LOCUS       NM_001316764            2059 bp    mRNA    linear   PRI 11-FEB-2024
DEFINITION  Homo sapiens chromosome 2 open reading frame 81 (C2orf81),
            transcript variant 1, mRNA.
ACCESSION   NM_001316764
VERSION     NM_001316764.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2059)
  AUTHORS   Hillier,L.W., Graves,T.A., Fulton,R.S., Fulton,L.A., Pepin,K.H.,
            Minx,P., Wagner-McPherson,C., Layman,D., Wylie,K., Sekhon,M.,
            Becker,M.C., Fewell,G.A., Delehaunty,K.D., Miner,T.L., Nash,W.E.,
            Kremitzki,C., Oddy,L., Du,H., Sun,H., Bradshaw-Cordum,H., Ali,J.,
            Carter,J., Cordes,M., Harris,A., Isak,A., van Brunt,A., Nguyen,C.,
            Du,F., Courtney,L., Kalicki,J., Ozersky,P., Abbott,S.,
            Armstrong,J., Belter,E.A., Caruso,L., Cedroni,M., Cotton,M.,
            Davidson,T., Desai,A., Elliott,G., Erb,T., Fronick,C., Gaige,T.,
            Haakenson,W., Haglund,K., Holmes,A., Harkins,R., Kim,K.,
            Kruchowski,S.S., Strong,C.M., Grewal,N., Goyea,E., Hou,S., Levy,A.,
            Martinka,S., Mead,K., McLellan,M.D., Meyer,R., Randall-Maher,J.,
            Tomlinson,C., Dauphin-Kohlberg,S., Kozlowicz-Reilly,A., Shah,N.,
            Swearengen-Shahid,S., Snider,J., Strong,J.T., Thompson,J.,
            Yoakum,M., Leonard,S., Pearman,C., Trani,L., Radionenko,M.,
            Waligorski,J.E., Wang,C., Rock,S.M., Tin-Wollam,A.M., Maupin,R.,
            Latreille,P., Wendl,M.C., Yang,S.P., Pohl,C., Wallis,J.W.,
            Spieth,J., Bieri,T.A., Berkowicz,N., Nelson,J.O., Osborne,J.,
            Ding,L., Meyer,R., Sabo,A., Shotland,Y., Sinha,P., Wohldmann,P.E.,
            Cook,L.L., Hickenbotham,M.T., Eldred,J., Williams,D., Jones,T.A.,
            She,X., Ciccarelli,F.D., Izaurralde,E., Taylor,J., Schmutz,J.,
            Myers,R.M., Cox,D.R., Huang,X., McPherson,J.D., Mardis,E.R.,
            Clifton,S.W., Warren,W.C., Chinwalla,A.T., Eddy,S.R., Marra,M.A.,
            Ovcharenko,I., Furey,T.S., Miller,W., Eichler,E.E., Bork,P.,
            Suyama,M., Torrents,D., Waterston,R.H. and Wilson,R.K.
  TITLE     Generation and annotation of the DNA sequences of human chromosomes
            2 and 4
  JOURNAL   Nature 434 (7034), 724-731 (2005)
   PUBMED   15815621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005041.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001316764.2.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3546867.1,
                                           SRR14038191.541489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684111.1/ ENSP00000507340.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC005041.2         113680-113756
            78-308              AC005041.2         119058-119288
            309-2059            AC005041.2         119372-121122
FEATURES             Location/Qualifiers
     source          1..2059
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..2059
                     /gene="C2orf81"
                     /gene_synonym="hCG40743"
                     /note="chromosome 2 open reading frame 81"
                     /db_xref="GeneID:388963"
                     /db_xref="HGNC:HGNC:34350"
     exon            1..77
                     /gene="C2orf81"
                     /gene_synonym="hCG40743"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1907
                     /gene="C2orf81"
                     /gene_synonym="hCG40743"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C2orf81"
                     /codon_start=1
                     /product="uncharacterized protein C2orf81 isoform 1"
                     /protein_id="NP_001303693.1"
                     /db_xref="CCDS:CCDS92782.1"
                     /db_xref="GeneID:388963"
                     /db_xref="HGNC:HGNC:34350"
                     /translation="MAHEGSRQERQVRDRGVTRSKAEKVRPPTVPVPQVDIVPGRLSE
                     AEWMALTALEEGEDVVGDILADLLARVMDSAFKVYLTQQCIPFTISQAREAMLQITEW
