LOCUS       NM_001042519            4035 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens chromosome 2 open reading frame 88 (C2orf88),
            transcript variant 1, mRNA.
ACCESSION   NM_001042519
VERSION     NM_001042519.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4035)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4035)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4035)
  AUTHORS   Burgers,P.P., Bruystens,J., Burnley,R.J., Nikolaev,V.O.,
            Keshwani,M., Wu,J., Janssen,B.J., Taylor,S.S., Heck,A.J. and
            Scholten,A.
  TITLE     Structure of smAKAP and its regulation by PKA-mediated
            phosphorylation
  JOURNAL   FEBS J 283 (11), 2132-2148 (2016)
   PUBMED   27028580
REFERENCE   4  (bases 1 to 4035)
  AUTHORS   Kapoor,M., Wang,J.C., Wetherill,L., Le,N., Bertelsen,S.,
            Hinrichs,A.L., Budde,J., Agrawal,A., Almasy,L., Bucholz,K.,
            Dick,D.M., Harari,O., Xiaoling,X., Hesselbrock,V., Kramer,J.,
            Nurnberger,J.I. Jr., Rice,J., Schuckit,M., Tischfield,J.,
            Porjesz,B., Edenberg,H.J., Bierut,L., Foroud,T. and Goate,A.
  TITLE     Genome-wide survival analysis of age at onset of alcohol dependence
            in extended high-risk COGA families
  JOURNAL   Drug Alcohol Depend 142, 56-62 (2014)
   PUBMED   24962325
REFERENCE   5  (bases 1 to 4035)
  AUTHORS   Lin,C., Guo,X., Lange,S., Liu,J., Ouyang,K., Yin,X., Jiang,L.,
            Cai,Y., Mu,Y., Sheikh,F., Ye,S., Chen,J., Ke,Y. and Cheng,H.
  TITLE     Cypher/ZASP is a novel A-kinase anchoring protein
  JOURNAL   J Biol Chem 288 (41), 29403-29413 (2013)
   PUBMED   23996002
REFERENCE   6  (bases 1 to 4035)
  AUTHORS   Burgers,P.P., Ma,Y., Margarucci,L., Mackey,M., van der Heyden,M.A.,
            Ellisman,M., Scholten,A., Taylor,S.S. and Heck,A.J.
  TITLE     A small novel A-kinase anchoring protein (AKAP) that localizes
            specifically protein kinase A-regulatory subunit I (PKA-RI) to the
            plasma membrane
  JOURNAL   J Biol Chem 287 (52), 43789-43797 (2012)
   PUBMED   23115245
REFERENCE   7  (bases 1 to 4035)
  AUTHORS   Okada,Y., Kubo,M., Ohmiya,H., Takahashi,A., Kumasaka,N., Hosono,N.,
            Maeda,S., Wen,W., Dorajoo,R., Go,M.J., Zheng,W., Kato,N., Wu,J.Y.,
            Lu,Q., Tsunoda,T., Yamamoto,K., Nakamura,Y., Kamatani,N. and
            Tanaka,T.
  CONSRTM   GIANT consortium
  TITLE     Common variants at CDKAL1 and KLF9 are associated with body mass
            index in east Asian populations
  JOURNAL   Nat Genet 44 (3), 302-306 (2012)
   PUBMED   22344221
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA247977.1, BX648070.1 and AC010679.6.
