LOCUS       NM_001282537             961 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens chromosome 21 open reading frame 140 (C21orf140),
            mRNA.
ACCESSION   NM_001282537 XM_005261086 XM_005275897 XM_005276689
VERSION     NM_001282537.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 961)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   2  (bases 1 to 961)
  AUTHORS   Hattori,M., Fujiyama,A., Taylor,T.D., Watanabe,H., Yada,T.,
            Park,H.S., Toyoda,A., Ishii,K., Totoki,Y., Choi,D.K., Groner,Y.,
            Soeda,E., Ohki,M., Takagi,T., Sakaki,Y., Taudien,S.,
            Blechschmidt,K., Polley,A., Menzel,U., Delabar,J., Kumpf,K.,
            Lehmann,R., Patterson,D., Reichwald,K., Rump,A., Schillhabel,M.,
            Schudy,A., Zimmermann,W., Rosenthal,A., Kudoh,J., Schibuya,K.,
            Kawasaki,K., Asakawa,S., Shintani,A., Sasaki,T., Nagamine,K.,
            Mitsuyama,S., Antonarakis,S.E., Minoshima,S., Shimizu,N.,
            Nordsiek,G., Hornischer,K., Brant,P., Scharfe,M., Schon,O.,
            Desario,A., Reichelt,J., Kauer,G., Blocker,H., Ramser,J., Beck,A.,
            Klages,S., Hennig,S., Riesselmann,L., Dagand,E., Haaf,T.,
            Wehrmeyer,S., Borzym,K., Gardiner,K., Nizetic,D., Francis,F.,
            Lehrach,H., Reinhardt,R. and Yaspo,M.L.
  CONSRTM   Chromosome 21 mapping and sequencing consortium
  TITLE     The DNA sequence of human chromosome 21
  JOURNAL   Nature 405 (6784), 311-319 (2000)
   PUBMED   10830953
  REMARK    Erratum:[Nature 2000 Sep 7;407(6800):110]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000322.2 and AA860112.1.
            
            On May 17, 2019 this sequence version replaced NM_001282537.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660809.128547.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000410005.2/ ENSP00000386791.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-573               AP000322.2         5482-6054           c
            574-961             AA860112.1         5-392               c
FEATURES             Location/Qualifiers
     source          1..961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.12"
     gene            1..961
                     /gene="C21orf140"
                     /gene_synonym="FAM243A"
                     /note="chromosome 21 open reading frame 140"
                     /db_xref="GeneID:101928147"
                     /db_xref="HGNC:HGNC:39602"
     exon            1..961
                     /gene="C21orf140"
                     /gene_synonym="FAM243A"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..756
                     /gene="C21orf140"
                     /gene_synonym="FAM243A"
                     /note="protein FAM243A; family with sequence similarity
                     243 member A"
                     /codon_start=1
                     /product="uncharacterized protein C21orf140"
                     /protein_id="NP_001269466.1"
                     /db_xref="CCDS:CCDS63357.1"
                     /db_xref="GeneID:101928147"
                     /db_xref="HGNC:HGNC:39602"
                     /translation="MPRFASPLLRNVIIRSQFDGIKRKQCLQYLKTLRTLQYDGFKTV
                     YFGETNIPESLVTGEDISDGYFIQTPTWCIVHAAGSQGWVPWKYRVFLRDELCIKQED
                     SLFSEFCDVVRKAYGKCVIVVKERRQQEEQRPKEDREAEGQFYIPTVISLASIMCCPE
                     VAKSCGHELLSLPSPCNYLNPLDSAWSSLKWFIINNRNEFCLQSIDSGYSYQCILFSN
                     LISKGIERINASKWRTLTSKVRRWENYYLGKFS"
     regulatory      940..945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C21orf140"
                     /gene_synonym="FAM243A"
                     /note="hexamer: ATTAAA"
     polyA_site      961
                     /gene="C21orf140"
                     /gene_synonym="FAM243A"
                     /note="major polyA site"
ORIGIN      
        1 atgcctcgct ttgcaagccc tcttttaaga aatgtcatta tcagaagtca atttgatggc
       61 atcaagagga agcaatgcct ccaatatctg aaaaccctga gaacactgca atatgatgga
      121 tttaagaccg tatattttgg ggaaaccaat atcccagaaa gtctcgtaac tggggaagat
      181 attagtgatg gatatttcat acaaacccca acttggtgta ttgtgcatgc tgcgggtagt
      241 caaggatggg tgccttggaa atatcgggtg ttcctaagag acgagctgtg tatcaaacaa
      301 gaagacagcc tcttctctga gttctgtgat gtggtgagga aggcctatgg aaagtgtgtc
      361 atcgtggtca aagagagaag gcagcaggaa gagcagaggc caaaggaaga cagagaggct
      421 gagggccagt tctatatccc tacagtcatt agcttagcaa gcattatgtg ttgcccagag
      481 gtggccaagt cctgtggcca tgaactactc tctctgcctt ccccttgtaa ttatctgaac
      541 cctttagact cagcctggtc ttctctgaaa tggtttatca tcaataacag aaacgagttt
      601 tgtttgcagt ccattgacag tggctattct taccaatgta tacttttcag caatttaatt
      661 agcaaaggaa ttgaaaggat aaacgcaagc aagtggagaa cattaactag caaagtacgg
      721 agatgggaaa actactatct tgggaaattt tcttaagggt ggttcctcca acaagcagtg
      781 aggctgctac atgtctggtc tttaccgtca actctgttga gatgaattcc acaccactgc
      841 agccaaagat acttcaacag cgacctcaca tggggtgctg cgagaactgg gttgctccta
      901 aggatgttgg caaagcgctt tgagtttact agaagtttca ttaaaatttg ttggtaagtt
      961 a
//