                     RFLARDEGESAVAEDPTWGEDEEPSACTTDSWAQGSVPVLHASTSEGLENFQGEVHSS
                     GASPDSSAIAPALPFPTSHCPSAFPQDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQL
                     RVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEEAPADDADPSL
                     DPYLVASPQASTGRGHPLGFHLSLEDLYCCMPQLDAAGDRLELRSEGVPCIASGVLVS
                     YPSVGGATRPSASCQQQRAGHSDVRLSAHHHRMRRKAAVKRLDPARLPCHWVRPLAEV
                     LVPDSQTRPLEAYRGRQRGEKTKARAEPQALGPGTRVSPAAFFPLRPGIPFRDLDSGP
                     ALLFPTLNLGLSSPSLESKLPLPNSRIRFLTTHPVLPDVARSRSPKLWPSVRWPSGWE
                     GKAELLGELWAGRTRVPPQGLELADREGQDPGRWPRTTPPVLEATSQVMWKPVLLPEA
                     LKLAPGVSMWNRSTQVLLSSGVPEQEDKEGSTFPPVEQHPIQTGAPKPR"
     exon            78..308
                     /gene="C2orf81"
                     /gene_synonym="hCG40743"
                     /inference="alignment:Splign:2.1.0"
     exon            309..2059
                     /gene="C2orf81"
                     /gene_synonym="hCG40743"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2031..2036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2orf81"
                     /gene_synonym="hCG40743"
                     /note="hexamer: AATAAA"
     polyA_site      2059
                     /gene="C2orf81"
                     /gene_synonym="hCG40743"
                     /note="major polyA site"
ORIGIN      
        1 ggtggcttac gcggcccgga tgcagcagaa acaccagcgt tgctgcgacc gcgttggcga
       61 tggcgcacga aggctcgagg caggagaggc aggtccgaga ccgcggggtg acccggtcca
      121 aggcggaaaa agtgcggccg cccactgtgc cagtgccgca ggtggatatt gtgcctgggc
      181 ggctcagtga ggccgagtgg atggcgctta cagccctcga ggagggcgag gacgtcgtag
      241 gggacatctt ggccgacttg ctggctcgag tcatggactc tgctttcaaa gtctacctga
      301 ctcagcagtg cattccattc accatcagcc aggcccggga ggccatgctg cagatcaccg
      361 agtggcgctt cctggcccgg gacgagggag aatctgcagt agctgaggac cccacatggg
      421 gtgaggacga ggagccttcg gcatgcacga cggactcctg ggctcagggt tcagtgcccg
      481 tgctgcacgc gtccacctcg gagggcctgg agaacttcca aggcgaagta cactcctcag
      541 gagcctctcc ggactcctct gccattgctc ctgctctccc ctttccgaca tctcactgcc
      601 cgagtgcatt tccccaggac cctgggggcg tggaccggat ccctttagga aggtcgtgga
      661 tgggtcgagg ctcccaggag cagatggaat cttgggagcc ttctccgcag ctgagagtca
      721 cgtcggcccc tcctcccaca tcagagctgt ttcaggaggc agggcccgga ggtcctgtag
      781 aggaagcgga cggccagtct agaggcctct cctcggccgg gtccttgagc gcgagcttcc
      841 aactgtcggt ggaggaggcg cctgccgacg atgccgaccc ttctctggat ccgtacctgg
      901 tagccagccc ccaggcctca actgggaggg gacaccccct cggcttccat ttgtcgttgg
      961 aagacctcta ctgttgcatg cctcaactgg acgcggctgg ggatcggctg gaactcaggt
     1021 cagagggggt gccctgcatc gcctcgggcg tgttggtgtc ctacccctct gtgggcggcg
     1081 ccacccgccc ctccgcgtcc tgccagcagc agcgggccgg gcactcggat gtgcggctga
     1141 gcgcccacca ccacaggatg cgccgcaagg cggccgtgaa acgcctggac cctgcgaggc
     1201 tcccgtgcca ctgggtgcgc cctctggctg aggtcctggt cccagactct caaacacgcc
     1261 ccttggaagc ctaccgcgga cgccagcggg gcgagaagac caaggcccgg gccgaacccc
     1321 aagccctcgg ccccggcacc cgtgtctccc cggcagcgtt cttccctctc cggccaggca
     1381 ttcctttccg tgacttggac tcgggccccg cactcctgtt ccccacttta aatttaggcc
     1441 tatcgtcgcc atccctcgag tcaaagctgc cactcccaaa ctccaggatc cgcttcctca
     1501 ccacacaccc ggtgctccct gatgtggccc gcagccgcag ccccaagctg tggcccagtg
     1561 tcaggtggcc cagcggttgg gaggggaagg ccgagctgct gggcgagctg tgggctggcc
     1621 ggacccgcgt gcctccacag ggtctggagc tggcagacag ggagggccag gatcctggca
     1681 gatggcctcg aaccacaccc ccggtccttg aagccacttc ccaggtgatg tggaagcccg
     1741 tgttgctgcc agaagccctg aagctggccc ctggtgtgag catgtggaac cggagcaccc
     1801 aggtgttgct cagctctggt gtgcctgaac aagaggacaa agaaggtagc acctttcctc
     1861 ccgttgagca acatcccatc cagacaggtg ccccaaagcc caggtgaccg tagcacagct
     1921 aatgaagaac tcagccccca aagtgtggtc acgctcctct aagcctgctg cctccctctg
     1981 atccctgagc ctctggcagt agtaactggt ccctccctct gctagccaga aataaacacc
     2041 tgagttgcct taggaacta
//
