LOCUS       NM_001286577            7939 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens C2 domain containing 3 centriole elongation regulator
            (C2CD3), transcript variant 1, mRNA.
ACCESSION   NM_001286577 XM_005273894
VERSION     NM_001286577.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7939)
  AUTHORS   Gaudin,N., Martin Gil,P., Boumendjel,M., Ershov,D.,
            Pioche-Durieu,C., Bouix,M., Delobelle,Q., Maniscalco,L.,
            Phan,T.B.N., Heyer,V., Reina-San-Martin,B. and Azimzadeh,J.
  TITLE     Evolutionary conservation of centriole rotational asymmetry in the
            human centrosome
  JOURNAL   Elife 11, e72382 (2022)
   PUBMED   35319462
  REMARK    GeneRIF: Evolutionary conservation of centriole rotational
            asymmetry in the human centrosome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7939)
  AUTHORS   Tsai,J.J., Hsu,W.B., Liu,J.H., Chang,C.W. and Tang,T.K.
  TITLE     CEP120 interacts with C2CD3 and Talpid3 and is required for
            centriole appendage assembly and ciliogenesis
  JOURNAL   Sci Rep 9 (1), 6037 (2019)
   PUBMED   30988386
  REMARK    GeneRIF: CEP120 interacts with C2CD3 and Talpid3 and is required
            for centriole appendage assembly and ciliogenesis.
            Erratum:[Sci Rep. 2020 Jan 22;10(1):1265. doi:
            10.1038/s41598-020-58151-y.. PMID: 31965052]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7939)
  AUTHORS   Boczek,N.J., Hopp,K., Benoit,L., Kraft,D., Cousin,M.A.,
            Blackburn,P.R., Madsen,C.D., Oliver,G.R., Nair,A.A., Na,J.,
            Bianchi,D.W., Beek,G., Harris,P.C., Pichurin,P. and Klee,E.W.
  TITLE     Characterization of three ciliopathy pedigrees expands the
            phenotype associated with biallelic C2CD3 variants
  JOURNAL   Eur J Hum Genet 26 (12), 1797-1809 (2018)
   PUBMED   30097616
  REMARK    GeneRIF: Biallelic C2CD3 variants lead to a broad spectrum of
            ciliopathy phenotypes.
REFERENCE   4  (bases 1 to 7939)
  AUTHORS   Wang,L., Failler,M., Fu,W. and Dynlacht,B.D.
  TITLE     A distal centriolar protein network controls organelle maturation
            and asymmetry
  JOURNAL   Nat Commun 9 (1), 3938 (2018)
   PUBMED   30258116
  REMARK    GeneRIF: Talpid3, C2CD3, and OFD1 differentially regulate the
            assembly of centriole sub-distal appendages, the CEP350/FOP/CEP19
            module, centriolar satellites, and actin networks.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7939)
  AUTHORS   Thauvin-Robinet,C., Lee,J.S., Lopez,E., Herranz-Perez,V., Shida,T.,
            Franco,B., Jego,L., Ye,F., Pasquier,L., Loget,P., Gigot,N.,
            Aral,B., Lopes,C.A., St-Onge,J., Bruel,A.L., Thevenon,J.,
            Gonzalez-Granero,S., Alby,C., Munnich,A., Vekemans,M., Huet,F.,
            Fry,A.M., Saunier,S., Riviere,J.B., Attie-Bitach,T.,
            Garcia-Verdugo,J.M., Faivre,L., Megarbane,A. and Nachury,M.V.
  TITLE     The oral-facial-digital syndrome gene C2CD3 encodes a positive
            regulator of centriole elongation
  JOURNAL   Nat Genet 46 (8), 905-911 (2014)
   PUBMED   24997988
  REMARK    GeneRIF: Loss of C2CD3 results in short centrioles without
            subdistal and distal appendages.
REFERENCE   6  (bases 1 to 7939)
  AUTHORS   Balestra,F.R., Strnad,P., Fluckiger,I. and Gonczy,P.
