LOCUS       NM_001308229            1811 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens chromosome 3 open reading frame 33 (C3orf33),
            transcript variant 1, mRNA.
ACCESSION   NM_001308229 XM_005247378
VERSION     NM_001308229.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1811)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1811)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1811)
  AUTHORS   Hu,F., Yang,S., Lv,S., Peng,Y., Meng,L., Gou,L. and Zhang,X.
  TITLE     Analysis of AC3-33 gene expression in multiple organ cancer and
            adjacent normal tissue by RNA in situ hybridization
  JOURNAL   Oncol Lett 9 (6), 2795-2798 (2015)
   PUBMED   26137149
REFERENCE   4  (bases 1 to 1811)
  AUTHORS   Hao,D., Gao,P., Liu,P., Zhao,J., Wang,Y., Yang,W., Lu,Y., Shi,T.
            and Zhang,X.
  TITLE     AC3-33, a novel secretory protein, inhibits Elk1 transcriptional
            activity via ERK pathway
  JOURNAL   Mol Biol Rep 38 (2), 1375-1382 (2011)
   PUBMED   20680465
  REMARK    GeneRIF: AC3-33 is a novel member of the secretory family and
            inhibits Elk1 transcriptional activity via ERK1/2 MAP
REFERENCE   5  (bases 1 to 1811)
  AUTHORS   Zhang,X., Ma,X., Xue,Y., Meng,L., He,B., He,S., Zhao,J., Wang,Y.
            and Yang,W.
  TITLE     Prokaryotic expression and characterization of human AC3-33 protein
  JOURNAL   Front Biosci (Elite Ed) 2 (3), 1134-1142 (2010)
   PUBMED   20515784
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1811)
  AUTHORS   Liu,P., Deng,W.W., Gao,P., Lu,Y., Sun,B., Li,M., Zhao,J., Shi,T.P.
            and Zhang,X.J.
  TITLE     [Molecular cloning and preliminary function study of a novel human
            gene AC3-33 related to suppress AP-1 activity]
  JOURNAL   Yi Chuan 30 (5), 575-582 (2008)
   PUBMED   18487146
  REMARK    GeneRIF: The preliminary results showed that AC3-33 is an important
            novel gene related to supress AP-1 activity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA275323.1, AF115515.1 and AC104472.14.
            
            On Nov 22, 2018 this sequence version replaced NM_001308229.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832165.1, SRR3476690.104523.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340171.7/ ENSP00000342512.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DA275323.1         10-37
            29-452              AF115515.1         1-424
            453-453             AC104472.14        121935-121935
            454-504             AF115515.1         426-476
            505-505             AC104472.14        121987-121987
            506-1811            AF115515.1         478-1783
FEATURES             Location/Qualifiers
     source          1..1811
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.31"
     gene            1..1811
                     /gene="C3orf33"
                     /gene_synonym="AC3-33"
                     /note="chromosome 3 open reading frame 33"
                     /db_xref="GeneID:285315"
                     /db_xref="HGNC:HGNC:26434"
                     /db_xref="MIM:619654"
     exon            1..140
                     /gene="C3orf33"
                     /gene_synonym="AC3-33"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..911
                     /gene="C3orf33"
                     /gene_synonym="AC3-33"
                     /note="isoform 1 is encoded by transcript variant 1; AP-1
                     activity suppressor; protein C3orf33"
                     /codon_start=1
                     /product="protein C3orf33 isoform 1"
                     /protein_id="NP_001295158.1"
                     /db_xref="CCDS:CCDS77843.1"
                     /db_xref="GeneID:285315"
                     /db_xref="HGNC:HGNC:26434"
