LOCUS       NM_017860               2085 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 56 (C1orf56), mRNA.
ACCESSION   NM_017860
VERSION     NM_017860.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2085)
  AUTHORS   Wang,Y., Zhao,W., Mei,S., Chen,P., Leung,T.Y., Lee,C.L.,
            Yeung,W.S.B., Ou,J.P., Liang,X. and Chiu,P.C.N.
  TITLE     Identification of Sialyl-Lewis(x)-Interacting Protein on Human
            Spermatozoa
  JOURNAL   Front Cell Dev Biol 9, 700396 (2021)
   PUBMED   34354992
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2085)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2085)
  AUTHORS   Alkebsi,L., Handa,H., Sasaki,Y., Osaki,Y., Yanagisawa,K., Ogawa,Y.,
            Yokohama,A., Hattori,H., Koiso,H., Saitoh,T., Mitsui,T.,
            Tsukamoto,N., Nojima,Y. and Murakami,H.
  TITLE     DNMT3B7 expression related to MENT expression and its promoter
            methylation in human lymphomas
  JOURNAL   Leuk Res 37 (12), 1662-1667 (2013)
   PUBMED   24094886
  REMARK    GeneRIF: DNMT3B7 overexpression might interfere with the normal DNA
            methylation mechanism required for silencing the MENT
            proto-oncogene, and may accelerate human lymphomagenesis.
REFERENCE   4  (bases 1 to 2085)
  AUTHORS   Hlady,R.A., Novakova,S., Opavska,J., Klinkebiel,D., Peters,S.L.,
            Bies,J., Hannah,J., Iqbal,J., Anderson,K.M., Siebler,H.M.,
            Smith,L.M., Greiner,T.C., Bastola,D., Joshi,S., Lockridge,O.,
            Simpson,M.A., Felsher,D.W., Wagner,K.U., Chan,W.C., Christman,J.K.
            and Opavsky,R.
  TITLE     Loss of Dnmt3b function upregulates the tumor modifier Ment and
            accelerates mouse lymphomagenesis
  JOURNAL   J Clin Invest 122 (1), 163-177 (2012)
   PUBMED   22133874
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358436.1, BC002469.2,
            HY211880.1 and AL590133.32.
            
            On May 17, 2019 this sequence version replaced NM_017860.4.
            
            Summary: This gene is a proto-oncogene whose promoter is methylated
            by DNA methyltransferase 3B (DNMT3B), which represses the
            proto-oncogene. However, a catalytically inactive isoform of DNMT3B
            is overexpressed in lymphomas, leading to hypomethylation of the
            proto-oncogene's promoter and derepression of the proto-oncogene.
            [provided by RefSeq, Sep 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002469.2, SRR1660805.111642.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368926.6/ ENSP00000357922.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AY358436.1         12-43
            33-1037             BC002469.2         1-1005
            1038-1461           HY211880.1         35-458              c
            1462-2085           AL590133.32        136990-137613
FEATURES             Location/Qualifiers
     source          1..2085
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2085
                     /gene="C1orf56"
                     /gene_synonym="MENT"
                     /note="chromosome 1 open reading frame 56"
                     /db_xref="GeneID:54964"
                     /db_xref="HGNC:HGNC:26045"
     exon            1..1102
                     /gene="C1orf56"
                     /gene_synonym="MENT"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1123
                     /gene="C1orf56"
                     /gene_synonym="MENT"
                     /note="methylated in normal thymocytes protein; protein
                     MENT"
                     /codon_start=1
                     /product="protein MENT precursor"
                     /protein_id="NP_060330.2"
                     /db_xref="CCDS:CCDS980.1"
                     /db_xref="GeneID:54964"
                     /db_xref="HGNC:HGNC:26045"
