LOCUS       NM_001322331             685 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens chromosome 2 open reading frame 76 (C2orf76),
            transcript variant 4, mRNA.
ACCESSION   NM_001322331 XM_005263595
VERSION     NM_001322331.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 685)
  AUTHORS   McQuown,A.J., Nelliat,A.R., Reif,D., Sabbarini,I.M., Membreno,B.S.,
            Wu,C.C. and Denic,V.
  TITLE     A Zpr1 co-chaperone mediates folding of eukaryotic translation
            elongation factor 1A via a GTPase cycle
  JOURNAL   Mol Cell 83 (17), 3108-3122 (2023)
   PUBMED   37597513
REFERENCE   2  (bases 1 to 685)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 685)
  AUTHORS   Pelak,K., Goldstein,D.B., Walley,N.M., Fellay,J., Ge,D.,
            Shianna,K.V., Gumbs,C., Gao,X., Maia,J.M., Cronin,K.D.,
            Hussain,S.K., Carrington,M., Michael,N.L. and Weintrob,A.C.
  CONSRTM   Infectious Disease Clinical Research Program HIV Working Group;
            National Institute of Allergy and Infectious Diseases Center for
            HIV/AIDS Vaccine Immunology (CHAVI)
  TITLE     Host determinants of HIV-1 control in African Americans
  JOURNAL   J Infect Dis 201 (8), 1141-1149 (2010)
   PUBMED   20205591
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Erratum:[J Infect Dis. 2010 Aug 15;202(3):501]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016736.6, BC105805.1 and AW015242.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001322331.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.194241.1,
                                           SRR1803614.183023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334816.12/ ENSP00000335041.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC016736.6         108017-108022       c
            7-676               BC105805.1         5-674
            677-685             AW015242.1         24-32               c
FEATURES             Location/Qualifiers
     source          1..685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.2"
     gene            1..685
                     /gene="C2orf76"
                     /gene_synonym="AIM29"
                     /note="chromosome 2 open reading frame 76"
                     /db_xref="GeneID:130355"
                     /db_xref="HGNC:HGNC:27017"
     exon            1..45
                     /gene="C2orf76"
                     /gene_synonym="AIM29"
                     /inference="alignment:Splign:2.1.0"
     exon            46..190
                     /gene="C2orf76"
                     /gene_synonym="AIM29"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..438
                     /gene="C2orf76"
                     /gene_synonym="AIM29"
                     /note="isoform 1 is encoded by transcript variant 4;
                     UPF0538 protein C2orf76"
                     /codon_start=1
                     /product="UPF0538 protein C2orf76 isoform 1"
                     /protein_id="NP_001309260.1"
                     /db_xref="CCDS:CCDS42739.1"
                     /db_xref="GeneID:130355"
                     /db_xref="HGNC:HGNC:27017"
                     /translation="MAPGEVTITVRLIRSFEHRNFKPVVYHGVNLDQTVKEFIVFLKQ
                     DIPLRTNLPPPFRNYKYDALKIIHQAHKSKTNELVLSLEDDERLLLKEDSTLKAAGIA
                     SETEIAFFCEEDYKNYKANPISSW"
     exon            191..241
                     /gene="C2orf76"
                     /gene_synonym="AIM29"
                     /inference="alignment:Splign:2.1.0"
     exon            242..279
                     /gene="C2orf76"
                     /gene_synonym="AIM29"
                     /inference="alignment:Splign:2.1.0"
     exon            280..361
                     /gene="C2orf76"
                     /gene_synonym="AIM29"
                     /inference="alignment:Splign:2.1.0"
     exon            362..685
                     /gene="C2orf76"
                     /gene_synonym="AIM29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      664..669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2orf76"
                     /gene_synonym="AIM29"
                     /note="hexamer: AATAAA"
     polyA_site      685
                     /gene="C2orf76"
                     /gene_synonym="AIM29"
                     /note="major polyA site"
ORIGIN      
        1 gcttgcgcaa acgccgggag tagccgaagg ggacgccggg aacaggaatt tcttcacatg
       61 gctcctggag aagtgaccat cacagttcgc ctcatccgtt cctttgaaca tcgcaatttc
      121 aaacctgtag tgtatcacgg agtgaatttg gaccaaactg taaaggaatt tatcgtattt
      181 ctaaagcaag atatcccttt aaggaccaac ctgccaccac cattcagaaa ttataaatat
      241 gatgcactaa agattattca tcaagcacat aaatcaaaga caaatgaact tgtgttgagt
      301 ttggaagatg acgaaagact cctgctgaaa gaagacagca ctctgaaagc agctggaatc
      361 gccagtgaaa ctgaaattgc attcttctgt gaagaagatt ataagaacta caaagctaat
      421 cccatttcat cctggtgaaa acatctcgag ggcttccttt ttgcatacct gtattaagct
      481 ctttattcca ctgctgaatt tttgaaattg acaaacaaat cttaaaaaat taatcccagg
      541 ctatactctt tgagctaaaa tctggttatt tctttctctt caggtctttc cttctctctt
      601 tctttttctt tgttgttgta aaataatata ttatgagaaa aacatttgat ctttttaaag
      661 ggaaataaat tgttattaaa aatta
//
