LOCUS       NM_001013649            4274 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens chromosome 2 open reading frame 68 (C2orf68), mRNA.
ACCESSION   NM_001013649 XM_371506
VERSION     NM_001013649.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4274)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 4274)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4274)
  AUTHORS   Lv,Z., He,K., Shi,L., Shi,K., Jiang,T. and Chen,Y.
  TITLE     Interaction between C2ORF68 and HuR in human colorectal cancer
  JOURNAL   Oncol Rep 41 (3), 1918-1928 (2019)
   PUBMED   30664176
  REMARK    GeneRIF: Study suggested that c2orf68 is a potential carcinogenesis
            factor in colorectal cancer (CRC). Furthermore, c2orf68 may have a
            synergistic effect with HuR in the onset and development of CRC.
REFERENCE   4  (bases 1 to 4274)
  AUTHORS   Chen,Y., Jiang,T., Shi,L. and He,K.
  TITLE     hcrcn81 promotes cell proliferation through Wnt signaling pathway
            in colorectal cancer
  JOURNAL   Med Oncol 33 (1), 3 (2016)
   PUBMED   26607374
  REMARK    GeneRIF: hcrcn81 might promote carcinogenesis and progression
            through regulation of the Wnt/beta-catenin signaling pathway and
            plays an important role in the carcinogenesis of colorectal cancer.
REFERENCE   5  (bases 1 to 4274)
  AUTHORS   Wen,X., Zhu,J., Dong,L. and Chen,Y.
  TITLE     The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal
            cancer
  JOURNAL   Med Oncol 31 (8), 92 (2014)
   PUBMED   25023051
  REMARK    GeneRIF: c2orf68 expression correlates with the pathogenesis of
            colorectal cancer through PI3K/Akt/mTOR pathway.
REFERENCE   6  (bases 1 to 4274)
  AUTHORS   Wen,X., Dong,L., Zhu,J. and Chen,Y.
  TITLE     Hcrcn81 is upregulated by rapamycin treatment in human colorectal
            adenocarcinoma cells
  JOURNAL   Mol Med Rep 7 (4), 1257-1260 (2013)
   PUBMED   23404111
  REMARK    GeneRIF: Observations of the current study indicate that hcrcn81
            may play a role in tumorigenesis by regulating the mTOR signaling
            pathway.
REFERENCE   7  (bases 1 to 4274)
  AUTHORS   Jiang,Q., Zhang,C. and Chen,Y.
  TITLE     NM_001013649.3 gene is down-regulated in human colorectal
            adenocarcinoma
  JOURNAL   Mol Med Rep 4 (6), 1279-1281 (2011)
   PUBMED   21874238
  REMARK    GeneRIF: The mRNA levels of NM_001013649.3 are significantly
            down-regulated in colorectal adenocarcinoma tissue, and this
            down-regulation is most likely correlated with the differentiation
            status of the cancer.
REFERENCE   8  (bases 1 to 4274)
  AUTHORS   Kashima,I., Jonas,S., Jayachandran,U., Buchwald,G., Conti,E.,
            Lupas,A.N. and Izaurralde,E.
  TITLE     SMG6 interacts with the exon junction complex via two conserved
            EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay
  JOURNAL   Genes Dev 24 (21), 2440-2450 (2010)
   PUBMED   20930030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012454.8, CN303296.1, BC111483.1, AC016753.9 and BU619982.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001013649.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111483.1, SRR1163657.207023.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2151358
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306336.6/ ENSP00000304410.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC012454.8         4226-4235           c
            11-37               CN303296.1         4-30
            38-825              BC111483.1         1-788
            826-1696            AC012454.8         1-871               c
            1697-3743           AC016753.9         172744-174790       c
            3744-4274           BU619982.1         20-550              c
FEATURES             Location/Qualifiers
     source          1..4274
