LOCUS       NM_001387010             954 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens chromosome 20 open reading frame 204 (C20orf204),
            transcript variant 1, mRNA.
ACCESSION   NM_001387010 XM_024451876
VERSION     NM_001387010.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 954)
  AUTHORS   Lu,C., Shao,X., Zhou,S. and Pan,C.
  TITLE     LINC00176 facilitates CD4+T cell adhesion in systemic lupus
            erythematosus via the WNT5a signaling pathway by regulating WIF1
  JOURNAL   Mol Immunol 134, 202-209 (2021)
   PUBMED   33813201
  REMARK    GeneRIF: LINC00176 facilitates CD4(+)T cell adhesion in systemic
            lupus erythematosus via the WNT5a signaling pathway by regulating
            WIF1.
REFERENCE   2  (bases 1 to 954)
  AUTHORS   Burbano De Lara,S., Tran,D.D.H., Allister,A.B., Polenkowski,M.,
            Nashan,B., Koch,M. and Tamura,T.
  TITLE     C20orf204, a hepatocellular carcinoma-specific protein interacts
            with nucleolin and promotes cell proliferation
  JOURNAL   Oncogenesis 10 (3), 31 (2021)
   PUBMED   33731669
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 954)
  AUTHORS   Dai,L., Niu,J. and Feng,Y.
  TITLE     Knockdown of long non-coding RNA LINC00176 suppresses ovarian
            cancer progression by BCL3-mediated down-regulation of
            ceruloplasmin
  JOURNAL   J Cell Mol Med 24 (1), 202-213 (2020)
   PUBMED   31668012
  REMARK    GeneRIF: Knockdown of long non-coding RNA LINC00176 suppresses
            ovarian cancer progression by BCL3-mediated down-regulation of
            ceruloplasmin.
REFERENCE   4  (bases 1 to 954)
  AUTHORS   Tran,D.D.H., Kessler,C., Niehus,S.E., Mahnkopf,M., Koch,A. and
            Tamura,T.
  TITLE     Myc target gene, long intergenic noncoding RNA, Linc00176 in
            hepatocellular carcinoma regulates cell cycle and cell survival by
            titrating tumor suppressor microRNAs
  JOURNAL   Oncogene 37 (1), 75-85 (2018)
   PUBMED   28869604
  REMARK    GeneRIF: Study identified a novel long intergenic noncoding RNA,
            Linc00176, that plays a role in proliferation and survival of
            hepatocellular carcinoma.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355803.16.
            
            On Sep 18, 2020 this sequence version replaced XM_024451876.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1929724.1,
                                           SRR14038196.1882818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2156266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000636176.2/ ENSP00000489747.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AL355803.16        29314-29458
            146-421             AL355803.16        31059-31334
            422-574             AL355803.16        31428-31580
            575-954             AL355803.16        31754-32133
FEATURES             Location/Qualifiers
     source          1..954
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..954
                     /gene="C20orf204"
                     /gene_synonym="LINC00176; NCRNA00176; PRR17"
                     /note="chromosome 20 open reading frame 204"
                     /db_xref="GeneID:284739"
                     /db_xref="HGNC:HGNC:27655"
     exon            1..145
                     /gene="C20orf204"
                     /gene_synonym="LINC00176; NCRNA00176; PRR17"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..712
                     /gene="C20orf204"
                     /gene_synonym="LINC00176; NCRNA00176; PRR17"
                     /note="proline rich 17; putative proline-rich protein 17;
                     long intergenic non-protein coding RNA 176;
                     uncharacterized protein C20orf204"
                     /codon_start=1
                     /product="uncharacterized protein C20orf204 precursor"
                     /protein_id="NP_001373939.1"
                     /db_xref="CCDS:CCDS86971.1"
                     /db_xref="GeneID:284739"
                     /db_xref="HGNC:HGNC:27655"
                     /translation="MVPPKPALWALLLALLGTAPSRAYSPACSVPDVLRHYRAIIFED
                     LQAAVKWGGAGAEKTRPGSRHFHFIQKNLTRPGSSGRRGRPRASCGAQKEHSILLSIS
                     SLGRTLRGAVAGGRRGALERAAWTVAVRTEAVMRRHCRTLRQRSRRPKMRPARRRGGR
                     RQLLLRALDAVATCWEKLFALRAPASRDS"
     exon            146..421
                     /gene="C20orf204"
                     /gene_synonym="LINC00176; NCRNA00176; PRR17"
                     /inference="alignment:Splign:2.1.0"
     exon            422..574
                     /gene="C20orf204"
                     /gene_synonym="LINC00176; NCRNA00176; PRR17"
                     /inference="alignment:Splign:2.1.0"
     exon            575..954
                     /gene="C20orf204"
                     /gene_synonym="LINC00176; NCRNA00176; PRR17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      924..929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C20orf204"
                     /gene_synonym="LINC00176; NCRNA00176; PRR17"
                     /note="hexamer: AATAAA"
     polyA_site      954
                     /gene="C20orf204"
                     /gene_synonym="LINC00176; NCRNA00176; PRR17"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcctcc aggcagcctg tccagggaag cggttggctg gtgttggacc tggtgcggca
       61 gtgcacaccc tgcccaagga ccccaggatc atgtgcgtgg cctgctggcg ggagtgaggg
      121 agggcaagac cctgaaaggc ccatggtacc ccctaagcct gcactctggg cgctcctgct
      181 ggcgctgctg gggaccgcgc caagccgcgc ctattccccg gcctgcagcg tccccgacgt
      241 gctccgccac tatcgcgcca tcatcttcga ggatctgcag gccgccgtga agtggggcgg
      301 ggcgggggcc gaaaagacca ggccaggctc cagacacttt catttcatac agaaaaacct
      361 gactagaccc gggagctcgg gacggcgggg acggcctcgg gcctcctgtg gcgcccagaa
      421 ggagcacagt atcctcctgt ccatctcgtc cctgggtcgg accctgcgcg gggcggtggc
      481 cgggggccgc cgcggggccc tggagagagc tgcttggacc gtggctgtgc gcaccgaggc
      541 ggtgatgcgg cgccactgca ggacgctgcg ccagcggagc cggcggccca agatgcgccc
      601 tgcccggcgt cgcggcggcc gaaggcagct cctgctgcgc gccctggacg ccgtcgccac
      661 ctgctgggag aagctcttcg cgctgcgcgc cccggcctcc agggactcct agcgcggccc
      721 gtcctggccc tgcgcgggga ggagaaccag cggggccgcg gcagagcctg gagacgcgcc
      781 tcgttctgta gacttgttgg tgacctcggc ccctcgctcg acgcagcccg cgctccccgg
      841 agggcccagg acttggagaa gggagcgcgc ctggccgccg ctgggtcacg gaggaggccc
      901 gccctccacg cgccgaaggc ctcaataaac ggagctggcg ctgcgggtcc ggca
//
