LOCUS       NM_001134734            3050 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 94 (C1orf94),
            transcript variant 1, mRNA.
ACCESSION   NM_001134734
VERSION     NM_001134734.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3050)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3050)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3050)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3050)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 3050)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3050)
  AUTHORS   Steffens,M., Leu,C., Ruppert,A.K., Zara,F., Striano,P.,
            Robbiano,A., Capovilla,G., Tinuper,P., Gambardella,A., Bianchi,A.,
            La Neve,A., Crichiutti,G., de Kovel,C.G., Kasteleijn-Nolst
            Trenite,D., de Haan,G.J., Lindhout,D., Gaus,V., Schmitz,B.,
            Janz,D., Weber,Y.G., Becker,F., Lerche,H., Steinhoff,B.J.,
            Kleefuss-Lie,A.A., Kunz,W.S., Surges,R., Elger,C.E., Muhle,H., von
            Spiczak,S., Ostertag,P., Helbig,I., Stephani,U., Moller,R.S.,
            Hjalgrim,H., Dibbens,L.M., Bellows,S., Oliver,K., Mullen,S.,
            Scheffer,I.E., Berkovic,S.F., Everett,K.V., Gardiner,M.R.,
            Marini,C., Guerrini,R., Lehesjoki,A.E., Siren,A., Guipponi,M.,
            Malafosse,A., Thomas,P., Nabbout,R., Baulac,S., Leguern,E.,
            Guerrero,R., Serratosa,J.M., Reif,P.S., Rosenow,F., Morzinger,M.,
            Feucht,M., Zimprich,F., Kapser,C., Schankin,C.J., Suls,A.,
            Smets,K., De Jonghe,P., Jordanova,A., Caglayan,H., Yapici,Z.,
            Yalcin,D.A., Baykan,B., Bebek,N., Ozbek,U., Gieger,C.,
            Wichmann,H.E., Balschun,T., Ellinghaus,D., Franke,A., Meesters,C.,
            Becker,T., Wienker,T.F., Hempelmann,A., Schulz,H., Ruschendorf,F.,
            Leber,M., Pauck,S.M., Trucks,H., Toliat,M.R., Nurnberg,P.,
            Avanzini,G., Koeleman,B.P. and Sander,T.
  CONSRTM   EPICURE Consortium; EMINet Consortium
  TITLE     Genome-wide association analysis of genetic generalized epilepsies
            implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
  JOURNAL   Hum Mol Genet 21 (24), 5359-5372 (2012)
   PUBMED   22949513
REFERENCE   7  (bases 1 to 3050)
  AUTHORS   Lambert,B., Vandeputte,J., Remacle,S., Bergiers,I., Simonis,N.,
            Twizere,J.C., Vidal,M. and Rezsohazy,R.
  TITLE     Protein interactions of the transcription factor Hoxa1
  JOURNAL   BMC Dev Biol 12, 29 (2012)
   PUBMED   23088713
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3050)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   9  (bases 1 to 3050)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   10 (bases 1 to 3050)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115286.3, DB456109.1, BC064845.1 and AW117410.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001134734.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064845.1, SRR5189667.401714.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000488417.2/ ENSP00000435634.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC115286.3         15566-15610
            46-535              DB456109.1         1-490
            536-763             AC115286.3         16101-16328
            764-2706            BC064845.1         1-1943
