LOCUS       NM_152377               2028 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 87 (C1orf87), mRNA.
ACCESSION   NM_152377
VERSION     NM_152377.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2028)
  AUTHORS   Blackburn,K., Bustamante-Marin,X., Yin,W., Goshe,M.B. and
            Ostrowski,L.E.
  TITLE     Quantitative Proteomic Analysis of Human Airway Cilia Identifies
            Previously Uncharacterized Proteins of High Abundance
  JOURNAL   J Proteome Res 16 (4), 1579-1592 (2017)
   PUBMED   28282151
REFERENCE   2  (bases 1 to 2028)
  AUTHORS   Lindskog,C., Fagerberg,L., Hallstrom,B., Edlund,K., Hellwig,B.,
            Rahnenfuhrer,J., Kampf,C., Uhlen,M., Ponten,F. and Micke,P.
  TITLE     The lung-specific proteome defined by integration of
            transcriptomics and antibody-based profiling
  JOURNAL   FASEB J 28 (12), 5184-5196 (2014)
   PUBMED   25169055
REFERENCE   3  (bases 1 to 2028)
  AUTHORS   Delgado,A.P., Brandao,P., Chapado,M.J., Hamid,S. and Narayanan,R.
  TITLE     Open reading frames associated with cancer in the dark matter of
            the human genome
  JOURNAL   Cancer Genomics Proteomics 11 (4), 201-213 (2014)
   PUBMED   25048349
REFERENCE   4  (bases 1 to 2028)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD707889.1 and BC027878.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152377.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027878.1, AK124828.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371201.3/ ENSP00000360244.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CD707889.1         38-53
            17-2028             BC027878.1         1-2012
FEATURES             Location/Qualifiers
     source          1..2028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.1"
     gene            1..2028
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /note="chromosome 1 open reading frame 87"
                     /db_xref="GeneID:127795"
                     /db_xref="HGNC:HGNC:28547"
                     /db_xref="MIM:618860"
     exon            1..81
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /inference="alignment:Splign:2.1.0"
     exon            82..215
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1749
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /note="carcinoma-related EF-hand protein"
                     /codon_start=1
                     /product="uncharacterized protein C1orf87"
                     /protein_id="NP_689590.1"
                     /db_xref="CCDS:CCDS614.1"
                     /db_xref="GeneID:127795"
                     /db_xref="HGNC:HGNC:28547"
                     /db_xref="MIM:618860"
                     /translation="MSSAWKTPRGSDAMPEIMVKIIGSKHFQYLVEKPKIKENDSLKT
                     ETQTMHQKPMTDNARQMSRDTPVPINFTDQQTTDNPDDVKEKKHPENNQKSENNQKLL
                     TGANSSRFLDGNIPSQANVHCSSVPTGDQSLSYVHGIPRRKLRDWSLEQMVRGSSDQP
                     EDIGQSPSGTTNEDAFLLALVRRELKSRPLSSNLLEKLQKELKILDPISSGFLLQSQL
                     SRLFLKHEVPLQLPTVKILCQRFSKRGSPEMVNYEKLLWFLNSAASDYPQQNKAAADL
                     RKTESHGTHSQSTPPQHSSSQPEVNRSLLEILKMALRTTNGRLNIDNLNLSFRKEDRS
                     FSGCLPLPKVRAICGKHGLYLTLSLLETLLNHQDLGYQNEIKWQNFVEMLTRASSDLL
                     SDLPTGKNEKKAPAPPMEPEVPEMSQSKTEHMKTPEEELQPESSPAETSACKDPLKPL
                     KIRPVSQPFVNPAVKNKAEECETWIDRFRKLENALYLCDLSNTGVLEKERARRLIHNY
                     NLIYNLSLSPQKIDQALRRFRSGENMLLEPALRYLKEL"
     exon            216..450
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /inference="alignment:Splign:2.1.0"
