., Hubalek,M.,
            Thompson,M., Zoltner,M. and Zoll,S.
  TITLE     Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human
            complement C3 and C3b and their roles in alternative pathway
            restriction
  JOURNAL   Nat Commun 14 (1), 2403 (2023)
   PUBMED   37105991
  REMARK    GeneRIF: Cryo-EM structures of Trypanosoma brucei gambiense ISG65
            with human complement C3 and C3b and their roles in alternative
            pathway restriction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5427)
  AUTHORS   Lin,L., Wu,Y., Hang,H., Lu,J. and Ding,Y.
  TITLE     Plasma Complement 3 and Complement 4 Are Promising Biomarkers for
            Distinguishing NMOSD From MOGAD and Are Associated With the
            Blood-Brain-Barrier Disruption in NMOSD
  JOURNAL   Front Immunol 13, 853891 (2022)
   PUBMED   35898513
  REMARK    GeneRIF: Plasma Complement 3 and Complement 4 Are Promising
            Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated
            With the Blood-Brain-Barrier Disruption in NMOSD.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5427)
  AUTHORS   Yang,Z., Mendoza,A.R., Welch,T.R., Zipf,W.B. and Yu,C.Y.
  TITLE     Modular variations of the human major histocompatibility complex
            class III genes for serine/threonine kinase RP, complement
            component C4, steroid 21-hydroxylase CYP21, and tenascin TNX (the
            RCCX module). A mechanism for gene deletions and disease
            associations
  JOURNAL   J Biol Chem 274 (17), 12147-12156 (1999)
   PUBMED   10207042
REFERENCE   5  (bases 1 to 5427)
  AUTHORS   Yu,C.Y.
  TITLE     The complete exon-intron structure of a human complement component
            C4A gene. DNA sequences, polymorphism, and linkage to the
            21-hydroxylase gene
  JOURNAL   J Immunol 146 (3), 1057-1066 (1991)
   PUBMED   1988494
REFERENCE   6  (bases 1 to 5427)
  AUTHORS   Hessing,M., van 't Veer,C., Hackeng,T.M., Bouma,B.N. and Iwanaga,S.
  TITLE     Importance of the alpha 3-fragment of complement C4 for the binding
            with C4b-binding protein
  JOURNAL   FEBS Lett 271 (1-2), 131-136 (1990)
   PUBMED   1699796
REFERENCE   7  (bases 1 to 5427)
  AUTHORS   Palsdottir,A., Fossdal,R., Arnason,A., Edwards,J.H. and Jensson,O.
  TITLE     Heterogeneity of human C4 gene size. A large intron (6.5 kb) is
            present in all C4A genes and some C4B genes
  JOURNAL   Immunogenetics 25 (5), 299-304 (1987)
   PUBMED   2883116
REFERENCE   8  (bases 1 to 5427)
  AUTHORS   Yu,C.Y., Belt,K.T., Giles,C.M., Campbell,R.D. and Porter,R.R.
  TITLE     Structural basis of the polymorphism of human complement components
            C4A and C4B: gene size, reactivity and antigenicity
  JOURNAL   EMBO J 5 (11), 2873-2881 (1986)
   PUBMED   2431902
REFERENCE   9  (bases 1 to 5427)
  AUTHORS   Belt,K.T., Carroll,M.C. and Porter,R.R.
  TITLE     The structural basis of the multiple forms of human complement
            component C4
  JOURNAL   Cell 36 (4), 907-914 (1984)
   PUBMED   6546707
REFERENCE   10 (bases 1 to 5427)
  AUTHORS   Teisberg,P., Akesson,I., Olaisen,B., Gedde-Dahl,T. Jr. and
            Thorsby,E.
  TITLE     Genetic polymorphism of C4 in man and localisation of a structural
            C4 locus to the HLA gene complex of chromosome 6
  JOURNAL   Nature 264 (5583), 253-254 (1976)
   PUBMED   1088823
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645922.12.
