LOCUS       NM_001168221            5702 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens C2 calcium dependent domain containing 6 (C2CD6),
            transcript variant 1, mRNA.
ACCESSION   NM_001168221
VERSION     NM_001168221.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5702)
  AUTHORS   Hwang,J.Y., Wang,H., Lu,Y., Ikawa,M. and Chung,J.J.
  TITLE     C2cd6-encoded CatSpertau targets sperm calcium channel to Ca2+
            signaling domains in the flagellar membrane
  JOURNAL   Cell Rep 38 (3), 110226 (2022)
   PUBMED   34998468
REFERENCE   2  (bases 1 to 5702)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5702)
  AUTHORS   Lin,W.Y., Camp,N.J., Ghoussaini,M., Beesley,J., Michailidou,K.,
            Hopper,J.L., Apicella,C., Southey,M.C., Stone,J., Schmidt,M.K.,
            Broeks,A., Van't Veer,L.J., Th Rutgers,E.J., Muir,K.,
            Lophatananon,A., Stewart-Brown,S., Siriwanarangsan,P.,
            Fasching,P.A., Haeberle,L., Ekici,A.B., Beckmann,M.W., Peto,J.,
            Dos-Santos-Silva,I., Fletcher,O., Johnson,N., Bolla,M.K., Wang,Q.,
            Dennis,J., Sawyer,E.J., Cheng,T., Tomlinson,I., Kerin,M.J.,
            Miller,N., Marme,F., Surowy,H.M., Burwinkel,B., Guenel,P.,
            Truong,T., Menegaux,F., Mulot,C., Bojesen,S.E., Nordestgaard,B.G.,
            Nielsen,S.F., Flyger,H., Benitez,J., Zamora,M.P., Arias Perez,J.I.,
            Menendez,P., Gonzalez-Neira,A., Pita,G., Alonso,M.R., Alvarez,N.,
            Herrero,D., Anton-Culver,H., Brenner,H., Dieffenbach,A.K.,
            Arndt,V., Stegmaier,C., Meindl,A., Lichtner,P., Schmutzler,R.K.,
            Muller-Myhsok,B., Brauch,H., Bruning,T., Ko,Y.D., Tessier,D.C.,
            Vincent,D., Bacot,F., Nevanlinna,H., Aittomaki,K., Blomqvist,C.,
            Khan,S., Matsuo,K., Ito,H., Iwata,H., Horio,A., Bogdanova,N.V.,
            Antonenkova,N.N., Dork,T., Lindblom,A., Margolin,S., Mannermaa,A.,
            Kataja,V., Kosma,V.M., Hartikainen,J.M., Wu,A.H., Tseng,C.C., Van
            Den Berg,D., Stram,D.O., Neven,P., Wauters,E., Wildiers,H.,
            Lambrechts,D., Chang-Claude,J., Rudolph,A., Seibold,P.,
            Flesch-Janys,D., Radice,P., Peterlongo,P., Manoukian,S.,
            Bonanni,B., Couch,F.J., Wang,X., Vachon,C., Purrington,K.,
            Giles,G.G., Milne,R.L., Mclean,C., Haiman,C.A., Henderson,B.E.,
            Schumacher,F., Le Marchand,L., Simard,J., Goldberg,M.S.,
            Labreche,F., Dumont,M., Teo,S.H., Yip,C.H., Hassan,N.,
            Vithana,E.N., Kristensen,V., Zheng,W., Deming-Halverson,S.,
            Shrubsole,M.J., Long,J., Winqvist,R., Pylkas,K.,
            Jukkola-Vuorinen,A., Kauppila,S., Andrulis,I.L., Knight,J.A.,
