LOCUS       NM_001256538             617 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens chromosome 20 open reading frame 141 (C20orf141),
            transcript variant 2, mRNA.
ACCESSION   NM_001256538
VERSION     NM_001256538.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 617)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 617)
  AUTHORS   Sprooten,E., Fleming,K.M., Thomson,P.A., Bastin,M.E., Whalley,H.C.,
            Hall,J., Sussmann,J.E., McKirdy,J., Blackwood,D., Lawrie,S.M. and
            McIntosh,A.M.
  TITLE     White matter integrity as an intermediate phenotype: exploratory
            genome-wide association analysis in individuals at high risk of
            bipolar disorder
  JOURNAL   Psychiatry Res 206 (2-3), 223-231 (2013)
   PUBMED   23218918
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK312218.1 and BX094374.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001256538.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB036876.1, AK312218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000603872.2/ ENSP00000473907.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               AK312218.1         1-377
            378-617             BX094374.1         347-586
FEATURES             Location/Qualifiers
     source          1..617
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..617
                     /gene="C20orf141"
                     /gene_synonym="dJ860F19.4"
                     /note="chromosome 20 open reading frame 141"
                     /db_xref="GeneID:128653"
                     /db_xref="HGNC:HGNC:16134"
     exon            1..31
                     /gene="C20orf141"
                     /gene_synonym="dJ860F19.4"
                     /inference="alignment:Splign:2.1.0"
     exon            32..324
                     /gene="C20orf141"
                     /gene_synonym="dJ860F19.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..562
                     /gene="C20orf141"
                     /gene_synonym="dJ860F19.4"
                     /codon_start=1
                     /product="uncharacterized protein C20orf141"
                     /protein_id="NP_001243467.1"
                     /db_xref="CCDS:CCDS13034.1"
                     /db_xref="GeneID:128653"
                     /db_xref="HGNC:HGNC:16134"
                     /translation="MTRLCLPRPEAREDPIPVPPRGLGAGEGSGSPVRPPVSTWGPSW
                     AQLLDSVLWLGALGLTIQAVFSTTGPALLLLLVSFLTFDLLHRPAGHTLPQRKLLTRG
                     QSQGAGEGPGQQEALLLQMGTVSGQLSLQDALLLLLMGLGPLLRACGMPLTLLGLAFC
                     LHPWA"
     exon            325..617
                     /gene="C20orf141"
                     /gene_synonym="dJ860F19.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      593..598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C20orf141"
                     /gene_synonym="dJ860F19.4"
                     /note="hexamer: AATATA"
     polyA_site      617
                     /gene="C20orf141"
                     /gene_synonym="dJ860F19.4"
                     /note="major polyA site"
ORIGIN      
        1 actcccagaa tgctgaccaa agtgggagga gcactaggtc ttcccgtcac ctccacctct
       61 ctccatgacc cggctctgct tacccagacc cgaagcacgt gaggatccga tcccagttcc
      121 tccaaggggc ctgggtgctg gggaggggtc aggtagtcca gtgcgtccac ctgtatccac
      181 ctggggccct agctgggccc agctcctgga cagtgtccta tggctggggg cactaggact
      241 gacaatccag gcagtctttt ccaccactgg cccagccctg ctgctgcttc tggtcagctt
      301 cctcaccttt gacctgctcc ataggcccgc aggtcacact ctgccacagc gcaaacttct
      361 caccaggggc cagagtcagg gggccggtga aggtcctgga cagcaggagg ctctactcct
      421 gcaaatgggt acagtctcag gacaacttag cctccaggac gcactgctgc tgctgctcat
      481 ggggctgggc ccgctcctga gagcctgtgg catgcccttg accctgcttg gcctggcttt
      541 ctgcctccat ccttgggcct gagagcccct ccccacaact cagtgtcctt caaatataca
      601 atgaccaccc ttcttca
//
