LOCUS       NM_004054               3434 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens complement C3a receptor 1 (C3AR1), transcript variant
            1, mRNA.
ACCESSION   NM_004054
VERSION     NM_004054.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3434)
  AUTHORS   Ge,T.Q., Guan,P.P. and Wang,P.
  TITLE     Complement 3a induces the synapse loss via C3aR in
            mitochondria-dependent NLRP3 activating mechanisms during the
            development and progression of Alzheimer's disease
  JOURNAL   Neurosci Biobehav Rev 165, 105868 (2024)
   PUBMED   39218048
  REMARK    GeneRIF: Complement 3a induces the synapse loss via C3aR in
            mitochondria-dependent NLRP3 activating mechanisms during the
            development and progression of Alzheimer's disease.
            Review article
REFERENCE   2  (bases 1 to 3434)
  AUTHORS   Zhang,Q., Bin,S., Budge,K., Petrosyan,A., Villani,V., Aguiari,P.,
            Vink,C., Wetzels,J., Soloyan,H., La Manna,G., Podesta,M.A.,
            Molinari,P., Sedrakyan,S., Lemley,K.V., De Filippo,R.E., Perin,L.,
            Cravedi,P. and Da Sacco,S.
  TITLE     C3aR-initiated signaling is a critical mechanism of podocyte injury
            in membranous nephropathy
  JOURNAL   JCI Insight 9 (4), e172976 (2024)
   PUBMED   38227377
  REMARK    GeneRIF: C3aR-initiated signaling is a critical mechanism of
            podocyte injury in membranous nephropathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3434)
  AUTHORS   Bode,M., Herrnstadt,G.R., Dreher,L., Ehnert,N., Kirkerup,P.,
            Lindenmeyer,M.T., Meyer-Schwesinger,C.F., Ehmke,H., Kohl,J.,
            Huber,T.B., Krebs,C.F., Steinmetz,O.M., Wiech,T. and Wenzel,U.O.
  TITLE     Deficiency of Complement C3a and C5a receptors Does Not Prevent
            Angiotensin II-Induced Hypertension and Hypertensive End-Organ
            Damage
  JOURNAL   Hypertension 81 (1), 138-150 (2024)
   PUBMED   37909169
  REMARK    GeneRIF: Deficiency of Complement C3a and C5a receptors Does Not
            Prevent Angiotensin II-Induced Hypertension and Hypertensive
            End-Organ Damage.
REFERENCE   4  (bases 1 to 3434)
  AUTHORS   Tampe,D., Hakroush,S. and Tampe,B.
  TITLE     Molecular signatures of intrarenal complement receptors C3AR1 and
            C5AR1 correlate with renal outcome in human lupus nephritis
  JOURNAL   Lupus Sci Med 9 (1) (2022)
   PUBMED   36521939
  REMARK    GeneRIF: Molecular signatures of intrarenal complement receptors
            C3AR1 and C5AR1 correlate with renal outcome in human lupus
            nephritis.
REFERENCE   5  (bases 1 to 3434)
  AUTHORS   Suzuki,R., Okubo,Y., Takagi,T., Sugimoto,M., Sato,Y., Irie,H.,
            Nakamura,J., Takasumi,M., Kato,T., Hashimoto,M., Kobashi,R.,
            Hikichi,T. and Ohira,H.
  TITLE     The Complement C3a-C3a Receptor Axis Regulates
            Epithelial-to-Mesenchymal Transition by Activating the ERK Pathway
            in Pancreatic Ductal Adenocarcinoma
  JOURNAL   Anticancer Res 42 (3), 1207-1215 (2022)
   PUBMED   35220210
  REMARK    GeneRIF: The Complement C3a-C3a Receptor Axis Regulates
            Epithelial-to-Mesenchymal Transition by Activating the ERK Pathway
            in Pancreatic Ductal Adenocarcinoma.
