LOCUS       NM_144706               1627 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens chromosome 2 open reading frame 15 (C2orf15),
            transcript variant 2, mRNA.
ACCESSION   NM_144706
VERSION     NM_144706.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1627)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1627)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1627)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 1627)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092587.3 and BC021264.2.
            
            On Apr 23, 2020 this sequence version replaced NM_144706.3.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR compared to variant 1. Variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021264.2, AK314133.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000650052.2/
                                                ENSP00000497775.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC092587.3         12561-12575
            16-1342             BC021264.2         1-1327
            1343-1627           AC092587.3         22239-22523
FEATURES             Location/Qualifiers
     source          1..1627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..1627
                     /gene="C2orf15"
                     /note="chromosome 2 open reading frame 15"
                     /db_xref="GeneID:150590"
                     /db_xref="HGNC:HGNC:28436"
     exon            1..231
                     /gene="C2orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            232..348
                     /gene="C2orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            349..440
                     /gene="C2orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            441..1627
                     /gene="C2orf15"
                     /inference="alignment:Splign:2.1.0"
     CDS             517..792
                     /gene="C2orf15"
                     /codon_start=1
                     /product="uncharacterized protein C2orf15"
                     /protein_id="NP_653307.2"
                     /db_xref="CCDS:CCDS2038.2"
                     /db_xref="GeneID:150590"
                     /db_xref="HGNC:HGNC:28436"
                     /translation="MGFSLSKSATQVSAIHMDSKVDDHLIRGTEKSRLEPATQLFQNT
                     KKIRLEDTNQENFTRIEGTGTGSLSGKALGSVVYVKESDGLEMTDVE"
     regulatory      1585..1590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2orf15"
                     /note="hexamer: AATAAA"
     regulatory      1603..1608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2orf15"
                     /note="hexamer: AATAAA"
     polyA_site      1608
                     /gene="C2orf15"
                     /note="major polyA site"
     polyA_site      1627
                     /gene="C2orf15"
                     /note="major polyA site"
ORIGIN      
        1 ctctcgcagc cccgccttcc ctcagcttga aacacctgct gcttcgcggc ggtggctttg
       61 tgccactttt cccagggctt gggcatcatt ctggacccat gttcggtgaa ccggttactc
      121 tcagagctgc tttcgggcgc agctcctgct gcagccaggg cccgttttaa gagaggcttc
      181 caggtccagc cctcccgctg cagcctgcag ggagcgagcc ggcctgtccc gatgacatag
      241 acactaggtt tttacagcaa ttctctgatg accttgatat ggtagaacgc tgtgtatttc
      301 aagagtaagc tctcgtttga ggagactaac aattcctgtt ttcgccagat ttcttcttga
      361 atggcaacct aaatgccagt ccaaagaggc ccccaataga cttgttcacc cttcatgtcc
      421 tcaactctgg ggaagttaag taatcaagtt gaagaaacac ttccactact taaaaaggta
      481 cctgcaaatt actttcacat ttgttcagct atcctaatgg gattttcact tagtaaatct
      541 gctactcagg tatctgctat acatatggat tcaaaagtgg atgatcactt aatacgaggg
      601 actgaaaaaa gcaggttgga accagcgact cagttatttc aaaacaccaa gaaaataaga
      661 ttagaagaca caaatcaaga aaactttaca aggattgaag ggactggcac aggatctctt
      721 tctgggaaag ccttgggttc agtggtatat gtcaaagaaa gtgatggact agaaatgaca
      781 gatgtggaat gaagcaattt gtacgtatta ccaaagaaac caaaaactgc ctttgactaa
      841 ggggggtgtt gaaagagaac ttaaccttat taggaaaccc tgacaaaatg atggaagact
      901 attgccttat tttgcactat ttgtgaatca tcttacactg cattttttta tgatgcttat
      961 tcaaaaggca gttgctttag ggtgaaaaag ccttccaaga ttcaaagcag atttctctgg
     1021 tattatatta tatccttctt aaaaaccaga gtttttaagt aacagtattt gaatggcatc
     1081 aaaacatttt cattttaatg tatttcttta acaagtggtt aaaaaaagtg tccaagcagc
     1141 cgggcgcagt ggctcacacc tgtaatccca gcactttggg aggccaaggc gggtcaatca
     1201 cctgaggtca ggagttcgca accagcctgg ccaatatggt gagaccccat ctctactaaa
     1261 aatgcaaaaa gttagccagg catggtggtg ggcacctgtg atcccagcta cctgggaggc
     1321 tgaggaagga gaatcgcttg aaccctggag gcggaggctg cactgagctg aggtcatgcc
     1381 attgtactcc agcctgggca acaagagcaa aactccgtct caaaaaaaaa aaaaaaaaaa
     1441 aaaaagtcca agcaatgtga catccgtatt tcacaatatt tctggtgtat cagttttgta
     1501 tgttacattt ccattttggg attctgcttt atgatacttt actttcttac attttgcatt
     1561 tttgttctgt aaaagatcac tgccaataaa ctgcaaaaga ccaataaatt gcatatcttc
     1621 agaagga
//
