LOCUS       NM_017880               2524 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens chromosome 2 open reading frame 42 (C2orf42),
            transcript variant 2, mRNA.
ACCESSION   NM_017880
VERSION     NM_017880.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 2524)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK000565.1.
            
            On Jun 2, 2019 this sequence version replaced NM_017880.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-8 all encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000565.1, SRR1803616.193093.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264434.7/ ENSP00000264434.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2524              AK000565.1         1-2524
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..2524
                     /gene="C2orf42"
                     /note="chromosome 2 open reading frame 42"
                     /db_xref="GeneID:54980"
                     /db_xref="HGNC:HGNC:26056"
     exon            1..47
                     /gene="C2orf42"
                     /inference="alignment:Splign:2.1.0"
     exon            48..316
                     /gene="C2orf42"
                     /inference="alignment:Splign:2.1.0"
     exon            317..1151
                     /gene="C2orf42"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..2053
                     /gene="C2orf42"
                     /codon_start=1
                     /product="uncharacterized protein C2orf42"
                     /protein_id="NP_060350.1"
                     /db_xref="CCDS:CCDS1899.1"
                     /db_xref="GeneID:54980"
                     /db_xref="HGNC:HGNC:26056"
                     /translation="MEPNSLRTKVPAFLSDLGKATLRGIRKCPRCGTYNGTRGLSCKN
                     KTCGTIFRYGARKQPSVEAVKIITGSDLQVYSVRQRDRGPDYRCFVELGVSETTIQTV
                     DGTIITQLSSGRCYVPSCLKAATQGVVENQCQHIKLAVNCQAEATPLTLKSSVLNAMQ
                     ASPETKQTIWQLATEPTGPLVQRITKNILVVKCKASQKHSLGYLHTSFVQKVSGKSLP
                     ERRFFCSCQTLKSHKSNASKDETAQRCIHFFACICAFASDETLAQEFSDFLNFDSSGL
                     KEIIVPQLGCHSESTVSACESTASKSKKRRKDEVSGAQMNSSLLPQDAVSSNLRKSGL
                     KKPVVASSLKRQACGQLLDEAQVTLSFQDWLASVTERIHQTMHYQFDGKPEPLVFHIP
                     QSFFDALQQRISIGSAKKRLPNSTTAFVRKDALPLGTFSKYTWHITNILQVKQILDTP
                     EMPLEITRSFIQNRDGTYELFKCPKVEVESIAETYGRIEKQPVLRPLELKTFLKVGNT
                     SPDQKEPTPFIIEWIPDILPQSKIGELRIKFEYGHHRNGHVAEYQDQRPPLDQPLELA
                     PLTTITFP"
     exon            1152..1262
                     /gene="C2orf42"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1367
                     /gene="C2orf42"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1472
                     /gene="C2orf42"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1580
                     /gene="C2orf42"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1681
                     /gene="C2orf42"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1844
                     /gene="C2orf42"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2524
                     /gene="C2orf42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2496..2501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2orf42"
                     /note="hexamer: AATAAA"
