LOCUS       NM_001145350            1051 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens chromosome 20 open reading frame 173 (C20orf173),
            transcript variant 1, mRNA.
ACCESSION   NM_001145350 XM_001126789 XM_001130725 XM_001719105 XR_042063
            XR_042064 XR_042065
VERSION     NM_001145350.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1051)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1051)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FO393401.1.
            
            On Aug 22, 2019 this sequence version replaced NM_001145350.1.
            
            Transcript Variant: This variant (1) encodes the protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.380432.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000444723.3/ ENSP00000403566.1
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                FO393401.1         120059-120152       c
            95-454              FO393401.1         119565-119924       c
            455-633             FO393401.1         119201-119379       c
            634-727             FO393401.1         118951-119044       c
            728-779             FO393401.1         118733-118784       c
            780-1051            FO393401.1         117479-117750       c
FEATURES             Location/Qualifiers
     source          1..1051
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..1051
                     /gene="C20orf173"
                     /gene_synonym="dJ477O4.4"
                     /note="chromosome 20 open reading frame 173"
                     /db_xref="GeneID:140873"
                     /db_xref="HGNC:HGNC:16166"
     exon            1..94
                     /gene="C20orf173"
                     /gene_synonym="dJ477O4.4"
                     /inference="alignment:Splign:2.1.0"
     exon            95..454
                     /gene="C20orf173"
                     /gene_synonym="dJ477O4.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..754
                     /gene="C20orf173"
                     /gene_synonym="dJ477O4.4"
                     /note="uncharacterized protein C20orf173"
                     /codon_start=1
                     /product="uncharacterized protein C20orf173 precursor"
                     /protein_id="NP_001138822.1"
                     /db_xref="CCDS:CCDS46594.1"
                     /db_xref="GeneID:140873"
                     /db_xref="HGNC:HGNC:16166"
                     /translation="MKRWQIFVLWVFWVLILWLMTPYLDLTPESAPQEKRMYLVPQHC
                     DCPWFSSGKCGCPSETLNCSSCHHTADEWNWLDACSRKTMGYLMRTRESMTSDTVLWW
                     LGMNSGSELGKLWRKLFKGIPRLSVSHFDFYCGTCVLLGRPQIPQGSSLGNDIDQYPV
                     VFRNASDQGSWMQLEMLLRKLSDLVWTSDALSDKILEDGLVP"
     exon            455..633
                     /gene="C20orf173"
                     /gene_synonym="dJ477O4.4"
                     /inference="alignment:Splign:2.1.0"
     exon            634..727
                     /gene="C20orf173"
                     /gene_synonym="dJ477O4.4"
                     /inference="alignment:Splign:2.1.0"
     exon            728..779
                     /gene="C20orf173"
                     /gene_synonym="dJ477O4.4"
                     /inference="alignment:Splign:2.1.0"
     exon            780..1051
                     /gene="C20orf173"
                     /gene_synonym="dJ477O4.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1029..1034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C20orf173"
                     /gene_synonym="dJ477O4.4"
                     /note="hexamer: AATAAA"
     polyA_site      1051
                     /gene="C20orf173"
                     /gene_synonym="dJ477O4.4"
                     /note="major polyA site"
ORIGIN      
        1 actgaggtat tccttcccct ctcaggacta gccacatgct gtctctctgc cctggcctct
       61 tccaccccat gcccagtcag agaccgtttt gagggtagag aagccagtct acggcccacc
      121 acgggagcca ccgcctgggc cagacatgaa gcgctggcag atttttgtcc tgtgggtctt
      181 ttgggtgctc atcctctggc tgatgacccc ctatctggat ctgacacctg aatcagcacc
      241 ccaggaaaaa cgaatgtact tggtaccaca gcattgcgac tgcccttggt tcagttccgg
      301 gaagtgtggc tgcccttctg agaccctcaa ctgctcctcc tgccaccaca cagccgacga
      361 atggaactgg cttgatgcgt gctccaggaa gactatgggg tacctgatga ggacaagaga
      421 gtctatgacc tctgacactg tgctctggtg gttgggcatg aactcaggga gcgagcttgg
      481 gaaattgtgg aggaagctgt ttaaagggat tcccaggctc tcggtgagcc attttgattt
      541 ctattgtggg acttgtgtgc tgttggggcg cccacagatc ccgcagggct ccagccttgg
      601 caacgacatc gaccaatacc ccgtggtttt caggaatgcc agcgaccagg gctcctggat
      661 gcagctggag atgctactgc ggaagctctc tgacctggtg tggacttcag atgctctaag
      721 tgataagatt ttggaagatg gtctggttcc ctagtggagt ggaagatagc aaagacacgg
      781 tcaccctctt tggatttgga tcagaatagc aaggaaagtg tttctatcac tggaaggagg
      841 ataatcagac caagggctcc aaggaaatac tgcccacgtc tagtgcagga gcagaaatcg
      901 aagtcatcca tcagctagcg tgtggacaag ctcactattc acacaagctc agcctagctg
      961 agtccataca aatcctattt ctgggtgggt aaagggcagg aggaaattgt aagatcagtc
     1021 tggtactgaa taaaatcctg gcctgattgt c
//