            
            On Dec 4, 2019 this sequence version replaced NM_001002029.3.
            
            Summary: This gene encodes the basic form of complement factor 4,
            and together with the C4A gene, is part of the classical activation
            pathway. The protein is expressed as a single chain precursor which
            is proteolytically cleaved into a trimer of alpha, beta, and gamma
            chains prior to secretion. The trimer provides a surface for
            interaction between the antigen-antibody complex and other
            complement components. The alpha chain may be cleaved to release C4
            anaphylatoxin, a mediator of local inflammation. Deficiency of this
            protein is associated with systemic lupus erythematosus. This gene
            localizes to the major histocompatibility complex (MHC) class III
            region on chromosome 6. Varying haplotypes of this gene cluster
            exist, such that individuals may have 1, 2, or 3 copies of this
            gene. In addition, this gene exists as a long form and a short form
            due to the presence or absence of a 6.4 kb endogenous HERV-K
            retrovirus in intron 9. [provided by RefSeq, May 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.327879.1,
                                           SRR14038195.1663018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000435363.7/ ENSP00000415941.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AL645922.12        111061-111176
            117-315             AL645922.12        111309-111507
            316-517             AL645922.12        111722-111923
            518-588             AL645922.12        112133-112203
            589-677             AL645922.12        112282-112370
            678-760             AL645922.12        112589-112671
            761-857             AL645922.12        112842-112938
            858-963             AL645922.12        113077-113182
            964-1096            AL645922.12        113280-113412
            1097-1212           AL645922.12        120196-120311
            1213-1392           AL645922.12        120411-120590
            1393-1575           AL645922.12        120736-120918
            1576-1761           AL645922.12        121051-121236
            1762-1920           AL645922.12        121390-121548
            1921-2047           AL645922.12        121800-121926
            2048-2122           AL645922.12        122094-122168
            2123-2320           AL645922.12        122429-122626
            2321-2432           AL645922.12        122718-122829
            2433-2503           AL645922.12        122920-122990
            2504-2643           AL645922.12        123249-123388
            2644-2853           AL645922.12        123502-123711
            2854-2905           AL645922.12        123956-124007
            2906-2995           AL645922.12        124109-124198
            2996-3205           AL645922.12        124334-124543
            3206-3281           AL645922.12        124723-124798
            3282-3438           AL645922.12        124959-125115
            3439-3555           AL645922.12        125211-125327
            3556-3727           AL645922.12        125433-125604
            3728-3960           AL645922.12        125832-126064
            3961-4128           AL645922.12        126147-126314
            4129-4188           AL645922.12        126708-126767