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..4274
                     /gene="C2orf68"
                     /gene_synonym="HCRCN81"
                     /note="chromosome 2 open reading frame 68"
                     /db_xref="GeneID:388969"
                     /db_xref="HGNC:HGNC:34353"
                     /db_xref="MIM:618519"
     exon            1..189
                     /gene="C2orf68"
                     /gene_synonym="HCRCN81"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..583
                     /gene="C2orf68"
                     /gene_synonym="HCRCN81"
                     /codon_start=1
                     /product="UPF0561 protein C2orf68"
                     /protein_id="NP_001013671.2"
                     /db_xref="CCDS:CCDS42704.1"
                     /db_xref="GeneID:388969"
                     /db_xref="HGNC:HGNC:34353"
                     /db_xref="MIM:618519"
                     /translation="MEAGPHPRPGHCCKPGGRLDMNHGFVHHIRRNQIARDDYDKKVK
                     QAAKEKVRRRHTPAPTRPRKPDLQVYLPRHRDVSAHPRNPDYEESGESSSSGGSELEP
                     SGHQLFCLEYEADSGEVTSVIVYQGDDPGKVSEKVSAHTPLDPPMREALKLRIQEEIA
                     KRQSQH"
     exon            190..308
                     /gene="C2orf68"
                     /gene_synonym="HCRCN81"
                     /inference="alignment:Splign:2.1.0"
     exon            309..460
                     /gene="C2orf68"
                     /gene_synonym="HCRCN81"
                     /inference="alignment:Splign:2.1.0"
     exon            461..4274
                     /gene="C2orf68"
                     /gene_synonym="HCRCN81"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2852..2857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2orf68"
                     /gene_synonym="HCRCN81"
                     /note="hexamer: ATTAAA"
     polyA_site      2874
                     /gene="C2orf68"
                     /gene_synonym="HCRCN81"
                     /note="major polyA site"
     regulatory      4251..4256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2orf68"
                     /gene_synonym="HCRCN81"
                     /note="hexamer: AATAAA"
     polyA_site      4274
                     /gene="C2orf68"
                     /gene_synonym="HCRCN81"
ORIGIN      
        1 aaggggcggc gcggagctct gtgggcgggt ggctgttgtt ggggccgtcg aggcggcggc
       61 gactctgcgt ccccggctcc tgatggaggc ggggccgcat ccccggccgg ggcactgctg
      121 caagcctggg gggcggctgg acatgaacca cggcttcgtg caccatatcc gacggaacca
      181 gatcgctcgg gacgactatg acaagaaggt gaagcaggcg gccaaggaga aggtgaggag
      241 gcggcacacg cccgcgccga cgcggccccg caagccagac ctgcaggtgt acctgccgcg
      301 acaccgagat gtctctgccc acccacgcaa cccagactat gaagagtccg gtgaaagcag
      361 cagtagtgga ggctctgagc tggagccttc tggccatcag ctcttctgct tagaatacga
      421 ggcagacagt ggagaggtca catcagttat cgtctatcag ggtgatgacc caggaaaggt
      481 gagtgagaag gtgtcggcac acacgcctct ggatccaccc atgcgagaag ccctcaagtt
      541 gcgtatccag gaggagattg caaagcgcca gagccaacac tgaccatgtt gaaggcgttc
      601 tctccaggct ggattcactg cactcggaag aattctgccc agggaattta gtgtgggggt
      661 accaggacca gtttgtctga tcttgagacc cccagagctg ctgcatccat agggtgttgc
      721 aggactacac ctggcctgcc ttgcagtcat tctttcttat atgttgaccc atttgcccag
      781 cctgatattc tggaattctt tttttttttt tttttttttt ttttttgagg attttgtgtg
      841 gctaatgtgt tctagaagca gagactccag ggagaaccag aatttatgaa gcctcgtgca
      901 acatggtgct ttctcaccga ggtcatatgc ctggctgctg ctgttccact cagctccatg
      961 agccacgttt gttattttat gtttcttctg tgcttttgct catttccacc catgtgttta
     1021 tagacctttt ttcagccctt tttctttgtt cctttccctc atctttttgc ctcaggtaga
     1081 atccatcagt tttcctcccc ctccaaatga ctgtgtacct ccagctgctc aggactttgg
     1141 aggtgggggc ggggcctggg gatctaccct tctaaaaaac tctccaagta attctgatac