REFERENCE   6  (bases 1 to 3434)
  AUTHORS   Martin,U., Bock,D., Arseniev,L., Tornetta,M.A., Ames,R.S.,
            Bautsch,W., Kohl,J., Ganser,A. and Klos,A.
  TITLE     The human C3a receptor is expressed on neutrophils and monocytes,
            but not on B or T lymphocytes
  JOURNAL   J Exp Med 186 (2), 199-207 (1997)
   PUBMED   9221749
REFERENCE   7  (bases 1 to 3434)
  AUTHORS   Ames,R.S., Nuthulaganti,P. and Kumar,C.
  TITLE     In Xenopus oocytes the human C3a and C5a receptors elicit a
            promiscuous response to the anaphylatoxins
  JOURNAL   FEBS Lett 395 (2-3), 157-159 (1996)
   PUBMED   8898085
REFERENCE   8  (bases 1 to 3434)
  AUTHORS   Ames,R.S., Li,Y., Sarau,H.M., Nuthulaganti,P., Foley,J.J.,
            Ellis,C., Zeng,Z., Su,K., Jurewicz,A.J., Hertzberg,R.P.,
            Bergsma,D.J. and Kumar,C.
  TITLE     Molecular cloning and characterization of the human anaphylatoxin
            C3a receptor
  JOURNAL   J Biol Chem 271 (34), 20231-20234 (1996)
   PUBMED   8702752
REFERENCE   9  (bases 1 to 3434)
  AUTHORS   Crass,T., Raffetseder,U., Martin,U., Grove,M., Klos,A., Kohl,J. and
            Bautsch,W.
  TITLE     Expression cloning of the human C3a anaphylatoxin receptor (C3aR)
            from differentiated U-937 cells
  JOURNAL   Eur J Immunol 26 (8), 1944-1950 (1996)
   PUBMED   8765043
REFERENCE   10 (bases 1 to 3434)
  AUTHORS   Roglic,A., Prossnitz,E.R., Cavanagh,S.L., Pan,Z., Zou,A. and
            Ye,R.D.
  TITLE     cDNA cloning of a novel G protein-coupled receptor with a large
            extracellular loop structure
  JOURNAL   Biochim Biophys Acta 1305 (1-2), 39-43 (1996)
   PUBMED   8605247
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC020742.1, AC006511.5 and
            BU074964.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004054.3.
            
            Summary: C3a is an anaphylatoxin released during activation of the
            complement system. The protein encoded by this gene is an orphan G
            protein-coupled receptor for C3a. Binding of C3a by the encoded
            receptor activates chemotaxis, granule enzyme release, superoxide
            anion production, and bacterial opsonization. [provided by RefSeq,
            May 2016].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. All three variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.18934.1, BC020742.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307637.5/ ENSP00000302079.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1955              BC020742.1         1-1955
            1956-3289           AC006511.5         72097-73430
            3290-3434           BU074964.1         13-157              c
FEATURES             Location/Qualifiers
     source          1..3434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..3434
                     /gene="C3AR1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /note="complement C3a receptor 1"
                     /db_xref="GeneID:719"
                     /db_xref="HGNC:HGNC:1319"
                     /db_xref="MIM:605246"
     exon            1..82
                     /gene="C3AR1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /inference="alignment:Splign:2.1.0"