  TITLE     Discovering regulators of centriole biogenesis through siRNA-based
            functional genomics in human cells
  JOURNAL   Dev Cell 25 (6), 555-571 (2013)
   PUBMED   23769972
  REMARK    Erratum:[Dev Cell. 2013 Jul 29;26(2):220]
REFERENCE   7  (bases 1 to 7939)
  AUTHORS   Wang,V.W., Laborde,R.R., Asmann,Y.W., Li,Y., Ma,J., Eckloff,B.W.,
            Tombers,N.M., Olsen,S.M., Moore,E.J., Olsen,K.D. and Smith,D.I.
  TITLE     Search for chromosome rearrangements: new approaches toward
            discovery of novel translocations in head and neck squamous cell
            carcinoma
  JOURNAL   Head Neck 35 (6), 831-835 (2013)
   PUBMED   22807096
REFERENCE   8  (bases 1 to 7939)
  AUTHORS   Zhang,D. and Aravind,L.
  TITLE     Novel transglutaminase-like peptidase and C2 domains elucidate the
            structure, biogenesis and evolution of the ciliary compartment
  JOURNAL   Cell Cycle 11 (20), 3861-3875 (2012)
   PUBMED   22983010
REFERENCE   9  (bases 1 to 7939)
  AUTHORS   Hoover,A.N., Wynkoop,A., Zeng,H., Jia,J., Niswander,L.A. and Liu,A.
  TITLE     C2cd3 is required for cilia formation and Hedgehog signaling in
            mouse
  JOURNAL   Development 135 (24), 4049-4058 (2008)
   PUBMED   19004860
REFERENCE   10 (bases 1 to 7939)
  AUTHORS   Parisi,M. and Glass,I.
  TITLE     Joubert Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002392.3 and AP003717.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 27, 2020 this sequence version replaced NM_001286577.1.
            
            Summary: This gene encodes a protein that functions as a regulator
            of centriole elongation. Studies of the orthologous mouse protein
            show that it promotes centriolar distal appendage assembly and is
            also required for the recruitment of other ciliogenic proteins,
            including intraflagellar transport proteins. Mutations in this gene
            cause orofaciodigital syndrome XIV (OFD14), a ciliopathy resulting
            in malformations of the oral cavity, face and digits. Alternative
            splicing of this gene results in multiple transcript variants.
            [provided by RefSeq, Nov 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.240449.1,
                                           SRR14038195.944629.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334126.12/ ENSP00000334379.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AP002392.3         111533-111797       c
            266-535             AP002392.3         109139-109408       c
            536-693             AP002392.3         102194-102351       c
            694-917             AP002392.3         80400-80623         c
            918-1165            AP002392.3         79515-79762         c
            1166-1298           AP002392.3         74220-74352         c
            1299-1427           AP002392.3         73639-73767         c
            1428-1575           AP002392.3         63783-63930         c
            1576-1730           AP002392.3         59023-59177         c
            1731-1940           AP002392.3         55179-55388         c
            1941-2053           AP002392.3         54575-54687         c
            2054-2172           AP002392.3         49829-49947         c
            2173-2295           AP002392.3         47166-47288         c
            2296-2790           AP002392.3         43926-44420         c
            2791-2942           AP002392.3         41320-41471         c
            2943-3189           AP002392.3         38804-39050         c
            3190-3370           AP002392.3         36023-36203         c