            Glendon,G., Tchatchou,S., Devilee,P., Tollenaar,R.A., Seynaeve,C.,
            Van Asperen,C.J., Garcia-Closas,M., Figueroa,J., Lissowska,J.,
            Brinton,L., Czene,K., Darabi,H., Eriksson,M., Brand,J.S.,
            Hooning,M.J., Hollestelle,A., Van Den Ouweland,A.M., Jager,A.,
            Li,J., Liu,J., Humphreys,K., Shu,X.O., Lu,W., Gao,Y.T., Cai,H.,
            Cross,S.S., Reed,M.W., Blot,W., Signorello,L.B., Cai,Q.,
            Pharoah,P.D., Perkins,B., Shah,M., Blows,F.M., Kang,D., Yoo,K.Y.,
            Noh,D.Y., Hartman,M., Miao,H., Chia,K.S., Putti,T.C., Hamann,U.,
            Luccarini,C., Baynes,C., Ahmed,S., Maranian,M., Healey,C.S.,
            Jakubowska,A., Lubinski,J., Jaworska-Bieniek,K., Durda,K.,
            Sangrajrang,S., Gaborieau,V., Brennan,P., Mckay,J., Slager,S.,
            Toland,A.E., Yannoukakos,D., Shen,C.Y., Hsiung,C.N., Wu,P.E.,
            Ding,S.L., Ashworth,A., Jones,M., Orr,N., Swerdlow,A.J.,
            Tsimiklis,H., Makalic,E., Schmidt,D.F., Bui,Q.M., Chanock,S.J.,
            Hunter,D.J., Hein,R., Dahmen,N., Beckmann,L., Aaltonen,K.,
            Muranen,T.A., Heikkinen,T., Irwanto,A., Rahman,N., Turnbull,C.A.,
            Waisfisz,Q., Meijers-Heijboer,H.E., Adank,M.A., Van Der Luijt,R.B.,
            Hall,P., Chenevix-Trench,G., Dunning,A., Easton,D.F. and Cox,A.
  CONSRTM   GENICA Network; kConFab Investigators; Australian Ovarian Cancer
            Study Group; Breast and Ovarian Cancer Susceptibility (BOCS) Study
  TITLE     Identification and characterization of novel associations in the
            CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk
  JOURNAL   Hum Mol Genet 24 (1), 285-298 (2015)
   PUBMED   25168388
REFERENCE   4  (bases 1 to 5702)
  AUTHORS   Jia,L., Young,M.F., Powell,J., Yang,L., Ho,N.C., Hotchkiss,R.,
            Robey,P.G. and Francomano,C.A.
  TITLE     Gene expression profile of human bone marrow stromal cells:
            high-throughput expressed sequence tag sequencing analysis
  JOURNAL   Genomics 79 (1), 7-17 (2002)
   PUBMED   11827452
REFERENCE   5  (bases 1 to 5702)
  AUTHORS   Hadano,S., Hand,C.K., Osuga,H., Yanagisawa,Y., Otomo,A.,
            Devon,R.S., Miyamoto,N., Showguchi-Miyata,J., Okada,Y.,
            Singaraja,R., Figlewicz,D.A., Kwiatkowski,T., Hosler,B.A.,
            Sagie,T., Skaug,J., Nasir,J., Brown,R.H. Jr., Scherer,S.W.,
            Rouleau,G.A., Hayden,M.R. and Ikeda,J.E.
  TITLE     A gene encoding a putative GTPase regulator is mutated in familial
            amyotrophic lateral sclerosis 2
  JOURNAL   Nat Genet 29 (2), 166-173 (2001)
   PUBMED   11586298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007282.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001168221.1.