            4189-4282           AL645922.12        127817-127910
            4283-4469           AL645922.12        128008-128194
            4470-4560           AL645922.12        128309-128399
            4561-4635           AL645922.12        128490-128564
            4636-4738           AL645922.12        130056-130158
            4739-4828           AL645922.12        130324-130413
            4829-4927           AL645922.12        130499-130597
            4928-5011           AL645922.12        130780-130863
            5012-5144           AL645922.12        131126-131258
            5145-5427           AL645922.12        131402-131684
FEATURES             Location/Qualifiers
     source          1..5427
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..5427
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /note="complement C4B (Chido/Rodgers blood group)"
                     /db_xref="GeneID:721"
                     /db_xref="HGNC:HGNC:1324"
                     /db_xref="MIM:120820"
     exon            1..116
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..5286
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /note="Chido form of C4; complement C4-B; complement
                     C4B1a; complement C4B (Chido blood group); basic
                     complement C4; C3 and PZP-like alpha-2-macroglobulin
                     domain-containing protein 3; complement component 4B
                     (Chido blood group)"
                     /codon_start=1
                     /product="complement C4-B preproprotein"
                     /protein_id="NP_001002029.3"
                     /db_xref="CCDS:CCDS47405.1"
                     /db_xref="GeneID:721"
                     /db_xref="HGNC:HGNC:1324"
                     /db_xref="MIM:120820"
                     /translation="MRLLWGLIWASSFFTLSLQKPRLLLFSPSVVHLGVPLSVGVQLQ
                     DVPRGQVVKGSVFLRNPSRNNVPCSPKVDFTLSSERDFALLSLQVPLKDAKSCGLHQL
                     LRGPEVQLVAHSPWLKDSLSRTTNIQGINLLFSSRRGHLFLQTDQPIYNPGQRVRYRV
                     FALDQKMRPSTDTITVMVENSHGLRVRKKEVYMPSSIFQDDFVIPDISEPGTWKISAR
                     FSDGLESNSSTQFEVKKYVLPNFEVKITPGKPYILTVPGHLDEMQLDIQARYIYGKPV
                     QGVAYVRFGLLDEDGKKTFFRGLESQTKLVNGQSHISLSKAEFQDALEKLNMGITDLQ
                     GLRLYVAAAIIESPGGEMEEAELTSWYFVSSPFSLDLSKTKRHLVPGAPFLLQALVRE
                     MSGSPASGIPVKVSATVSSPGSVPEVQDIQQNTDGSGQVSIPIIIPQTISELQLSVSA
                     GSPHPAIARLTVAAPPSGGPGFLSIERPDSRPPRVGDTLNLNLRAVGSGATFSHYYYM
                     ILSRGQIVFMNREPKRTLTSVSVFVDHHLAPSFYFVAFYYHGDHPVANSLRVDVQAGA
                     CEGKLELSVDGAKQYRNGESVKLHLETDSLALVALGALDTALYAAGSKSHKPLNMGKV
                     FEAMNSYDLGCGPGGGDSALQVFQAAGLAFSDGDQWTLSRKRLSCPKEKTTRKKRNVN
                     FQKAINEKLGQYASPTAKRCCQDGVTRLPMMRSCEQRAARVQQPDCREPFLSCCQFAE
                     SLRKKSRDKGQAGLQRALEILQEEDLIDEDDIPVRSFFPENWLWRVETVDRFQILTLW
                     LPDSLTTWEIHGLSLSKTKGLCVATPVQLRVFREFHLHLRLPMSVRRFEQLELRPVLY
                     NYLDKNLTVSVHVSPVEGLCLAGGGGLAQQVLVPAGSARPVAFSVVPTAATAVSLKVV
                     ARGSFEFPVGDAVSKVLQIEKEGAIHREELVYELNPLDHRGRTLEIPGNSDPNMIPDG
                     DFNSYVRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLDK
                     TEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRGSSTWLTAFVLKVLSL
                     AQEQVGGSPEKLQETSNWLLSQQQADGSFQDLSPVIHRSMQGGLVGNDETVALTAFVT
                     IALHHGLAVFQDEGAEPLKQRVEASISKASSFLGEKASAGLLGAHAAAITAYALTLTK
