LOCUS       NM_001286176            4585 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens C2 calcium dependent domain containing 5 (C2CD5),
            transcript variant 1, mRNA.
ACCESSION   NM_001286176 XM_005253536
VERSION     NM_001286176.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4585)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4585)
  AUTHORS   Chapman,D.E., Reddy,B.J.N., Huy,B., Bovyn,M.J., Cruz,S.J.S.,
            Al-Shammari,Z.M., Han,H., Wang,W., Smith,D.S. and Gross,S.P.
  TITLE     Regulation of in vivo dynein force production by CDK5 and
            14-3-3epsilon and KIAA0528
  JOURNAL   Nat Commun 10 (1), 228 (2019)
   PUBMED   30651536
  REMARK    GeneRIF: Study finds that CDK5, 14-3-3 epsilon, and KIAA0528 are
            all essential for cytoplasmic dynein force adaptation and that they
            regulate the transport of lipid droplets, lysosomes, and
            mitochondria.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4585)
  AUTHORS   Lu,Y., Ma,J., Li,Y., Huang,J., Zhang,S., Yin,Z., Ren,J., Huang,K.,
            Wu,G., Yang,K. and Xu,S.
  TITLE     CDP138 silencing inhibits TGF-beta/Smad signaling to impair
            radioresistance and metastasis via GDF15 in lung cancer
  JOURNAL   Cell Death Dis 8 (9), e3036 (2017)
   PUBMED   28880265
  REMARK    GeneRIF: Enhanced radiosensitivity and decreased migration in cells
            caused by CDP138 knockdown are partially dependent on GDF15
            inhibition.
            Erratum:[Cell Death Dis. 2024 Jul 31;15(7):549. doi:
            10.1038/s41419-024-06823-2.. PMID: 39085215]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4585)
  AUTHORS   Xu,S., Li,X., Gong,Z., Wang,W., Li,Y., Nair,B.C., Piao,H., Yang,K.,
            Wu,G. and Chen,J.
  TITLE     Proteomic analysis of the human cyclin-dependent kinase family
            reveals a novel CDK5 complex involved in cell growth and migration
  JOURNAL   Mol Cell Proteomics 13 (11), 2986-3000 (2014)
   PUBMED   25096995
REFERENCE   5  (bases 1 to 4585)
  AUTHORS   Xie,X., Gong,Z., Mansuy-Aubert,V., Zhou,Q.L., Tatulian,S.A.,
            Sehrt,D., Gnad,F., Brill,L.M., Motamedchaboki,K., Chen,Y.,
            Czech,M.P., Mann,M., Kruger,M. and Jiang,Z.Y.
  TITLE     C2 domain-containing phosphoprotein CDP138 regulates GLUT4
            insertion into the plasma membrane
  JOURNAL   Cell Metab 14 (3), 378-389 (2011)
   PUBMED   21907143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK310753.1, BC143859.1, BC117143.1, BP418369.1 and AY166851.1.
            
            On Jul 15, 2020 this sequence version replaced NM_001286176.1.
            
            Transcript Variant: This variant (1) encodes isoform a. Variants 1
            and 2 encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.793246.1, BC143859.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446597.6/ ENSP00000388756.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AK310753.1         5-137
            134-2683            BC143859.1         1-2550
            2684-3305           BC117143.1         2524-3145
            3306-3306           BP418369.1         270-270
            3307-4585           AY166851.1         3130-4408
FEATURES             Location/Qualifiers
     source          1..4585
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.1"
     gene            1..4585
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /note="C2 calcium dependent domain containing 5"
                     /db_xref="GeneID:9847"
                     /db_xref="HGNC:HGNC:29062"
                     /db_xref="MIM:618044"
     exon            1..223
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            224..342
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..3408
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /note="isoform a is encoded by transcript variant 1; 138
                     kDa C2 domain-containing phosphoprotein; C2
                     domain-containing protein 5"
                     /codon_start=1
                     /product="C2 domain-containing protein 5 isoform a"
                     /protein_id="NP_001273105.1"
                     /db_xref="CCDS:CCDS66337.1"
                     /db_xref="GeneID:9847"
                     /db_xref="HGNC:HGNC:29062"
                     /db_xref="MIM:618044"
                     /translation="MPGKLKVKIVAGRHLPVMDRASDLTDAFVEVKFGNTTFKTDVYL
                     KSLNPQWNSEWFKFEVDDEDLQDEPLQITVLDHDTYSANDAIGKVYIDIDPLLYSEAA