            
            Summary: An autosomal recessive form of juvenile amyotrophic
            lateral sclerosis was originally mapped to a region of chromosome 2
            that includes this gene. The encoded protein contains a
            calcium-dependent membrane targeting C2 domain. This domain is
            often found in proteins that are involved in membrane trafficking
            and signal transduction. [provided by RefSeq, Jun 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648732.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000439140.6/ ENSP00000409937.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AC007282.4         8333-8611
            280-366             AC007282.4         22814-22900
            367-418             AC007282.4         24236-24287
            419-564             AC007282.4         25627-25772
            565-687             AC007282.4         45294-45416
            688-732             AC007282.4         52185-52229
            733-801             AC007282.4         53234-53302
            802-881             AC007282.4         55491-55570
            882-1025            AC007282.4         61639-61782
            1026-1131           AC007282.4         79901-80006
            1132-1210           AC007282.4         81890-81968
            1211-1254           AC007282.4         90032-90075
            1255-1554           AC007282.4         91191-91490
            1555-1629           AC007282.4         131542-131616
            1630-5220           AC007282.4         132752-136342
            5221-5702           AC007282.4         139609-140090
FEATURES             Location/Qualifiers
     source          1..5702
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..5702
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /note="C2 calcium dependent domain containing 6"
                     /db_xref="GeneID:151254"
                     /db_xref="HGNC:HGNC:14438"
                     /db_xref="MIM:619776"
     exon            1..279
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..5511
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     amyotrophic lateral sclerosis 2 chromosomal region
                     candidate gene 11 protein; amyotrophic lateral sclerosis 2
                     (juvenile) chromosome region, candidate 11; testicular
                     tissue protein Li 16; amyotrophic lateral sclerosis 2
                     chromosome region candidate 11; C2 calcium-dependent
                     domain-containing protein 6; catSper-tau; cation channel
                     sperm-associated targeting subunit tau"
                     /codon_start=1
                     /product="cation channel sperm-associated targeting
                     subunit tau isoform 1"
                     /protein_id="NP_001161693.1"
                     /db_xref="CCDS:CCDS54430.1"
                     /db_xref="GeneID:151254"
                     /db_xref="HGNC:HGNC:14438"
                     /db_xref="MIM:619776"
                     /translation="MEPPQETNRPFSTLDNRSGQVQVLSATPLLQRNPYSSPDIMHIK
                     GSEASSVPYALNQGTTALPKNKNQEGTGHRLLNMLRKTLKESDSEELEITQETPNLVP
                     FGDVVGCLGIHIKNCRHFMPKISLQHYANLFIRISINKAVKCTKMCSLLSKNDEKNTV
                     IKFDEVKYFSVQVPRRYDDKRNNILLELIQYDNREKRAFLLGSVQIHLYEVIQKGCFI
                     EEVQVLHGNIFVCRLEVEFMFSYGNFGYGFSHQLKPLQKITEPSMFMNLAPPPERTDP
                     VTKVITPQTVEYPAFLSPDLNVTVGTPAVQSSNQPSVVRLEKLQQQPRERLEKMKKEY
                     RNLNTWIDKANYLESILMPKLEHKDSEETNIDEASENTKSNHPEEELENIVGVDIPLV