     polyA_site      2524
                     /gene="C2orf42"
                     /note="major polyA site"
ORIGIN      
        1 agtttggccc cgtttgtaaa aggccgcggc aggcgaagag agaagagact atcaagatct
       61 ccacttaggg aagtgggaat cttatttgcg gaacattggg cagaagcttt gccattggct
      121 ggtggagaag gaggaggcag aatgtctgca ttgttacacc atacagctca aacttcagaa
      181 gattttgggt taagcagtta tcattagtct gcaaatgatc gtgttttcac ctgatcatta
      241 gaaactaatg aaacaccttt taagtcttat gaattcaggt tacactgttt tccagatgcc
      301 ttggcagctg gtacagggcc tctgaaaaat ggaaccaaat tctctgagga ctaaagtccc
      361 agctttctta tctgatttgg ggaaggccac attgagggga atcagaaagt gtccccgatg
      421 tggcacatac aatggaaccc ggggactgag ctgtaagaac aagacatgtg gaaccatatt
      481 ccgctacggt gcacgcaagc agcctagtgt tgaagctgtc aaaatcatta caggctctga
      541 tcttcaggtc tactcagtgc ggcaaagaga ccggggccct gattaccgat gctttgtgga
      601 gctcggggtt tcagagacaa caatccagac agtggatggg acgatcatca ctcagctgag
      661 ctctggacgg tgttatgtcc cctcatgcct gaaagctgcc actcaaggcg ttgtggaaaa
      721 ccagtgccag cacatcaagc tggcggtgaa ctgccaggca gaggccaccc ctctgaccct
      781 gaagagctcg gtcctgaatg caatgcaggc ctccccggaa accaaacaga ccatctggca
      841 gttggccacg gaacccacag gtcctctggt gcagagaatt actaaaaaca tcttggtggt
      901 gaaatgcaag gcaagccaga agcacagttt ggggtatttg catacatctt ttgtgcagaa
      961 agtcagtggc aaaagcttgc ctgagcgccg cttcttctgc tcctgtcaga ctctgaaatc
     1021 gcacaagtca aatgcctcca aggatgagac agcccagaga tgcattcatt tctttgcttg
     1081 catctgtgcc tttgccagtg atgagacact ggctcaggaa ttctcagact tcctaaattt
     1141 tgattccagc ggtcttaaag agattattgt accccagtta ggttgccatt cagaatcaac
     1201 agtatctgct tgtgagtcta ctgcctctaa gtcaaagaag aggagaaagg atgaagtatc
     1261 tggtgcacag atgaacagtt cactactgcc tcaagatgca gtgagcagta atctaaggaa
     1321 aagtggcctg aaaaagcctg tggttgcttc ctcgttaaaa aggcaggcct gtggtcagct
     1381 gttagatgag gcacaagtga ctttatcctt ccaagactgg ctggccagtg tcacagaacg
     1441 catccatcaa accatgcact atcagtttga tggcaaacca gaaccattgg tgttccacat
     1501 tcctcagtca ttttttgatg ccctgcaaca aagaatatct ataggaagtg caaaaaaacg
     1561 gctccccaac tccaccacag cttttgttcg gaaagatgcc ttgccactgg gaaccttttc
     1621 caagtatact tggcatatca ctaatatcct gcaagttaaa caaatcttag ataccccaga
     1681 gatgcccttg gaaatcaccc gtagctttat ccagaaccga gatgggactt atgagctatt
     1741 taaatgccct aaagtggaag tagaaagcat agcagaaacc tacggtcgta tagaaaaaca
     1801 accagtgctg cgacccttgg aactaaaaac ttttctcaaa gttggcaaca cttccccaga
     1861 tcaaaaggag ccaacacctt tcatcatcga gtggatccca gatatccttc cccaatctaa
     1921 gattggcgag ctgcggatca agtttgagta tggccaccac cggaatgggc atgtggcgga
     1981 gtaccaagac cagcggcccc ccttggacca gcccttggaa ctggcccctc tgaccactat
     2041 tactttccct taaagcaaaa caagataata atcttttgct gcttaatttg cacatcccca
     2101 ccccttgaca actttaaatg ctagttaggc acttagatgg ccctgttcct tggtaaactg
     2161 ctcttagcta agatgcaaat tctcagtgct ttcaagtgga ttctgttgaa gaaaatctct
     2221 tgtaaatagc ctttttgatg ctgctgtgta cagtcttcat tatgcattgg gcagtatttc
     2281 tggctagagt tttaaaagga acagaaagaa aaccagctta ttttccttct tacggactca
     2341 tctttagcgt ttatttcaac cttttgctaa ttctctgaga aatctgcagc actcagccat
     2401 acaccaacag tgttggaaag ttaacaccct ggttagggca gaatgttaaa gaccatcttg
     2461 gcagagttcc agccacgctc tttattctgt tctcaaataa agcagtgtca ctagtttttc
     2521 ctaa
//