            
            On Nov 23, 2018 this sequence version replaced NM_001042519.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All four variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.150128.1,
                                           SRR1660805.156354.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340623.4/ ENSP00000345107.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-585               DA247977.1         1-585
            586-1461            BX648070.1         91-966
            1462-2594           AC010679.6         124353-125485
            2595-4035           BX648070.1         2100-3540
FEATURES             Location/Qualifiers
     source          1..4035
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.2"
     gene            1..4035
                     /gene="C2orf88"
                     /gene_synonym="smAKAP"
                     /note="chromosome 2 open reading frame 88"
                     /db_xref="GeneID:84281"
                     /db_xref="HGNC:HGNC:28191"
                     /db_xref="MIM:615117"
     exon            1..247
                     /gene="C2orf88"
                     /gene_synonym="smAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            248..4035
                     /gene="C2orf88"
                     /gene_synonym="smAKAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             412..699
                     /gene="C2orf88"
                     /gene_synonym="smAKAP"
                     /note="small A-kinase anchoring protein; small membrane
                     AKAP"
                     /codon_start=1
                     /product="small membrane A-kinase anchor protein"
                     /protein_id="NP_001035984.1"
                     /db_xref="CCDS:CCDS42792.1"
                     /db_xref="GeneID:84281"
                     /db_xref="HGNC:HGNC:28191"
                     /db_xref="MIM:615117"
                     /translation="MGCMKSKQTFPFPTIYEGEKQHESEEPFMPEERCLPRMASPVNV
                     KEEVKEPPGTNTVILEYAHRLSQDILCDALQQWACNNIKYHDIPYIESEGP"
     regulatory      743..748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2orf88"
                     /gene_synonym="smAKAP"
                     /note="hexamer: AATAAA"
     polyA_site      765
                     /gene="C2orf88"
                     /gene_synonym="smAKAP"
                     /note="major polyA site"
     regulatory      1007..1012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2orf88"
                     /gene_synonym="smAKAP"
                     /note="hexamer: AATAAA"
     polyA_site      1030
                     /gene="C2orf88"
                     /gene_synonym="smAKAP"
                     /note="major polyA site"
     regulatory      4013..4018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2orf88"
                     /gene_synonym="smAKAP"
                     /note="hexamer: AATAAA"
     polyA_site      4035
                     /gene="C2orf88"
                     /gene_synonym="smAKAP"
                     /note="major polyA site"
ORIGIN      
        1 acatgctgcc acttggctga gccgggcgcc ggcgagaagg cggcgccgct gccctggcag
       61 ctggactgca ctttgccccc gcccggcctc agctgccgcc cgcccagacg ccagcaagcc
      121 cccctcccac gacagggctg ctccgggagc ttcggagacc cgccccgggc ctgagcgcag
      181 gctgcctccg ggaccccacg gctgtccgga cgtgccatgg gcgcgcagct gccgggcaac
      241 gtgttgtgta aacactacac gtgaagagtg gtgaaaggga acattgatta ctgaagtgcc
      301 ctggagaggg aaagcactgg tcaacatcac atggacaaat ttcattgttt tctaaagatg
      361 gcctggaagt agtctttgcc actgcttcct ccacaaacag ctcttcataa catgggctgc
      421 atgaaatcaa agcaaacttt cccatttcct accatatatg aaggtgagaa gcagcatgag
      481 agtgaagaac cctttatgcc agaagagaga tgtctaccta ggatggcttc tccagttaat
      541 gtcaaagagg aagtgaagga acctccaggg accaatactg tgatcttgga atatgcacac
      601 cgcctgtctc aggatatctt gtgtgatgcc ttgcagcaat gggcatgcaa taacatcaag
      661 taccatgaca ttccatacat tgagagtgag gggccttgag gctgtaggat gacaacactt
      721 tgactgtgga ggtgctagtt tgaataaatg tgacaaaagc aaaaactggt gtgaaaaagt
