LOCUS       NM_001351368            1139 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens chromosome 2 open reading frame 92 (C2orf92),
            transcript variant 1, mRNA.
ACCESSION   NM_001351368
VERSION     NM_001351368.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1139)
  AUTHORS   He,T., Xia,H., Chen,B., Duan,Z. and Huang,C.
  TITLE     m6A Writer METTL3-Mediated lncRNA LINC01125 Prevents the Malignancy
            of Papillary Thyroid Cancer
  JOURNAL   Crit Rev Immunol 43 (3), 43-53 (2023)
   PUBMED   37824376
  REMARK    GeneRIF: m6A Writer METTL3-Mediated lncRNA LINC01125 Prevents the
            Malignancy of Papillary Thyroid Cancer.
REFERENCE   2  (bases 1 to 1139)
  AUTHORS   Xian,J., Zeng,Y., Chen,S., Lu,L., Liu,L., Chen,J., Rao,B., Zhao,Z.,
            Liu,J., Xie,C., Zhu,L., Zhang,D., Qiu,F., Lu,J. and Yang,L.
  TITLE     Discovery of a novel linc01125 isoform in serum exosomes as a
            promising biomarker for NSCLC diagnosis and survival assessment
  JOURNAL   Carcinogenesis 42 (6), 831-841 (2021)
   PUBMED   33928340
  REMARK    GeneRIF: Discovery of a novel linc01125 isoform in serum exosomes
            as a promising biomarker for NSCLC diagnosis and survival
            assessment.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC017099.11.
            
            On Aug 14, 2020 this sequence version replaced NM_001351368.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000627399.4/ ENSP00000490587.1
            RefSeq Select criteria    :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AC017099.11        180095-180216
            123-224             AC017099.11        184838-184939
            225-308             AC017099.11        186227-186310
            309-407             AC017099.11        199277-199375
            408-479             AC017099.11        200638-200709
            480-590             AC017099.11        209408-209518
            591-741             AC017099.11        211536-211686
            742-1139            AC017099.11        213051-213448
FEATURES             Location/Qualifiers
     source          1..1139
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..1139
                     /gene="C2orf92"
                     /gene_synonym="LINC01125"
                     /note="chromosome 2 open reading frame 92"
                     /db_xref="GeneID:728537"
                     /db_xref="HGNC:HGNC:49272"
     exon            1..122
                     /gene="C2orf92"
                     /gene_synonym="LINC01125"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..874
                     /gene="C2orf92"
                     /gene_synonym="LINC01125"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; long intergenic non-protein coding RNA 1125;
                     uncharacterized protein C2orf92"
                     /codon_start=1
                     /product="uncharacterized protein C2orf92 isoform 1
                     precursor"
                     /protein_id="NP_001338297.1"
                     /db_xref="CCDS:CCDS86862.1"
                     /db_xref="GeneID:728537"
                     /db_xref="HGNC:HGNC:49272"
                     /translation="MSRAMALFFVLCWIQDEIVLQVFSKVPYDPSFDETRTAVRSITK
                     RDTQKSYSQQKSLNNAAFASGSNEREEHLAKIFDEILLQVFPKFPYDPSFNEATAVRS
                     ITKTDMRKGTSIAWNSPKPEYFLGSVDKIPDKDHLSEEKNFKESCLFDRDLREQLTTI
                     DKETLQGAAKPDAHFRTMPCGQLLHFLQRNTIIAAVSGVAILMAIVLLLLGLASYIRK
                     KQPSSPLANTTYNIFIMDGKTWWHNSEEKNFTKLAKKQKQLKSSSCV"
     exon            123..224
                     /gene="C2orf92"
                     /gene_synonym="LINC01125"
                     /inference="alignment:Splign:2.1.0"
     exon            225..308
                     /gene="C2orf92"
                     /gene_synonym="LINC01125"
                     /inference="alignment:Splign:2.1.0"
     exon            309..407
                     /gene="C2orf92"
                     /gene_synonym="LINC01125"
                     /inference="alignment:Splign:2.1.0"
     exon            408..479
                     /gene="C2orf92"
                     /gene_synonym="LINC01125"
                     /inference="alignment:Splign:2.1.0"
     exon            480..590
                     /gene="C2orf92"
                     /gene_synonym="LINC01125"
                     /inference="alignment:Splign:2.1.0"
     exon            591..741
                     /gene="C2orf92"
                     /gene_synonym="LINC01125"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1139
                     /gene="C2orf92"
                     /gene_synonym="LINC01125"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1111..1116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2orf92"
                     /gene_synonym="LINC01125"
                     /note="hexamer: AATAAA"
     polyA_site      1139
                     /gene="C2orf92"
                     /gene_synonym="LINC01125"
                     /note="major polyA site"
ORIGIN      
        1 ggagtccaca gctgctgaat ctgaagggcc atcagaagac tggcttctcc atgatggttt
       61 atggactaag gcaaagatga gcagagccat ggccctcttc tttgttctct gctggatcca
      121 agatgaaatt gtgctccaag tgttttccaa ggttccgtat gacccatcat ttgatgaaac
      181 aagaacagca gtcagatcca ttacaaagag agacacacaa aaaagctatt cccaacagaa
      241 gagcttgaac aatgctgcat ttgcatcagg ttcaaatgag cgagaggaac atttggctaa
      301 aatatttgat gaaattctac tgcaggtgtt tccaaagttt ccgtatgacc catcatttaa
      361 cgaagcaaca gcagtcagat ccattacaaa gacagacatg agaaaaggaa ccagcattgc
      421 ttggaattct cctaaaccag aatatttcct tggcagtgtg gacaaaattc ctgataaaga
      481 tcacctttca gaggagaaga attttaaaga atcctgtctg ttcgacaggg atttaagaga
      541 gcagttaact actatagata aagaaacact tcaaggagca gctaaaccag atgctcactt
      601 taggactatg ccctgcgggc agcttctgca cttcctgcag aggaacacca tcatcgccgc
      661 cgtctcaggg gtggccatcc tcatggccat cgtgctgttg ctgcttgggt tggcctcata
      721 catcaggaag aaacagccat catctcctct ggcaaacacg acatataata tttttataat
      781 ggatggaaag acatggtggc acaattctga agaaaaaaat ttcacaaaac ttgcaaaaaa
      841 acagaaacag ttgaagagca gctcctgtgt ctaagccagg tcgtggggcc gtcaaaccag
      901 gacttgaaac cacaatgcga ggacattctc catctgcgca ccacagggag gcaattccat
      961 ttctgcccgg gaggtgtatt ctacaaaaac gtctgcttcc catcccaatt tgaatggacc
     1021 aagaaaaact gctttaccat aggacacttg tggcaatatg gcaccgatgg ctggcgtcgg
     1081 tgaacccgac agactatgga tttatcattt aataaagcat tgattcattt tttcagtca
//
