LOCUS       NM_001166242            1024 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens chromosome 22 open reading frame 39 (C22orf39),
            transcript variant 2, mRNA.
ACCESSION   NM_001166242
VERSION     NM_001166242.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1024)
  AUTHORS   Kragness,S., Clark,Z., Mullin,A., Guidry,J. and Earls,L.R.
  TITLE     An Rtn4/Nogo-A-interacting micropeptide modulates synaptic
            plasticity with age
  JOURNAL   PLoS One 17 (6), e0269404 (2022)
   PUBMED   35771867
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1024)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1024)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1024)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1024)
  AUTHORS   Kragness,S., Harrison,M.A.A., Westmoreland,J.J., Burstain,A. and
            Earls,L.R.
  TITLE     Age-dependent expression pattern in the mammalian brain of a novel,
            small peptide encoded in the 22q11.2 deletion syndrome region
  JOURNAL   Gene Expr Patterns 28, 95-103 (2018)
   PUBMED   29571919
REFERENCE   6  (bases 1 to 1024)
  AUTHORS   Reina Ortiz,M., Schreiber,F., Benitez,S., Broncano,N., Chico,M.E.,
            Vaca,M., Alexander,N., Lewis,D.J., Dougan,G. and Cooper,P.J.
  TITLE     Effects of chronic ascariasis and trichuriasis on cytokine
            production and gene expression in human blood: a cross-sectional
            study
  JOURNAL   PLoS Negl Trop Dis 5 (6), e1157 (2011)
   PUBMED   21666788
REFERENCE   7  (bases 1 to 1024)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC000068.2.
            
            On Apr 28, 2020 this sequence version replaced NM_001166242.1.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The encoded isoform (2)
            has a distinct C-terminus and is shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030758.1, SRR14038197.2222439.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC000068.2         27428-27474         c
            48-215              AC000068.2         27141-27308         c
            216-1024            AC000068.2         20649-21457         c
FEATURES             Location/Qualifiers
     source          1..1024
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..1024
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /note="chromosome 22 open reading frame 39"
                     /db_xref="GeneID:128977"
                     /db_xref="HGNC:HGNC:27012"
     exon            1..47
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..266
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /note="isoform 2 is encoded by transcript variant 2;
                     UPF0545 protein C22orf39; Plasticity Associated Neural
                     Transcript; synaptic plasticity regulator PANTS"
                     /codon_start=1
                     /product="synaptic plasticity regulator PANTS isoform 2"
                     /protein_id="NP_001159714.2"
                     /db_xref="CCDS:CCDS54498.2"
                     /db_xref="GeneID:128977"
                     /db_xref="HGNC:HGNC:27012"
                     /translation="MADGSGWQPPRPCEAYRAEWKLCRSARHFLHHYYVHGERPACEQ
                     WQRDLASCRDWEERRNAEAQVLSVVAHTCNLSYLGG"
     exon            48..215
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /inference="alignment:Splign:2.1.0"
     exon            216..1024
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /inference="alignment:Splign:2.1.0"
     regulatory      387..392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /note="hexamer: AATAAA"
     polyA_site      411
                     /gene="C22orf39"
                     /gene_synonym="Pants"
     regulatory      1005..1010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /note="hexamer: AATAAA"
     polyA_site      1024
                     /gene="C22orf39"
                     /gene_synonym="Pants"
                     /note="major polyA site"
ORIGIN      
        1 cttggcgcgc cggtcgccca gacatggcgg acggcagcgg ctggcagccg ccgcgcccct
       61 gcgaggccta ccgcgccgag tggaagctct gccgcagcgc caggcacttc ctacaccact
      121 actacgtcca cggcgagcgg ccggcctgcg aacagtggca gcgcgacctg gccagctgcc
      181 gcgactggga ggagcgccgg aacgccgagg cccaggtgct aagtgtggtg gctcacacct
      241 gtaatctcag ctacttggga ggctgaggca gaagaatcac ttgaggatag gagtttgagg
      301 ttgcagtcag ctatgatcgt gccactgcac tccagcctgg gcaacagagc aagaccccat
      361 ctctaaataa atgttttaaa aataaaaata aatgttttgg ataaaacccc atattaataa
      421 taagtatttt acattattat ctggcataga ctgttatata tagcatatta ttgttgaaat
      481 acaaaacaat atgtatccgt actgtatgtg atatagtgcc attttcagta actgctgtac
      541 acacagcaac tcagatgaaa ctcaaggaaa ttcttcagag caaaaacagc caatcttgaa
      601 aacatacatg tagcaggatt ccatttatgt aacattggtg aaataatgta attatagaga
      661 tggaaaacag attaaaggtt accaggggtt taggttaggg atggtgaggg ggtggttcat
      721 acgagggagt cctgtggtgt tgaaaaccat ctgtcagcct gactggtggt tacacagggc
      781 tatacatgaa gttaaaattg tgtagagtta ggtacacaaa ggagtacaga tgtaactggg
      841 gaaactgagt atgttctgta gactgtacca atgtcaattt ctgcgtcctg atgctgtgct
      901 gtagtgtata aggtgttaac attgggggag gctggggcaa gggtacccag gacctcccta
      961 gacaacctcc tatgcaacct cctgtgaatc tataattact tcaaaataaa aagttgaaaa
     1021 caaa
//
