LOCUS       NM_213608               1333 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens chromosome 2 open reading frame 66 (C2orf66), mRNA.
ACCESSION   NM_213608
VERSION     NM_213608.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1333)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358249.1, AC012486.9 and AW768745.1.
            
            On Feb 13, 2020 this sequence version replaced NM_213608.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.193718.1,
                                           SRR14038193.294714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342506.4/ ENSP00000339384.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               AY358249.1         922-1426
            506-940             AC012486.9         63335-63769         c
            941-1333            AW768745.1         6-398               c
FEATURES             Location/Qualifiers
     source          1..1333
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..1333
                     /gene="C2orf66"
                     /gene_synonym="IIDS6411; UNQ6411"
                     /note="chromosome 2 open reading frame 66"
                     /db_xref="GeneID:401027"
                     /db_xref="HGNC:HGNC:33809"
     exon            1..142
                     /gene="C2orf66"
                     /gene_synonym="IIDS6411; UNQ6411"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..322
                     /gene="C2orf66"
                     /gene_synonym="IIDS6411; UNQ6411"
                     /note="uncharacterized protein C2orf66"
                     /codon_start=1
                     /product="uncharacterized protein C2orf66 precursor"
                     /protein_id="NP_998773.2"
                     /db_xref="CCDS:CCDS2317.2"
                     /db_xref="GeneID:401027"
                     /db_xref="HGNC:HGNC:33809"
                     /translation="MTRAPLLLLCVALVLLGHVNGATVRNEDKWKPLNNPRNRDLFFR
                     RLQAYFKGRGLDLGTFPNPFPTNENPRPLSFQSELTASASADYEEQKNSFHNYLKG"
     exon            143..341
                     /gene="C2orf66"
                     /gene_synonym="IIDS6411; UNQ6411"
                     /inference="alignment:Splign:2.1.0"
     exon            342..1333
                     /gene="C2orf66"
                     /gene_synonym="IIDS6411; UNQ6411"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1311..1316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2orf66"
                     /gene_synonym="IIDS6411; UNQ6411"
                     /note="hexamer: AATAAA"
     polyA_site      1333
                     /gene="C2orf66"
                     /gene_synonym="IIDS6411; UNQ6411"
                     /note="major polyA site"
ORIGIN      
        1 cactcagctt cactccacca tgaccagagc acctctcctg ctactatgtg ttgccctggt
       61 gctgcttggg catgtgaatg gagccacagt aagaaatgag gacaaatgga agccactcaa
      121 caaccccaga aacagagatc tgtttttcag aaggcttcag gcatatttta agggcagagg
      181 tcttgatctt ggaacatttc caaatccttt ccccacgaat gaaaatccta gacctctctc
      241 tttccagtca gaacttactg cttctgcatc tgcagattat gaagagcaga aaaactcctt
      301 tcacaattat ctcaaaggct gaaagtttct tctgagctca ggtgtctggc tattttaaaa
      361 ctacagatga agcttctcat tagaaaaatt caaccattgt catagctaaa ctttcatgga
      421 gtttctttcc ccctcacttt tatttttcag tttgtaatga ttttattcca catttccata
      481 tttacatata aatcgctgga actatgattt ctatgcatat ttatggagtt tttttcctat
      541 gaaaccataa atattgatgt agagcaccgc atgtatttgt aggagttaca aaaacatcac
      601 aaactgaaaa aagattataa tctaaattag atgtttcttt aagcttgttt ttaaaacttg
      661 tcttttatgt ttattatctt ttatcgacca atatattttt ttaaagggac atgctcactt
      721 ttagtatagt aaaattcatt atatgtgata gagggttggg tttaaaattt gtcttccttt
      781 cctaaaaaga agatgcattc ccatgttcag catacactac caaaatactt cacagtttta
      841 gtttcataag aaatgagggc aagtgataaa cagccacaat taagttaaaa tggaagcaaa
      901 caacaacaac aaacatggga ttctagaagt tgtcaacgcc tccaaagatg ctctttgcca
      961 gagtattcag aggtggacat tgtgccacat caaatattct agcaatgccc gagcccttgc
     1021 tctcatacac aacctcctca ggaaggaaaa gtagaaacag gtgatttcct ctctttccaa
     1081 ccagcccctg ctctccttac tctagctcat gctgagttat tctgattccc atactcacat
     1141 ttggaatagc tgcttttcct gtatctttat agatagctgc atcatcttct ctgtgattcc
     1201 tgcaaaagga atgttgcact aaaatgcaac attgtcctaa cattagtctg tgcatttcaa
     1261 aatattttaa tgtggctttt ttgggtggat tattgatatt gtatatgaag aataaaatat
     1321 ttgtgcaaga aca
//
