LOCUS       NM_198562               3748 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens chromosome 3 open reading frame 62 (C3orf62), mRNA.
ACCESSION   NM_198562 XM_351550
VERSION     NM_198562.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3748)
  AUTHORS   Alerasool,N., Leng,H., Lin,Z.Y., Gingras,A.C. and Taipale,M.
  TITLE     Identification and functional characterization of transcriptional
            activators in human cells
  JOURNAL   Mol Cell 82 (3), 677-695 (2022)
   PUBMED   35016035
REFERENCE   2  (bases 1 to 3748)
  AUTHORS   Li,M., Zheng,J., Li,G., Lin,Z., Li,D., Liu,D., Feng,H., Cao,D.,
            Ng,E.H.Y., Li,R.H.W., Han,C., Yeung,W.S.B., Chow,L.T., Wang,H. and
            Liu,K.
  TITLE     The male germline-specific protein MAPS is indispensable for
            pachynema progression and fertility
  JOURNAL   Proc Natl Acad Sci U S A 118 (8) (2021)
   PUBMED   33602822
REFERENCE   3  (bases 1 to 3748)
  AUTHORS   Vandenbrouck,Y., Pineau,C. and Lane,L.
  TITLE     The Functionally Unannotated Proteome of Human Male Tissues: A
            Shared Resource to Uncover New Protein Functions Associated with
            Reproductive Biology
  JOURNAL   J Proteome Res 19 (12), 4782-4794 (2020)
   PUBMED   33064489
REFERENCE   4  (bases 1 to 3748)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3748)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3748)
  AUTHORS   Wu,X.L., Yun,D.M., Gao,S., Liang,A.J., Duan,Z.Z., Wang,H.S.,
            Wang,G.S. and Sun,F.
  TITLE     The testis-specific gene 1700102P08Rik is essential for male
            fertility
  JOURNAL   Mol Reprod Dev 87 (2), 231-240 (2020)
   PUBMED   31930642
REFERENCE   7  (bases 1 to 3748)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121247.2, BC053629.1, BC023586.2 and AK056215.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198562.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125642.1, SRR1803616.194270.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151358 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343010.8/ ENSP00000341139.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC121247.2         103669-103825
            158-1466            BC053629.1         1-1309
            1467-1979           BC023586.2         2144-2656
            1980-3747           AK056215.1         642-2409
            3748-3748           AC121247.2         112305-112305
FEATURES             Location/Qualifiers
     source          1..3748
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3748
                     /gene="C3orf62"
                     /gene_synonym="MAPS"
                     /note="chromosome 3 open reading frame 62"
                     /db_xref="GeneID:375341"
                     /db_xref="HGNC:HGNC:24771"
     exon            1..806
                     /gene="C3orf62"
                     /gene_synonym="MAPS"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..1164
                     /gene="C3orf62"
                     /gene_synonym="MAPS"
                     /note="male pachynema-specific protein"
                     /codon_start=1