                     /db_xref="MIM:619654"
                     /translation="MAGQPAATGSPSADKDGMEPNVVARISQWADDHLRLVRNISTGM
                     AIAGIMLLLRSIRLTSKFTSSSDIPVEFIRRNVKLRGRLRRITENGLEIEHIPITLPI
                     IASLRKEPRGALLVKLAGVELAETGKAWLQKELKPSQLLWFQLLGKENSALFCYLLVS
                     KGGYFSVNLNEEILRRGLGKTVLVKGLKYDSKIYWTVHRNLLKAELTALKKGEGIWKE
                     DSEKESYLEKFKDSWREIWKKDSFLKTTGSDFSLKKESYYEKLKRTYEIWKDNMNNCS
                     LILKFRELISRINFRRKG"
     exon            141..200
                     /gene="C3orf33"
                     /gene_synonym="AC3-33"
                     /inference="alignment:Splign:2.1.0"
     exon            201..348
                     /gene="C3orf33"
                     /gene_synonym="AC3-33"
                     /inference="alignment:Splign:2.1.0"
     exon            349..509
                     /gene="C3orf33"
                     /gene_synonym="AC3-33"
                     /inference="alignment:Splign:2.1.0"
     exon            510..1811
                     /gene="C3orf33"
                     /gene_synonym="AC3-33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1788..1793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3orf33"
                     /gene_synonym="AC3-33"
                     /note="hexamer: AATAAA"
     polyA_site      1811
                     /gene="C3orf33"
                     /gene_synonym="AC3-33"
                     /note="major polyA site"
ORIGIN      
        1 agggccgctc gcaggaggcc gggaacatgg cggggcagcc cgcggccacc ggctcgccgt
       61 ctgccgacaa ggacggaatg gagcccaacg tcgtggctcg gatctcgcag tgggcagacg
      121 accacctgcg cctagtccgg aacatcagca ctggaatggc catagctgga ataatgttac
      181 ttttgagaag cattcgactg acatcaaaat ttacaagctc ttcggatatt ccagtagaat
      241 ttataagaag aaatgttaaa ctacgtggac gattacgccg aataactgag aatggtttag
      301 aaattgaaca tatacctatt actttaccta ttatagcttc attgagaaaa gagccacgtg
      361 gtgctttgct ggttaagttg gctggagtag aactcgctga aactgggaag gcatggttac
      421 aaaaagagct aaaaccttcc caattactat ggttccaact tcttggaaag gagaattcag
      481 cactcttttg ctatcttctg gtgagtaagg gtggatattt cagcgtgaat ctgaatgaag
      541 aaattttgag aagaggcctt ggcaaaactg ttcttgttaa agggcttaaa tatgattcta
      601 aaatctactg gacagttcac agaaacttac ttaaagctga attaacagcc ttaaaaaaag
      661 gagaaggaat atggaaggaa gactctgaaa aagaaagtta cttagaaaaa ttcaaagatt
      721 cctggagaga aatatggaaa aaggacagtt ttttaaaaac aacaggatca gatttcagct
      781 tgaaaaaaga aagttattat gaaaaactta aaaggactta tgaaatatgg aaagacaaca
      841 tgaacaactg ctccttaata ctgaagttca gagaacttat aagtcgcata aactttcgta
      901 gaaaagggtg aaacggtcaa gaaatctaga ggtaaccttc tccaaagagt gaaatatgta
      961 aatatatgga cgtttttcat tgaatcaaaa tggaagtttt gccaaatgat caaagtgtta
     1021 gtccaatggt atttaaatat taaaaagaga tgattattat aagcataatg tcagaattaa
     1081 tttaaacaaa ttataattaa tgtaatatga ttttaggaag gatgaaacac tttatgagaa
     1141 gttaccaggc tgaatgattt acatatatag tgctaatgtg tgaagagaaa gtttaactct
     1201 tcacccacta tgttgttttt agttattttg ggctgccata ttgaattttt tgtttgtttg
     1261 ttttgagaag gcgtttcgct cttgttgccc aggctggagt gcaatggcgt gatcttggct
     1321 cactgcaacc tcctgcttcc tgggttcaag cgattctcct gcctcagcct cctgagtagc
     1381 tgggattaca ggcatgcacc accatgcccg gctaattttg catttttagt agagacgggg
     1441 tttctccatg ttggtcaggc tggtctcaaa ctcttgactt cagatgatct acccaccttg
     1501 gcatcctaaa gtgctgggat tacaggcgtg agctaccaag cccggctttt tttgttttga
     1561 catggagttt cgctcttgtc acccaggcag gagtgcagtg gcgttatctt ggttcactgc
     1621 aacctccgcc tcctggattc aagtgattct cctgcctgag cctcccaagt acctgggatt
     1681 acaggagctc ccaccaagcc tggctaagtt ttgtattgcc atattgaatt tttgtttaga
     1741 aaagatatgt gtttatgttt ccagttttat tacctttcac tatttataat aaaggaattc
     1801 tttatgcttt a
//