            3371-3554           AP002392.3         34611-34794         c
            3555-3727           AP002392.3         33211-33383         c
            3728-3851           AP002392.3         31608-31731         c
            3852-4120           AP002392.3         26413-26681         c
            4121-4210           AP002392.3         25676-25765         c
            4211-4813           AP002392.3         18910-19512         c
            4814-5161           AP002392.3         15048-15395         c
            5162-5300           AP003717.3         117488-117626       c
            5301-5365           AP003717.3         114689-114753       c
            5366-5571           AP003717.3         109419-109624       c
            5572-5705           AP003717.3         108287-108420       c
            5706-5870           AP003717.3         102136-102300       c
            5871-6091           AP003717.3         97560-97780         c
            6092-7019           AP003717.3         93433-94360         c
            7020-7131           AP003717.3         88369-88480         c
            7132-7939           AP003717.3         72800-73607         c
FEATURES             Location/Qualifiers
     source          1..7939
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..7939
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /note="C2 domain containing 3 centriole elongation
                     regulator"
                     /db_xref="GeneID:26005"
                     /db_xref="HGNC:HGNC:24564"
                     /db_xref="MIM:615944"
     exon            1..265
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..7272
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /note="isoform 1 is encoded by transcript variant 1; C2
                     domain-containing protein 3; C2 calcium dependent domain
                     containing 3"
                     /codon_start=1
                     /product="C2 domain-containing protein 3 isoform 1"
                     /protein_id="NP_001273506.1"
                     /db_xref="CCDS:CCDS66167.1"
                     /db_xref="GeneID:26005"
                     /db_xref="HGNC:HGNC:24564"
                     /db_xref="MIM:615944"
                     /translation="MKQRKGQGSGGSRGRKKRGLSDISPSTSLPPLVEGQLRCFLKLT
                     VNRVIWKIAKPPTCVLVRVRWWGETSDGTLFCPRDALQTEPKAVRTTTRYAIRCGPKQ
                     FTSYLTDMAVLVLEVITKLDGLPIGRVQINGLAQLSPTHQINGFFTIVSSTSKKLGEL
                     QVSLALEPLSETYDSYHPLPTTDMTENVLLSKQGFRENTEPSSTQFQVPSRPRDIHTI
                     KIDGKELAANSSRSTTPRGKDHVCFAENPDTIKDSSFGLQHSLNSGQSLESVTLKGRA
                     PRKQMSLLNSSEFQPQIRTVAKSHSDSCILSSNNLPTKDLLSALLEQGNKLRNAMVIS
                     AMKSSPETSMLLDQVHPPINEDSLRASTQIRAFSRNRFKDHIEDHLLPSTENTFWRHD
                     TKADTRAIQLLLGSAELSQGNFWDGLGSPPDSPSPGSDVYCISELNDPQYDQSLLENL
                     FYTAPKSDTSISDFLSEEDDIVPSKKISQSTALARSSKVLESSDHKLKKRSAGKRNRN
                     LVEQQMLSETPEDAQTMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQMTPGKKSYAG
                     PPPKVTTAKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITDGKVKFQQRFVF
                     PVQFGGPMIEHWWNSNLTFQIYVKKTPQKKPEVIGSVSLSLRAVIQSELLSFSDQLPV
                     QQENGQSPFGPLKVTMELITDNKDFTGINTKLSGNTHYTPLCAPTSPNKALPELNQDM
                     TCTKNPQNLNQIHEETAKKAQNLVLPNRKSPSPVAPHPSTFVATPASHNLVNQTNGTT
                     KESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRSVIAWGTTQPVF
                     NFSQVIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLPLHQFYMSFKDAK
                     ISRLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSNQIMALQRLKNEEGTL
                     PPFSPRPAHFLDQPTAASVAMAEDRGNGLMEHCFEIHIEMVKGLAPLQATVWGEADCY
                     VQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEHHHSLLLPAEVP
                     VQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQKVAKGTLPLSRICAMVTTQHRE
                     DVGIQTFNLPLTPRIENRKELRNQSSGLLDVGLRYRRSPRTAEGVLAARTVSISVQII
                     RACGLQAAAKALAEREPALQFSATVGVNASVTTHLSFLPQGEQRRTHPVACSFCPEFS
                     HHVEFTCNLVTQHCSGEACFLAELLEFAEVIFAVYHENTKSASDIISIESCKEYLLGV
                     VKVPTKELLIKRSGITGWYPIILPEDGGLPHGLELMQKIVGGLELSISFTHRGDRERV
                     LEAAEHLGWSFENSLKDFVRMDEGEPATVTISTPRLWLPIHCVLLAGHNHIHKNTYCY
                     LRYKFYDHEAFWTPLKKPKESVNKKQIMVTFKASKRAEVTRGPSLLWYFREERLEIQV
                     WRAYGNDSVERPHQTDSWIGSAYVDLARLGERSARTLTVSGVYPLFGRNASNLSGAAL
                     RVHVVLSSLSSHLEPTHELDSMDCSSHSESEQLPRRNDEVQLSPPEVISCHQKSPAST
                     QVPCSSTTAEVRLTQEGPADLDGTFAVSILVERAMHLSLKGSPLTERKVSIPSCCVSF
                     ATADESSPVYTQVVENTDSPIWNFQQQSRLSKELLLDPQQTLVFKVWHKGDEERVIGF
                     ASVDLSPLLSGFQFVCGWYNITDFSGECQGQIKVAVSPLESLIHFKEERQARRGVETS
                     KSLIPIYSPFSFPASDTYAAFSSHMARQTLDQLAHASSKELDFSSPGRSDTTRSQASR
                     HEEHVQNIRRFHESLHLQGEAPLPCDDKLTTSPLSSQTSILTSLRKNLSELDQIQRYF
                     RQKLTKPFLPLSPQTQTAISQHQESCRDHLGPGASSLDPGSQCILEKSSNLVLQVSSL
                     ITDLQTITRDSQAALSSHRARSRSNKATTLPDAQDTEALQERCTMPDEPLVRAPDKGT
                     DSPSPPPLEETSNGGRMLHESLRHAVPITRMQSSEDTEAGPAYSDEDYEEDIIEPRTL
                     NEITTVTDKTSPWSSVISDTSEVISPQPDEVQREGPSCPSPGPFCREELMVKSSFLSS
                     PERAVNPHLPRQGSPSQSLVACECEASKARVGGESASANPQPIPCPTLSGAQQSSTFV
                     GWSSPQTDQNKEPKSEAPAENEAATSELGDSADSFKKLPLNLASQSRRENHKGPPIDS
                     SDIRQRQVTTGSETSTKQSLLLPGPIVVPNFFLPPQQLEASLRMLSLSATLPPAATTD
                     QDKSEATRGALSQRPCRPRPNSLPLNLPEEETLRIARIFSSQYSQKD"
     exon            266..535
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            536..693
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            694..917
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1165
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1298
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1427
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1575
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1730
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1940
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2053
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2172
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2295
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2790
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2942
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3189
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3370
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3554
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3727
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            3728..3851
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            3852..4120
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            4121..4210
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            4211..4813
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            4814..5161
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            5162..5300
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            5301..5365
