LOCUS       NM_058180               2970 bp    mRNA    linear   PRI 24-APR-2024
DEFINITION  Homo sapiens chromosome 21 open reading frame 58 (C21orf58),
            transcript variant 1, mRNA.
ACCESSION   NM_058180
VERSION     NM_058180.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2970)
  AUTHORS   Jiang,H., Wang,Y., Wen,D., Yu,R., Esa,S.S., Lv,K., Feng,Q., Liu,J.,
            Li,F., He,L., Di,X. and Zhang,S.
  TITLE     Targeting C21orf58 is a Novel Treatment Strategy of Hepatocellular
            Carcinoma by Disrupting the Formation of JAK2/C21orf58/STAT3
            Complex
  JOURNAL   Adv Sci (Weinh) 11 (15), e2306623 (2024)
   PUBMED   38342622
  REMARK    GeneRIF: Targeting C21orf58 is a Novel Treatment Strategy of
            Hepatocellular Carcinoma by Disrupting the Formation of
            JAK2/C21orf58/STAT3 Complex.
REFERENCE   2  (bases 1 to 2970)
  AUTHORS   Reymond,A., Friedli,M., Henrichsen,C.N., Chapot,F., Deutsch,S.,
            Ucla,C., Rossier,C., Lyle,R., Guipponi,M. and Antonarakis,S.E.
  TITLE     From PREDs and open reading frames to cDNA isolation: revisiting
            the human chromosome 21 transcription map
  JOURNAL   Genomics 78 (1-2), 46-54 (2001)
   PUBMED   11707072
REFERENCE   3  (bases 1 to 2970)
  AUTHORS   Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
            Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
  TITLE     [IMAGE: molecular integration of the analysis of the human genome
            and its expression]
  JOURNAL   C R Acad Sci III 318 (2), 263-272 (1995)
   PUBMED   7757816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000471.2.
            
            On Aug 31, 2019 this sequence version replaced NM_058180.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056387.1, SRR14038195.199935.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158569 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291691.12/ ENSP00000291691.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1232              AP000471.2         54771-56002         c
            1233-1441           AP000471.2         50144-50352         c
            1442-1502           AP000471.2         49340-49400         c
            1503-1576           AP000471.2         47606-47679         c
            1577-1741           AP000471.2         46848-47012         c
            1742-1853           AP000471.2         43588-43699         c
            1854-1945           AP000471.2         34617-34708         c
            1946-2970           AP000471.2         33262-34286         c
FEATURES             Location/Qualifiers
     source          1..2970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..2970
                     /gene="C21orf58"
                     /note="chromosome 21 open reading frame 58"
                     /db_xref="GeneID:54058"
                     /db_xref="HGNC:HGNC:1300"
     exon            1..1232
                     /gene="C21orf58"
                     /inference="alignment:Splign:2.1.0"
     CDS             1133..2101
                     /gene="C21orf58"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C21orf58"
                     /codon_start=1
                     /product="uncharacterized protein C21orf58 isoform 1"
                     /protein_id="NP_478060.2"
                     /db_xref="CCDS:CCDS13735.1"
                     /db_xref="GeneID:54058"
                     /db_xref="HGNC:HGNC:1300"
                     /translation="MARSRLPATSLRKPWKLDRQKLPSPDSGHSLLCGWSPGGKARPA
                     GNTGAWAPAEQFFPASNRTREGGGLWPPLPLQSSPAAPTMLDSSAAEQVTRLTLKLLG
                     QKLEQERQNVEGGPEGLHLEPGNEDRPDDALQTALKRRRDLLQRLREQHLLDELSRAQ
                     AWSGPSRGALGSALPPELPPTGILPTASPSPLAPDPPRIILPTVPQPPATIIQQLPQQ
                     PLIAQIPPPQAFPTQRSGSIKEDMVELLLLQNAQVHQLVLQNWMLKALPPALQDPPHV
                     PPRVPRAARPRLPAVHHHHHHHHAVWPPGAATVLQPAPSLWTPGPP"
     exon            1233..1441
                     /gene="C21orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1502
                     /gene="C21orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1576
                     /gene="C21orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1741
                     /gene="C21orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1853
                     /gene="C21orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1945
                     /gene="C21orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2970
                     /gene="C21orf58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2777..2782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C21orf58"