                     TVISGWFPIYDTIHGIRGEINVVVKVDLFNDLNRFRQSSCGVKFFCTTSIPKCYRAVI
                     IHGFVEELVVNEDPEYQWIDRIRTPRASNEARQRLISLMSGELQRKIGLKVLEMRGNA
                     VVGYLQCFDLEGESGLVVRAIGTACTLDKLSSPAAFLPACNSPSKEMKEIPFNEDPNP
                     NTHSSGPSTPLKNQTYSFSPSKSYSRQSSSSDTDLSLTPKTGMGSGSAGKEGGPFKAL
                     LRQQTQSALEQREFPFFTLTAFPPGFLVHVGGVVSARSVKLLDRIHNPDEPETRDAWW
                     AEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRFLQDGTVEGCL
                     EQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVI
                     GKGCLIQARLCRLKKKAQAEANATAISNLLPFMEYEVHTQLMNKLKLKGMNALFGLRI
                     QITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKKINDTIAK
                     NKELYEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEI
                     DDTDAMEDVHSLLTDVPPPSGFYSCNTEIMPGINNWTSEIQMFTSVRVIRLSSLNLTN
                     QALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQVTVTAVAITFDK
                     NQALQTTKTPVEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKEHLESASSNSGI
                     PAAQRATSVDYSSFADRCSSWIELIKLKAQTIRRGSIKTTMTVEKASPVGDGNFRNRS
                     APPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIA
                     EVFAMVRAHVAALGGNAVVSYIMKQCVFMENPNKNQAQCLINVSGDAVVFVRESDLEV
                     VSSQQPTTNCQSSCTEGEVTT"
     exon            343..429
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            430..601
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            602..697
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            698..853
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1052
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1204
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1290
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1399
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1514
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1610
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1802
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1989
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2154
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2295
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2359
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2421
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2520
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2610
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2698
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2785
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2836
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..2938
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3129
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3276
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..4585
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4563..4568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /note="hexamer: AATAAA"
     polyA_site      4585
                     /gene="C2CD5"
                     /gene_synonym="CDP138; KIAA0528"
                     /note="major polyA site"
ORIGIN      
        1 gatcgatgct ttcttccgcg ccccgagagc cgccattttt gagagcgggg gaggagagac
       61 aagcaggggc ggcagaggct caacgggatg ctgactgggt tttgcttttc gtcccagcct
      121 tgtggggccg ggacggaaga acccatcaaa gcccttcctc ccgccgcctc tccggaatga
      181 ggtctcagca cccgcgcggg acagcaccct tcctcctgcg acagagccca agaagaggcc
      241 gaaaccgaga ccatgccagg gaagctgaag gtgaaaatcg tggccgggcg ccatttgcca
      301 gtgatggacc gtgctagtga cctgactgat gccttcgtgg aggtaaaatt tggtaatacc
      361 acctttaaaa cagatgtgta ccttaagtca ctcaaccctc agtggaactc ggagtggttt
      421 aaatttgagg tggatgatga agacttacaa gatgaacctt tacagatcac agttcttgac
      481 catgatactt acagtgcaaa tgatgccatt ggtaaagtgt acattgatat tgatccttta
      541 ctgtatagtg aagctgcaac agtcatctca ggatggtttc caatttatga caccatacat
      601 ggtatccgtg gggaaatcaa tgtagttgtc aaagtagacc tcttcaatga tttaaatcga
      661 tttaggcagt catcatgtgg agtcaaattc ttttgcacaa cgtctattcc aaaatgctat
      721 agagctgtga taattcatgg atttgtagaa gaacttgtgg tcaatgaaga cccagaatat
      781 cagtggattg atcgaattcg cacaccaagg gcatcaaatg aggccagaca gagactcatt
      841 tcgttaatgt caggtgagct gcagaggaag attggcttga aagtacttga aatgagagga
      901 aatgcagttg tggggtactt acagtgtttc gatctggagg gcgagtctgg gttagtggtg
      961 cgagccatag gaacggcgtg tactctggat aaattaagta gcccagcagc attccttcct
