LOCUS       NM_173824               2414 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens chromosome 3 open reading frame 38 (C3orf38), mRNA.
ACCESSION   NM_173824
VERSION     NM_173824.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2414)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2414)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 2414)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 2414)
  AUTHORS   Moyer,A.M., Fridley,B.L., Jenkins,G.D., Batzler,A.J.,
            Pelleymounter,L.L., Kalari,K.R., Ji,Y., Chai,Y., Nordgren,K.K. and
            Weinshilboum,R.M.
  TITLE     Acetaminophen-NAPQI hepatotoxicity: a cell line model system
            genome-wide association study
  JOURNAL   Toxicol Sci 120 (1), 33-41 (2011)
   PUBMED   21177773
REFERENCE   5  (bases 1 to 2414)
  AUTHORS   Park,K.M., Kang,E., Jeon,Y.J., Kim,N., Kim,N.S., Yoo,H.S.,
            Yeom,Y.I. and Kim,S.J.
  TITLE     Identification of novel regulators of apoptosis using a
            high-throughput cell-based screen
  JOURNAL   Mol Cells 23 (2), 170-174 (2007)
   PUBMED   17464193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC128650.6.
            
            On Nov 23, 2018 this sequence version replaced NM_173824.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832398.1, SRR1660809.136074.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318887.8/ ENSP00000322469.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               AC128650.6         109395-109621       c
            228-469             AC128650.6         106109-106350       c
            470-2414            AC128650.6         101615-103559       c
FEATURES             Location/Qualifiers
     source          1..2414
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p11.1"
     gene            1..2414
                     /gene="C3orf38"
                     /note="chromosome 3 open reading frame 38"
                     /db_xref="GeneID:285237"
                     /db_xref="HGNC:HGNC:28384"
     exon            1..227
                     /gene="C3orf38"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1084
                     /gene="C3orf38"
                     /note="dense incisors"
                     /codon_start=1
                     /product="uncharacterized protein C3orf38"
                     /protein_id="NP_776185.2"
                     /db_xref="CCDS:CCDS2921.2"
                     /db_xref="GeneID:285237"
                     /db_xref="HGNC:HGNC:28384"
                     /translation="MEMSGLSFSEMEGCRNLLGLLDNDEIMALCDTVTNRLVQPQDRQ
                     DAVHAILAYSQSAEELLRRRKVHREVIFKYLATQGIVIPPATEKHNLIQHAKDYWQKQ
                     PQLKLKETPEPVTKTEDIHLFQQQVKEDKKAEKVDFRRLGEEFCHWFFGLLNSQNPFL
                     GPPQDEWGPQHFWHDVKLRFYYNTSEQNVMDYHGAEIVSLRLLSLVKEEFLFLSPNLD
                     SHGLKCASSPHGLVMVGVAGTVHRGNTCLGIFEQIFGLIRCPFVENTWKIKFINLKIM
                     GESSLAPGTLPKPSVKFEQSDLEAFYNVITVCGTNEVRHNVKQASDSGTGDQV"
     exon            228..469
                     /gene="C3orf38"
                     /inference="alignment:Splign:2.1.0"
     exon            470..2414
                     /gene="C3orf38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1345..1350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3orf38"
                     /note="hexamer: AATAAA"
     polyA_site      1367