            2707-3050           AW117410.1         1-344               c
FEATURES             Location/Qualifiers
     source          1..3050
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..3050
                     /gene="C1orf94"
                     /note="chromosome 1 open reading frame 94"
                     /db_xref="GeneID:84970"
                     /db_xref="HGNC:HGNC:28250"
     exon            1..1203
                     /gene="C1orf94"
                     /inference="alignment:Splign:2.1.0"
     CDS             884..2680
                     /gene="C1orf94"
                     /note="isoform a is encoded by transcript variant 1;
                     uncharacterized protein C1orf94"
                     /codon_start=1
                     /product="uncharacterized protein C1orf94 isoform a"
                     /protein_id="NP_001128206.1"
                     /db_xref="CCDS:CCDS44108.1"
                     /db_xref="GeneID:84970"
                     /db_xref="HGNC:HGNC:28250"
                     /translation="MRGGGGCVLALGGQRGFQKERRRMASGNGLPSSSALVAKGPCAL
                     GPFPRYIWIHQDTPQDSLDKTCHEIWKRVQGLPEASQPWTSMEQLSVPVVGTLRGNEL
                     SFQEEALELSSGKDEISLLVEQEFLSLTKEHSILVEESSGELEVPGSSPEGTRELAPC
                     ILAPPLVAGSNERPRASIIVGDKLLKQKVAMPVISSRQDCDSATSTVTDILCAAEVKS
                     SKGTEDRGRILGDSNLQVSKLLSQFPLKSTETSKVPDNKNVLDKTRVTKDFLQDNLFS
                     GPGPKEPTGLSPFLLLPPRPPPARPDKLPELPAQKRQLPVFAKICSKPKADPAVERHH
                     LMEWSPGTKEPKKGQGSLFLSQWPQSQKDACGEEGCCDAVGTASLTLPPKKPTCPAEK
                     NLLYEFLGATKNPSGQPRLRNKVEVDGPELKFNAPVTVADKNNPKYTGNVFTPHFPTA
                     MTSATLNQPLWLNLNYPPPPVFTNHSTFLQYQGLYPQQAARMPYQQALHPQLGCYSQQ
                     VMPYNPQQMGQQIFRSSYTPLLSYIPFVQPNYPYPQRTPPKMSANPRDPPLMAGDGPQ
                     YLFPQGYGFGSTSGGPLMHSPYFSSSGNGINF"
     exon            1204..1892
                     /gene="C1orf94"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2153
                     /gene="C1orf94"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2329
                     /gene="C1orf94"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2407
                     /gene="C1orf94"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2604
                     /gene="C1orf94"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..3050
                     /gene="C1orf94"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3027..3032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf94"
                     /note="hexamer: GATAAA"
     polyA_site      3050
                     /gene="C1orf94"
                     /note="major polyA site"
ORIGIN      
        1 gcgcaccgag ccgttgcgtt tgaaacccac agaaagaatt cccccgctcg acgacggcga
       61 gggtgtggga gctactggca ggcaaattgg tgggagccgc ccggcccagc ctgccttgcc
      121 gagtcagcgc gctcttgagc cgctgggccc ttcccggtgc ccgcctggca gcgcggcgcg
      181 gctggggcag gggtctgctg ggggccgggg actaagggct gtgggcccat ccacacacgc
      241 ctcatccctt ctttccgggg gcagcagagc agcagcggga gaccgggagc aggaggggta
      301 gggcgagaga aaagcaggac ctgggccggg ggtgggagtc gggccgttga cgctcgctct
      361 gcgaggggct ccctgggaac gcccaggcga gcgcctcctg cggggccccg ccccccgagt
      421 gcctacaatg gtgccaggcc cgcacccagt cctccgcgtg gcttagcggg acagcatggg
