LOCUS       NM_024579                509 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 54 (C1orf54),
            transcript variant 3, mRNA.
ACCESSION   NM_024579
VERSION     NM_024579.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Xie,H., Wang,Y., Zhang,H., Fan,Q., Dai,D., Zhuang,L., Tao,R.,
            Chen,Q., Shen,W., Lu,L., Ding,X., Zhang,R. and Yan,X.
  TITLE     Tubular epithelial C1orf54 mediates protection and recovery from
            acute kidney injury
  JOURNAL   J Cell Mol Med 22 (10), 4985-4996 (2018)
   PUBMED   29999589
REFERENCE   2  (bases 1 to 509)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI342055.1, AK026874.1, BC017761.1 and AI004135.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024579.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            an alternate in-frame splice site in the 3' coding region, compared
            to variant 1. The encoded isoform (b) is shorter than isoform a.
            Variants 2 and 3 encode the same isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026874.1, AW005929.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369099.8/ ENSP00000358095.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AI342055.1         404-408             c
            6-388               AK026874.1         1-383
            389-501             BC017761.1         384-496
            502-509             AI004135.1         25-32               c
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..509
                     /gene="C1orf54"
                     /note="chromosome 1 open reading frame 54"
                     /db_xref="GeneID:79630"
                     /db_xref="HGNC:HGNC:26258"
     exon            1..74
                     /gene="C1orf54"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..424
                     /gene="C1orf54"
                     /note="isoform b precursor is encoded by transcript
                     variant 3; uncharacterized protein C1orf54"
                     /codon_start=1
                     /product="uncharacterized protein C1orf54 isoform b
                     precursor"
                     /protein_id="NP_078855.2"
                     /db_xref="CCDS:CCDS948.1"
                     /db_xref="GeneID:79630"
                     /db_xref="HGNC:HGNC:26258"
                     /translation="MDVLFVAIFAVPLILGQEYEDEERLGEDEYYQVVYYYTVTPSYD
                     DFSADFTIDYSIFESEDRLNRLDKDITEAIETTISLETARADHPKPVTVKPVTTEPSP
                     DLNDAVSSLRSPIPLLLSCAFVQVGMYFM"
     exon            75..158
                     /gene="C1orf54"
                     /inference="alignment:Splign:2.1.0"
     exon            159..217
                     /gene="C1orf54"
                     /inference="alignment:Splign:2.1.0"
     exon            218..328
                     /gene="C1orf54"
                     /inference="alignment:Splign:2.1.0"
     exon            329..427
                     /gene="C1orf54"
                     /inference="alignment:Splign:2.1.0"
     exon            428..509
                     /gene="C1orf54"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      509
                     /gene="C1orf54"
                     /note="major polyA site"
ORIGIN      
        1 ctttcacagc aatagtgcag aatccagaat ggatgtcctc tttgtagcca tctttgctgt
       61 gccacttatc ctgggacaag aatatgagga tgaagaaaga ctgggagagg atgaatatta
      121 tcaggtggtc tattattata cagtcacccc cagttatgat gactttagtg cagatttcac
      181 cattgattac tccatatttg agtcagagga caggctgaac aggttggata aggacataac
      241 agaagcaata gagactacca ttagtcttga aacagcacgt gcagaccatc cgaagcctgt
      301 aactgtgaaa ccagtaacaa cggaacctag tccagatctg aacgatgccg tgtccagttt
      361 gcgaagtcct attcccctcc tcctgtcgtg tgcctttgtt caggtgggga tgtatttcat
      421 gtagaaggtg gaagaaggct gctatgactc tttggatggg agtctggcaa gaggaaattg
      481 gaagataaaa taaataataa gtgaaataa
//
