LOCUS       NM_015370                982 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens chromosome 22 open reading frame 31 (C22orf31),
            transcript variant 1, mRNA.
ACCESSION   NM_015370
VERSION     NM_015370.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 982)
  AUTHORS   Wolpin,B.M., Rizzato,C., Kraft,P., Kooperberg,C., Petersen,G.M.,
            Wang,Z., Arslan,A.A., Beane-Freeman,L., Bracci,P.M., Buring,J.,
            Canzian,F., Duell,E.J., Gallinger,S., Giles,G.G., Goodman,G.E.,
            Goodman,P.J., Jacobs,E.J., Kamineni,A., Klein,A.P., Kolonel,L.N.,
            Kulke,M.H., Li,D., Malats,N., Olson,S.H., Risch,H.A., Sesso,H.D.,
            Visvanathan,K., White,E., Zheng,W., Abnet,C.C., Albanes,D.,
            Andreotti,G., Austin,M.A., Barfield,R., Basso,D., Berndt,S.I.,
            Boutron-Ruault,M.C., Brotzman,M., Buchler,M.W.,
            Bueno-de-Mesquita,H.B., Bugert,P., Burdette,L., Campa,D.,
            Caporaso,N.E., Capurso,G., Chung,C., Cotterchio,M., Costello,E.,
            Elena,J., Funel,N., Gaziano,J.M., Giese,N.A., Giovannucci,E.L.,
            Goggins,M., Gorman,M.J., Gross,M., Haiman,C.A., Hassan,M.,
            Helzlsouer,K.J., Henderson,B.E., Holly,E.A., Hu,N., Hunter,D.J.,
            Innocenti,F., Jenab,M., Kaaks,R., Key,T.J., Khaw,K.T., Klein,E.A.,
            Kogevinas,M., Krogh,V., Kupcinskas,J., Kurtz,R.C., LaCroix,A.,
            Landi,M.T., Landi,S., Le Marchand,L., Mambrini,A., Mannisto,S.,
            Milne,R.L., Nakamura,Y., Oberg,A.L., Owzar,K., Patel,A.V.,
            Peeters,P.H., Peters,U., Pezzilli,R., Piepoli,A., Porta,M.,
            Real,F.X., Riboli,E., Rothman,N., Scarpa,A., Shu,X.O.,
            Silverman,D.T., Soucek,P., Sund,M., Talar-Wojnarowska,R.,
            Taylor,P.R., Theodoropoulos,G.E., Thornquist,M., Tjonneland,A.,
            Tobias,G.S., Trichopoulos,D., Vodicka,P., Wactawski-Wende,J.,
            Wentzensen,N., Wu,C., Yu,H., Yu,K., Zeleniuch-Jacquotte,A.,
            Hoover,R., Hartge,P., Fuchs,C., Chanock,S.J.,
            Stolzenberg-Solomon,R.S. and Amundadottir,L.T.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pancreatic cancer
  JOURNAL   Nat Genet 46 (9), 994-1000 (2014)
   PUBMED   25086665
REFERENCE   2  (bases 1 to 982)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   3  (bases 1 to 982)
  AUTHORS   Collins,J.E., Goward,M.E., Cole,C.G., Smink,L.J., Huckle,E.J.,
            Knowles,S., Bye,J.M., Beare,D.M. and Dunham,I.
  TITLE     Reevaluating human gene annotation: a second-generation analysis of
            chromosome 22
  JOURNAL   Genome Res 13 (1), 27-36 (2003)
   PUBMED   12529303
REFERENCE   4  (bases 1 to 982)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL021393.1.