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            5366..5571
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            5572..5705
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            5706..5870
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            5871..6091
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            6092..7019
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            7020..7131
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     exon            7132..7939
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7915..7920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /note="hexamer: AATAAA"
     polyA_site      7939
                     /gene="C2CD3"
                     /gene_synonym="OFD14"
                     /note="major polyA site"
ORIGIN      
        1 gtagtgtatt ggagggaagg cgtcttggcg ccttctcttc gcaccgtttt ccggagactg
       61 ttagaggaag agtcgctttt tcctgcctcc caggctgccc agcggcgccg gttgccgggg
      121 aacgcaggcg ccgtggggag ggatggcggg aggatactgc ttaggtgctg gagacggagt
      181 tgagctggtg aagaagagct cgggctcatc atgaaacaac gaaaaggcca agggtctggg
      241 ggcagccgtg ggcgcaaaaa aagaggttta agtgacattt ctccatctac aagcctgcca
      301 cctctggttg aaggccagct acgctgtttt ctaaaactta ctgttaatag agtcatatgg
      361 aagattgcaa agcctcccac ttgtgtactt gtccgagtga gatggtgggg agaaacatca
      421 gatggaaccc tcttttgtcc cagggatgca ttgcagactg aaccaaaagc tgtgagaaca
      481 actacacgtt acgctattcg ttgtggtcca aaacagttta cctcttatct aacagatatg
      541 gctgtgctgg tgctggaagt aatcaccaaa cttgatggtc ttccaattgg tagagttcag
      601 atcaatggac tagctcaact ttctccaacc catcaaatca atggattttt taccattgtt
      661 tcatcaacgt ctaagaaact tggagaactc caggtctcac ttgccctgga acctctgtca
      721 gaaacttacg acagctacca tccacttcct accactgaca tgacagaaaa tgtgctttta
      781 tctaagcagg gattcagaga gaatactgaa cccagcagta cccagtttca ggttccatca
      841 aggcctcgcg acatacatac catcaaaatt gatggaaaag agttagcagc caacagcagt
      901 agatcaacca ctccgagggg aaaagaccat gtatgctttg cagagaaccc tgatacaata
      961 aaggattctt cctttggact acagcacagt cttaattcag gacagagttt agagtctgta
     1021 actctgaaag gcagagctcc acggaagcag atgtcccttc tgaacagttc tgaattccag
     1081 cctcaaatta gaacagttgc caagagtcac agtgactcat gcattctttc ttcaaacaac
     1141 ctccctacca aggatcttct ttcagctctg ttagaacaag gcaataaact gcgtaatgcc
     1201 atggtgattt ctgcaatgaa atcaagccca gagaccagca tgttgttgga ccaagttcat
     1261 cctcctatta atgaagattc tcttagagca tcaacacaga tcagagcctt ttctaggaat
     1321 cggtttaaag accacattga agatcacctc ctcccttcaa ctgagaatac attttggaga
     1381 catgacacaa aagctgatac cagagctata cagctgctat taggcagtgc tgaattatcc
     1441 caaggcaatt tctgggatgg gctaggctct cctccagatt ccccatctcc tgggagtgat
     1501 gtgtattgca tcagtgagct gaatgaccct cagtatgacc agagtcttct ggagaattta
     1561 ttttatacag cacctaaatc tgataccagc atcagtgatt tcctcagtga agaggatgat
     1621 atcgtccctt ctaaaaaaat aagccagtca acagctcttg ccagatcatc taaggttctg
     1681 gagtcaagtg atcataagct gaagaagagg tcagcaggca agagaaatag aaatttggtt
     1741 gaacaacaga tgctctcaga aactccagaa gatgcccaaa cgatgacact aagtgtggat
     1801 agactggccc ttttgggtag aacacattca gtcagaatca tcatcgaaac catgggagtt
     1861 cctccagata gtcctcagat gacccctggc aaaaaaagct atgctggtcc accacctaag
     1921 gtgactacag caaaaaagcg cactttcttt gtagaatatc actttcctgt gggcttttcg
     1981 gaaagcggat tgggaaagac agctttgatc actgaggttg ttcgactcgc ctccagtaaa
     2041 attacagatg gaaaggtgaa gttccagcag cgatttgtgt ttccagtaca gtttggtggc
     2101 ccaatgatag agcactggtg gaattccaac ctcactttcc aaatttatgt aaagaaaact
     2161 ccacagaaaa agccagaagt cattggatct gtgtcacttt ctttgcgagc tgtcattcaa