      481 ctgagcccag gcgccgaaag ttgtcacggc ggcgtcgcaa gggggcagtg ccagggactg
      541 tggggagagc cagccctccc cttccagctg ttcccagatg tcattctgcc cgcccaggcg
      601 cctggttcct gagctccgca gcattccact gttcctaagc tactggtttt tgttgacttt
      661 taaatatttt cttctaaggg agagggggag ggaggcaaaa gtcaggaaag agcaaataaa
      721 aacaaatcaa aataagccct cccctcccca aaagaaagct gtcctccacc cacccctccc
      781 acacaaatag aaggcctctg aacctaacca ccttgctgga gcgaaagcca gacagaactg
      841 acccacttct gccaagcccc atcctcatct ccctttctgg tgaatgaggg gtggtggtgg
      901 ttgtgttcta gccctgggtg gacagagggg cttccagaaa gagaggagga ggatggccag
      961 cgggaatggg cttccttcat cctcggccct ggtggccaag ggcccctgcg ccctgggccc
     1021 attccccaga tacatctgga tccaccagga cacaccccaa gacagcctag acaagacttg
     1081 ccatgaaatc tggaagagag ttcaaggcct gcctgaggcc tcacagccct ggacctccat
     1141 ggagcagctc tctgtccctg tggttggaac tctaagaggc aatgagctca gctttcaaga
     1201 agaagctctg gagctcagca gtggcaaaga tgagatctcc ttgttggtgg aacaggagtt
     1261 cctaagcctc accaaagagc actcgatcct ggtcgaagag agttctgggg agctggaggt
     1321 acccggcagc tctcccgagg ggaccagaga gctggctccc tgcattcttg cccctcctct
     1381 agtggcaggc agtaatgagc gccccagagc ctccatcatt gtcggagaca agcttctgaa
     1441 gcagaaggtg gccatgcccg ttatcagcag caggcaggac tgtgattctg ccacttctac
     1501 tgtcacagac attctgtgtg ccgccgaggt caagagcagc aaggggacag aggacagggg
     1561 ccgcatccta ggtgactcca acttgcaagt cagcaagctt ctgtcccagt tcccactgaa
     1621 gtccactgag acatccaagg tccctgacaa caagaatgtg ctggacaaga caagggtcac
     1681 caaggacttc ctacaggaca acctgttcag tggccctgga cccaaggagc ccacagggct
     1741 gagcccattt ctgctgctgc ctccccgacc tcctcctgca cgtcctgaca agctccctga
     1801 gctccctgct cagaagaggc agctcccagt gtttgccaag atctgttcca agcccaaggc
     1861 tgaccctgct gtggagaggc accacttgat ggaatggagc cctggcacca aggagccaaa
     1921 aaagggtcaa gggagcctct ttctcagcca gtggccccag agccagaagg acgcctgtgg
     1981 tgaggagggt tgctgtgacg cagtgggcac cgcatcactg accctgccgc ccaagaaacc
     2041 tacatgtcca gccgagaaga acttgctcta tgagttcctt ggggccacca agaacccaag
     2101 cgggcagccg agacttcgaa acaaagtgga agtggatggg ccggagctga aatttaacgc
     2161 acctgtgacg gttgctgaca agaacaaccc gaagtacaca gggaatgttt tcactccaca
     2221 ctttcctaca gccatgacct cagcaaccct gaaccagcca ctctggctca acctgaacta
     2281 tccacctcca ccagtgttca cgaatcactc taccttcttg cagtatcagg gcctgtaccc
     2341 acagcaggca gcgaggatgc cctatcagca ggctttgcac ccgcagctgg gatgttactc
     2401 ccaacaggtg atgccataca acccacagca gatgggacag cagatcttcc gctcttccta
     2461 cacccctctg ctgagctaca tcccttttgt ccagcccaat tatccctacc ctcagaggac
     2521 acctccaaag atgtctgcca acccccgaga ccctccccta atggcaggag atggaccgca
     2581 gtacctcttt ccccaaggat atgggttcgg ctcgacatcc ggagggccct tgatgcacag
     2641 cccctatttt tcttccagtg ggaatggcat aaacttttag atctcctctt ctcccttctc
     2701 ctcccttagc ccttggatca ggactagggg ctctgatttt tggattctgc aaaagcttgg
     2761 tatgaagttt ggaaaagcaa ggttctgacc aggtcacaga caaaacagca agaccagatt
     2821 catctattgg ccaacactga cacaaaaata gccctcctca cacatggcac aagctacaca
     2881 cacacacaca cacatgaccc tcatattcat acttgcttgc tcaaccactt atgcatctat
     2941 atttagctaa catgagtgat ttttgttttt gtttttgttg gtaaaataga agtaagacac
     3001 ttaattttag aaagtttgta ttttatgata aaagtatgag ctacttgaaa
//
