LOCUS       NM_016210               2657 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens chromosome 3 open reading frame 18 (C3orf18),
            transcript variant 1, mRNA.
ACCESSION   NM_016210
VERSION     NM_016210.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2657)
  AUTHORS   Pelak,K., Goldstein,D.B., Walley,N.M., Fellay,J., Ge,D.,
            Shianna,K.V., Gumbs,C., Gao,X., Maia,J.M., Cronin,K.D.,
            Hussain,S.K., Carrington,M., Michael,N.L. and Weintrob,A.C.
  CONSRTM   Infectious Disease Clinical Research Program HIV Working Group;
            National Institute of Allergy and Infectious Diseases Center for
            HIV/AIDS Vaccine Immunology (CHAVI)
  TITLE     Host determinants of HIV-1 control in African Americans
  JOURNAL   J Infect Dis 201 (8), 1141-1149 (2010)
   PUBMED   20205591
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Erratum:[J Infect Dis. 2010 Aug 15;202(3):501]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833938.1, DA535127.1 and AA716515.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016210.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1, 2 and 3
            encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.37863.1, AL833938.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357203.8/ ENSP00000349732.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1020              AL833938.1         5-1024
            1021-1021           DA535127.1         412-412
            1022-2651           AL833938.1         1026-2655
            2652-2657           AA716515.1         17-22               c
FEATURES             Location/Qualifiers
     source          1..2657
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2657
                     /gene="C3orf18"
                     /gene_synonym="G20"
                     /note="chromosome 3 open reading frame 18"
                     /db_xref="GeneID:51161"
                     /db_xref="HGNC:HGNC:24837"
     exon            1..285
                     /gene="C3orf18"
                     /gene_synonym="G20"
                     /inference="alignment:Splign:2.1.0"
     exon            286..374
                     /gene="C3orf18"
                     /gene_synonym="G20"
                     /inference="alignment:Splign:2.1.0"
     exon            375..770
                     /gene="C3orf18"
                     /gene_synonym="G20"
                     /inference="alignment:Splign:2.1.0"
     CDS             537..1025
                     /gene="C3orf18"
                     /gene_synonym="G20"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C3orf18"
                     /codon_start=1
                     /product="uncharacterized protein C3orf18 isoform 1"
                     /protein_id="NP_057294.2"
                     /db_xref="CCDS:CCDS2829.1"
                     /db_xref="GeneID:51161"
                     /db_xref="HGNC:HGNC:24837"
                     /translation="MNSRTASARGWFSSRPPTSESDLEPATDGPASETTTLSPEATTF
                     NDTRIPDAAGGTAGVGTMLLSFGIITVIGLAVALVLYIRKKKRLEKLRHQLMPMYNFD
                     PTEEQDELEQELLEHGRDAASVQAATSVQAMQGKTTLPSQGPLQRPSRLVFTDVANAI
                     HA"
     exon            771..796
                     /gene="C3orf18"
                     /gene_synonym="G20"
                     /inference="alignment:Splign:2.1.0"
     exon            797..944
                     /gene="C3orf18"
                     /gene_synonym="G20"
                     /inference="alignment:Splign:2.1.0"
     exon            945..2657
                     /gene="C3orf18"
                     /gene_synonym="G20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2627..2632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3orf18"
