LOCUS       NM_182584               5103 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens chromosome 20 open reading frame 203 (C20orf203),
            mRNA.
ACCESSION   NM_182584
VERSION     NM_182584.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5103)
  AUTHORS   Wu,D.D., Irwin,D.M. and Zhang,Y.P.
  TITLE     De novo origin of human protein-coding genes
  JOURNAL   PLoS Genet 7 (11), e1002379 (2011)
   PUBMED   22102831
REFERENCE   2  (bases 1 to 5103)
  AUTHORS   Li,C.Y., Zhang,Y., Wang,Z., Zhang,Y., Cao,C., Zhang,P.W., Lu,S.J.,
            Li,X.M., Yu,Q., Zheng,X., Du,Q., Uhl,G.R., Liu,Q.R. and Wei,L.
  TITLE     A human-specific de novo protein-coding gene associated with human
            brain functions
  JOURNAL   PLoS Comput Biol 6 (3), e1000734 (2010)
   PUBMED   20376170
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5103)
  AUTHORS   Uhl,G.R., Liu,Q.R., Drgon,T., Johnson,C., Walther,D., Rose,J.E.,
            David,S.P., Niaura,R. and Lerman,C.
  TITLE     Molecular genetics of successful smoking cessation: convergent
            genome-wide association study results
  JOURNAL   Arch Gen Psychiatry 65 (6), 683-693 (2008)
   PUBMED   18519826
REFERENCE   4  (bases 1 to 5103)
  AUTHORS   Saccone,S.F., Pergadia,M.L., Loukola,A., Broms,U., Montgomery,G.W.,
            Wang,J.C., Agrawal,A., Dick,D.M., Heath,A.C., Todorov,A.A.,
            Maunu,H., Heikkila,K., Morley,K.I., Rice,J.P., Todd,R.D.,
            Kaprio,J., Peltonen,L., Martin,N.G., Goate,A.M. and Madden,P.A.
  TITLE     Genetic linkage to chromosome 22q12 for a heavy-smoking
            quantitative trait in two independent samples
  JOURNAL   Am J Hum Genet 80 (5), 856-866 (2007)
   PUBMED   17436240
REFERENCE   5  (bases 1 to 5103)
  AUTHORS   Uhl,G.R., Liu,Q.R., Drgon,T., Johnson,C., Walther,D. and Rose,J.E.
  TITLE     Molecular genetics of nicotine dependence and abstinence: whole
            genome association using 520,000 SNPs
  JOURNAL   BMC Genet 8, 10 (2007)
   PUBMED   17407593
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5103)
  AUTHORS   Wang,D., Ma,J.Z. and Li,M.D.
  TITLE     Mapping and verification of susceptibility loci for smoking
            quantity using permutation linkage analysis
  JOURNAL   Pharmacogenomics J 5 (3), 166-172 (2005)
   PUBMED   15724146
  REMARK    Erratum:[Pharmacogenomics J. 2005;5(3):215-6]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            GU931819.1, BC105014.1, FO393400.1 and BM662904.1.
            
            On May 17, 2019 this sequence version replaced NM_182584.3.