            
            On Sep 14, 2020 this sequence version replaced NM_015370.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL035364.1, BC126264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216071.5/ ENSP00000216071.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AL021393.1         55097-55138         c
            43-471              AL021393.1         53722-54150         c
            472-982             AL021393.1         51979-52489         c
FEATURES             Location/Qualifiers
     source          1..982
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.1"
     gene            1..982
                     /gene="C22orf31"
                     /gene_synonym="bK747E2.1; HS747E2A"
                     /note="chromosome 22 open reading frame 31"
                     /db_xref="GeneID:25770"
                     /db_xref="HGNC:HGNC:26931"
     exon            1..42
                     /gene="C22orf31"
                     /gene_synonym="bK747E2.1; HS747E2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..912
                     /gene="C22orf31"
                     /gene_synonym="bK747E2.1; HS747E2A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C22orf31"
                     /codon_start=1
                     /product="uncharacterized protein C22orf31 isoform 1"
                     /protein_id="NP_056185.1"
                     /db_xref="CCDS:CCDS13848.1"
                     /db_xref="GeneID:25770"
                     /db_xref="HGNC:HGNC:26931"
                     /translation="MHPINVRRDPSIPIYGLRQSILLNTRLQDCYVDSPALTNIWMAR
                     TCAKQNINAPAPATTSSWEVVRNPLIASSFSLVKLVLRRQLKNKCCPPPCKFGEGKLS
                     KRLKHKDDSVMKATQQARKRNFISSKSKQPAGHRRPAGGIRESKESSKEKKLTVRQDL
                     EDRYAEHVAATQALPQDSGTAAWKGRVLLPETQKRQQLSEDTLTIHGLPTEGYQALYH
                     AVVEPMLWNPSGTPKRYSLELGKAIKQKLWEALCSQGAISEGAQRDRFPGRKQPGVHE
                     EPVLKKWPKLKSKK"
     exon            43..471
                     /gene="C22orf31"
                     /gene_synonym="bK747E2.1; HS747E2A"
                     /inference="alignment:Splign:2.1.0"
     exon            472..982
                     /gene="C22orf31"
                     /gene_synonym="bK747E2.1; HS747E2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      960..965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C22orf31"
                     /gene_synonym="bK747E2.1; HS747E2A"
                     /note="hexamer: AATAAA"
     polyA_site      982
                     /gene="C22orf31"
                     /gene_synonym="bK747E2.1; HS747E2A"
                     /note="major polyA site"
ORIGIN      
        1 tactaagcta gcgaaaataa aatttaaggc aactgaaata tgcacccaat caatgtgaga
       61 cgagacccca gcatccctat ctatggactc cgacagtcca tcttattaaa taccaggctt
      121 caggactgct atgtggactc accggctctc accaacatct ggatggccag aacatgtgca
      181 aagcagaaca ttaatgcccc agcaccagct accacttcct cttgggaagt tgtaaggaac
      241 ccattaattg ccagttcctt ctccctggtt aagcttgtac tcaggcggca actgaagaat
      301 aagtgctgcc caccaccatg caagtttgga gaaggaaaac tctcgaagag attaaagcac
      361 aaggacgatt cagtgatgaa agccacccag caggccagga aaagaaactt catcagttcc
      421 aagagcaagc agccagcagg gcataggagg cctgcaggag gcatcagaga gagtaaagaa
      481 agttcaaagg agaaaaaact aacagtccgc caagatcttg aggacagata tgctgaacat
      541 gtggctgcca cccaagcgct accccaggac agtgggacag cagcctggaa gggccgagtg
      601 ttgcttcctg aaacccaaaa gagacagcag ttgtcggagg acacgctaac catccatggt
      661 ctccccacag agggttacca ggctctgtac cacgctgtgg tggagccaat gctgtggaat
      721 ccttcaggga cccccaagag gtacagcctg gagctgggca aggccattaa acaaaagctc
      781 tgggaggctc tttgcagtca gggtgccatc tctgaaggtg ctcagaggga ccggttccct
      841 ggcaggaagc agccaggtgt ccacgaggag cctgtactca agaaatggcc caagttaaag
      901 agcaaaaaat aggaacaaga actcatggga ttagagtatt ctctgctaga gatctgaaaa
      961 ataaacacaa ctttgcacct tc
//