     exon            83..3434
                     /gene="C3AR1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1541
                     /gene="C3AR1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /note="complement component 3a receptor 1; complement
                     component 3 receptor 1"
                     /codon_start=1
                     /product="C3a anaphylatoxin chemotactic receptor"
                     /protein_id="NP_004045.1"
                     /db_xref="CCDS:CCDS8588.1"
                     /db_xref="GeneID:719"
                     /db_xref="HGNC:HGNC:1319"
                     /db_xref="MIM:605246"
                     /translation="MASFSAETNSTDLLSQPWNEPPVILSMVILSLTFLLGLPGNGLV
                     LWVAGLKMQRTVNTIWFLHLTLADLLCCLSLPFSLAHLALQGQWPYGRFLCKLIPSII
                     VLNMFASVFLLTAISLDRCLVVFKPIWCQNHRNVGMACSICGCIWVVAFVMCIPVFVY
                     REIFTTDNHNRCGYKFGLSSSLDYPDFYGDPLENRSLENIVQPPGEMNDRLDPSSFQT
                     NDHPWTVPTVFQPQTFQRPSADSLPRGSARLTSQNLYSNVFKPADVVSPKIPSGFPIE
                     DHETSPLDNSDAFLSTHLKLFPSASSNSFYESELPQGFQDYYNLGQFTDDDQVPTPLV
                     AITITRLVVGFLLPSVIMIACYSFIVFRMQRGRFAKSQSKTFRVAVVVVAVFLVCWTP
                     YHIFGVLSLLTDPETPLGKTLMSWDHVCIALASANSCFNPFLYALLGKDFRKKARQSI
                     QGILEAAFSEELTRSTHCPSNNVISERNSTTV"
     regulatory      1933..1938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3AR1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /note="hexamer: ATTAAA"
     polyA_site      1967
                     /gene="C3AR1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /note="major polyA site"
     regulatory      3384..3389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C3AR1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /note="hexamer: AATAAA"
     polyA_site      3409
                     /gene="C3AR1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
ORIGIN      
        1 actgtggcta agtgtgggga ccagacagga ctcgtggaga catccaggtg ctgaagcctt
       61 cagctactgt ctcagttttt tgaagtttag caatggcgtc tttctctgct gagaccaatt
      121 caactgacct actctcacag ccatggaatg agcccccagt aattctctcc atggtcattc
      181 tcagccttac ttttttactg ggattgccag gcaatgggct ggtgctgtgg gtggctggcc
      241 tgaagatgca gcggacagtg aacacaattt ggttcctcca cctcaccttg gcggacctcc
      301 tctgctgcct ctccttgccc ttctcgctgg ctcacttggc tctccaggga cagtggccct
      361 acggcaggtt cctatgcaag ctcatcccct ccatcattgt cctcaacatg tttgccagtg
      421 tcttcctgct tactgccatt agcctggatc gctgtcttgt ggtattcaag ccaatctggt
      481 gtcagaatca tcgcaatgta gggatggcct gctctatctg tggatgtatc tgggtggtgg
      541 cttttgtgat gtgcattcct gtgttcgtgt accgggaaat cttcactaca gacaaccata
      601 atagatgtgg ctacaaattt ggtctctcca gctcattaga ttatccagac ttttatggag
      661 atccactaga aaacaggtct cttgaaaaca ttgttcagcc gcctggagaa atgaatgata
      721 ggttagatcc ttcctctttc caaacaaatg atcatccttg gacagtcccc actgtcttcc
      781 aacctcaaac atttcaaaga ccttctgcag attcactccc taggggttct gctaggttaa
      841 caagtcaaaa tctgtattct aatgtattta aacctgctga tgtggtctca cctaaaatcc
      901 ccagtgggtt tcctattgaa gatcacgaaa ccagcccact ggataactct gatgcttttc
