LOCUS       NM_001136263            3099 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens C2 calcium dependent domain containing 4C (C2CD4C),
            mRNA.
ACCESSION   NM_001136263 XM_001718840 XM_065166 XM_939576
VERSION     NM_001136263.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3099)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   2  (bases 1 to 3099)
  AUTHORS   Warton,K., Foster,N.C., Gold,W.A. and Stanley,K.K.
  TITLE     A novel gene family induced by acute inflammation in endothelial
            cells
  JOURNAL   Gene 342 (1), 85-95 (2004)
   PUBMED   15527968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008988.13.
            
            On Nov 22, 2018 this sequence version replaced NM_001136263.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB075837.1, SRR3476690.64516.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267757 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332235.8/ ENSP00000328677.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC008988.13        20086-20227         c
            143-3099            AC008988.13        16525-19481         c
FEATURES             Location/Qualifiers
     source          1..3099
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3099
                     /gene="C2CD4C"
                     /gene_synonym="FAM148C; KIAA1957; NLF3"
                     /note="C2 calcium dependent domain containing 4C"
                     /db_xref="GeneID:126567"
                     /db_xref="HGNC:HGNC:29417"
                     /db_xref="MIM:610336"
     exon            1..142
                     /gene="C2CD4C"
                     /gene_synonym="FAM148C; KIAA1957; NLF3"
                     /inference="alignment:Splign:2.1.0"
     exon            143..3099
                     /gene="C2CD4C"
                     /gene_synonym="FAM148C; KIAA1957; NLF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1448
                     /gene="C2CD4C"
                     /gene_synonym="FAM148C; KIAA1957; NLF3"
                     /note="family with sequence similarity 148, member C;
                     nuclear-localized factor 3"
                     /codon_start=1
                     /product="C2 calcium-dependent domain-containing protein
                     4C"
                     /protein_id="NP_001129735.1"
                     /db_xref="CCDS:CCDS45890.1"
                     /db_xref="GeneID:126567"
                     /db_xref="HGNC:HGNC:29417"
                     /db_xref="MIM:610336"
                     /translation="MRKTNMWFLERLRGSGENGAARGVGSEAGDKASKGPLYSNVLTP
                     DKIPDFFIPPKLPSGPAEGEGQAALGPSTSEQNLASAAPRQTPRSPRLPAKLAAESKS
                     LLKAATRHVIQIESAEDWLSEEATDADPQAQGAMSLPSVPKAQTSYGFAMLAESPHTR
                     RKESLFHSEHGALAQVGSPGAGRRRAAAKANGGDGGPREAGGALMSPGRYFSGGESDT
                     GSSAESSPFGSPLLSRSVSLLKGFAQDSQAKVSQLRHSVGRHGSLSADDSTPDASPGS
                     RRRLTRRAPPEPGPESGQARGEHTVHVGPRGSVRLLAEYEAGQARLRVHLLAAEGLYD
                     RLCDARSINCCVGLCLVPGKLQKQRSTIVKNSRRPVFNEDFFFDGLGPASVRKLALRI
                     KVVNKGSSLKRDTLLGEKELPLTSLLPFL"
     regulatory      3081..3086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2CD4C"
                     /gene_synonym="FAM148C; KIAA1957; NLF3"
                     /note="hexamer: AATAAA"
     polyA_site      3099
                     /gene="C2CD4C"
                     /gene_synonym="FAM148C; KIAA1957; NLF3"
                     /note="major polyA site"
ORIGIN      
        1 gagtccgact gcgctgccgc cgccgccgcc gcccgcatcg aagctccggc cgcgtccccc
       61 gcgccagccc cgggagcctg cgcgccgaga cccctgcgtg tctgcgaaca gacctccggc
      121 ctcgggccat caccccgggc agacgctgca gcccctgtcc gggcctcttg cctgccgccc