                     NEEAETTANELLDNDSEKGLTIPTLNQSDQDNSTADASKNDESTPSPTEVHSLCTISN
                     QETIKAGRIPPLGERQSESMPDRKMKNVFFPLEVKLKDNYPSILKADSSLSEVAFSPK
                     EYNSPSFRPEYIEFKPKFQFQKFNKNGFDPFLRNINKMSVRKRKDQDIYKYRNILGAE
                     VIEHEDQDPPYPAQSKTAGPANTTWAHDPNIFTTKMLETENKLAPDPTINTIKGLDTK
                     NSLKENLPNVSLPSIKGESSRAGNVQANTCHLSKSLNFTPHIEYLKQSMILKSILSEN
                     LQDLSDKLFSKPEVSMNSEAREKSSSPLLSIHDKSSSSMEDNVLEKKQDLNNWLSEKD
                     ILNSKTTLSQIIKNIPADSFSEGSQIIENIPADSLLEGGQVIKNIPEYSLSEGGQIIK
                     NIPADSFLESGPGQSPEVEEHVSKKHFEADERDFPIKKNSSTKKKHLISEVPNSKSGS
                     SGTVHDYIMRQIFTAPIFSELEIEVKEPSETPMNLENQLPTPWKRSLSSHILFHEENA
                     DEIELPQPRSATSQIIQAFPIDTLLESGIIKVIELDKEHHKSSLLGTGITSPKGNLKD
                     SQEYYSEIRSETEPLSEQSIPIIPKDTTSVSRAEFIQEDQNMFPQDSSYYSIANKELY
                     LPRNGQRLCKDKNDLSSTLESLTNSLMDKLSESDEIMLKSFLKNIFNVFFKYNHSERR
                     GQPEKELERLIQPSFTSDTEHLEELQEDFDKADKLDRKPILSPKLRVFLEELSESEVK
                     HLKSELSKQIQHYLVERLSESGHITKEDLPKIYQNLYLMNEKAEQKGPNSFQGKYSET
                     VKEIMSFVNNFNHHFIDKHLEIKLRSFLKEILQNYFLKNISESSLFNETASETIYPNI
                     SSLRTKSVSISFHELEQDISKGSFGRRFEINMKYPLSKSLQNYLIALSENELLHLKAD
                     LSKHLQSLFIEKLSKSGLMTKKQLEGINQHINLLNSSSIPLKYIKTHLPFRDDCHFVE
                     KHSEKQNKYSRIVQQTTLQTVSEDKLREAELIREKEKKYFPLQNLKGNSSLIKEQKSY
                     YTKEEAKTPSLIKVQPSSNENIQASPLSKSSEILTDILLKKLRKEHVFTQLPQAENSV
                     HKTEIQDPYSWGGKSKITQSKAWCEKTLKMKSLDRKEHVNIYKWTVQEKPEAVLTSYP
                     RIPNARMPREDEYLNRITFPSWQSSTLTHFNTETGEKSKLEDQYCQTLKGNNNNNKKH
                     LVTFAQYKKEIQTLYIKPDEICSEKCAKFPEIQSFQYKVVEDEKNLKPHLFPELFKIE
                     DLKPKVRKERDRVAQPKKSFNKIVRILPTTLPTTRIHLKKSVPRTLLHWTARRTIHDC
                     SDKFEDLHDMTSFTHLKKVKSRSRLLGKSSDDIHNHARHSARPYTAPEVNKQRESYSG
                     KFTSRRMVSSGLVHINDKTSDYEMHKMRPKKIKRGY"
     exon            280..366
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     exon            367..418
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     exon            419..564
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     exon            565..687
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     exon            688..732
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     exon            733..801
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     exon            802..881
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1025
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1131
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1210
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1254
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1554
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1629
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..5220
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     exon            5221..5702
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5494..5499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /note="hexamer: ATTAAA"
     polyA_site      5515
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /note="major polyA site"
     regulatory      5681..5686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /note="hexamer: ATTAAA"
     polyA_site      5702
                     /gene="C2CD6"
                     /gene_synonym="ALS2CR11; SPGF68"
                     /note="major polyA site"
ORIGIN      
        1 agtagcgggc cgtcggttgg gcgcagacag gccgcagaag atggagagat ggagccaccc
