LOCUS       NM_182520                895 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens chromosome 22 open reading frame 15 (C22orf15),
            transcript variant 1, mRNA.
ACCESSION   NM_182520
VERSION     NM_182520.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 895)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 895)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000348.1 and AP000349.1.
            
            On Nov 26, 2019 this sequence version replaced NM_182520.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM713608.1, ERR279834.8424.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402217.8/ ENSP00000384965.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               AP000348.1         30943-31284
            343-429             AP000349.1         449-535
            430-567             AP000349.1         622-759
            568-642             AP000349.1         1001-1075
            643-752             AP000349.1         1155-1264
            753-895             AP000349.1         2083-2225
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..895
                     /gene="C22orf15"
                     /gene_synonym="N27C7-3"
                     /note="chromosome 22 open reading frame 15"
                     /db_xref="GeneID:150248"
                     /db_xref="HGNC:HGNC:15558"
     exon            1..342
                     /gene="C22orf15"
                     /gene_synonym="N27C7-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..764
                     /gene="C22orf15"
                     /gene_synonym="N27C7-3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein N27C7-3; uncharacterized protein C22orf15"
                     /codon_start=1
                     /product="uncharacterized protein C22orf15 isoform 1"
                     /protein_id="NP_872326.2"
                     /db_xref="CCDS:CCDS13814.2"
                     /db_xref="GeneID:150248"
                     /db_xref="HGNC:HGNC:15558"
                     /translation="MFIKVMFGAGCSVLVNTSCRLVNLTAHLRQKAGLPPDATIALLA
                     EDGNLVSLEEDLKEGASRAQTMGNSLLKERAIYVLVRIIKGEDMASTRYESLLENLDD
                     HYPELAEELRRLSGLSSVGHNWRKRMGTRRGRHEQSPTSRPRKGPD"
     exon            343..429
                     /gene="C22orf15"
                     /gene_synonym="N27C7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            430..567
                     /gene="C22orf15"
                     /gene_synonym="N27C7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            568..642
                     /gene="C22orf15"
                     /gene_synonym="N27C7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            643..752
                     /gene="C22orf15"
                     /gene_synonym="N27C7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            753..895
                     /gene="C22orf15"
                     /gene_synonym="N27C7-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      876..881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C22orf15"
                     /gene_synonym="N27C7-3"
                     /note="hexamer: AATAAA"
     polyA_site      895
                     /gene="C22orf15"
                     /gene_synonym="N27C7-3"
                     /note="major polyA site"
ORIGIN      
        1 agatgtctcc gcccccactg ccatggagac cagcttggaa gcttagggga gctgctgtgg
       61 cccagggctc agtggggagg aagaggaggc caggagtctt ggactagctg cagggtttga
      121 gctaggctga agcagcagaa ccacagaggt ggctgagcag gggcctggcc ctgggaccca
      181 gccatccaca ctcacacatc cacttctccc tccagagccc ggccctgaag caggtctctg
      241 ctccacgctt ttccttagtt ggggaatcga gagttggggg atcaaagccc cccacatctc
      301 cctcacccgc tgcagctatg tttatcaagg tgatgtttgg ggctggctgc tcggtgctgg
      361 tgaacacctc ttgcaggctg gtgaacctca ccgcccacct gaggcagaaa gcagggttgc
      421 ccccagatgc gaccattgct ctcctggctg aggatggcaa cctagtgagc ctggaggagg
      481 acctgaagga aggggcttcc cgggcccaga ccatgggcaa ctccctactg aaggagcgag
      541 ccatatatgt cctcgttcgg atcatcaagg gagaggacat ggcctccacc cgctatgagt
      601 ccctattgga gaacctggat gaccattacc cagagctggc agaggaactg cgcaggctgt
      661 caggcctctc ctctgtgggc cacaactgga ggaagcgtat gggcactcgg cgaggccgcc
      721 atgagcaaag ccccacttca aggcccagaa agggccctga ttaaggggat ggattgcaca
      781 ctgtagtgag acatccatcc tgaccccacc tcatcagcca gggagctccc tgaagacagg
      841 ccatcgagag aggcacacaa caggctgtgg tctaaaataa acttttaatt gcaca
//