                     /product="uncharacterized protein C3orf62"
                     /protein_id="NP_940964.1"
                     /db_xref="CCDS:CCDS2792.1"
                     /db_xref="GeneID:375341"
                     /db_xref="HGNC:HGNC:24771"
                     /translation="MHYIKTWSLLGEMSEKLRRCRKELTAAIDRAFEGVSYSQECTGQ
                     QRLELSAAPLSFSLPVHRLLCRRHPLAACSSAAPFAAVPCAPENENPAFATNHAPVNA
                     KPHALCPERKPLTSKENVLMHSSILAPERESWRTAGEGENWRKENLRKDMERDLKADS
                     NMPLNNSSQEVTKDLLDMIDHTSIRTIEELAGKIEFENELNHMCGHCQDSPFKEEAWA
                     LLMDKSPQKATDADPGSLKQAFDDHNIVETVLDLEEDYNVMTSFKYQIE"
     exon            807..898
                     /gene="C3orf62"
                     /gene_synonym="MAPS"
                     /inference="alignment:Splign:2.1.0"
     exon            899..3748
                     /gene="C3orf62"
                     /gene_synonym="MAPS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1429..1434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3orf62"
                     /gene_synonym="MAPS"
                     /note="hexamer: AATATA"
     polyA_site      1467
                     /gene="C3orf62"
                     /gene_synonym="MAPS"
     regulatory      3726..3731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3orf62"
                     /gene_synonym="MAPS"
                     /note="hexamer: AATAAA"
     polyA_site      3748
                     /gene="C3orf62"
                     /gene_synonym="MAPS"
                     /note="major polyA site"
ORIGIN      
        1 acgcgcatgc gatgaccgtt ggatgggtcg gcgtcactgc gctgcgggtg aggacaagga
       61 cgtggctgcc gactcgccaa agggggggtg ccggtagggc cagcggcctg ggagccgcgg
      121 tggggcggga ggcagcggcg gggcgggcca ggaagctgtg ggaagtgggg cggggcgtct
      181 ttggggcttc tggcagatgg cgggttcctc cgcgagagcc gagaaccgcc tactccagga
      241 ggaaagcccg agggttgtgg gtcctgctat agccagggcc aagctccagg aaatcgtggc
      301 cattcagggg tagtttgcag cctcatttgt aacattattg tgttgtcctg tgcatttcca
      361 atgcattaca taaagacatg gtcgctttta ggagaaatgt ctgaaaaact aagaagatgc
      421 agaaaggaac tgactgcagc cattgaccgg gcctttgaag gagttagtta ttcccaggag
      481 tgcacaggcc agcagaggct ggaactgagc gccgcgccgc tctccttctc gctgcccgtg
      541 cacaggctcc tctgcagaag acatcctctg gcagcctgct cttctgctgc tccttttgct
      601 gctgtcccat gtgctcctga gaatgagaac cctgcctttg caacaaacca tgccccggta
      661 aatgcaaaac cacatgctct gtgccccgag agaaaacctc taaccagcaa ggaaaatgta
      721 ttgatgcatt cctccatttt ggcacctgaa agagagtctt ggagaactgc aggagagggg
      781 gaaaactgga gaaaagaaaa tttaaggaaa gatatggaga gagatttgaa ggctgactca
      841 aacatgccac tcaacaattc tagccaagag gtcacaaagg atctgcttga tatgattgac
      901 catacaagca tccgaactat tgaagaattg gctggaaaaa tagaatttga aaacgaattg
      961 aaccacatgt gtggtcattg ccaagattca cccttcaaag aggaagcctg ggccctgctc
     1021 atggacaaga gccctcagaa ggccacagat gctgaccctg gcagcctcaa acaggctttt
     1081 gatgatcata atattgttga gactgttctg gacttggaag aggactacaa tgtgatgacg
     1141 tcttttaaat accaaattga gtaaggacag ttatctaagc tttgattcct tacagcagga
     1201 ggctgccctt gagcctgagc agaagcagct acaatggccg tcaggggcca catttctcaa