       61 caagagacaa ataggccttt cagcacactt gataaccgca gcgggcaggt ccaagtcctg
      121 tccgccaccc cgctattgca gaggaatccc tacagcagcc cggatatcat gcacattaaa
      181 gggtcggagg cttcttcggt cccttacgcc ctgaaccagg gcacgacggc cctgcctaag
      241 aacaagaacc aggagggcac cgggcaccgg ctgctgaaca tgctgagaaa aactcttaaa
      301 gagtctgata gtgaagaact ggaaataaca caggagacgc caaatttggt gccatttggg
      361 gatgtggttg gctgcctggg cattcatata aagaactgca gacattttat gcctaagatc
      421 agtttacaac attatgctaa tttattcatt cgcatctcta taaacaaagc tgtgaaatgt
      481 acaaaaatgt gtagcttgct atccaaaaac gatgagaaga acactgtaat taagttcgat
      541 gaagtgaagt atttttctgt acaggttccc agacgttatg atgataagcg gaataatatt
      601 ttattggaac tcatacaata tgacaataga gaaaaacgtg ctttcttgtt agggagtgtt
      661 cagatacatc tttatgaggt aattcagaaa gggtgcttca ttgaagaggt ccaagtgttg
      721 catggaaaca tatttgtctg caggctggag gtggaattta tgttctccta tggaaacttt
      781 ggttatggat tttcacatca gttaaaacct cttcagaaaa ttactgagcc atccatgttt
      841 atgaatcttg caccacctcc agaaagaaca gatcccgtga caaaagttat tacaccacag
      901 acagtagaat atccagcatt cttatcccca gacctgaatg ttactgttgg gactccagct
      961 gtgcaatcct ccaaccagcc atctgtagtg cgacttgaaa aacttcagca acaaccccgg
     1021 gaaaggctgg aaaagatgaa aaaagaatat agaaatctga atacatggat agataaagct
     1081 aactatttag aaagcattct aatgccaaaa ttggaacata aggattctga ggaaactaat
     1141 atagatgagg catctgaaaa cacgaaaagt aatcatcctg aagaggagct tgaaaatatt
     1201 gtaggagtag atatccctct tgtaaatgag gaagctgaaa ctactgcaaa tgagttactg
     1261 gataatgatt ctgagaaagg cctgactata ccaactttga accaatcgga ccaagataat
     1321 tcaactgctg atgcttctaa aaatgatgaa tcaacacctt cacccacaga agtgcactca
     1381 ttgtgcacta tttctaacca ggaaacaata aaagcaggca gaataccacc tttaggtgaa
     1441 cgtcaatcag aaagcatgcc agacagaaaa atgaaaaatg tattttttcc attagaagta
     1501 aaattaaaag ataactatcc aagcatttta aaagcagact catctctatc agaggtggct
     1561 ttttcaccaa aagaatataa ttcaccatct ttcagaccag aatatataga attcaaacca
     1621 aaatttcagt ttcagaaatt caacaagaac ggttttgatc cttttctaag gaatataaac
     1681 aaaatgtcag tcagaaaaag aaaagatcaa gatatataca aatatagaaa tatcttaggt
     1741 gcagaggtca tagagcatga agaccaggat cctccttatc cagcacaatc aaaaactgca
     1801 ggacctgcta atacaacctg ggcccatgac cctaatatct tcacaacaaa gatgttagaa
     1861 actgagaata agttagcccc tgatcctact atcaatacaa taaagggttt agatacaaag
     1921 aatagtttaa aagaaaatct accaaatgta tctttaccaa gcatcaaagg agaatcatca
     1981 agggctggaa atgtacaggc aaacacatgt cacctctcga agtctttaaa ttttaccccc
     2041 catatagaat atttaaaaca atcaatgata ctcaagtcaa ttttaagtga aaatctgcaa
     2101 gacctttcag acaaattatt ttctaaacca gaagttagta tgaacagtga agcaagagag
     2161 aaaagtagtt ctccacttct aagcattcat gataaatcat caagtagtat ggaagacaac
     2221 gtattggaaa aaaaacaaga tttaaacaac tggctttcag aaaaagacat tttaaattca
     2281 aagactactt taagtcaaat aattaaaaat attcctgcag attcattttc agaaggtagt
     2341 caaataattg aaaatattcc tgcagattca cttttagaag gtggtcaagt aattaaaaat
     2401 attcctgaat attcactttc agaagggggt cagataatta aaaatattcc tgcagattca
     2461 tttttagaaa gtggaccagg acaatctcca gaggtagaag aacatgtctc taaaaaacac
     2521 ttcgaagctg atgagagaga ttttccaatt aaaaaaaata gtagtaccaa aaagaaacat
     2581 ttaataagcg aagtacctaa ctccaaatca ggttcaagtg gcactgtaca tgactacatt
     2641 atgaggcaaa tattcactgc accaatattc tcagaattgg agatagaagt gaaagagcca
     2701 agtgaaacac caatgaactt ggaaaatcaa ttacctacac cttggaagag aagtttgtca
     2761 tcacatattc tatttcatga agaaaatgct gatgaaatag aattgccaca gcccagatct
     2821 gctacaagcc agataataca agcatttcct atagatacac ttttagaatc tgggataatc
