LOCUS       NM_001025266            7159 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens chromosome 3 open reading frame 70 (C3orf70), mRNA.
ACCESSION   NM_001025266 XM_211871
VERSION     NM_001025266.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7159)
  AUTHORS   Cao,R., Ma,B., Wang,G., Xiong,Y., Tian,Y. and Yuan,L.
  TITLE     An Epithelial-Mesenchymal Transition (EMT) Preoperative Nomogram
            for Prediction of Lymph Node Metastasis in Bladder Cancer (BLCA)
  JOURNAL   Dis Markers 2020, 8833972 (2020)
   PUBMED   33204364
  REMARK    GeneRIF: An Epithelial-Mesenchymal Transition (EMT) Preoperative
            Nomogram for Prediction of Lymph Node Metastasis in Bladder Cancer
            (BLCA).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7159)
  AUTHORS   Ashikawa,Y., Shiromizu,T., Miura,K., Adachi,Y., Matsui,T.,
            Bessho,Y., Tanaka,T. and Nishimura,Y.
  TITLE     C3orf70 Is Involved in Neural and Neurobehavioral Development
  JOURNAL   Pharmaceuticals (Basel) 12 (4), 156 (2019)
   PUBMED   31623237
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7159)
  AUTHORS   Wray,N.R., Pergadia,M.L., Blackwood,D.H., Penninx,B.W.,
            Gordon,S.D., Nyholt,D.R., Ripke,S., MacIntyre,D.J., McGhee,K.A.,
            Maclean,A.W., Smit,J.H., Hottenga,J.J., Willemsen,G.,
            Middeldorp,C.M., de Geus,E.J., Lewis,C.M., McGuffin,P.,
            Hickie,I.B., van den Oord,E.J., Liu,J.Z., Macgregor,S.,
            McEvoy,B.P., Byrne,E.M., Medland,S.E., Statham,D.J., Henders,A.K.,
            Heath,A.C., Montgomery,G.W., Martin,N.G., Boomsma,D.I., Madden,P.A.
            and Sullivan,P.F.
  TITLE     Genome-wide association study of major depressive disorder: new
            results, meta-analysis, and lessons learned
  JOURNAL   Mol Psychiatry 17 (1), 36-48 (2012)
   PUBMED   21042317
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007934.7, HY136108.1, BC150565.1, AC025573.13 and BM683735.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001025266.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137179.1, SRR1803614.97866.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335012.3/ ENSP00000334974.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC007934.7         116452-116463
            13-168              HY136108.1         4-159
            169-1017            BC150565.1         1-849
            1018-6532           AC025573.13        52882-58396
            6533-7159           BM683735.1         18-644              c
FEATURES             Location/Qualifiers
     source          1..7159
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.2"
     gene            1..7159
                     /gene="C3orf70"
                     /note="chromosome 3 open reading frame 70"
                     /db_xref="GeneID:285382"
                     /db_xref="HGNC:HGNC:33731"
     exon            1..433
                     /gene="C3orf70"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..990
                     /gene="C3orf70"
                     /codon_start=1
                     /product="UPF0524 protein C3orf70"
                     /protein_id="NP_001020437.1"
                     /db_xref="CCDS:CCDS33900.1"
                     /db_xref="GeneID:285382"
                     /db_xref="HGNC:HGNC:33731"
                     /translation="MSAAASPASERGWKSEKLDEAQALARSCAARRPDFQPCDGLSIC
                     ATHSHGKCFKLHWCCHLGWCHCKYMYQPMTPVEQLPSTEIPARPREPTNTIQISVSLT