            
            Summary: The protein encoded by this gene is thought to be a
            human-specific protein. Currently available evidence suggests that
            orthologous regions in other organisms contain sequence differences
            that would not support production of a protein product. Genome-wide
            association studies have suggested the possibility that a SNP in
            the 3' UTR, rs17123507, could be associated with nicotine
            addiction. Expression of this gene may be elevated in some
            individuals with Alzheimer's disease. [provided by RefSeq, Mar
            2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GU931820.1, GU931819.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968968,
                                           SAMEA2149004 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000608990.6/ ENSP00000495424.1
            NMD candidate          :: PMID: 20376170
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-939               GU931819.1         1-939
            940-1200            BC105014.1         406-666
            1201-2335           FO393400.1         31746-32880         c
            2336-2457           FO393400.1         23057-23178         c
            2458-4936           FO393400.1         14283-16761         c
            4937-5103           BM662904.1         17-183              c
FEATURES             Location/Qualifiers
     source          1..5103
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..5103
                     /gene="C20orf203"
                     /note="chromosome 20 open reading frame 203"
                     /db_xref="GeneID:284805"
                     /db_xref="HGNC:HGNC:26592"
     exon            1..310
                     /gene="C20orf203"
                     /inference="alignment:Splign:2.1.0"
     exon            311..559
                     /gene="C20orf203"
                     /inference="alignment:Splign:2.1.0"
     exon            560..708
                     /gene="C20orf203"
                     /inference="alignment:Splign:2.1.0"
     CDS             574..1158
                     /gene="C20orf203"
                     /note="alugen"
                     /codon_start=1
                     /product="uncharacterized protein C20orf203"
                     /protein_id="NP_872390.2"
                     /db_xref="CCDS:CCDS13203.1"
                     /db_xref="GeneID:284805"
                     /db_xref="HGNC:HGNC:26592"
                     /translation="MFPRPVLNSRAQAILLPQPPNMLDHRQWPPRLASFPFTKTGMLS
                     RATSVLAGLTAHLWDLGGGAGRRTSKAQRVHPQPSHQRQPPPPQHPGPYQERIWVGGE
                     GWGEVGGLRLSKVGRRDREVGRGLRAPAGRGRAMGGMPRMGTVGDFGQALSSLAWTST
                     CFQDFCLPSLPGKLPAPLISKQQFLSNSSRSLFN"
     exon            709..2335
                     /gene="C20orf203"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2457
                     /gene="C20orf203"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..5103
                     /gene="C20orf203"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5063..5068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C20orf203"
                     /note="hexamer: AATAAA"
     regulatory      5077..5082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C20orf203"
                     /note="hexamer: AATAAA"