      961 tctctactca tttaaagctg ttccctagcg cttctagcaa ttccttctac gagtctgagc
     1021 taccacaagg tttccaggat tattacaatt taggccaatt cacagatgac gatcaagtgc
     1081 caacacccct cgtggcaata acgatcacta ggctagtggt gggtttcctg ctgccctctg
     1141 ttatcatgat agcctgttac agcttcattg tcttccgaat gcaaaggggc cgcttcgcca
     1201 agtctcagag caaaaccttt cgagtggccg tggtggtggt ggctgtcttt cttgtctgct
     1261 ggactccata ccacattttt ggagtcctgt cattgcttac tgacccagaa actcccttgg
     1321 ggaaaactct gatgtcctgg gatcatgtat gcattgctct agcatctgcc aatagttgct
     1381 ttaatccctt cctttatgcc ctcttgggga aagattttag gaagaaagca aggcagtcca
     1441 ttcagggaat tctggaggca gccttcagtg aggagctcac acgttccacc cactgtccct
     1501 caaacaatgt catttcagaa agaaatagta caactgtgtg aaaatgtgga gcagccaaca
     1561 agcaggggct cttaggcaat cacatagtga aagtttataa gaggatgaag tgatatggtg
     1621 agcagcggac ttcaaaaact gtcaaagaat caatccagcg gttctcaaac ggtacacaga
     1681 ctattgacat cagcatcacc tagaaacttg ttagaaatgc aaattctcaa gccgcatccc
     1741 agacttgctg aatcggaatc tctgggggtt gggacccagc aagggcactt aacaaaccct
     1801 cgtttctgat taatgctaaa tgtaagaatc attgtaaaca ttagttctat ttctatccca
     1861 aactaagcta tgtgaaataa gagaagctac tttgttttta aatgatgttg aatatttgtc
     1921 gatatttcca tcattaaatt tttccttagc attgtctaag tcttccagat tccatttaaa
     1981 accatttctt gttctcctac gtgagtgaaa gatgatcata tatcctaatg ctttgttgtc
     2041 gtgtggtgtt gatggtttta aacgaaaaga aagtgcaaaa agaaaatgcc tgtgaagaca
     2101 agaagccatg agactgagtc tggagcatag ggttatgcaa tgatgcctgt ccctgggaac
     2161 acccctgggt acaggatata gaaatttcca ctattacata gagtttccac tattacaact
     2221 aaataagcat ctattgtgtg aaaactgact catgaaatgt tatgaaagct gtggtttggg
     2281 gagttctgtt tcttctaact gcctaccggt tgggcaccta ttttccactc ctcttcctaa
     2341 gctccttaat ttccttatta ctccccagcc tccaaatctt ccacatcaga ctttgtgcct
     2401 caaacaacct ctaatttcgt aagattctag ttactccctt cctcttgctc caaatgaata
     2461 ctttctaaga aagtatttca agtggaagga gaaagagggt ggaggatgga gcagcaattc
     2521 ttctactctc tgcaactgag taccctacca ggcttgccat cacattttaa aacatgacga
     2581 caggcaactt acatgccaaa attaccaaat atatcttctg ggttttttaa atccttttct
     2641 ttgccaaagt aatacatgca catagtttta aaataattta ataaggtata taatgaaata
     2701 tgaggtctcc tacctcactg tgcccaaaag ttccctcctc ccactctcat ttcccagaga
     2761 taatccttgc acaattttag atgtttcctt tgataattat catgatgttt ctaaatcatg
     2821 tgcttatgct gctcttttct ggaggcatga taaaacgact tcttgttttg aaagatgaag
     2881 atgtttatcc aagcacccca tatttttaat ttgtttatcc agcatcccaa cattcattaa
     2941 taaccatatt ttaattcatt catgaccaca tatttttctt ctactttgtc tatacactcc
     3001 aaccatttat atagctttcc ttctgtccct ttttcattta aaacaaaatt acctaactcc
     3061 ctaccacctt ctcatttttc tgtatatata aatgtttgtg tcaaacgtct gaaatttctg
     3121 gcttgtttgt atcacaacgt ggcctcatct aaaccaaata caatgatgta gtctaaaaac
     3181 agaaaatgac atgtgtttta gacctgcaag acactatctg ttcaatggct gaggtgaggg
     3241 tctggactac agatttttta taaagtatat gcagaaaaat tacaaatcac taggaattct
     3301 ttcagttgtg aagaatgtct gacataagat ttgaagtgct acctttccag cttatatatt
     3361 aatttgctta tatatttgat atgaataaat gctttttttc tcatgggtcc ttgcgaggct
     3421 cagagattta tgaa
//