                     EHFLKFASVFQPPLPPDSPRYCMISDLFIDNYQVKCINGKMCYVQKQPAPHSHRMSPE
                     EVSAHDALISKESNTPKIDHCSSPSSSEDSGINAIGAHYVESCDEDTEEGAELSSEED
                     YSPESSWEPDECTLLSPSQSDLEVIETIETTV"
     exon            434..7159
                     /gene="C3orf70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4447..4452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3orf70"
                     /note="hexamer: ATTAAA"
     polyA_site      4473
                     /gene="C3orf70"
                     /note="major polyA site"
     regulatory      5913..5918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3orf70"
                     /note="hexamer: AATAAA"
     polyA_site      5939
                     /gene="C3orf70"
                     /note="major polyA site"
     regulatory      6068..6073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3orf70"
                     /note="hexamer: ATTAAA"
     polyA_site      6105
                     /gene="C3orf70"
     regulatory      6462..6467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3orf70"
                     /note="hexamer: AATAAA"
     polyA_site      6486
                     /gene="C3orf70"
     regulatory      7136..7141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3orf70"
                     /note="hexamer: AATAAA"
     polyA_site      7159
                     /gene="C3orf70"
ORIGIN      
        1 ggggcgcggc gcgcgccgcg ccggagggag ggaggctgcc agcccggacc cggtcgcagc
       61 gcccggggcg gctcctcctc gagcctggga ccgccgcgct cccgccgccg ccgcgtgctg
      121 gcgtgactcc cggcccgtgc cgcgccctcc cgcgtccgca gccggctcgg cttcctgccc
      181 acccagacgt cgcttctccc gggctcccgg tgtcggctcc gcgcggaggg agaggaaatg
      241 agtgcggcgg cctcgccggc gtcggagcgg ggttggaaga gcgagaaact agatgaggct
      301 caggccctgg cgcggagttg cgccgcccgc agacccgact tccagccgtg cgacgggctg
      361 tctatctgtg ccacgcacag ccatggcaag tgcttcaagc tgcactggtg ctgtcaccta
      421 ggatggtgtc actgcaaata catgtatcag cctatgaccc ctgtggaaca gcttccaagc
      481 actgagattc ctgccaggcc tcgggaaccc acaaacacca ttcagatctc agtctcgctc
      541 accgaacact ttttgaaatt tgcatctgtc ttccagcctc cccttccccc tgactcaccg
      601 aggtactgta tgatttcaga cctttttatt gacaactatc aggttaaatg tattaatggg
      661 aagatgtgtt atgtgcagaa gcagccggca ccacattccc acagaatgag ccctgaggag
      721 gtctctgcac acgatgcctt aatttcaaaa gagagcaata caccaaaaat agatcactgc
      781 tcttctccct caagttctga ggactctggg atcaatgcga ttggggctca ctatgtggaa
      841 tcgtgtgacg aggacacaga agaaggagca gaactgagtt cagaggaaga ttacagtcca
      901 gagagcagct gggaaccgga tgagtgcacc cttctctccc cctcgcagtc tgacctggaa
      961 gtgattgaaa cgatagaaac gactgtgtga gagtccagac aggaagccac agcctcggac
     1021 ccacgccgag cttttgtacc tttgtctggt ggatcctttt ttccaatgct gttgatattt
     1081 tctacccacc ccgccccgct ccaaccaaca accgtagcag ttcagtggta tgctgattag
     1141 cttctctccg tcttacaact aagacattct ttttattata aacagttttc ttttgtatcc
     1201 tgacttactt tctatgtagc atctggtgtc atgaattgtg accccgcctt aatttcactg
     1261 ggagatttga aggcggtgaa gtgatggtcg cagagaatct tggatcagat tgaggaggta
     1321 ccgaaaggga aggagccggt gttttctcgg tagccagtcc ttcacagaga ctcttgccat
     1381 tccctttggc atgttcacag gcactcccgt cctgtcctgc ttgtcctacg caagtagcac
     1441 tccctactga gtgtgcactg gtagatgccg tttcttccct tccccttctc cccacacctg
     1501 cactgggtct ggatcagagc tgcctcggct tacttctggg aggtcactgg aggccagctc
     1561 agcccatggt ttgtggccag tgtctgtaca aggctccgtg actggggctg agctaaacat