     polyA_site      5083
                     /gene="C20orf203"
                     /note="major polyA site"
     polyA_site      5103
                     /gene="C20orf203"
                     /note="major polyA site"
ORIGIN      
        1 acatagccag tgggtctgag ctgacttttc ttcccaagcc tgtgtgatcc ccaaaaccct
       61 tggctgcccc cactctgccc cccgcctccc agcccttcca gctgcagcct tttcactcat
      121 tccaccacca ctcagctctg agtggctacg ctggcgggct ctctgctttg cgtcggagac
      181 atcacagtga gcaaaggcag atatgtttta tgtgcccttg aagaatctcc cagacaaacg
      241 tgtcattgca gtcggagcca aatggccggg gcaggtggca cagatgaatg ccgggcagag
      301 gagcctgcag actggggtcc ccttaaaggc agagtgaatc tcagattcat cttagtccct
      361 tcctggggtc ttgttcagga ccctgcatcc agtagatgct caacaaatgt caacatagga
      421 atccaggtcc catcctctcc tcactcaagg gatccaaggc tgcctcttcc tcttccgtag
      481 tggtgtggct ttgcagaagt cacttaagct ctctaatcct cctcctcaga gtgccagact
      541 gcagctgcca catgaagaga gagagggtct cctatgtttc ctaggcctgt cttgaactcc
      601 cgggctcaag cgattctcct gcctcagcct cccaacatgc tggatcacag gcagtggcca
      661 cctcgcctgg ccagttttcc ctttacaaaa actggaatgc tgagccgggc cacatcagtc
      721 ttggctggac tcactgccca cctctgggac cttggcggtg gggcgggaag gaggacctca
      781 aaggctcagc gagtccaccc ccagcccagc caccagcgcc agcctcctcc tccgcaacac
      841 ccaggccctt atcaggaaag gatttgggtt ggtggggagg ggtgggggga agttggaggc
      901 ctcaggctca gcaaggtggg tcggagagat agggaagtgg ggagggggct gcgggcccct
      961 gctgggcggg ggagggcaat gggagggatg cccagaatgg gcacggtggg ggactttggc
     1021 caagctctgt cctcgctggc ctggacctca acatgtttcc aggacttctg cctcccatcc
     1081 ttgccaggca agttgcctgc acctttaatt agcaagcagc agtttctctc caattcatca
     1141 cggtcgctgt ttaattagcc gagcccaggg cgcccccacc cccagctctg cctgcctgtc
     1201 ctaccaaggc caccaccacc tcagggtgtc ccctgttacc accccccaca atcattctgc
     1261 tccccagagt gggggatggg cccggcacgc ccagctgaaa cctcaaggag attctgggca
     1321 ccggcgcttg tattcaaggc attcagcaaa catgattagg gaccgaggct gtgccaggct
     1381 ggctctgggt agaaccccgg ccggacatgc ggggcaggct ctggtcctgt ccagctgctg
     1441 gagaatggct tctcccttgg gaggcgctgg cacatctctc tggcttggtc cctgagtgct
     1501 gggaggaggc tgcagtactc ctgtgtgtca ctcccacccc acatccggaa agggacacca
     1561 tgtcttcctc ttcctctctc ttccagagcc cagaaagctc ctctgagaat gctggacctc
     1621 aggacagggg cccatgctct gcacccggcc ctcagcagcc agatcctaga ggcccagtcc
     1681 aagctgtggg ccaagggagc ggggcgggct gaggcctgct ttgtgtcggc agggtctggg
     1741 gaattgggag cactggcggg agcccatggt ccggggccga accagccccc ttctgtttcc
     1801 ctgaagaagg gtgaggctga gggccctcgg aacagagccc ctgtgtcatt ctgtgcaggg
     1861 ccgggatagc cactagtcac tgtgggcaga agcaagaagc agaggctcag gctccatccc
     1921 aagcctgtgc tcctgctggg ctgtgggagg tgtgaccctt ccactgtttc gtagactgag
     1981 aacatggagg gactggcatt tgctgtgtta ccctgtggtg ccatcagcgt gttgtgacag
     2041 gggcaggagg agtgtgctag aacccaccca ctctggtact gcccatctct gtggccttgg
     2101 gccagccacc aaaccgtacc atgccttagt tcccctatga ttcatagctg cttcatgggc
     2161 tgatgtgagg attaaacagc ttactatgtg ttgggtctgg ttttgtttgg ctttgttttg
     2221 ttttttgaga caaggtctca ctctgctgct caggctggag tgcagtggtg caatcacagc
     2281 tcacagcagg ctccacctct caggctcaag cgatcctccc atctcagcct ccctgagtct
     2341 cgctcttttg cccaggctgg atggagtgca gtggcgtgat ctcagctcgc tgcaacctcc
     2401 accttccggg ttcaagtgat tctcctatct cagcctcctg agtagctggg attacagact