     exon            451..591
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /inference="alignment:Splign:2.1.0"
     exon            592..855
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /inference="alignment:Splign:2.1.0"
     exon            856..971
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1137
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1235
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1300
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1380
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1588
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..2028
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2006..2011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /note="hexamer: AATAAA"
     polyA_site      2028
                     /gene="C1orf87"
                     /gene_synonym="CREF"
                     /note="major polyA site"
ORIGIN      
        1 gggtctgaga gtgtcagctt cctggggaga agcacggacc gcgcacctct gagctgccag
       61 ggtggggacg ctgccctagc gggatctgaa gggattttga aaggaatcat gtcttcagcc
      121 tggaagactc cccgtggatc agatgcaatg cctgagatca tggtgaaaat cattggaagt
      181 aaacactttc aatacctcgt ggagaagcca aagatcaagg agaatgacag cttgaaaaca
      241 gaaacccaaa caatgcacca gaaaccaatg actgataatg caaggcagat gagcagagac
      301 accccagttc ccattaactt cactgatcag caaaccactg ataatccaga tgatgtgaaa
      361 gagaaaaagc acccagagaa caaccagaaa tcagaaaaca accagaaact actaacaggg
      421 gcaaacagta gcagattcct ggatggcaat attcccagtc aagcaaatgt ccactgcagc
      481 tctgtaccaa ccggagacca gtccttatcc tatgtgcatg gcattcccag gagaaagctt
      541 agagactggt ccttggaaca gatggtgaga ggcagctctg accaacctga ggatattggc
      601 cagagcccaa gtgggacaac aaatgaagac gcttttcttc ttgccctggt cagaagagaa
      661 ctcaagtcac gtcctttgag ttccaactta ttagaaaagc ttcagaaaga gctgaagatc
      721 ctggacccaa tctcttcagg atttcttctc caatctcagc tgagccgcct ctttttgaag
      781 catgaagtcc ctctacagtt accaacagtt aaaatccttt gtcagagatt ttctaagagg
      841 ggttctcctg aaatggtgaa ttatgaaaag ctactctggt ttttaaacag tgcagcatca
      901 gattatccac agcaaaataa agcagctgca gacctgagaa aaactgagag tcatggcact
      961 catagccaaa gcactccacc tcagcactcc agctcacagc cagaagtgaa caggagtctg
     1021 ttggagattt tgaagatggc actaaggaca accaatggca gactcaacat agacaatctc
     1081 aatctgagtt ttcgaaaaga agatcgctcg ttctctggct gcctccctct acctaaggtc
     1141 agggctatat gtgggaagca tggattatat ctgaccctga gcctgctgga aacattgctt
     1201 aaccatcaag atttgggtta ccaaaatgaa ataaaatggc agaattttgt tgagatgctg
     1261 accagagctt cttctgattt gttatctgat ttgcctacag ggaagaatga aaagaaagcc
     1321 cctgcccctc caatggagcc tgaagtcccc gagatgtctc aaagcaaaac tgaacatatg
     1381 aaaactccag aagaggagct gcagccagaa agctctcctg ctgaaacttc agcctgcaaa
     1441 gatcctctga aacctttaaa gatcaggcca gtctcccagc ccttcgtgaa tccagctgtg
     1501 aagaacaagg ctgaggaatg tgagacgtgg atagacaggt tcaggaagct ggaaaatgcc
     1561 ctctacctgt gtgatctgag taacacagga gttctggaga aggaacgagc cagacgcctc
     1621 attcacaact acaatctcat ttacaacctg tccctgagcc ctcagaaaat cgaccaggcc
     1681 ttgcgcagat tccgttcggg agaaaatatg ctcttggagc cagcactgcg gtacttaaag
     1741 gagctatgat aacaagccca tattgtgaga acagatgttt cccttatctc cctttttacc
     1801 cagacacatg tttctcccca gcctaagtgt agtggcggag gcattgtcag agtggaggcc
     1861 gatgcagcta ttgtagatgc ttttgatttg gacttagttt ctggctatga tgctcactca
     1921 taagcagttc aaagtgatca gaggaaacct agttttatct tttgatgtgg caagaaccca
     1981 gctacttaga atctccttct gttttaataa aacttattat taatatta
//