     1201 caataaagtg ggagacctcc atttttgagg cctatttgca agcatgtctc cctccctttc
     1261 catggctttt tcgtttctcg catgttccac tgctttgcac tgtctagaca ggaaacctag
     1321 gaagatgttg gtgctaaact gaaaagattt cttacagcaa aacctgcctc ggccagggct
     1381 acagaattcc aactttcaac ttgattccta gccgtgaaca gactgtcctc tgctcagact
     1441 aaaagggaat tataaacaag tgggaactta ctctccagtt gtgacttaac agttctgaac
     1501 atacctacaa agggaaagtc aatattagca ataattgcct gattgacagc acgccagagg
     1561 gaatgaaatg aggccttctc tcctacctcc caggagtatg taactcagat ccttagcata
     1621 aagatcccca ggaataccac tgctctaacc cggtgaacat tttttctaat gcagggttag
     1681 gcttacgtct gaattccaca agacatcctc cccctccagt acggaagttc caaggcactt
     1741 gttttccagc atatcagcct aacctcagtg ccttgaaata tggctttaag cctttgagaa
     1801 ctgagatttc ctgaaaccat aggcccttgc cccaggggtt tctccacatc cgggtgttaa
     1861 gacacctgat ggcactgttg gtttgtcccc tataccccag aaaatctatc ctgcaaggta
     1921 gctacttcaa tcttgtcatt aaaatgtgtc aagtcacagc tcgcaatgcc aaaggaatgc
     1981 tggggcagta agtgaggtgg ataagtgaga agggcctggt ggtgaaagcg gccagggacc
     2041 agaatgctcc agacctacag agctggtcaa ggttaagtgc cttaaactta ccaatcctgg
     2101 gctcagttct cctttgaaag gagaaagtct ttgtcctcta cttaggcagc tgggctagaa
     2161 gtgccttttg acttctaatg ttaactaccc tccaaagcct cctgggtcaa gaaggctctc
     2221 ccaaactcca cccctgttct tcctggtcag agaaccagtc agtcattcta gtcttctagt
     2281 ccttaaactg atctgatgac ttggaacata ggatttcact gcaagtctgg ctttttagtc
     2341 tggaaataca tttgaggtct gttttcgcac agctggatca cctgtttcct ggttttatta
     2401 cacaattcag aaggctagaa gaggagtttg ggggcttggc acctgaaaat ttagaccgca
     2461 ttcttattaa gtaaaggaag aggtagggag gccgaggcgg gcggatcatg aaatcaggag
     2521 atccagaccg tcctggctaa cacagaaacc ccgtctctac taaaaataca aaaaattagc
     2581 tgggcatggt gacatgtgcc tgtagtccat cccagctact cgggaggccg aggcaagaga
     2641 atcacctaaa cctggaaggc ggaggttgca gtgagccgag atcacaccac tgcacttcag
     2701 gctgggcagc agagcgagac tccatctcaa aaaaaaaaaa aaaaggaaga ggtaaaaggc
     2761 aaggcagcat ttaataagta cctgttgtat ccttttaagt gtttgttgtg gtaatcctca
     2821 caaagaccgg gactgatgga aactccttgc tattaaactt tttttcttga ggaattttgc
     2881 ttttcaagtg catatacact attaatattt tttacccaag agagcattct aagctaattt
     2941 atgcagtgtg actgtattaa gcattaagct tccttcagag ctggcctatc ggagatgcta
     3001 ctgccctctc tacagatgtg tctgaaatgc ctgcccaagg atggccctta gccagttaac
     3061 agctttatag cccatcctca ttgcttactg ccacccctca gctggggtcc aaggcagtac
     3121 tattcagttt attcaccaga cctgcctcca gacatctact tctttcaaaa attagtgttt
     3181 tccatcaagg agcatgttcc agagcatttc ccagagatgt cccaaagaac actgtccggt
     3241 gctgtggcgt acagtggcaa cagcattaga ctaagtggaa catcccagca ggctgcttta
     3301 gaatccgctc atttgactag atacgatgta attggctgtc tttaaaaaac gcgcacacac
     3361 acacaatctg ataggcatat ctcatgccca ttcaatatgg aatgttcttc gcttgctgaa
     3421 tttaagcctg tattttaagg ttttgtggtt cctcggccac aatgggtgat gtcactgata
     3481 gaacgaagct gagtttccaa gggtttgggg ctgtgcaaga gtaaacacta gagcttgagt
     3541 tgttatccag ctggcaagca cggaagtctt tgaagaatgt aatgtaaaaa gggaaaagaa
     3601 tgtaaagctt tttgtaccaa atgagagttg gagcccagcc aacaaatgct tttccctgtg
     3661 taaaagtctc tctggaaggg acattccatc tccatggtgc actctgaggg gcactgtcaa
     3721 ctagagattg gccccatcca ggtgggagga acccctttgg gatggtgagt atccaatctg
     3781 ctgtgcattt gacaggatct ctgaatggct aggtaatgga tcccaagcag gctcacaaat
     3841 ttaaatgagg gctttgtgtg cagaaagagg aataagtaca gattattttc ctaccactag
     3901 atttttgggg agagtcacca tggaatgttg acaattactt aaaatatttt aagctccctt
     3961 gctgaattcc tgtcctgtcc ctgaggaatc agatggtcat acagccatag gcacccaccc
     4021 gaaatttccc taggagttgg agtaatgcta gaattgaaga ccttctgagt aaagggcttc
     4081 tctgccttct cagaggcagg agaatttgca ctggttgtgt taaatgtata aaaagctata
     4141 tgttcaccag tttactcatt tccaatgtgt agatgaataa aatgtagtgt acaaattatt
     4201 tgaaaatccc agaaggaagg tacttttcaa atacagtatt ttttttaaca aataaactta
     4261 cgatttttac agca
//