     1261 aaggttggca gaacctgaat taccagaccc tttttaaatc ccagttgtgt ccctttttaa
     1321 gctgtgagac cagttttttg aattccattg ctttgaaatg tttcctatta ctgatttttt
     1381 tttttaactt tccttgacat cttgaatgtg tttttttgat tgatgttcaa tatacccagt
     1441 acccatggta ggtgtgggtc atgggcctct gctgtgtctc ttagtgttct tttccacggg
     1501 cccctaaaaa agtacaggag tggccaggca cagtggctca cgtctgtaat cccagcactt
     1561 tgggaggcca aggcgagtgg atcacttgag gttaggagtt tgagaccagc ctggccaaca
     1621 tggcgaaacc ccatctccac taaaaataca aaaattagcc aggagtggtg gtgtgcacct
     1681 gtagtcccag ctactttgga ggctgaggta ggagaattgc ttgaacctgg aggcggaggt
     1741 tgcaatgagc cgagatggca ccgctcccct ccatcctgag tgacagagca agactctgtc
     1801 tcaaaaaaat aataatttag ctggtcatgg tggttcgtgc ctgtagttcc agctacttgg
     1861 gtagggactg aggcgaaagg atcacttgag gccaggaggc agagattgca gtgagctgag
     1921 atcacgccac tgcactccag catgagtgac agagtgagac cctgtctcaa aaaaaaaaag
     1981 aaaaaaaaag ggaagaaagg aaactgaatc tcagggaagt gcccacctcc tgagctaata
     2041 agaggaagga atatgggggt gaggcagagc tggcaaaagg ctgttttttg ttttgattgt
     2101 ttttaaagac caagtgaagt atagtataag aagtggggaa ggagtggaac aaggagttag
     2161 atctgtaact gtgagtagtc aattgagata actcaatacc tttggacctg attgttttta
     2221 aagactgagg gtagtataag aagaggggaa ggagtagaac aaggagttag atctgaaact
     2281 gtgagtagtc gattgagata actcactacc tttggaccag ccagggctgt ttataagtgc
     2341 taaagcccga acaaaccaaa gagttgggga gaaaggccta actaacagct gagtgattgt
     2401 ctaacagact gtcttttagg ccagtgactc tggcataggg caggctgcat agccagcaac
     2461 atcccttacc acaggtctag tgattcctct gggctcaaat gtggaggcta cacacccact
     2521 ccttagcaga ggttggcctg gcacctgctg gtgccccaag aactatggca tggttagacc
     2581 ctggccactt gattgcatgt gcctccccag tgggcgtgcc ctggttccca accagttgtg
     2641 gccactgcca ctgccctgcc tggggcagga gttgaggtta aggctaacta caggctcctt
     2701 ccaggccacc taccactcag accctgcagg aggtagcaca aagcattcac agcctgtgga
     2761 gtcagaggcc aatttcttct ccctgagcaa gaagaatgga agcaaatgaa aagtgctcac
     2821 agtatgctca actgcccctg ctcaggtgaa gaatagcctg tctggatgga gagatgtcag
     2881 gctacttgat actcagaaaa acaggtctca aaacagtgcc ttccaaataa tacatgtgga
     2941 tgtggacact cttctataga cgaggtggag cttaattcct gtccttaccc ccatattccc
     3001 acctcattac caccctttga aggtgaacta gacttaatga tacttcccac gactaaagta
     3061 gggaaaggga aaagtcacaa acttatagtg gggaagcctg gcagacacct aaccaagtga
     3121 tgtcatgtat atgtcatgag aggggtgcat cacttccctg gtattcctac caaaaaccca
     3181 aattcccagt gtatgatctt gagacaaatg ttagacaaat ccagacgtgg ggtacattct
     3241 acaagatacc tggccagaac tcaagactgt tgagatggcc gggtgcagtg gctcatgcct
     3301 ataatccccg acactttggg aggctgaggc gggcagatca cttgaggtca gaagttcgag
     3361 accagcctgg caaacatggt gaaaccccat ctctgctaaa aatacaaaaa ttagccaggc
     3421 atcatggcat gtgcctttag tcatagctac acaggaggct gaggcaggag aattgcttga
     3481 acccaggagg tggaggttgc agtgagccaa gatcgcatca ctgcactcca gcctgggcaa
     3541 caagcaagac tccacctcaa aaagaaaaaa aaagactgtt gaggtcatga aaaataagga
     3601 aagactcaaa aactatcaac agaccactaa agaccaagaa gacacaatgg ctaaatgcaa
     3661 catggaatcc tggagtgcat cctggaagag aaagagaaca ttattggaaa aactgataaa
     3721 acttgaataa aaactagtgt ttaatgta
//