                     APADLRGVAHNNLMAMAQETGDNLYWGSVTGSQSNAVSPTPAPRNPSDPMPQAPALWI
                     ETTAYALLHLLLHEGKAEMADQAAAWLTRQGSFQGGFRSTQDTVIALDALSAYWIASH
                     TTEERGLNVTLSSTGRNGFKSHALQLNNRQIRGLEEELQFSLGSKINVKVGGNSKGTL
                     KVLRTYNVLDMKNTTCQDLQIEVTVKGHVEYTMEANEDYEDYEYDELPAKDDPDAPLQ
                     PVTPLQLFEGRRNRRRREAPKVVEEQESRVHYTVCIWRNGKVGLSGMAIADVTLLSGF
                     HALRADLEKLTSLSDRYVSHFETEGPHVLLYFDSVPTSRECVGFEAVQEVPVGLVQPA
                     SATLYDYYNPERRCSVFYGAPSKSRLLATLCSAEVCQCAEGKCPRQRRALERGLQDED
                     GYRMKFACYYPRVEYGFQVKVLREDSRAAFRLFETKITQVLHFTKDVKAAANQMRNFL
                     VRASCRLRLEPGKEYLIMGLDGATYDLEGHPQYLLDSNSWIEEMPSERLCRSTRQRAA
                     CAQLNDFLQEYGTQGCQV"
     exon            117..315
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            316..517
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            518..588
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            589..677
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            678..760
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            761..857
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            858..963
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1096
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1212
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1392
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1575
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1761
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1920
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2047
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2122
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2320
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2432
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2503
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2643
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2853
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..2905
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..2995
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3205
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3281
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3438
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3555
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3727
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3728..3960
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3961..4128
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4129..4188
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4189..4282
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4283..4469
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4470..4560
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4561..4635
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4636..4738
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4739..4828
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4829..4927
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4928..5011
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            5012..5144
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            5145..5427
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5391..5396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /note="hexamer: ATTAAA"
     polyA_site      5412
                     /gene="C4B"
                     /gene_synonym="C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2;