                     /note="hexamer: AATAAA"
     polyA_site      2794
                     /gene="C21orf58"
                     /note="major polyA site"
     regulatory      2944..2949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C21orf58"
                     /note="hexamer: AATAAA"
     regulatory      2949..2954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C21orf58"
                     /note="hexamer: AATAAA"
     polyA_site      2957
                     /gene="C21orf58"
                     /note="major polyA site"
     polyA_site      2963
                     /gene="C21orf58"
     polyA_site      2970
                     /gene="C21orf58"
                     /note="major polyA site"
ORIGIN      
        1 aaaaagttcg cgctgctggt cccgcgcggg cggcccctgg gctttgtgtc caccaggaca
       61 gcgggccggg ctccctgcag gcgcgggcgg cgccgaacgg tgctcagcaa ccacccggac
      121 agggccaggc cgttttctcc cgctcaggca ttagtcgttg gctgtgggcc gccgcgggaa
      181 gttgaggcct accacggagg aggctgctga ggtggatctc aggggatccg caagggctcc
      241 ctcacccttg ccgggaccct gggaacccga aacaaaatcc tacgccacca gcccgccgaa
      301 tgcgccccct cggccggggg tcctgggtct tcagagaaga actcggccga atgcggtcag
      361 aaagcccgcg aaccgcctgg acctgcaggc cccgccgctt ggagctcccg cctttcccga
      421 ccgagcccgt gtctgctcgt gtgtctcact gatgtcttag gtctcaaaaa aaaaagaaaa
      481 gaaaaggttt ttagtagaca gaagagaaat ggggccgtgg gttcgtggtc ccagggggaa
      541 actgacgtcg catgaggtcg tcgtccctca gcttgagctc agcggaacat aagcttgcag
      601 aggtggaaac cacggaaggt ttgggtgtct tggagctctc tggacaccga agcccggaca
      661 cagtcccggg gtccgcaccg cctgtgacct gtggcgggac cgccggggtg ggcgttttct
      721 cagctggcgc gcgcgtaggt ggaacttggg aaactaactg gagcgaagtg gcaaaaaacc
      781 aagacagggc cggtgacctc gcgcaggccg tccttaactg tggagtattc cttcagctaa
      841 cccctttatt tcatgtgtcc aagtctggtt tctgggtttc tttgtagtcc tccgggcctg
      901 ttcgtgcgcc ttcacttgca aaaggttcgt cgtggagggc cgtgtgcttg tttgcagcag
      961 taacgatgcc cttcccgagc gtgctggagt ggctcctcgc tgacgcaagc tcaccttgca
     1021 gcctcctcag caactgcaac ttaaacgcgc cctcaggaag ccctggaatc tcgctcagaa
     1081 ttttttttct ttttttgaga cagtctcgct gcgacgccca ggctatagcg caatggcgcg
     1141 atctcggctc cctgcaacct ccctcaggaa gccgtggaag ctcgaccgcc agaaacttcc
     1201 ttctcctgac tcaggccaca gtcttctgtg tggctggtct ccaggaggta aggcccgccc
     1261 tgcaggcaac accggtgctt gggctcctgc tgagcagttc tttcctgcga gtaacagaac
     1321 cagggaggga ggtgggctgt ggcctcccct gcccctacag tcgtctcctg cagctcccac
     1381 catgctggac tcatcagcag cagagcaagt gacccgactg acgctgaagc tcttgggaca
     1441 gaagctggag caagaacggc agaacgtgga agggggacct gagggcctcc acctcgagcc
     1501 aggaaatgag gaccggccgg acgatgccct gcagactgct ctgaagagaa ggagggacct
     1561 tctgcagaga ctccgggaac aacacctcct ggacgagctc tctcgggccc aggcctggag
     1621 cgggccaagc agaggagccc tcgggtcagc cctgccccca gagctgcccc ccacgggcat
     1681 cctacccact gcctccccat ccccgctggc cccagacccg ccaaggatca tcctgcctac
     1741 ggtcccccag cctcctgcca ccatcattca gcagctccct cagcagccac tcatagcaca
     1801 gattcctcct ccccaggcct tccctactca acggtcagga agtattaagg aagacatggt
     1861 ggagctgctg ctgctgcaga acgcacaggt gcaccagttg gtcctgcaga actggatgct
     1921 caaggccctg cccccagccc tgcaggaccc gccacatgtg cccccgaggg tcccacgagc
     1981 tgccaggcca aggctgcctg ccgtgcacca ccaccaccac caccaccatg ctgtgtggcc
     2041 acctggggct gccactgtcc tccagcccgc ccccagcctg tggacgcctg gcccaccctg
     2101 agtgtgagtc acagagaccc tggccggggc accctccacc cccaggcttc ctcagggctg
     2161 tgggctgtgg cgggactatg gaagggagca gggagagacc ctgccaccac ccggagtggc
     2221 tacgcgagtg tggactgcag gctcctcctg gggaagctgg gcaggctcgc tttctggtca
     2281 cggggccatt ccagggggca tcccttgctc cgggtcccct gcagtgaggg gcctgtgaac
     2341 cccaccaggg caacagcccc tcccagggac ccctcctttc ctgtagggcg gcgccggccc
     2401 acctgggagc ctcagatccc cctcttccat cacggaggta aagttgaggc cgtggacgcc
     2461 accagcctga tgaaataaag atttcatcca gaaagagttt aagaaaatct cagctcagga
     2521 gccagaacag aaaagatcaa tagctttagc cacatggaag tgtgaacatc ctgatgggga
     2581 aaataccaca aagtctaatt taataactag ggacacctgt gtccacagct gtggcacaga
     2641 ctcccactaa agaagtaggg gtgcatggct catgcctgta atcccagcac tttaagaggc
     2701 tgaggcagga ggatcacttg agctcaggaa ttcgagacca gcctgggtca catagcaaga
     2761 ccccgtctct acaaaaaata aatttaaaaa actagccagg tgtggtgata tgcgcctgtt
     2821 atctcagcag ctctgggggc tgaggtggga ggattgcttg agcccaggag ttagaagctg
     2881 cagtgagctc tgatggaacc actgcactat agcctggacc acagagcagg cccctgtctc
     2941 aaaaataaaa taaaaaagtg aaagaagcaa
//