     2461 ccagcataac cttctccagg aagcttttcc agagccccca ggctaggaac ctccccccaa
     2521 cccctgaact caagccccag cagcccgtgc ctgcgccatc tccatcagag ctgcatctct
     2581 ctgggtctct gggtaacaag tgccatttct ttgttgtttt ctgtgtcccc caaggacaaa
     2641 gctcaggctg gattcatctc ggaattccca acaccggggt agaactggct catttcaatt
     2701 tcagtcaatg tttgttgagg aaaggagtga agagttggac acatgaatga acgcatgaaa
     2761 cagtccggag tggggaagct gaagctcagg catcaggatc cgggagaagc atccagtcca
     2821 ggcggacggg gtggaaggtt cagagcaggg gccccaagtc aggagtaggg aggcagacgg
     2881 caagacctcc ttccatgaaa ggaggctggg accaggggac caggtagtgc aacgcggtga
     2941 gggggctgtc agggcgactg gccggaggag tcagaggcag gaggcaccac caggttacag
     3001 acaaggacct tctacaagag ggaaacgtgt catgggctct ggagcccctg tccaggttca
     3061 aattgtgacc ctgtgccagg gacagcttct ttgtgcctca gtttttccca taaaatgagg
     3121 ataataatac ttcattcatg cctttttttc ccctcaacaa acatttgttg tatgtctgct
     3181 gtgggcccag gacaggaggc tgagaaggag ctgaccacag tggtcacaca gccaagccct
     3241 gctgctgaga tctgacccca gttcgcctgt cacaagttct atctgtgcct cgttgtctgc
     3301 ctcctggggc tgttatgagg gctgaagaag gggcaggcac agaggagaca cttactatat
     3361 gatcattgtc ctcctagagt atcatcacca tcaggtggac ttcagtggcc atcccaggcc
     3421 tccacggatc aaccacaaga tcttggagaa tgtccttacc ctccaagcct cagtttacct
     3481 ttagggtgac caaccatcct ggtttgtcca aaactgaggg ttttcctggc acagtcccag
     3541 gcaaactggg atggtgagtc actgatatag tttgactctg tgtccccacc aaatctcacc
     3601 ttgaatttta ataatcccta ggtgtcaaga gcaggaccaa gtagagataa ttgaataatg
     3661 gtggcagttt cccccatgct gttctcatga tagtgagtga gttctcacga gatctgatgg
     3721 ttttataagc agcttccccc tttgctcagt atcactctcc ctcctgccgc cctgtgaaga
     3781 gctgccttcc accatgattg taagtttcct gaggcctccc cagccacgca gaactgtgag
     3841 tcaattaaac ctcttttctt tataaattac cccagtctcg ggcatttctt cacagcagcg
     3901 tgagaacaga ctaatcccgt caccctggtt tcctcatctc taacacaggg accacctgcc
     3961 tcccagggct gttgtgcaga acagaaataa gcctatggaa aaggcagaaa accatggagc
     4021 cagaattcta gatctggtta catgaatact aaagactttt gcatgccatg gaattctagg
     4081 catgaaaaag aacgaggcgg tcccgtgtac tgctgtggaa gaagctctga gatacatgtt
     4141 ttttttgtga aaaaggccag atacagcgca ctttgtgggg agcgcttctg ttagtaccaa
     4201 ggagggggca ggaacacacg tgcatgtgct ccagtgcgca catgggttct cccgggcggg
     4261 gactgggggc tgaggagaaa agacttgttt ttcactgtac atccctttgc tttgtttgaa
     4321 ttattttacc cctttgtttt cagtagctgg ccgaaaaact tcccaagctt ccatgtgtca
     4381 aaaagaactc actgaacgag atttaaaggc caaagttagg gagtaggaaa tgtgtctagc
     4441 tcagggccca gcatctaagg agtgctccat gaaaggcctt ctcccctctc ccactcctga
     4501 ccttgctgac tgctgggagt gcaggggcac agacgggctg ttgcctcccc cagtgcggta
     4561 tttgtgaggc tcaaatgcaa gcccaggctg gggagactgc tctgggttcc acgcggcatc
     4621 ctgcctaagc cctgggggtc ctagaggtca ctggctccct tctctgcctg catgtctcag
     4681 gtcgccctct ggccaattct gaagtcctgc cctgcctcaa ggagcagagg tggcagaggt
     4741 gggcccaccg cacagggtaa atgtcccggt gtcacatacc tccagattgc agggacctgc
     4801 gtatgctact gctgctgtgg aaaccagctc tctctggctc tggccttggg gagagggagc
     4861 cacagtggat ttaggaagag tctccagatg tagcttgaga ctaccaaaca ggcctgaccc
     4921 ccacagaccc tgcctcttat gagcgcccag actgagccct gcttcaggct cccagccatg
     4981 tggccagctg cttttcttct ttaattttta gcatcagacg aatatttcag gaaaatattc
     5041 tcattgtaaa atctcaaaca ttaataaaat gtagtgaata aaaggccatg taattcctct
     5101 tta
//