     1021 gcatgtaatt ccccatccaa agaaatgaag gagattccct tcaatgaaga tcccaatccc
     1081 aatactcact catcaggacc ctcaacccct ctgaaaaacc aaacttattc cttttcacct
     1141 tccaagtcct acagtcgaca gtcctcttct tctgacacag atttgagttt gacacccaaa
     1201 actggaatgg gaagtggtag tgctggaaaa gaaggggggc cctttaaagc tcttttaaga
     1261 caacagactc aatcagcgtt ggaacagagg gaatttccat tttttacctt gacggcattt
     1321 cctcctggat tccttgtaca cgttgggggt gtagttagtg cacgttctgt gaagcttttg
     1381 gatcgtatcc acaatcctga tgaaccagaa actcgagatg catggtgggc agaaatcaga
     1441 caagaaataa aatcacatgc taaagcatta ggctgtcatg ctgtagtggg ctacagtgaa
     1501 tcaactagca tctgtgaaga ggtctgcatt ttatctgcat ctggcacagc ggctgtactg
     1561 aatcctagat ttctgcagga tggcaccgtg gaaggctgtt tggaacagag gcttgaagaa
     1621 aatttgccta cacgttgtgg attttgtcat ataccatatg atgaactgaa tatgccattt
     1681 ccagctcatc tcacatattg ctataactgc aggaaacaaa aagttcctga tgttctgttt
     1741 acaactatag acctcccaac agatgcaaca gttattggaa aaggttgtct tattcaagca
     1801 aggttatgtc gcttaaaaaa gaaagcacag gcagaagcaa atgctacagc tatcagtaat
     1861 ctcttgccat ttatggaata tgaagtgcat actcagctaa tgaataaact aaaactcaaa
     1921 ggaatgaatg ctttgtttgg actaagaatt cagatcacag tgggtgaaaa tatgttgatg
     1981 ggcttagcgt ctgccacagg tgtgtattta gcagctttac caactcctgg tggtattcag
     2041 attgctggga agactcctaa tgatggctca tatgaacaac acatctctca tatgcagaag
     2101 aagataaatg acacaattgc taaaaacaaa gagttatatg aaatcaatcc tccagagata
     2161 tctgaagaga ttataggatc acccatccca gaacctaggc aacgctcaag acttctaaga
     2221 tctcaatcag aaagctcgga tgaagttaca gaattagacc tttcacatgg gaaaaaagat
     2281 gcttttgttt tggagattga tgacacagat gccatggaag atgtccattc tctacttact
     2341 gatgttcctc ctccttcagg cttttatagt tgtaatacag aaattatgcc cggtataaat
     2401 aattggacct ctgaaataca gatgttcact tcagtaagag taatcagatt aagcagcctc
     2461 aacctgacta atcaagctct caataagaac tttaatgatc tctgtgaaaa tttgctcaag
     2521 agcctgtact ttaaactacg atctatgatc ccctgctgcc tttgccatgt aaattttaca
     2581 gtatctctgc ctgaagatga attaattcag gttacagtca cggcagtcgc aatcactttt
     2641 gacaaaaatc aggctttaca aaccacaaaa acccctgttg aaaagtcatt gcaaagagcc
     2701 tcaacagata atgaagaact tttacaattt ccactggaac tgtgttcaga ttcacttcct
     2761 tctcatcctt ttccaccagc taaagaacac ctggagagtg caagttctaa ctcaggtata
     2821 ccagctgcac agagagcaac gtcagttgat tacagttcct ttgcagacag atgcagcagc
     2881 tggatagagc tcattaaact gaaagctcag accataaggc gtggatcaat taagacaacc
     2941 atgacagttg aaaaagcaag tccagtgggt gatggaaatt tccggaatcg ttctgctcca
     3001 ccttgtgcaa attccacagt tggggttgtt aagatgacac ctctttcttt tattcctgga
     3061 gcaaaaataa ctaagtatct tgggataatt aacatgtttt ttattcgaga gactacttct
     3121 cttcgggagg aaggaggagt cagtggtttt ctccatgctt ttattgctga agtgtttgca
     3181 atggtgagag ctcatgttgc tgcattagga gggaatgctg ttgtctccta cataatgaag
     3241 cagtgtgtct tcatggagaa tccaaataaa aaccaggcac agtgtcttat aaatgtaagt
     3301 ggtgatgcag tggtttttgt tcgtgaatct gacttagaag tggtgtcatc tcagcaacct
     3361 actaccaact gccagtcatc atgtactgaa ggcgaagtta caacctgagg aaaattagga
     3421 aaaaagagct caactaaatg aaattcatca atctctgtta ttttgtcatt aattatcttc
     3481 ttagacttaa aattgaactt gagataaata aggaagaatt gagtagattt gatttgcctg
     3541 gagtcttttg gaggcatgag aattttctaa tcttgacatt ttgtttgcct gttctagaca
     3601 ggccctgtgg ggtcttgacc cttcagtaag ttaagataaa tttttaaaag aaccgtagca
     3661 aagatggaac ctttgtaatt tatgttgatt ttaataaaat cataatttaa aaaatgaaat
     3721 gggaagattg tcaggaaatt aggatagcta ctctagtata atttagaaaa actaagcaag
     3781 agattctcca gttgctagtg agtaagcact ctgatttgag aaatgtgtgg ggacaatgga
     3841 gaaaagtttt cagaaaactg ctatgtagat ttctgaatgt gttgtatttt gctgaggaat
     3901 tcggtaacaa ctgaaaggga aaagtgcttc agccatcttt tgaaaacaag ttaaaattct
     3961 ggaacttgta tctgtaatac atcctaactc ttgtaaaaga aaataattta tcatagctgg
     4021 tgtcctttca ttgaaagttg taatactgtc tctaaggagg gaggaaaaga ttattatata
     4081 attttataac tggcaacatt tgagttagta ttgactttgt ctaaaagagg cttgacttca
     4141 actgggataa aaatgtcagt gaattttgtt aaagtagtaa aaatgcagtt gacttagtag
     4201 gaacataaaa ttatttccta ataagataat attgcactcc taccaaataa acaggatttt
     4261 agtaatatct gagggattgt tgatggtgag ttagactgta tttggcatag aatttggaaa
     4321 tgtaacttga atgtaaatat gctgcaaaat gttgaatgta tacatagaaa gactttttct
     4381 gtcgacgcca aatgcccgtt gtaaatgaac cttaaatatt acattcctcc tttgcacaat
     4441 aatatttctt tataacactt atgatttttt cccccaggac aacaaactgc ccttaagagt
     4501 catttccttg ttatcacagg tgtcaatatt tttctgtatt ttgtttataa ttttattttt
     4561 taaataaaaa gtgtataaaa ataaa
//
