LOCUS       NM_173793               3720 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens chromosome 22 open reading frame 39 (C22orf39),
            transcript variant 1, mRNA.
ACCESSION   NM_173793
VERSION     NM_173793.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3720)
  AUTHORS   Kragness,S., Clark,Z., Mullin,A., Guidry,J. and Earls,L.R.
  TITLE     An Rtn4/Nogo-A-interacting micropeptide modulates synaptic
            plasticity with age
  JOURNAL   PLoS One 17 (6), e0269404 (2022)
   PUBMED   35771867
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3720)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3720)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3720)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3720)
  AUTHORS   Kragness,S., Harrison,M.A.A., Westmoreland,J.J., Burstain,A. and
            Earls,L.R.
  TITLE     Age-dependent expression pattern in the mammalian brain of a novel,
            small peptide encoded in the 22q11.2 deletion syndrome region
  JOURNAL   Gene Expr Patterns 28, 95-103 (2018)
   PUBMED   29571919
REFERENCE   6  (bases 1 to 3720)
  AUTHORS   Reina Ortiz,M., Schreiber,F., Benitez,S., Broncano,N., Chico,M.E.,
            Vaca,M., Alexander,N., Lewis,D.J., Dougan,G. and Cooper,P.J.
  TITLE     Effects of chronic ascariasis and trichuriasis on cytokine
            production and gene expression in human blood: a cross-sectional
            study
  JOURNAL   PLoS Negl Trop Dis 5 (6), e1157 (2011)
   PUBMED   21666788
REFERENCE   7  (bases 1 to 3720)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC000068.2.
            
            On Apr 28, 2020 this sequence version replaced NM_173793.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.503723.1,
                                           SRR14038193.2753743.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2142348,
                                           SAMN03465406 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399562.9/ ENSP00000382474.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC000068.2         27428-27474         c
            48-215              AC000068.2         27141-27308         c
            216-3720            AC000068.2         20649-24153         c
FEATURES             Location/Qualifiers
     source          1..3720
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..3720
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /note="chromosome 22 open reading frame 39"
                     /db_xref="GeneID:128977"
                     /db_xref="HGNC:HGNC:27012"
     exon            1..47
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..341
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0545 protein C22orf39; Plasticity Associated Neural
                     Transcript; synaptic plasticity regulator PANTS"
                     /codon_start=1
                     /product="synaptic plasticity regulator PANTS isoform 1"
                     /protein_id="NP_776154.4"
                     /db_xref="CCDS:CCDS33599.3"
                     /db_xref="GeneID:128977"
                     /db_xref="HGNC:HGNC:27012"
                     /translation="MADGSGWQPPRPCEAYRAEWKLCRSARHFLHHYYVHGERPACEQ
                     WQRDLASCRDWEERRNAEAQQSLCESERARVRAARKHILVWAPRQSPPPDWHLPLPQE
                     KDE"
     exon            48..215
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /inference="alignment:Splign:2.1.0"
     exon            216..3720
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3083..3088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /note="hexamer: AATAAA"
     polyA_site      3107
                     /gene="C22orf39"
                     /gene_synonym="Pants"
     regulatory      3701..3706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /note="hexamer: AATAAA"
     polyA_site      3720
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /note="major polyA site"
ORIGIN      
        1 cttggcgcgc cggtcgccca gacatggcgg acggcagcgg ctggcagccg ccgcgcccct
       61 gcgaggccta ccgcgccgag tggaagctct gccgcagcgc caggcacttc ctacaccact
      121 actacgtcca cggcgagcgg ccggcctgcg aacagtggca gcgcgacctg gccagctgcc
      181 gcgactggga ggagcgccgg aacgccgagg cccagcaatc cctctgtgag agcgagcggg
      241 cacgagtccg ggctgcacgg aagcacatcc tggtgtgggc cccgaggcag agcccccctc