      781 acaaataact atctggattt aaaaatgtgt ctacgataat gtcactatta taagaacaac
      841 taggatgaaa tgcattttaa gtacttctat gttaacagca atttctgttt agtcttagat
      901 tttagtcatc tgaagggctg aacagaggtc ctgtgacacc caataatcag ctgaatgtca
      961 cagcacttct tcctaagtaa tggcatcacc aaagaaaatg ctaaggaata aaaactgccc
     1021 caaattccaa tggttgaagt ttatccttta aaataacaat ttttgtttgt ttatacccaa
     1081 aaaaagtcca gatatgaaaa gggcttttct aaaatttctt ggcgagggaa tggcactcaa
     1141 atcatagtga ttaacagtaa gtcttgtttg tttgtcaagg atctctactt cttgacacaa
     1201 atgaaccctg tctttaataa gataagatat ttatttttgt agatgagaag tgtaactacc
     1261 accttggacc tcagggccct aactaattac agctgttact ggacgactca gactttgtgc
     1321 ctaaagccat cttagagata acagtttata gaagccatga cattagtgtt tattgcattg
     1381 aattaagccc agtgatataa ctatacaaga aaacaagtag gggtaccttt tacaaagagc
     1441 aatccaataa atcttaaaaa taacagaaac ttagtctgca aggtagaaag tttcagtttt
     1501 aattctgtat taagctttac tatctcagag gtacagaggg ctggaatatg ggcatttatt
     1561 tccagttttt tcttgactag taaggcggtc accattaaaa tagaccagat aatgcatgaa
     1621 gatttacagt tgtattgcaa aacggaaaag ataaaactgt cctttgagga gagtactcgt
     1681 tttctgggtt tttgttattt tttagtggta acacaagcct atagggcatt tatagccacc
     1741 tattatactg tttccataag cctggctacc ttttagggaa gctatttttt ctctttcatt
     1801 tttactgtca cagcacatac acacacacct ttttgtttta aaggattaag tactgtttga
     1861 agatcagtgg taacagaaaa tttgggaggg agaagaagaa attaagacat gacttgttag
     1921 aaaattaaga cttcagtttc tagaattatc ttttcatcaa gatttggtag acattgagtt
     1981 taaatggaaa ggaaattatt taagcctgtg tatgttagat ccacaataca ccattggtat
     2041 tgaaatataa aggttaaaaa aaaggcttat gacctcttta atgagataaa tatgtatttg
     2101 tcttgtaagc aggcagaaaa tctacctcta attttaacac taatactttg aaacccacaa
     2161 tcaaatagag tgaattctcc aagttacata agcaaggaaa acattatttg aaatatgcca
     2221 tgttttcgtt gcctttggac acctcatcat tcaactctaa ttttaccgag tcccgggatt
     2281 tgtactgtcc cattgtactt gcaatctaca atttatataa tagaaaaaca accaaaccca
     2341 ttcatacaag gatctgaagt tataaggtta agggcagaaa gtttcccata agtataaaac
     2401 atttccaggt catgaagagt agtttaggtt gagtgacaaa agcctaggtg tggttgtttt
     2461 tcattcattt tgcatctcac accaagacat ttttgctgca aggtcatctg ctgcttaaaa
     2521 tgtacaatta ggtatataaa ataagtacaa tggtgaaaac acaaagccag gtaaagcagc
     2581 atgccccact aaacttttca gtatacatag ggacagacaa gtgagttttg gttgtatcta
     2641 aatattttaa tttcaggttc cttctgtgcc ctgggccact atttcccagg ggtgtgacag
     2701 agatgcctgc cagatccata tcaactagaa gtctgatttc tgttgctgcc cttcctcagc
     2761 aactatggca gtatactttt atcaccaagc accactccct tgtccctgaa tcacatttta
     2821 atagagtaca atatcttctg tacaatattt ctgaaacact tatgtctgaa atatatgctg
     2881 tattgtatgt taacccatga catatatgaa ctacaaggct tgcataatca gtgagctagt
     2941 ggataaatca agacaggagc aaatgggaga aagatgaata aacaaatgaa aaaagatgaa
     3001 taaatgaata agagagatga ataaacaaat ttacattaca tgtgatagtt atcatggtat
     3061 ggccttcatg acaagatgga tgagaatatc actgatagga tattagcctt ctttcatatc
     3121 tttatattga aatatgggct ttacttcaat ttgaaggtct ttcatgaaca ataaaagaga
     3181 gtagaaggac tgtctgagaa ggcaggagac atataaaaca gatgactgaa agactgacta
     3241 gctcctggaa agggaaacat ttggaacatc cagagtaagg gcaaatgggc ttctaccagc
     3301 acaacaaaga gcctccaggt ggcaacatgg aagcaggtta tcagagaaaa taaatgtgca
     3361 aattccttat ttacaatgac tcacttaacc ccacaaacat gtttcactgc tgccttcccc
     3421 agttgtcgct tatgtactgt tgttaccttt cagttacatg cctttgatcc taaaattctc
     3481 tacttttgtt gccttatcag ttctttgcaa tctgcctgtg gttatcagca cttaaagcac
     3541 aattttgaag gggaaaaaaa tgataatcac cttagtccca aagaaataat ttgtcaaact
     3601 gccttattag tattaaaaac agacacactg aatgaagtag catgatacgc atatatccta
     3661 ctcagtatca ttggcctttt atcaaatggg gaaactatac ttttgtatta catagtttta
     3721 gaaatcgaaa gttagagact ctttataagt aatgtcaagg aacagtaatt taaaaacaaa
     3781 gttctaacaa atatattgtt tgcttaatca caatgccctc aacttgtatt tgaataacta
     3841 aataggacat gtcttccttg gagctgtggg cattagttca gaagcactac ctgcatctta
     3901 attttcaaaa cttaagtttt attagcaaat cctcttctct gtaagactta gctatgaagt
     3961 ggtatatttt ttccaaatat ttttctgaaa acatttgttg ttgtaactgc acaataaaag
     4021 tccagttgca attaa
//