     2221 tcagagctgc tttctttcag tgatcagctt ccagtgcaac aagaaaatgg tcagtctcca
     2281 tttggccccc tcaaggtaac catggagctt attacagata acaaagattt cactggtatc
     2341 aatactaagt taagtggcaa cacccattat accccacttt gtgctcctac aagtccaaat
     2401 aaggcactac cagaacttaa ccaagatatg acctgtacca aaaatccaca aaacttaaac
     2461 caaattcatg aggaaactgc aaagaaagca cagaacttgg tgctccccaa ccgaaagtca
     2521 ccaagccctg tagcaccaca tccttcaacc ttcgtagcta cgccagcctc ccataattta
     2581 gtcaatcaga caaatgggac aacaaaagag agtgctttgc tgttgcatgt gctgttgatg
     2641 gtgccagatg ggaaagattt tattagtgga gaatctgaga aacaatcacc atgcaatgtt
     2701 tatttaaatt gtaaactctt cagcacagag gaagtcacca gatctgtcat cgcatggggc
     2761 acaacacaac cggtctttaa cttttctcag gtgattcctg tctctctgtc ttccaaatac
     2821 ctggaaaggc ttaagaacaa tgtgatggta attgaaactt ggaataaggt gcggagccca
     2881 ggacaggaca agctgctcgg gctggtgaaa cttcccctcc accagtttta catgtcattc
     2941 aaagatgcta agatttctcg cctgctgctg gatgcccagt acccagttgt tgctgtcgac
     3001 agctacatgc ctgtgattga tgtgttttca ggccaccaaa atgggagtct tcgagtcttt
     3061 ttagctatgg gttcttcaaa tcaaataatg gcactacaaa gattaaagaa tgaagaagga
     3121 acactccctc ccttcagccc taggccagcc catttcctgg accagccaac tgcagcatct
     3181 gttgctatgg cagaggaccg aggaaatgga ctgatggagc actgctttga gatccatata
     3241 gagatggtta aagggctagc ccctcttcag gcaacagtct ggggagaagc agattgttat
     3301 gtccagtact actttccagt tcaacactct caatccagtg tgctgaaagg acctgagttc
     3361 cttgaaaatg gaattactct gaagcccttc agaactgcaa ccacactctg tgttccagat
     3421 cccatcttta atagtgaaca ccatcactct ctcctgttgc cagctgaggt tccagtgcaa
     3481 aggctcctac taagtgcttt ctctgcacag ggcctcgtgc ctggaggtgg agtccagttt
     3541 gaaatctggt gcagatacta ttatcctaat gtgagagacc agaaggtcgc caaaggaacc
     3601 ttgccattat caaggatctg tgctatggta accacccagc atcgtgagga tgtgggaata
     3661 cagaccttta atctcccttt aacccccagg attgagaaca ggaaagaatt gaggaaccag
     3721 tcatcaggtt tactggatgt gggcctaagg tacaggcgta gtccaagaac agcagaggga
     3781 gttcttgctg cccgaactgt ttccatctca gtccagatta tcagagcctg tggtctgcaa
     3841 gcagcagcca aggctttggc tgaacgggaa cccgctctac agtttagtgc cacagtcggg
     3901 gtcaatgcct ctgtcaccac tcatctctcc ttcctgcccc agggagaaca gcgccgaacc
     3961 caccctgtgg cctgttcttt ctgccctgag ttctcccatc acgttgagtt cacatgtaac
     4021 ttggtgactc agcactgtag tggagaggcc tgtttcctag cagagttgtt ggagtttgca
     4081 gaagttattt ttgctgtcta tcatgaaaat accaagtcag caagtgatat aatcagtatt
     4141 gagtcatgca aagagtatct gcttggagta gtaaaagttc caacaaaaga gctgctgatc
     4201 aagagatctg ggatcacagg atggtatcct atcattttac cagaagacgg gggcctacct
     4261 catggcctgg agctcatgca gaagatcgtg ggtggtctgg agctttcgat ttccttcacg
     4321 catcgtggag atagagaacg ggtgttggaa gctgctgagc atttgggctg gagctttgag
     4381 aacagcctga aagattttgt cagaatggat gaaggggagc cagccactgt caccatctcc
     4441 accccaaggc tgtggctgcc catccattgt gtgctgcttg ctggccacaa ccacattcat
     4501 aagaatacat attgctacct tcgctacaag ttctatgatc atgaagcctt ttggacccct
     4561 ctcaagaagc ctaaggaatc tgtaaacaaa aagcagatta tggtcacttt caaggcatcc
     4621 aaaagagcag aagtcaccag gggcccatca ctgctttggt acttcaggga ggagaggcta
     4681 gagatccaag tgtggcgagc ttatggcaat gacagtgtgg agagacccca tcagacagac
     4741 agctggattg gctcagccta tgtggacctg gccagacttg gggagaggtc agcgaggacg
     4801 ctaactgtca gtggtgtgta tcctctgttt ggacgaaatg cttccaacct ctcaggagct
     4861 gccttgcgag ttcatgtggt tctttcctct ctttcctcac accttgagcc cactcatgag
     4921 ctggactcca tggactgcag cagccacagt gagtctgagc agctccccag aaggaatgat
     4981 gaggtccagc tctctccacc agaagtcatc tcctgccacc agaagtctcc tgcctccacc
     5041 caggtcccct gcagcagcac cacagctgaa gtccgcctga cgcaggaggg ccctgctgat