                     C4F; CH; CO4; CPAMD3"
                     /note="major polyA site"
ORIGIN      
        1 agaaggtagc agacagacag acggatctaa cctctcttgg atcctccagc catgaggctg
       61 ctctgggggc tgatctgggc atccagcttc ttcaccttat ctctgcagaa gcccaggttg
      121 ctcttgttct ctccttctgt ggttcatctg ggggtccccc tatcggtggg ggtgcagctc
      181 caggatgtgc cccgaggaca ggtagtgaaa ggatcagtgt tcctgagaaa cccatctcgt
      241 aataatgtcc cctgctcccc aaaggtggac ttcaccctta gctcagaaag agacttcgca
      301 ctcctcagtc tccaggtgcc cttgaaagat gcgaagagct gtggcctcca tcaactcctc
      361 agaggccctg aggtccagct ggtggcccat tcgccatggc taaaggactc tctgtccaga
      421 acgacaaaca tccagggtat caacctgctc ttctcctctc gccgggggca cctctttttg
      481 cagacggacc agcccattta caaccctggc cagcgggttc ggtaccgggt ctttgctctg
      541 gatcagaaga tgcgcccgag cactgacacc atcacagtca tggtggagaa ctctcacggc
      601 ctccgcgtgc ggaagaagga ggtgtacatg ccctcgtcca tcttccagga tgactttgtg
      661 atcccagaca tctcagagcc agggacctgg aagatctcag cccgattctc agatggcctg
      721 gaatccaaca gcagcaccca gtttgaggtg aagaaatatg tccttcccaa ctttgaggtg
      781 aagatcaccc ctggaaagcc ctacatcctg acggtgccag gccatcttga tgaaatgcag
      841 ttagacatcc aggccaggta catctatggg aagccagtgc agggggtggc atatgtgcgc
      901 tttgggctcc tagatgagga tggtaagaag actttctttc gggggctgga gagtcagacc
      961 aagctggtga atggacagag ccacatttcc ctctcaaagg cagagttcca ggacgccctg
     1021 gagaagctga atatgggcat tactgacctc caggggctgc gcctctacgt tgctgcagcc
     1081 atcattgagt ctccaggtgg ggagatggag gaggcagagc tcacatcctg gtattttgtg
     1141 tcatctccct tctccttgga tcttagcaag accaagcgac accttgtgcc tggggccccc
     1201 ttcctgctgc aggccttggt ccgtgagatg tcaggctccc cagcttctgg cattcctgtc
     1261 aaagtttctg ccacggtgtc ttctcctggg tctgttcctg aagtccagga cattcagcaa
     1321 aacacagacg ggagcggcca agtcagcatt ccaataatta tccctcagac catctcagag
     1381 ctgcagctct cagtatctgc aggctcccca catccagcga tagccaggct cactgtggca
     1441 gccccacctt caggaggccc cgggtttctg tctattgagc ggccggattc tcgacctcct
     1501 cgtgttgggg acactctgaa cctgaacttg cgagccgtgg gcagtggggc caccttttct
     1561 cattactact acatgatcct atcccgaggg cagatcgtgt tcatgaatcg agagcccaag
     1621 aggaccctga cctcggtctc ggtgtttgtg gaccatcacc tggcaccctc cttctacttt
     1681 gtggccttct actaccatgg agaccaccca gtggccaact ccctgcgagt ggatgtccag
     1741 gctggggcct gcgagggcaa gctggagctc agcgtggacg gtgccaagca gtaccggaac
     1801 ggggagtccg tgaagctcca cttagaaacc gactccctag ccctggtggc gctgggagcc
     1861 ttggacacag ctctgtatgc tgcaggcagc aagtcccaca agcccctcaa catgggcaag
     1921 gtctttgaag ctatgaacag ctatgacctc ggctgtggtc ctgggggtgg ggacagtgcc
     1981 cttcaggtgt tccaggcagc gggcctggcc ttttctgatg gagaccagtg gaccttatcc
     2041 agaaagagac taagctgtcc caaggagaag acaacccgga aaaagagaaa cgtgaacttc
     2101 caaaaggcga ttaatgagaa attgggtcag tatgcttccc cgacagccaa gcgctgctgc
     2161 caggatgggg tgacacgtct gcccatgatg cgttcctgcg agcagcgggc agcccgcgtg
     2221 cagcagccgg actgccggga gcccttcctg tcctgctgcc aatttgctga gagtctgcgc
     2281 aagaagagca gggacaaggg ccaggcgggc ctccaacgag ccctggagat cctgcaggag
     2341 gaggacctga ttgatgagga tgacattccc gtgcgcagct tcttcccaga gaactggctc
     2401 tggagagtgg aaacagtgga ccgctttcaa atattgacac tgtggctccc cgactctctg
     2461 accacgtggg agatccatgg cctgagcctg tccaaaacca aaggcctatg tgtggccacc
     2521 ccagtccagc tccgggtgtt ccgcgagttc cacctgcacc tccgcctgcc catgtctgtc
     2581 cgccgctttg agcagctgga gctgcggcct gtcctctata actacctgga taaaaacctg