                     /gene="C3orf38"
     regulatory      2381..2386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3orf38"
                     /note="hexamer: AATAAA"
     polyA_site      2414
                     /gene="C3orf38"
                     /note="major polyA site"
ORIGIN      
        1 aagaaaggca cttccggtgt ctgttgccag gcgcgggccc agtgggccgt aggggcgaca
       61 ttgttgccgt tgtctttccc ccccagtccc ggggatggag atgtcgggac tcagcttttc
      121 agagatggag ggctgccgta acctacttgg cctactggac aacgacgaga tcatggccct
      181 atgcgacact gtcaccaacc gcctggtgca gcctcaggac cgccaagatg ctgttcatgc
      241 aatattagca tacagtcaaa gtgcagaaga acttctgagg cgtagaaaag tccaccgaga
      301 agttatattt aagtacttgg caacacaggg gattgttata cctccagcta ctgaaaaaca
      361 caatcttatt cagcatgcaa aagattactg gcaaaagcaa ccacaactga aattgaagga
      421 aacgccagag ccagttacaa agacagagga catccaccta tttcaacagc aggtgaaaga
      481 agataaaaaa gctgaaaaag ttgattttcg tcgcctagga gaagaattct gtcattggtt
      541 ctttggactt cttaattctc agaatccttt tctaggacca cctcaagatg aatggggacc
      601 acagcacttc tggcatgatg tgaagcttag gttttattac aacacatcag aacaaaatgt
      661 tatggactac catggagcag aaatcgtgag ccttcgtttg ctgtcactag taaaagaaga
      721 atttcttttt ctcagcccca acctagattc acatggactg aaatgtgcat cttctcctca
      781 tgggctggtt atggttggag ttgctgggac tgtccatcga ggaaacactt gtttgggcat
      841 ttttgaacaa atttttggac tcatccgctg cccttttgtg gagaatactt ggaaaatcaa
      901 atttatcaac ctgaaaatta tgggagagag ttcccttgct cctggaacat taccgaaacc
      961 atctgttaaa tttgaacaaa gtgatctaga ggccttttat aatgtaatca ctgtatgtgg
     1021 taccaatgaa gtacgacata atgtaaagca ggcttcggat agtggaactg gggaccaagt
     1081 ttgaggtagt ggaaatgaga cattgctgaa caaaagagaa ctgggtttac ctgaccctct
     1141 aaagcgctaa gtactgtcag cctgaaaaaa atcttctata cagaaactct tccaaatact
     1201 atatcagtaa tgtctgaatg atttcagatg tgaaaattga catattttag ttgaaatacc
     1261 tttctggact acagacttac atatcatgtg aatacttacc tatttctacc cgagttgcag
     1321 caagtattct gaaagcttaa tgcaaataaa tcccacttta gatcttacag ctaactgtgt
     1381 gccttagaaa ccaggtaata ttttcctttt acttagtgaa tattctgcta atatctgcac
     1441 ttttcatgtg ggaaaggatt aataatggtc caggcttccc ctctttaagt ttcatgttta
     1501 cttttgtcta actctggata attgtatttt acaaatgcat ctcactgtag tatattttta
     1561 aaactattaa atattttaga gatgtttaac gtaaactcaa agttctcatt ttagaaaatt
     1621 taaataacat tctttttgca aaaaagtcca ataatttaac agttgaagaa aaacttacta
     1681 cctctttaaa gatttgagaa acatttttca aagttatcag ctgtagtcca agctaaatat
     1741 cttttgtaat ctgcaacatt ttccttactg tttttgggca gtgataaatg ctgttctcga
     1801 aatagacttt attcttacct aggcttcaga caacagtttt atagagcagt tactgtaata
     1861 caatataaag gaaatatgct gttgaaattt taaaggtatg cccagttcct aacttttaaa
     1921 cgaattaccg ttcttcctct tggctgatct tggcagagat gacaaaaaaa accccaaaac
     1981 aacccatgca tgtataatgt gtgtatacac atatacataa gtatacatat actcccacat
     2041 tataacttag aatatttagt tttttacctg ttactaggtt tgagttacat ggttgagttg
     2101 ccaaattatt tacatgcttt gtttaaattc ttcatcacct agcaactgtt tgctgatcat
     2161 ggatttactt agttacttta atttataaaa ttaccatttg gaaaagaact caattgggaa
     2221 atgtgatgac gtattgtaca tgttactttt tcctttgcta taatcatcta gggagactga
     2281 taagaatttt ggaaatggga gcctggaaac tcatctttgt ttttttaatg ctatgcctct
     2341 tacgaggaat acgaattggt atgtcctaaa ataagaactt aataaaggag ggaaatccct
     2401 tttgtctgct ataa
//