      301 cagactggca tctccctctg ccacaggaga aggacgagtg acaagcatcc ctgccattgg
      361 cctgtgcagc ttcctcagtc tgtttcaagt tgctgttgca cagccctggg gactgtgacc
      421 agcctacaca gtctggtggg tccctgtgag ctcttgctca caggaacatg gagcaggaca
      481 ttgctagccc tacttgccca cccctcacct gcatgcagga taccctgaca ctgcgatgtt
      541 ctgcaggaca attgcaccgc tttagagctt ccaggaggcc aagcattatg gcaggtactt
      601 gtgagcagcc aggtcaggct gggcatggta gcataggaga tggcggtcct gaggtctagg
      661 cttctcaggt aaactgaagg gtagccctga cctgtgtgga cacacaggtg ggtcataatg
      721 aggtagctaa acagttgtgc cactgtgaat gtctttccta gtccttggga aactgcctgc
      781 cacgtcccag gtttggtgag cattgtgagt gctcacactc tgctccactc gctcagttcc
      841 actgcacatg caggcaggtg tgccgagcag gtagggcttg ctggcccctc tgcaccagca
      901 ggcttcactt cttaggctcc caggtcggcc cctggagact ctggttttta agaaatgcac
      961 acagctacag aacacacaac cttgcataaa gagggtttgt ggactcagct gaagaaatcc
     1021 aagtccaaga catatggaat taagcactcc ttccctcaaa atttcccctg gtggttaatg
     1081 tatcaaaagc tatttcatct gatttcaaat agaagctgaa aattaagttc acacttgtta
     1141 gattttgtgt gtaacagtgt tgtacctgga cagtattaga aatttgtatg cttattctct
     1201 tgttaagtgt tttaaaatgt atgaaccacc aaaaacacta tttcttgaag aggtctgttt
     1261 attactaata gaatggtttc tcatcctatg gtggccctgt tgtgtgatgc tgagggctag
     1321 gctgggtctg tgcccagcac cctccctgct ctcttcctgg acacaggcag caagttgaat
     1381 atcttttaat ttgttctttg gggcagaata atctatcacg ttagaagggt gtccattaaa
     1441 gaacagtatt tccctgcttg agtgtgtttt ctcctgtgct ccctaagagc ccctgtgtct
     1501 gtgaacagtg ggggtggggg tgggggttgt gctcacggga tcccaagagc aggagcatct
     1561 aaagaggagc cagcgttccc ccatcatcag gggagtactg atgtgtctaa ggcaaccagg
     1621 gtgcctccag catggctgtg gctggtttaa taatgagcat ttccacccag tgagggaaga
     1681 gaggaagact gctagagatc tacaaggttt ttcttactct taaacacagg gacggggcat
     1741 ctgaatttgc agtctgctgt aatcccagca ctttgggagg ccaaggtggg tggatcactt
     1801 gaggtctgga gtttgagacc agcctggcca acatggttga aaccccccat ctctattaaa
     1861 aatacaaaaa ttaactgggc atggtggcac gtgcctgtga tcccagctac tcgggaagct
     1921 gagacaggag aattgcttga accccagagg cagaggttgc agtgagctga gatcgtgcca
     1981 ctgtactcca gcctgggcga cagagtgaga ctcttgtctc aaagataaaa taataaaatg
     2041 agtttgcagc ctgcatgtga tgcctgggat tgcagcagct gccttcaggt tcctggggca
     2101 gagctggaga gtgcagcaaa agccagggca tgccagccag caccccagtc catgaggggc
     2161 ttcccctcag tgcagccacg ctccctgcca cctgcttgtt tagcaaggta tgcattgtgc
     2221 ggctgcatgc tctgttagga agcattaagt cctgcctctg tagtgtgact atcatgtttt
     2281 gcctcctcct tcactactca agttccacat caacagataa tctctctgga caggatgttc
     2341 ctgcatttgt ttctatgtca attgcttcac aacatctgag tgtccacatg ttggacaggg
     2401 tttgaggctt ataagaccac agttttgaaa cagacaagtt gtcttcaaag agtttctgtt
     2461 gtagtttggg taaaagacag acattaaaca tcaataaata ggaatttaaa acggtggctg
     2521 gatgtggtgg ctcacggctg ttatcccagc actttgggag gctgaggtgg gaggattgct
     2581 tgagcccagg agttcgagac cagcctgggc aacgtaacaa gaccccatct ctacaaaaaa
     2641 taaatgagct atgcatggtg gcgtgcattt gtagttccag ctacttcgga ggctgagata
     2701 ggaggattgt ttgagcccag gagtttgagg ctgcagtgag ccatgattgt gccccactgc
     2761 acttcaacct gggtgacaga gcaatatcct gtctcaaaat aaataaaaat aaaatggtgg
     2821 taatttctga agcagtttgg tattttatgg tggtggtatg aagaaaacaa atactgtaat
     2881 aagagcaata tctttcaaac tttttggaca ggtgctaagt gtggtggctc acacctgtaa
     2941 tctcagctac ttgggaggct gaggcagaag aatcacttga ggataggagt ttgaggttgc
     3001 agtcagctat gatcgtgcca ctgcactcca gcctgggcaa cagagcaaga ccccatctct
     3061 aaataaatgt tttaaaaata aaaataaatg ttttggataa aaccccatat taataataag
     3121 tattttacat tattatctgg catagactgt tatatatagc atattattgt tgaaatacaa
     3181 aacaatatgt atccgtactg tatgtgatat agtgccattt tcagtaactg ctgtacacac
     3241 agcaactcag atgaaactca aggaaattct tcagagcaaa aacagccaat cttgaaaaca
     3301 tacatgtagc aggattccat ttatgtaaca ttggtgaaat aatgtaatta tagagatgga
     3361 aaacagatta aaggttacca ggggtttagg ttagggatgg tgagggggtg gttcatacga
     3421 gggagtcctg tggtgttgaa aaccatctgt cagcctgact ggtggttaca cagggctata
     3481 catgaagtta aaattgtgta gagttaggta cacaaaggag tacagatgta actggggaaa
     3541 ctgagtatgt tctgtagact gtaccaatgt caatttctgc gtcctgatgc tgtgctgtag
     3601 tgtataaggt gttaacattg ggggaggctg gggcaagggt acccaggacc tccctagaca
     3661 acctcctatg caacctcctg tgaatctata attacttcaa aataaaaagt tgaaaacaaa
//