     5101 ttggatggaa cgtttgcagt cagcatccta gtagaaagag caatgcactt gagcttgaaa
     5161 gggagcccct tgacagagcg gaaagtatcg atacccagtt gttgtgtatc ctttgcaaca
     5221 gccgatgagt catctcctgt atacacccaa gtggttgaaa acacagattc ccccatctgg
     5281 aattttcaac agcagtcaag gctatcaaaa gagctgcttc tggacccaca acaaaccctg
     5341 gtcttcaaag tttggcataa aggagatgag gagagggtga ttggctttgc ctcggtggac
     5401 ctctccccac ttctctctgg cttccagttt gtctgtggct ggtacaacat cacagacttc
     5461 agtggagagt gccaggggca gataaaagtt gctgtctccc ctttggagag tttgatacac
     5521 ttcaaagaag aaaggcaagc aaggcgtgga gtggagacct caaaatcact gatcccaata
     5581 tacagtccct tttccttccc tgcctctgat acgtatgctg cattctccag ccacatggca
     5641 aggcagaccc tagaccaact tgctcatgcc tcctcaaagg agcttgattt ctcctctcct
     5701 gggagaagtg ataccacaag aagccaagca tcacgccatg aagagcatgt gcagaacatt
     5761 cgccggtttc atgaatccct gcatcttcag ggagaggcac ccttgccatg tgatgacaaa
     5821 ctgaccacat cacctttgtc ctcccaaacc tccattctga cttctctcag gaagaatctg
     5881 agtgagcttg atcagattca gaggtacttc cgccagaagc tcaccaagcc tttcctaccc
     5941 ctcagccctc agactcaaac ggccatctca cagcaccagg agagctgtag ggaccatctt
     6001 gggccaggtg ccagcagcct agaccctggg agccagtgta tcctggagaa atccagtaac
     6061 ctggtgttgc aagtcagctc cttaatcaca gatctgcaga ctatcaccag ggattcgcaa
     6121 gcagctttga gttctcaccg agccaggagt agaagcaaca aggccaccac cctcccagat
     6181 gctcaggaca cagaagcact gcaagaacga tgcacaatgc cagatgagcc attggtaaga
     6241 gctccagata aaggcacaga ttccccatca ccccctcctc tcgaagagac ttcaaatgga
     6301 ggaagaatgc tccatgagtc cctgaggcat gcagtaccca ttacaaggat gcagagcagt
     6361 gaagacactg aggcaggccc agcctacagt gatgaggact atgaagaaga catcattgag
     6421 cccaggacct taaatgagat caccacggtg acagacaaaa ctagcccttg gtctagtgtc
     6481 atatcagaca caagtgaggt catcagccct cagcctgacg aggtgcagag ggaaggcccc
     6541 tcttgtcctt ctccagggcc tttctgcaga gaggagctta tggtcaaaag tagctttctc
     6601 tccagcccag aaagggctgt caacccccac ctgcctaggc agggttctcc tagccaaagt
     6661 cttgttgctt gtgagtgtga ggcctctaag gccagggttg gtggcgagtc tgcctcagcc
     6721 aaccctcagc ccatcccatg cccaacactc tcaggagctc aacagagcag cacgtttgtt
     6781 ggatggagct caccacagac agatcagaac aaggagccca agtcagaggc cccagctgag
     6841 aatgaagctg ccaccagtga gctcggtgac tctgctgata gcttcaagaa gttgccgcta
     6901 aatctagcct cccagagcag aagggaaaac cataagggac cacccatcga ctcctctgac
     6961 atcaggcaga ggcaggtgac aactggatca gagacgtcca caaagcagag cctcctgctc
     7021 ccagggccca ttgtggtgcc caacttcttt ttgcctcccc agcagttgga ggcttccctg
     7081 cggatgcttt cactctcagc aactttgcca ccagcagcca caacagatca ggacaagagc
     7141 gaagccacca ggggagctct ctcccaaagg ccttgtcgcc ccagacctaa ctcgctcccc
     7201 ctcaacctgc ctgaggaaga aactctcagg attgcacgga tattttcttc tcagtactcc
     7261 cagaaagact gacgcagcct gaggggctgg ggggaaggag acacctgccc accctccgtc
     7321 agctttgtcc agcttgcagg aggcaccagg tctggctcct tcagggctgt cacagtcctg
     7381 aaaccaccac ttgcctaggc cacggatgcc tcaagagacc cggtcagccc agactggagg
     7441 agtgccccaa accagtccag tgtccacttg ccagaatttc agctcctttt ttctgtggtg
     7501 aggcaaaggc tagaaataaa atggaatccg cgcccaagtg ggacccaagc aggcatcttt
     7561 cggtggagaa acgcccccca gtgtccttga cacagctgac tgctggcatg agcccaccct
     7621 ctgcctgaag atgcaggacc atttttgcct taaaagttgg ggaggaggga catgtagatt
     7681 gtgtgcattg tgcatagtca aggaaatcct agggccacct ccagttcatt tgtgtgggaa
     7741 caaggatatt ttatagatac aaattatttt tatgctgtgt tgaattaatc aattaggaga
     7801 ggaaggggaa atcacttcct tcaaactttt tatctgattg tctaaaattc taaccatgct
     7861 tttaacttat tatttttacc cagctctgaa ggtcattgtt cttgcctgtg tttgaataaa
     7921 atcatattgg tgtttgtaa
//