                     /translation="MVPAAGALLWVLLLNLGPRAAGAQGLTQTPTEMQRVSLRFGGPM
                     TRSYRSTARTGLPRKTRIILEDENDAMADADRLAGPAAAELLAATVSTGFSRSSAINE
                     EDGSSEEGVVINAGKDSTSRELPSATPNTAGSSSTRFIANSQEPEIRLTSSLPRSPGR
                     STEDLPGSQATLSQWSTPGSTPSRWPSPSPTAMPSPEDLRLVLMPWGPWHCHCKSGTM
                     SRSRSGKLHGLSGRLRVGALSQLRTEHKPCTYQQCPCNRLREECPLDTSLCTDTNCAS
                     QSTTSTRTTTTPFPTIHLRSSPSLPPASPCPALAFWKRVRIGLEDIWNSLSSVFTEMQ
                     PIDRNQR"
     exon            1103..2085
                     /gene="C1orf56"
                     /gene_synonym="MENT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1215..1220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf56"
                     /gene_synonym="MENT"
                     /note="hexamer: AACAAA"
     polyA_site      1233
                     /gene="C1orf56"
                     /gene_synonym="MENT"
                     /note="major polyA site"
     polyA_site      1687
                     /gene="C1orf56"
                     /gene_synonym="MENT"
     polyA_site      1798
                     /gene="C1orf56"
                     /gene_synonym="MENT"
ORIGIN      
        1 aaacgacccg gtgggtctac agcggaaggg agggagcgaa ggtaggaggc agggcttgcc
       61 tcactggcca ccctcccaac cccaagagcc cagccccatg gtccccgccg ccggcgcgct
      121 gctgtgggtc ctgctgctga atctgggtcc ccgggcggcg ggggcccaag gcctgaccca
      181 gactccgacc gaaatgcagc gggtcagttt acgctttggg ggccccatga cccgcagcta
      241 ccggagcacc gcccggactg gtcttccccg gaagacaagg ataatcctag aggacgagaa
      301 tgatgccatg gccgacgccg accgcctggc tggaccagcg gctgccgagc tcttggccgc
      361 cacggtgtcc accggcttta gccggtcgtc cgccattaac gaggaggatg ggtcttcaga
      421 agagggggtt gtgattaatg ccggaaagga tagcaccagc agagagcttc ccagtgcgac
      481 tcccaataca gcggggagtt ccagcacgag gtttatagcc aatagtcagg agcctgaaat
      541 caggctgact tcaagcctgc cgcgctcccc cgggaggtct actgaggacc tgccaggctc
      601 gcaggccacc ctgagccagt ggtccacacc tgggtctacc ccgagccggt ggccgtcacc
      661 ctcacccaca gccatgccat ctcctgagga tctgcggctg gtgctgatgc cctggggccc
      721 gtggcactgc cactgcaagt cgggcaccat gagccggagc cggtctggga agctgcacgg
      781 cctttccggg cgccttcgag ttggggcgct gagccagctc cgcacggagc acaagccttg
      841 cacctatcaa caatgtccct gcaaccgact tcgggaagag tgccccctgg acacaagtct
      901 ctgtactgac accaactgtg cctctcagag caccaccagt accaggacca ccactacccc
      961 cttccccacc atccacctca gaagcagtcc cagcctgcca cccgccagcc cctgcccagc
     1021 cctggctttt tggaaacggg tcaggattgg cctggaggat atttggaata gcctctcttc
     1081 agtgttcaca gagatgcaac caatagacag aaaccagagg taatggccac ttcatccaca
     1141 tgaggagatg tcagtatctc aacctctctt gccctttcaa tcctagcacc cactagatat
     1201 ttttagtaca gaaaaacaaa actggaaaac acattgtttg gtcttgtgtt tctttacaga
     1261 ggtacctgag ggaggagaga cataaatccc ttcatcccta agactgaact atgtaactag
     1321 cagcctctgg cttgttttct actccctgtc cctcaggata aaatgttgat attgctcatt
     1381 ttcctcattt ccaacattgt tttaaaacaa gtacttcttt tacaggcttg aaaaatctca
     1441 aataaacgct aagaaaaggg agtaggaaga acaaggagtt gagcccttga aagatgacag
     1501 tggtcttctt gccttcatgc ttggccctct ctcctcaaaa gggcaatgtt ggtacaaaat
     1561 tccatctcag ccactttcga ggagttatct tcattagcta tatccatcct ttaatccaac
     1621 acacacctgc aatgattact gtgcaactat tttgcttaat tttttatttg aaaaaatgta
     1681 tttaaaagtc caacaacttt ttaatataaa ttacgactct caaacccatt cccatcactt
     1741 tattagtgat ggtagcatac atattagaga aggtagctaa aggcaagaga gcaccaaagg
     1801 aaaaagactg tccaaagaac aggtattaga atgaggccga agatcacggt gaccagagat
     1861 ttctaggagt ctctaacctt tccaccctat cctgttaacc ctttagatct ctagtataac
     1921 actcaggcta ctgaggtatt ttagagcaac aagctgggtt actttcagag caaccagctt
     1981 gactggaact gagagtaaat tgggaatgta tgaccaatct tagaccctga aaaatggcag
     2041 aaaatacatg gaaatttgaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