     2881 aaagtgatag aattagataa agaacaccat aagagttctt tgctgggtac ggggatcact
     2941 tctcctaaag gaaacctaaa ggattcccaa gagtattatt cagaaatcag aagcgagaca
     3001 gaacctcttt ctgagcagag tatacccatc attcccaaag acactacttc tgttagtaga
     3061 gctgaattta tacaggaaga ccaaaatatg ttcccacaag attcaagtta ttattcaata
     3121 gcaaataaag aactgtattt gccaagaaat ggtcagaggc tttgtaaaga caaaaatgat
     3181 ctcagttcta ctttagaaag tttaactaac tcattaatgg ataaacttag tgaatcagat
     3241 gaaataatgt taaaatcctt tttaaaaaac atcttcaatg tttttttcaa atataatcat
     3301 tctgaaagaa gaggacaacc agaaaaagaa ttagaaagac taattcaacc ttcttttaca
     3361 agtgacacag aacaccttga agaactccaa gaggattttg ataaagcaga caaattagac
     3421 agaaaaccta ttttgagtcc aaagttgcgt gtgtttctag aagaactctc agagtcagaa
     3481 gtaaaacatt taaaatctga attaagtaaa caaatccagc attaccttgt agaaagactt
     3541 tcagaatcag gacatatcac caaggaggac ttaccaaaaa tctatcaaaa tctgtatctg
     3601 atgaatgaga aagcagagca gaaagggcca aacagttttc aggggaaata ttctgaaact
     3661 gtgaaagaaa tcatgtcttt tgtcaacaat ttcaatcatc atttcataga taaacatttg
     3721 gaaataaagc tgagatcttt tttaaaagag attctccaaa actatttcct aaaaaacatt
     3781 tcagaaagca gtttatttaa tgagacagca tctgagacta tatacccaaa catatcttct
     3841 ctaaggacta aaagtgtctc aatatctttt catgaactag aacaagatat ttcaaagggg
     3901 agttttggta gaaggtttga aataaacatg aaatatcctt taagtaaatc tctacaaaac
     3961 tatctgatag ctttatcaga aaatgaatta ttacatctaa aagctgattt aagcaaacac
     4021 ctccagagtc tttttataga aaaactttca aaatcaggac taatgacaaa aaagcaatta
     4081 gaagggatca accagcatat aaatttgctt aattctagtt ctataccatt aaaatatata
     4141 aaaacacatt taccttttag agatgactgt cactttgtgg agaagcattc agaaaagcaa
     4201 aataaatatt caagaattgt tcaacaaacc actttacaaa cggtttctga ggataaactt
     4261 agagaagcag aattgattcg agagaaagaa aagaaatatt ttcccttaca gaatttaaag
     4321 ggaaattcat ctttaattaa ggaacagaaa agttattaca ctaaggaaga agctaaaaca
     4381 ccaagtttaa tcaaagtaca accttcttcc aatgaaaata tccaggcaag tccattaagt
     4441 aagtcatcag aaatacttac agatatactg cttaagaaac taaggaaaga acatgtattc
     4501 acgcagcttc ctcaagcaga aaattctgtt cataaaacag agattcaaga cccatatagt
     4561 tggggtggta aatcaaaaat aactcaatca aaagcttggt gtgaaaagac actgaaaatg
     4621 aagtcccttg atagaaagga gcatgtaaac atctataaat ggactgttca ggaaaaacct
     4681 gaagcagtat taacatcgta tccaagaatt cctaatgcca gaatgccaag ggaagatgag
     4741 tacttaaaca gaatcacttt cccttcctgg caaagtagca ctttaactca tttcaataca
     4801 gagactgggg aaaaatcaaa attagaagac cagtattgtc agacattgaa aggaaataat
     4861 aacaataata aaaagcattt agtaacattt gcacaataca aaaaagaaat acaaactctt
     4921 tatataaaac cagatgaaat ttgcagtgaa aaatgtgcca agttccctga aatacagtca
     4981 ttccaatata aggttgtaga agatgagaaa aacttgaaac cacacctctt cccagaatta
     5041 tttaagatag aagatctaaa acccaaggtc cgaaaagaaa gagaccgtgt cgcccaacca
     5101 aaaaagtcat ttaacaagat agtcaggata ctaccaacca cactgcccac cacaagaatt
     5161 cacctaaaga agtctgttcc aaggacactg cttcactgga ctgcaagaag aactatacat
     5221 gattgttcag ataaatttga ggatttacat gacatgacct catttacaca ccttaaaaaa
     5281 gtaaaatcaa gatcaaggct tttaggaaaa agctcagatg atatccataa ccatgccaga
     5341 cactctgcaa gaccatatac tgctccggag gttaacaagc aacgagaaag ctacagtgga
     5401 aagtttacaa gtcgtcgaat ggtttcatca ggcttagttc atataaatga taaaacatca
     5461 gattatgaaa tgcataaaat gcggccaaaa aaaattaaaa gaggatattg aaaaatgttc
     5521 gctcatttgt gatattataa aacatgttta actcagaatg atatgtgagg ccagcagtca
     5581 gaatatcact tctccattaa caaaatggtt tggagatctc ttcttttgtg tgacagaagt
     5641 cagcaaccaa atttcatctt gttagaacca ttttgttttg attaaaatga aaaacaaaca
     5701 ca
//
