LOCUS       NM_001099334            1195 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens chromosome 2 open reading frame 80 (C2orf80), mRNA.
ACCESSION   NM_001099334 XM_371592 XM_934662 XM_938967 XM_943977
VERSION     NM_001099334.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1195)
  AUTHORS   Quintens,R., Verreet,T., Janssen,A., Neefs,M., Leysen,L.,
            Michaux,A., Verslegers,M., Samari,N., Pani,G., Verheyde,J.,
            Baatout,S. and Benotmane,M.A.
  TITLE     Identification of novel radiation-induced p53-dependent transcripts
            extensively regulated during mouse brain development
  JOURNAL   Biol Open 4 (3), 331-344 (2015)
   PUBMED   25681390
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1195)
  AUTHORS   Norling,A., Linden Hirschberg,A., Iwarsson,E., Persson,B.,
            Wedell,A. and Barbaro,M.
  TITLE     Novel candidate genes for 46,XY gonadal dysgenesis identified by a
            customized 1 M array-CGH platform
  JOURNAL   Eur J Med Genet 56 (12), 661-668 (2013)
   PUBMED   24055526
REFERENCE   3  (bases 1 to 1195)
  AUTHORS   Hill,M.J., Jeffries,A.R., Dobson,R.J., Price,J. and Bray,N.J.
  TITLE     Knockdown of the psychosis susceptibility gene ZNF804A alters
            expression of genes involved in cell adhesion
  JOURNAL   Hum Mol Genet 21 (5), 1018-1024 (2012)
   PUBMED   22080834
REFERENCE   4  (bases 1 to 1195)
  AUTHORS   Xu,J., Zheng,S.L., Isaacs,S.D., Wiley,K.E., Wiklund,F., Sun,J.,
            Kader,A.K., Li,G., Purcell,L.D., Kim,S.T., Hsu,F.C., Stattin,P.,
            Hugosson,J., Adolfsson,J., Walsh,P.C., Trent,J.M., Duggan,D.,
            Carpten,J., Gronberg,H. and Isaacs,W.B.
  TITLE     Inherited genetic variant predisposes to aggressive but not
            indolent prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 107 (5), 2136-2140 (2010)
   PUBMED   20080650
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016697.8.
            
            On Nov 22, 2018 this sequence version replaced NM_001099334.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035737.1, SRR5189652.30989.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341287.9/ ENSP00000343171.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC016697.8         47886-47963         c
            79-194              AC016697.8         44879-44994         c
            195-276             AC016697.8         42884-42965         c
            277-359             AC016697.8         40898-40980         c
            360-447             AC016697.8         39151-39238         c
            448-519             AC016697.8         38678-38749         c
            520-607             AC016697.8         29921-30008         c
            608-726             AC016697.8         28878-28996         c
            727-1195            AC016697.8         23280-23748         c
FEATURES             Location/Qualifiers
     source          1..1195
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.3"
     gene            1..1195
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /note="chromosome 2 open reading frame 80"
                     /db_xref="GeneID:389073"
                     /db_xref="HGNC:HGNC:34352"
                     /db_xref="MIM:615536"
     exon            1..78
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            79..194
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..735
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /note="gonad development associated 1"
                     /codon_start=1
                     /product="uncharacterized protein C2orf80"
                     /protein_id="NP_001092804.2"
                     /db_xref="CCDS:CCDS42809.1"
                     /db_xref="GeneID:389073"
                     /db_xref="HGNC:HGNC:34352"
                     /db_xref="MIM:615536"
                     /translation="MERRLIKKEMKKLLGDYIGIRLRENEFDPKGRRQLTFLDDMAHY
                     DLAISVALQWLDPSEDLTWLEWEELKIPLHGRPIYPNRREREAMILSSYAGILMNSIP
                     IEEVFKIYGADSSADSGTIKVPRVSSLCLSLHPFAMLTAPKAAAYARKQSVKSRKVTT
                     NKNATSISAKEANATEWKSSQRFSDTQPKHKVT"
     exon            195..276
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..359
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            360..447
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..519
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..607
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..726
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..1195
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1106..1111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /note="hexamer: AATAAA"
     polyA_site      1127
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /note="major polyA site"
     regulatory      1174..1179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /note="hexamer: AATAAA"
     polyA_site      1195
                     /gene="C2orf80"
                     /gene_synonym="GONDA1"
                     /note="major polyA site"
ORIGIN      
        1 agtctgagat gcgcggatgc ttcagcatgc ctccagaagc agagaaagaa caaaagcact
       61 ggaaccggtc tccggttgcc tctagactca gagaagctgg gtctaagtgt agtgttagct
      121 gcagatacct gctcagctgg ctaagccttt aacatggaaa gaaggctcat aaagaaggaa
      181 atgaaaaagc tcttgggaga ttatattggc atcagacttc gggaaaatga atttgaccca
      241 aaaggaagac ggcaactcac ctttctagat gatatggcac actatgactt ggccatcagt
      301 gttgctttgc aatggctgga tccctcagaa gacttaactt ggctggagtg ggaggaactg
      361 aaaataccac tccatggcag acccatatat ccaaatcgta gagaacgaga agctatgatt
      421 ttatcatctt atgctggaat cttaatgaac agtatcccga ttgaggaagt ctttaaaatt
      481 tatggggctg attcttctgc cgattctggt accatcaagg ttccccgagt ttcatctctc
      541 tgcctctcct tgcacccctt tgccatgtta acagcaccca aagcagcagc atacgcccgc
      601 aaacagagtg tcaagtcaag aaaggtaaca acaaataaaa atgccaccag catctctgca
      661 aaggaagcaa atgccacaga atggaaatca tcacaaaggt tttcagacac acagccaaag
      721 cacaaagtca cttagaaaat tggaattgta ccatggaact tcataataga ttctctggga
      781 gcagacgaga agcatcatct taaaaccaca gctcttgcca gtacattttt ctttacaact
      841 gtttttggta caactgcact gaagtgttat ttttgatgtt gagctttctt cttttagaag
      901 catattgcat ggctacattt tcttaaaaaa aaaaactgtg accttatgct acttcattgt
      961 gactggaaga ctgctggaga attcagaaag tatatagtat ttctgtgtta gagcaagctg
     1021 gctttgtagc acattttaca aatgtgtggc attgaatatt gcacagtgat ggagtgggag
     1081 gcagatttcc aaagagttaa tccaaaataa aattaatctg tcattgattg cctttactgt
     1141 gttctcatat gaaaagaatg tttaaatcat ttcaataaag cattaaaaaa atgaa
//