     2641 actgtgagcg tccacgtgtc cccagtggag gggctgtgcc tggctggggg cggagggctg
     2701 gcccagcagg tgctggtgcc tgcgggctct gcccggcctg ttgccttctc tgtggtgccc
     2761 acggcagcca ccgctgtgtc tctgaaggtg gtggctcgag ggtccttcga attccctgtg
     2821 ggagatgcgg tgtccaaggt tctgcagatt gagaaggaag gggccatcca tagagaggag
     2881 ctggtctatg aactcaaccc cttggaccac cgaggccgga ccttggaaat acctggcaac
     2941 tctgatccca atatgatccc tgatggggac tttaacagct acgtcagggt tacagcctca
     3001 gatccattgg acactttagg ctctgagggg gccttgtcac caggaggcgt ggcctccctc
     3061 ttgaggcttc ctcgaggctg tggggagcaa accatgatct acttggctcc gacactggct
     3121 gcttcccgct acctggacaa gacagagcag tggagcacac tgcctcccga gaccaaggac
     3181 cacgccgtgg atctgatcca gaaaggctac atgcggatcc agcagtttcg gaaggcggat
     3241 ggttcctatg cggcttggtt gtcacggggc agcagcacct ggctcacagc ctttgtgttg
     3301 aaggtcctga gtttggccca ggagcaggta ggaggctcgc ctgagaaact gcaggagaca
     3361 tctaactggc ttctgtccca gcagcaggct gacggctcgt tccaggacct ctctccagtg
     3421 atacatagga gcatgcaggg gggtttggtg ggcaatgatg agactgtggc actcacagcc
     3481 tttgtgacca tcgcccttca tcatgggctg gccgtcttcc aggatgaggg tgcagagcca
     3541 ttgaagcaga gagtggaagc ctccatctca aaggcaagct catttttggg ggagaaagca
     3601 agtgctgggc tcctgggtgc ccacgcagct gccatcacgg cctatgccct gacactgacc
     3661 aaggcccctg cggacctgcg gggtgttgcc cacaacaacc tcatggcaat ggcccaggag
     3721 actggagata acctgtactg gggctcagtc actggttctc agagcaatgc cgtgtcgccc
     3781 accccggctc ctcgcaaccc atccgacccc atgccccagg ccccagccct gtggattgaa
     3841 accacagcct acgccctgct gcacctcctg cttcacgagg gcaaagcaga gatggcagac
     3901 caggctgcgg cctggctcac ccgtcagggc agcttccaag ggggattccg cagtacccaa
     3961 gacacggtga ttgccctgga tgccctgtct gcctactgga ttgcctccca caccactgag
     4021 gagaggggtc tcaatgtgac tctcagctcc acaggccgga atgggttcaa gtcccacgcg
     4081 ctgcagctga acaaccgcca gattcgcggc ctggaggagg agctgcagtt ttccttgggc
     4141 agcaagatca atgtgaaggt gggaggaaac agcaaaggaa ccctgaaggt ccttcgtacc
     4201 tacaatgtcc tggacatgaa gaacacgacc tgccaggacc tacagataga agtgacagtc
     4261 aaaggccacg tcgagtacac gatggaagca aacgaggact atgaggacta tgagtacgat
     4321 gagcttccag ccaaggatga cccagatgcc cctctgcagc ccgtgacacc cctgcagctg
     4381 tttgagggtc ggaggaaccg ccgcaggagg gaggcgccca aggtggtgga ggagcaggag
     4441 tccagggtgc actacaccgt gtgcatctgg cggaacggca aggtggggct gtctggcatg
     4501 gccatcgcgg acgtcaccct cctgagtgga ttccacgccc tgcgtgctga cctggagaag
     4561 ctgacctccc tctctgaccg ttacgtgagt cactttgaga ccgaggggcc ccacgtcctg
     4621 ctgtattttg actcggtccc cacctcccgg gagtgcgtgg gctttgaggc tgtgcaggaa
     4681 gtgccggtgg ggctggtgca gccggccagc gcaaccctgt acgactacta caaccccgag
     4741 cgcagatgtt ctgtgtttta cggggcacca agtaagagca gactcttggc caccttgtgt
     4801 tctgctgaag tctgccagtg tgctgagggg aagtgccctc gccagcgtcg cgccctggag
     4861 cggggtctgc aggacgagga tggctacagg atgaagtttg cctgctacta cccccgtgtg
     4921 gagtacggct tccaggttaa ggttctccga gaagacagca gagctgcttt ccgcctcttt
     4981 gagaccaaga tcacccaagt cctgcacttc accaaggatg tcaaggccgc tgctaatcag
     5041 atgcgcaact tcctggttcg agcctcctgc cgccttcgct tggaacctgg gaaagaatat
     5101 ttgatcatgg gtctggatgg ggccacctat gacctcgagg gacaccccca gtacctgctg
     5161 gactcgaata gctggatcga ggagatgccc tctgaacgcc tgtgccggag cacccgccag
     5221 cgggcagcct gtgcccagct caacgacttc ctccaggagt atggcactca ggggtgccag
     5281 gtgtgagggc tgccctccca cctccgctgg gaggaacctg aacctgggaa ccatgaagct
     5341 ggaagcactg ctgtgtccgc tttcatgaac acagcctggg accagggcat attaaaggct
     5401 tttggcagca aagtgtcagt gttggca
//