     1621 tcacatgaga agagatgacc tcatctgtct catgctcaat ccagccttag ctgagcacct
     1681 gtcccctgca gggggctgtg gggacacagc atgaataaga cctgattccc accatgaagg
     1741 ggcccacagt cctatatatg acacattcaa ctcatggcac ccaaaaagct ctgggaaccc
     1801 aggggaagga tgaggtttac ttggctgggg ctagctgggg aatgtgtttc agcatttgag
     1861 ctggcttctt ggtgggttcc ccaacatttt tctgctttta attgttcttc aagtctggga
     1921 aaaactctta ggaagttata taggtatcac atttaggtgg cagccacatc tgacatctta
     1981 aggaaaaaaa ataaattaat agttttagtt agcatggaaa tgctacagac agaagccctt
     2041 tagggattag gactgaatct aataggtttg attaattctg cttcatttgg ttgtatgaag
     2101 cattcgtatg gtttaagtga ggaatggatt agaattcagt gtgatgcatg gatttttatg
     2161 cagctgcaaa agcagttgaa atagtttgct gctaagtcag gagaaaatat ccagtgtaat
     2221 agccattcac tttcccacac agtctgtctg ttgtatgtgt tctctcccct cacatgcaca
     2281 aaatagtgac taattctttc ttatttagct ctcttcagaa ttctacttct actctccatt
     2341 tataccaggt attcttgtga gtcagttaac tgctatttct ccaaaccttc tatccatgag
     2401 gcatagtttc aaatcctgga aattttaagt atggcctaat gagaacatca gagttggaga
     2461 cagaacagta cttccatcct aactatccag aagcgcactc tcaggccatt gtgctctgag
     2521 attcccttgt gctctggcac cattatggta catctctacg tcacattaat tttttttttt
     2581 ttgagatgga gtttccctct tgctgcccag gctggagtgc agcggcgtga tcttggctct
     2641 ctacaacctc tgcctcctgg ggtcaagcga ttctcctgcc tcagcctcct gagtagctgg
     2701 gactatgggc acgtgccacc acacctggct aattttttgt atttttagta gagacgggct
     2761 ttcaccatgt tagccaggat ggtctcgatc tgaccttgtg atccacccac ctcggcctcc
     2821 ccaagtgctg ggattacaag catgagccac cacgcccggc cggatttgta agaaaaagtt
     2881 gtgttctccc ctgaagcctc catttggcat cattcacaaa ctactcaagg aagaatttgc
     2941 tttcccagtt gtatgtataa tttaagtcgt ttactagata gaactttttt ttaggtttag
     3001 atggccaaga catctatatg gtttagaagg cagagtatac attttccttt gcaaacagta
     3061 tgagttaaaa ctttctatgc taaatgagaa tgcggcataa agtctccact tactgaaatt
     3121 taaagattca acaagacaaa ccgagaaggg ggtcagagga gctctaggaa aggcccagga
     3181 gagggcagtt ggaggcaggt gtgagcatga ggagcttccc cctgccaggg catggctcag
     3241 gtggcacagg gacatctgat gaaccctgcc cgaggttctc ggtgcctccc gtgcatgagt
     3301 ggctcactga aggcaggtgt ggaagccaaa tgcctgcaag ccgtgtgtca ggccacagca
     3361 gtgcagtcat gcatcacgca ctcaggtttg taacagcaac accagggccc tgtctagatt
     3421 caccctgtgg gtgagcccgt tctccagatg ggcgtataaa ggggctttct cctctacacc
     3481 gttcctgtca atgttccgta caggcccaca ttcccaccac taagccaatg gagtcaacca
     3541 gatttctaaa gccatggata tacgtggtca cggggccaca tttctgcagc tggctcagtg
     3601 gcaggcttgg gccgtctctc agtaccatct aagacttctg tctaggttcc tgttttttta
     3661 gactcctgaa ctgccattct gattagacac aattttaatg gaatttttgg atttaataat
     3721 agttgataat caccttatgt atttgcacaa tctctttata attaaaaact cgctaagctt
     3781 cacttgctac tatctactat atagaattag agacattcca ttggattcta agcatcagac
     3841 actcctggat ctcaaaatga ccttttctaa ataagcacaa gatttatttt tgtcctagca
     3901 ctgttgataa cactctgaaa tatgttattg aactggaatt gtttctttat gcttgcattc
     3961 caaaaccaac tgaaacagat tgtagtttca ctttaaattc taggcctgtt ctatattatg
     4021 tgaaggaatt ctctgtaacg ctgatactat gttgctaatt tgtgtactta cagacacttt
     4081 agaaaatgtt tagactgcaa catgcactat aacattgaac tcagtcacat gaagtggtta
     4141 acacttgcac actgactgac agatatgaaa gctgtatact ttggacccag taatatgctc
     4201 attggagcaa gggttgggct gtgtggatgg ataaactgct ttcttgggtt tacatggaaa
     4261 cctggtacca ctcctacttt tggaaagttg gtataaaagc tattaggtag aagcttaatt
     4321 ccactaaatg tagaatttag ttttcttctc taaccaagat tttagaagtt tcaagtttca