      181 ccatgagaaa aaccaacatg tggttcttgg agcggcttcg ggggtctggg gaaaacggtg
      241 ctgcccgggg cgtggggagt gaggcggggg acaaggcctc caaggggccc ctgtacagca
      301 atgtgttgac gcccgacaag atccccgact ttttcatccc ccccaagctg ccctcgggcc
      361 ccgcggaggg cgagggacag gccgcgctgg gcccctccac gtcggaacag aacctggcct
      421 ctgcggcccc ccgccagacc ccacggagcc cccggctgcc tgccaagctg gcagccgaga
      481 gcaagagcct gctgaaggca gccacccggc acgtgatcca gatcgagagt gccgaggact
      541 ggctgtccga ggaggccact gacgccgacc cccaggccca gggtgccatg tccctgccct
      601 cggtgcccaa ggcccagacg tcctacggct tcgccatgct ggctgagagc ccccacacga
      661 ggcgcaagga gtctctgttc cacagtgagc acggggctct ggcccaggtg ggctccccag
      721 gggccgggcg ccgccgggca gctgccaagg ccaacggggg tgatgggggc cccagggagg
      781 ctggcggggc cctcatgagc cccggccgct acttcagtgg cggggagagc gacacagggt
      841 cctcggccga gtcctccccc ttcgggtccc ctctgctgtc ccgctccgtg tctctgctca
      901 aaggtttcgc ccaggacagc caggccaagg tgagccagct ccggcactcc gtgggccgcc
      961 acggctccct gtctgcggac gacagcaccc cggacgccag ccccgggagc cggcgccgcc
     1021 tgacccgccg ggcacccccg gaacctggcc ccgagtcggg ccaggcgcgt ggggagcaca
     1081 cggtccacgt gggccctcgg ggcagcgtgc ggctgctggc cgagtacgag gccggccagg
     1141 cccgcctgcg ggtgcacctg ctggccgccg agggcctcta cgaccgcctg tgcgacgccc
     1201 gcagcatcaa ctgctgcgtg ggcctgtgcc tggtgccggg caagctgcag aagcagcgca
     1261 gcaccatcgt gaagaacagc cgccgccccg tcttcaacga ggatttcttc ttcgacggcc
     1321 tggggcccgc cagcgtccgg aaactggccc tcaggatcaa ggtggtgaac aagggcagca
     1381 gcctcaagcg ggacacgctg ctcggggaga aggagctgcc cctgacctcc ctgctcccct
     1441 tcctgtagag cggggacctg ctcgctgtcc gctcgggtgc agagggcaga ccccggtctc
     1501 tcctccacac cgggtgctgg cgggcgggtc cgctggcttg ggctggggct ggccggggag
     1561 gggctcacac tcaggctggg ctgggcgctg atgctgtagc tgacgcaggg tttcctgggt
     1621 cacccgatgc tgactggagt attatttttc atgaattaat ttctcctttg gaggaggagg
     1681 aggaggagga gaggggcctc gggggaagag aaggggccac ttcgcggggc agagggtccc
     1741 cctttgcccc tccacactgc ctcgcgcctt tcacgcagag ttctagaagg aggttctcag
     1801 gggttcagga atccgtgcat gtggccaggg cggggccgtg gacagggagg tgacaagtct
     1861 tggagcccac agtctccttc actgcacgtg tgtcttcctc ccccacagcc tgccgccatc
     1921 cagttcccac cccgcggaga gcagggcctc gcggccacac caggcccagg ctctgcccgg
     1981 gacgccccct cccaggggtc aggcttggct ctgggagacc ccagcttccc aggctccggt
     2041 ggggagtggg gccaggcgag ggtgccctga cgagggtggg cgcggaggga gcagccgctg
     2101 ccacagtcgg agcagaggag gtcttggcag aggtccgcgg ggaggagacg gctctcctgg
     2161 cctgttttcc tccaacactg tcgccgctgg ctttttgggt acaggcccgt ctggccattt
     2221 ctgctgtggc gccggagggt cttgctcaga gatgcccaga gagcagccct atggcccatc
     2281 cgtcctcgct gggggctgcc accccgtcgc ccttttgtcc agcgtctgca gctgggagcg
     2341 acacgcagtg attgacggcc gtggctttga cgccacgtgt gtaaataggc tgtggctacg
     2401 gtgggtgggt cggagcccag gaggcagctg gggggacctg gctatggcct ttcctgctgt
     2461 taggtggctg caaggcttcc attgtgtggt tatgtgggtc cttgaatgat tttggggagg
     2521 tttccagctc agaatgatgc agaaatgata agactcaaag caggggccag gccaggccag
     2581 tgccttcgcc tctcccggct gctggtgggc acggaggaac cagggcacat ctgtggtacc
     2641 cagggacgtc ccttgtcagc ccgtttgcca cacattgttc ctcttgtcca ggggagggtg
     2701 gaggagctgc ttcccaggac tggaggagca gctgggcccc tgctgcacgt ccggtgggac
     2761 acacctgtga gccctccaga gggagagtgc aggccccttc tgagcctggt gttgcagggc
     2821 tccgctctct cccggaagcc agggcaccca gggcggaggc tcctcaggcc ggggaggcgg
     2881 ggagggtgcc ctgcatggag agagacgccg gcgctccccg ccttctctga tgctcacccc
     2941 tcccaggccc tgttctccct ggggtccccc gtttagtagc ccccctgcac tctttgatat
     3001 cttagtgtct gaggttgact gtgggtaaat ctttaagaca ctccccagct gtgtttgttt
     3061 ataaatgctg tttatagtgc aataaaggtg tttcgggaa
//