                     /gene_synonym="G20"
                     /note="hexamer: ATTAAA"
     polyA_site      2657
                     /gene="C3orf18"
                     /gene_synonym="G20"
                     /note="major polyA site"
ORIGIN      
        1 gctgtagctt cggggatccc ccgaggctgc tcggcccggc cccacctccg ccgtgggtcc
       61 cggccctacc caccctagct caggccggca gagccagcgc tcgcggatgc ggctggtgcg
      121 cagtagcggg cctggccagc ggctcggggc ttgcagggag ggcggatctc gggtcggacc
      181 cgcagcccca gacgccgggc ttgggggttc cccccgcccc ggcctcctgc cagtcactac
      241 cacccctagc ctctccaact gagctcggcg ccgggagagg attaagtttg atcactatga
      301 tcatctcacc cacagacaga ggatgcaggg cttcattttt gttcccaaaa acaggggcac
      361 cgtagatacg taaacaccca ggaaggcagg gggctccctt tatccaagga ggtggctgtg
      421 caggtggcca ccacaggtgg caggaaccac aggctggggc actccggagt caggagtgag
      481 tgggcaggtt gactggcatc aggcagcctc tcagccaggg ccctctccgc atcagcatga
      541 actccaggac cgcatctgct aggggctggt tcagcagccg cccacccacc tctgagtctg
      601 acctggaacc tgccacagat gggccagcct ccgagaccac taccctcagc ccagaggcca
      661 ccacctttaa tgacaccaga atccctgatg cagctggtgg cacggccggc gtgggtacca
      721 tgcttctgtc ctttgggatc atcacggtga taggcctggc tgtggccttg gttttgtaca
      781 tcaggaagaa gaagaggctg gagaagctac gccaccagct catgcccatg tacaacttcg
      841 accccacgga ggaacaagat gagttggagc aggagctgct ggagcatggg cgggacgccg
      901 cctctgtaca ggctgctact tctgtgcagg ccatgcaggg caagactact ctgccctccc
      961 agggcccact gcagagaccc agccggctgg tgtttaccga tgtggccaat gccatccatg
     1021 cgtgagtggc ctgggacaag cctggacttc tgatagagac ccatcacggt gcctacagag
     1081 ctccccactc cctgattgtc aagacctact ctgaagatct tccctgccaa gacacaagag
     1141 ggctgagcca ggtcctagct gttctccaga cccacctgct gactttagac tctaagagag
     1201 ggccctagcc aggctggact tctgaccact gacttctcct gacctgaggg ccctggcaca
     1261 gagggcatcc ctcatgctga gaaggtcaag agcctctgct ggcttcctca tcccctgtcc
     1321 agatccctca catcagggtc tgccccgcta atgtggagga aatgagggag atacggagtg
     1381 ggagggattg ggggaggaaa ggggaggttt ccctctgtta gggagagacc tgttttttgg
     1441 aatctggagc ctcctctggg gtggggagag gaaaccaccc aagttatagg gacagggtag
     1501 ggcagcatct gttatgggcc ctgagaagcc cagagatgga gctgaaactg tccagtatgc
     1561 aaggatgcca ggagaagggc aattcacacc cagggtccat ccatactacg gagggtccag
     1621 gaggtctccc agccacccat ccttggcaac cagatgttac tggggccaag ctaggatggg
     1681 agctgagggg gaaggaagta ggggaatgga agtggaagga tgcagccccc ccagacctgc
     1741 cgagaggcct catgcatgtg catgagtgtg cccatgggca gacatgtgcc tgtcccagca
     1801 cagcgggcag aatgagattg tccacactgg ccccaccctc caagtcgacc tctaccccat
     1861 ggtatgtagt ggagcatcag ggtaggctat cttctctgcc ttcaatcttc agggactgca
     1921 gggaagaggg aagcacgcac agcacggttc ctctctccac tgcattgttt cactgggctc
     1981 acctgcttct gaaaacggct ccctgtcttg ggctctaatg aggatctggg gttgggagag
     2041 gctgttggtc tgagggcagt aatcacaggc tgcaggctag agggggcagt tatgactgcc
     2101 tgaaagtggg tgagggattg cacttcagaa aaacatctaa aaaacttagt ctatgtttga
     2161 attccccacc tccatcccat ctatgggaag agccgttcag tgtttagaga gtggggagat
     2221 gggtccctgc acttggcctc tccataagcc ttggagggtc agggctgata ccaggggtcc
     2281 tggcaagcca ttgggcagag acagaccaca agagcagggc atttttttac gctgggcata
     2341 catatgcaca caagcatgca cagaggcatg tcccgtgccc agcctctcca ccgtcactgt
     2401 ccgctgctgg ctggagggga tgcaggggta gtgtatgcag accttccact gggcaaatgc
     2461 catgtgtcag gagggaaagg cctaggaagc ccccatgggg aaggttctgg atttattccc
     2521 tcctctaaat gctataaata cgttagcact tgagtcgact ggaggctgcc aggaattcag
     2581 gatgcataca gctgtaattt aacccagagc agctccacgt gagagcatta aagatgtaat
     2641 gaagatgttt acatgga
//