     4381 aatatgctta taacttttcc aagaaatgat gattacagtg cttttgtggt tacaactgtt
     4441 tggtatatta aaaaataagg gtttactatc acatctaggt cttttttact atgtcatttt
     4501 taagatatga aataagaatc tgaggacagc cctgaagaac agtcctttcc tgggagggga
     4561 agacttgtaa ttcaaggtca tacaatacaa aataaaacaa aaacaaaagc accaagagca
     4621 gaacaaaaca acgtagttgc tttcctgaaa tactttttgg atttgattct atcttgggag
     4681 tggtggcttt actttttttt tttttttttt ttttttgaga cagagtctcg ctccttcacc
     4741 caggctggag tgcagtggcg cgatctcggc tcactgccag ctctgcctcc caggttcatg
     4801 ccattctcct gcctcagcct cctgagtagc tgggactata ggtgcccgcc accatgcctc
     4861 gctaattttt tgtattttta gtagaaacgg ggtttcaccg tgttagccag gatggtcttg
     4921 atctcatgac ctcgtgatcc accctcctcg gcttcccaaa gtgctgggat tgcaggcgtg
     4981 aaccaccacg cccggccggc tttacttcta atcctccact tcttggtcta tttgaaccat
     5041 cacaagtatt ttgggaccga taacaaaccc cttttatgct aatttaattc ttgacttggg
     5101 taataggtgc acctggataa tttataaagc tgtccataga tctaagttta gtggtacaga
     5161 tactactggg caggagaaaa agcacaagtt aaaatatttc tacagtcagc tcttaatatt
     5221 cccacatctt gtttgcaaaa ttttatggtc acgttctggc ttttttacat gaggaaaaca
     5281 aagttttaac agttttctct tctgtcccct tctccagagg aggtgtgaac cagaactgag
     5341 gaggccagtt atattttagg cttttcagta gtacgatttt gtcctctccc actgaggagg
     5401 agggaagaag ggggaagcca gtgggagttc cacacacgtg gtcagtgctg taagttcccg
     5461 gatatcagtg tctctcacat caacacagaa atagggcact tctcaacatt aattttggaa
     5521 ttattcacca tttaaaaatt gtcactgctc tttttcatta ctgtagataa ctgagagtta
     5581 gctgttctag gaaaaggcca tgtttcagtt agtgctatga cttctttttt cgattaaggt
     5641 tgaagcagtg ttctcttagt agcctgaaca cttctcaaag cgacttatca ctagcggctt
     5701 taatattgag cttctatatc gttgtgtcca cctcactttt taaggctgtt catacctggc
     5761 aatattcact tactctgcta tttttaaaaa ctattttaaa gttttaagca caatgttgac
     5821 tcttctgtaa tttcctaaaa ttatattgtt ttcctacaga cagctcaact ttccttgata
     5881 tgtaacactt taggaaaata actgccttgt aaaataaacg tgattttttt tttcttttat
     5941 accagaacaa atctgctgtt ttggagtgta cccaacccca aaaccaaaac tcacgtttgc
     6001 aaagtgtgaa acatttatat atcaggtctt tcctacgtgc taggaaatag cgtatggcca
     6061 ttaccccatt aaacctttac aagacctcaa tgaggtgcag ataaactgta ctgtccgcag
     6121 tatctactca gagtcaccac tcatgataac tcccagaact ctggctacat tgggtttata
     6181 gcaaataaaa cttgataccc cccccccacc accaccaaat agcatttatt tcacacgcag
     6241 ttacagcctt tctgttcggc ttacacgtgt catgtggggc agtgttggct gcagttctaa
     6301 ctgaagatca ggcatcgagg gaggctgctg cccggcagag cttggggggg tcgcttggtc
     6361 accaagactc aggggccagg cctcagcgcg gcaagtccat actcagaaaa gaacagcttc
     6421 aagggttgga gtctattgaa caaccttcct aggaactgct aaataaagtc attatcagta
     6481 ataaaatcct tgttaatatt aattatagtt caatggctac cttaagcttt ctatgcataa
     6541 tctccacagc aaccctgtga gggagattaa agcagcccca tttcacagat caggaaaaga
     6601 gctcaagaag tccacatctt tacccagtgt ggcacagctc gtacatgagt ggcagtcagg
     6661 gtttgaaccc ggtcactttg gctctagagt ccgcactctt ggcccattgt ctgcattact
     6721 ccatccccct aacccagcag ataccttccc acagactagt gcctcgtcta cctcagtgca
     6781 cctggtccca acacagtgga ggagaaacac tgacaggctt ccctctttgt ccccttctct
     6841 gtcctccata cagtgccccc ccaccccgca ccctatacca tgtctctgca aatatctcta
     6901 tgctctgatg aggccattgc ttcttccatg tttaatcacc tcttgactag cattcaagac
     6961 tagctctgcc tttcctaaag ctaactgatc ttttaaagtg attcctgcag acagcgcatc
     7021 tcatctgcgt gtgcactcta ctgttttaac tctctaccta attgtattgc caagtcctag
     7081 aaggcatctc attgtagcct cttacaaatg ctgactgcac acacttttat tctgcaataa
     7141 actttaattt agcatctca
//
